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Tytuł:
Structural and biological characteristics of self-organising chitosan hydrogels
Autorzy:
Pieklarz, Katarzyna
Tylman, Michał
Modrzejewska, Zofia
Galita, Grzegorz
Majsterek, Ireneusz
Powiązania:
https://bibliotekanauki.pl/articles/2131528.pdf
Data publikacji:
2021
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
biomaterials
chitosan
cytotoxicity
self-organising hydrogels
structural properties
tissue engineering
Opis:
Creating innovative methods of treatment and regeneration of damaged tissues or organs is a key challenge of the twenty-first century. The aim of this study was to determine the possibility of producing and characterising the properties of self-organising chitosan hydrogels prepared with the use of chitosan lactate/chloride and disodium hydrogen phosphate dodecahydrate as a cross-linking agent. The structure and supramolecular architecture of the biomaterials were evaluated by Fourier-transform infrared spectroscopy and polarised optical microscopy. Biological studies assessed cytotoxicity by contact with a human colon adenocarcinoma cell line. The colourimetric resazurin assay showed that the obtained chitosan hydrogels are non-cytotoxic materials. Thus, self-organising biomaterials hold great promise for application in tissue engineering.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2021, 26; 191-199
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and potential cytotoxicity evaluation of carboxymethyl chitosan hydrogels
Autorzy:
Kłosiński, Karol K.
Girek, Małgorzata K.
Wach, Radosław A.
Czechowska-Biskup, Renata
Arkuszewski, Piotr T.
Szymański, Paweł B
Pasieka, Zbigniew
Powiązania:
https://bibliotekanauki.pl/articles/1034588.pdf
Data publikacji:
2017
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
PEGDA
XTT
carboxymethyl chitosan
cytotoxicity
hydrogel
radiation crosslinking
Opis:
The aim of the research was to employ radiation to produce flexible carboxymethyl chitosan (CMCS) based hydrogels of uniform structure to characterise their swelling properties and cytocompatibility for potential applications as hydrogel wound dressings. CMCS in aqueous solution was irradiated with an electron beam in the presence of a poly(ethylene glycol) diacrylate (PEGDA) macromonomer as a crosslinker, at 12 different compositions, i.e. 3–20% CMCS, 3 and 5% PEGDA. The obtained hydrogels were subjected to sol–gel analysis. The amount of insoluble fraction (up to 100%) rose with an increase in the PEGDA/polysaccharide ratio. Moreover, the equilibrium degree of swelling, ca. 15 to 200 g of water per g of gel, which was higher for lower content of crosslinker, decreased with the delivered dose, which was associated with an increase in crosslinking density. The in vitro XTT cell viability assay (murine fibroblasts, L929 cell line) showed no significant cytotoxicity of CMCS gels.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2017, 22; 82-96
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Chitosan hydrogels modified with silk, graphene oxide or reduced graphene oxide
Autorzy:
Szaraniec, Barbara
Boruchowski, Marcin
Gryń, Karol
Chłopek, Jan
Powiązania:
https://bibliotekanauki.pl/articles/1844967.pdf
Data publikacji:
2020
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
hydrogels
nanocomposites
chitosan
hydrożele
nanokompozyty
Źródło:
Engineering of Biomaterials; 2020, 23, 158 spec. iss.; 44
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Chitosan hydrogels modified with silk, graphene oxide or reduced graphene oxide
Autorzy:
Szaraniec, Barbara
Boruchowski, Marcin
Gryń, Karol
Chłopek, Jan
Powiązania:
https://bibliotekanauki.pl/articles/1844881.pdf
Data publikacji:
2020
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
hydrogels
nanocomposites
chitosan
hydrożele
nanokompozyty
chitozan
Źródło:
Engineering of Biomaterials; 2020, 23, 158 spec. iss.; 44
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis of chitosan and carboxymethyl chitosan hydrogels by electron beam irradiation
Autorzy:
Czechowska-Biskup, Renata
Wach, Radosław
Stojek, Piotr
Kamińska, Martyna
Rosiak, Janusz M.
Ulański, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1034681.pdf
Data publikacji:
2016
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
PEGDA
carboxymethyl chitosan
chitosan
hydrogel
radiation crosslinking
Opis:
Solutions of chitosan (CS) and carboxymethyl chitosan (CMCS) were subjected to irradiation by electron beam in presence of a crosslinking agent (poly(ethylene glycol) diacrylate - PEGDA) in order to produce carboxymethyl chitosan- and chitosan-based hydrogels. PEGDA macromonomer itself undergoes simultaneous polymerization and crosslinking either in neutral water or in acidic medium. Acidic solutions of chitosan of 0.5, 1 and 2% can be effectively crosslinked with PEGDA to form a gel. Although CMCS undergoes radiation-initiated crosslinking only at high concentration in water (over 10%), the presence of PEGDA in solution facilitated hydrogel formation even at lower concentration of CMCS. Formation of CS and CMCS hydrogels required irradiation doses lower than those needed for sterilization, i.e. 25 kGy, in some cases even as low as 200 Gy. Sol-gel analysis revealed relatively high gel fraction of obtained hydrogels, up to 80%, and good swelling ability. Both parameters can be easily controlled by composition of the initial solution and irradiation dose. Possible mechanisms of crosslinking reactions were proposed, involving addition of the polysaccharide macroradicals to a terminal double bond of PEGDA.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 27-45
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fabrication and characterization of graphene-loaded chitosan hydrogels with cross-linking gradient
Autorzy:
Kosowska, K.
Domalik-Pyzik, P.
Chłopek, J.
Powiązania:
https://bibliotekanauki.pl/articles/285566.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
hydrogels
chitosan
nanocomposites
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 40
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preparation and characterization of a new generation of chitosan hydrogels containing pyrimidine ribonucleotides
Autorzy:
Pieklarz, Katarzyna
Tylman, Michał
Modrzejewska, Zofia
Powiązania:
https://bibliotekanauki.pl/articles/1034023.pdf
Data publikacji:
2020
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
biomaterial
chitosan
hydrogel
neural tissue regeneration
Opis:
Damage to the nervous system, in particular spinal cord injuries, is a burden for the patient and is usually the cause of irreversible disability. The progress observed in the last decade in the fields of biology, biomaterial engineering and neurosurgery has created new treatment solutions while preventing further neurodegenerative processes. The most important research is focused on the implementation of polymer structures in clinical practice, especially chitosan hydrogels, which are the scaffolds for regenerating axons. This article presents a new generation of biomaterials that have the ability to gel in response to temperature changes; they are intended for injectable scaffolds for nerve cell cultures. Two types of hydrogels were prepared based on chitosan lactate and chitosan chloride using uridine 5’-monophosphate disodium salt. The structure of the systems was observed under a scanning electron microscope and examined using Fourier transform infrared spectroscopy. In addition, thermal properties were tested using differential scanning calorimetry.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2020, 25; 192-200
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Characteristics of physicochemical and rheological properties of chitosan hydrogels based on selected hydroxyacids
Autorzy:
Zavyalova, Olga
Gajewska, Sandra
Dąbrowska-Wisłocka, Dominika
Sionkowska, Alina
Powiązania:
https://bibliotekanauki.pl/articles/1844766.pdf
Data publikacji:
2021
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Źródło:
Engineering of Biomaterials; 2021, 24, 163; 92
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Acceleration of gelation and promotion of mineralization of chitosan hydrogels by alkaline phosphatase
Autorzy:
Douglas, T. E. L.
Skwarczyńska, A.
Modrzejewska, Z.
Balcaen, L.
Schaubroeck, D.
Lycke, S.
Vanhaecke, F.
Vandenabeele, P.
Dubruel, P.
Jansen, J. A.
Leeuwenburgh, S. C. G.
Powiązania:
https://bibliotekanauki.pl/articles/284363.pdf
Data publikacji:
2012
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
chitosan
thermosensitivity
composite
mineralization
Opis:
Thermosensitive chitosan hydrogels containing sodium beta-glycerophosphate (ß-GP), whose gelation is induced by increasing temperature to body temperature, were functionalized by incorporation of Alkaline Phosphatase (ALP), an enzyme involved in mineralization of bone. ALP incorporation led to acceleration of gelation upon increase of temperature for four different chitosan preparations of differing molecular weight, as demonstrated by rheometric time sweeps at 37°C. Hydrogels containing ALP were subsequently incubated in calcium glycerophosphate (Ca-GP) solution to induce their mineralization with calcium phosphate (CaP) in order to improve their suitability as materials for bone replacement. Incorporated ALP retained its bioactivity and induced formation of CaP mineral, as confirmed by SEM, FTIR, Raman spectroscopy, XRD, ICP-OES, and increases in dry mass percentage, which rose with increasing ALP concentration and incubation time in Ca-GP solution. The results demonstrate that ALP accelerates formation of thermosensitive chitosan/ß-GP hydrogels and induces their mineralization with CaP, which paves the way for applications as injectable bone replacement materials.
Źródło:
Engineering of Biomaterials; 2012, 15, no. 116-117 spec. iss.; 135-136
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Characterization of graphene oxide-loaded chitosan hydrogels and their application for 3D printing
Autorzy:
Domalik-Pyzik, P.
Chłopek, J.
Powiązania:
https://bibliotekanauki.pl/articles/286115.pdf
Data publikacji:
2017
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
hydrogels
graphene
chitosan
Źródło:
Engineering of Biomaterials; 2017, 20, no. 143 spec. iss.; 83
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Characteristics of physicochemical and rheological properties of chitosan hydrogels based on selected hydroxy acids
Autorzy:
Zavyalova, Olga
Gajewska, Sandra
Dąbrowska-Wisłocka, Dominika
Sionkowska, Alina
Powiązania:
https://bibliotekanauki.pl/articles/2058389.pdf
Data publikacji:
2021
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
chitosan
lactobionic acid
mandelic acid
rheology
FTIR spectra
chitozan
reologia
hydrożele
Opis:
Chitosan is a natural cationic polymer that dissolves in an acidic environment and forms gels. Its properties depend on the degree of deacetylation and molecular weight. It is a bioactive compound with antibacterial and film-forming properties that allow to increase the regenerative capacity of the skin. Moreover, it is biodegradable, biocompatible, non-toxic, and stable. In this research, chitosan was combined with mandelic and lactobionic acids which are characterized by biological activity and low toxicity. This combination not only has a positive effect on the chitosan solubility, but it also allows to obtain new biomaterials whose positive features of the base ingredients are enhanced by their synergistic effect. The obtained hydrogels were assessed regarding the interaction of chitosan and hydroxy acid molecules, and the stability of the resulting structures was examined. The research was performed by using rheological methods and IR spectroscopy. Chitosan hydrogels made with mandelic acid are characterized by higher viscosity values, as compared to hydrogels containing lactobionic acid. The samples of the obtained hydrogels stored for 7 days showed no signs of degradation and their viscosity values were constantly increasing, which proves the ongoing process of creating new bonds between hydroxy acid molecules and chitosan chains. After this time, the hydrogels with mandelic acid revealed higher viscosity values in comparison to hydrogels made with lactobionic acid. Based on the obtained IR spectra, the shifts of the characteristic chitosan bands as a result of interaction with the tested hydroxy acids were analyzed.
Źródło:
Engineering of Biomaterials; 2021, 24, 161; 2--7
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Application of texture profile analysis to investigate the mechanical properties of thermosensitive injectable chitosan hydrogels
Autorzy:
Owczarz, Piotr
Rył, Anna
Wichłacz, Żaneta
Powiązania:
https://bibliotekanauki.pl/articles/1034254.pdf
Data publikacji:
2019
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
TPA
chitosan
hydrogels
injectable scaffolds
mechanical properties
Opis:
In this paper, the mechanical properties of hybrid chitosan hydrogels were investigated using the texture profile analysis test. Scaffolds obtained from a polysaccharide of various molecular weights were studied, which, with the addition of glycerophosphate salt, formed a three-dimensional structure in vivo. The obtained systems were also enriched with collagen and calcium carbonate to improve the mechanical properties. The determined texture parameter values indicate that the mechanical properties of the hybrid hydrogel depend on the molecular weight of the polymer, the type of solvent and, the pH-neutralizing substance, as well as the type and concentration of the filler. Moreover, in some cases the TPA test was the only way to evaluate the mechanical properties of the obtained hydrogels due to the inability to determine the Young's modulus. Consequently, the texture analysis test is a valuable tool for selecting solutions depending on the intended application of the scaffolds.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2019, 24; 151-163
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Enrichment of thermosensitive chitosan hydrogels with glycerol and alkaline phosphatase for bone tissue engineering applications
Autorzy:
Douglas, T. E. L.
Krok-Borkowicz, M.
Macuda, A.
Pietryga, K.
Pamuła, E.
Powiązania:
https://bibliotekanauki.pl/articles/306906.pdf
Data publikacji:
2016
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
biomateriały
kompozyty
mineralizacja
hydrożel
biomaterials
composites
mineralization
hydrogels
Opis:
Thermosensitive injectable chitosan hydrogels can be formed by neutralization of acidic chitosan solutions with sodium betaglycerophosphate (Na-β-GP) coupled with increasing temperature to body temperature. Such hydrogels have been considered for applications in bone regeneration. In this study, chitosan hydrogels were enriched with glycerol and the enzyme alkaline phosphatase (ALP) with a view to improving their suitability as materials for bone tissue engineering. Mineral formation was confirmed by infrared spectroscopy (FTIR) and increases in the mass fraction of the hydrogel not consisting of water. Incorporation of ALP in hydrogels followed by incubation in a solution containing calcium ions and glycerophosphate, a substrate for ALP, led to formation of calcium phosphate within the hydrogel. MG-63 osteoblast-like cells were cultivated in eluates from hydrogels containing ALP and without ALP at different dilutions and directly on the hydrogel samples. Hydrogels containing ALP exhibited superior cytocompatibility to ALP-free hydrogels. These results pave the way for the use of glycerol- and ALP-enriched hydrogels in bone regeneration.
Źródło:
Acta of Bioengineering and Biomechanics; 2016, 18, 2; 51-57
1509-409X
2450-6303
Pojawia się w:
Acta of Bioengineering and Biomechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Structural characteristics of thermosensitive chitosan glutaminate hydrogels
Autorzy:
Modrzejewska, Zofia
Nawrotek, Katarzyna
Zarzycki, R
Douglas, Timothz
Powiązania:
https://bibliotekanauki.pl/articles/1035319.pdf
Data publikacji:
2013
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
chitosan
hydrogel
natural polymer
structural properties
Opis:
Hydrogels that possess the ability of gelling in response to changes in the local environment, such as pH or temperature, have been examined extensively recently. In this paper the properties of thermosensitive chitosan hydrogels prepared with the use of chitosan glutaminate and -glycerophosphate are presented. The sol/gel transition point was determined based on the rheological properties. The structure of gels was observed under the Scanning Electron Microscopy (SEM) and was investigated by thermogravimetric (TG) and differential themogravimetric (DTG) analy¬sis and infrared (IR) spectroscopy. The crystallinity of gel structure was determined by X-ray Diffraction analysis (XRD).
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2013, 18, 18; 93-105
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wpływ promieniowania mikrofalowego oraz UV na właściwości hydrożeli chitozanowych
Influence of microwave and UV radiation on properties of chitosan hydrogels
Autorzy:
Bialik-Wąs, K.
Kudłacik, S.
Drabczyk, A.
Tyliszczak, B.
Powiązania:
https://bibliotekanauki.pl/articles/101311.pdf
Data publikacji:
2016
Wydawca:
Polska Akademia Nauk. Stowarzyszenie Infrastruktura i Ekologia Terenów Wiejskich PAN
Tematy:
hydrożele
chitozan
Beetosan
promieniowanie UV
promieniowanie mikrofalowe
hydrogels
chitosan
UV radiation
microwave radiation
Opis:
W prezentowanym artykule porównano wpływ promieniowania mikrofalowego oraz UV na przebieg reakcji sieciowania hydrożeli chitozanowych. Syntezy prowadzono zarówno w oparciu o chitozan komercyjny, jak i Beetosan - chitozan pochodzący z pszczół z osypu zimowego oraz dla układów mieszanych chitozan - Beetosan. Otrzymane materiały hydrożelowe zostały poddane badaniom zdolności pęcznienia i badaniom inkubacyjnym w wodzie destylowanej oraz symulowanych płynach ustrojowych. Ponadto, dla wybranych układów określono morfologię powierzchni przy użyciu skaningowego mikroskopu elektronowego. Wyznaczono również kąty zwilżania θ metodą geometryczną poprzez naniesienie kropli cieczy na powierzchnię badanego materiału.
In this paper, the impact on microwave radiation and UV cross-linking of the course of reaction of obtaining chitosan hydrogels was presented. The synthesis were conducted using either commercial chitosan and Beetosan - chitosan derived from naturally died honeybees as well as using mixed systems containing both chitosan and Beetosan. The swelling capacity of obtained hydrogel materials as well as their tendency to degradation in distilled water and simulated body fluid have been tested. Moreover, morphology of the surface of selected samples using scanning electron microscope was characterized. Furthermore, the contact angles (θ) of attained materials were defined using geometrical method by applying a drop of liquid on the surface of the tested material.
Źródło:
Infrastruktura i Ekologia Terenów Wiejskich; 2016, II/2; 605-614
1732-5587
Pojawia się w:
Infrastruktura i Ekologia Terenów Wiejskich
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis of bees’ chitosan based hydrogels containing Aloe vera
Autorzy:
Kudłacik-Kramarczyk, S.
Drabczyk, A.
Tyliszczak, B.
Powiązania:
https://bibliotekanauki.pl/articles/101614.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Stowarzyszenie Infrastruktura i Ekologia Terenów Wiejskich PAN
Tematy:
beetosan
chitosan
hydrogels
Aloe vera
bees
waste management
Opis:
Chitosan based hydrogels due to their specific properties and structure belong to the group of materials widely used in medicine. They are used as drug carriers with controlled release of active substances and in the preparation of innovative wound dressings. The main aim of the conducted research was the choice of the most favorable parameters for carrying the cross-linking reaction by means of UV radiation and microwaves. Subsequently, an adequate composition of the mixture containing chitosan and gelatin for further modification of such prepared the polymer matrix with Aloe vera extract was selected. Subsequently, an impact of introduction of Aloe vera extract into hydrogel on its physicochemical properties and structure was determined. The scope of the research included the measurement of swelling abilities of hydrogels in distilled water and selected simulated body fluids as well as incubation studies aimed at determination of tendency of prepared materials to degradation in previously mentioned fluids and their compatibility in relation to such environments. In order to characterize the chemical structure of the polymers and impact of incubation on this structure spectroscopic analysis was performed. Microscopic analysis was used to define the surface morphology of the hydrogels. Moreover, materials containing Aloe vera extract were subjected to the studies of release of additive from hydrogel matrix. Research was conducted both in acid and alkaline environment.
Źródło:
Infrastruktura i Ekologia Terenów Wiejskich; 2017, IV/2; 1687-1698
1732-5587
Pojawia się w:
Infrastruktura i Ekologia Terenów Wiejskich
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wpływ substancji czynnych na własności reologiczne hydrożeli chitozanowych w pobliżu granicy przejścia fazowego zol-żel
Influence of active substances on rheological properties of chitosan hydrogels near sol-gel phase transition
Autorzy:
Owczarz, P.
Modrzejewska, Z.
Powiązania:
https://bibliotekanauki.pl/articles/2071912.pdf
Data publikacji:
2012
Wydawca:
Stowarzyszenie Inżynierów i Techników Mechaników Polskich
Tematy:
chitozan
hydrożele
reologia hydrożeli
matryce polimerowe
chitosan
hydrogel
rheology of hydrogels
polymeric network
Opis:
W pracy przedstawiono wyniki badań Teologicznych hydrożeli chitozanowych tworzących matrycę polimerową dla substancji czynnych. Jako substancje czynne stosowano albuminę wołową oraz wankomycynę. Inhibitorem przejścia fazowego zol-żel była zmiana temperatury roztworu. Wyznaczone własności reologiczne oraz krzywe temperaturowe roztworów wykazały, że w przypadku albuminy otrzymany roztwór zachowuje podobne własności jak wyjściowy roztwór chitozanu. W przypadku wankomycyny zainicjowany zmianą temperatury proces żelowania prowadzi do wytworzenia nieodwracalnej struktury.
Rheological properties of chitosan hydrogels forming polymeric network for active substances are presented in the paper. Bovine serum albumin and vancomycin were used as active substances. A change in solution tem-perature acted as an inhibitor of sol-gel phase transition. The determined rheological properties and temperature curves of solutions showed properties similar to those of initial chitosan solution. In case of vancomycin the gelation process initiated by a temperature change led to the formation of irreversible structure.
Źródło:
Inżynieria i Aparatura Chemiczna; 2012, 6; 364-365
0368-0827
Pojawia się w:
Inżynieria i Aparatura Chemiczna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and characterization of novel chitosan nanocomposite hydrogels for drug delivery and bone tissue engineering
Autorzy:
Pazdan, K.
Pielichowska, K.
Chłopek, J.
Powiązania:
https://bibliotekanauki.pl/articles/285119.pdf
Data publikacji:
2013
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
nanocomposites
tissue engineering
hydrogels
Opis:
Biodegradable materials for drug delivery and bone tissue engineering are currently intensively developing and improving, but there are still a lot of problems to solve related with bioactivity, biocompatibility, release profile etc. Osteosarcoma is an aggressive malignant neoplasm arising from primitive transformed cells of mesenchymal origin that exhibit osteoblastic differentiation and produce malignant osteoid. It is the most common histological form of primary bone cancer [1,2]. Treatment is most destinations and made up for: intensive multidrug short induction chemotherapy, amputation or tumor resection within the limits of normal tissue and in the last phase again chemotherapy. This kind of neoplasm is most recently detected in young male till 25 age, therefore improving methods of treatment is so important. Chitosan is a natural-based polymer obtained by alkaline deacetylation of chitin received from powdered shrimp shells was purchased from Acros Organics. Its main advantages are non-toxic, non-immunogenic, non-carcinogenic degradation products, biocompatible, bioactive and biodegradable. These properties cause chitosan a very good candidate for novel hydrogel drug delivery systems. Chitosan easily forms hydrogel particles and entraps biomolecules through a number of mechanisms, including chemical crosslinking, ionic crosslinking, and ionic complexation [3,4]. A possible alternative of chitosan by the chemical modification also has been useful for the association of bioactive molecules to polymer and controlling the drug release profile. There are few methods of modification, or example.: copolimerization, grafting, chemical and ionic crosslinking, polyelectrolyte complexes, etc [5]. Previous studies demonstrated that chitosan could promote the proliferation and osteogenesis but only with moderate swelling ratio of composite, too high ability of entrapment water solutions are not recommended. There are a lot of advantages in chitosan properties that can be used in research work to obtain the material of the best expected properties. Laponite® (LA) is a plate-like synthetic clay hectoritetype belongs to a family of phyllosolicates type 2:1 [6]. Its structure represent empirical formula: Na0.7+[Si8Mg5.5Li0.3 O20(OH)4]0.7-. The plates size is about 25 nm x 0,92 nm. LA has a large surface area, anionic surface charges and exchangeable Na+ cations in hydrated interlayers. Presence of sodium cations causes better adsorption properties for cationic drug molecules. Moreover, the exfoliated LA particles may act as multifunctional crosslinkers in forming the nanocomposite hydrogels, and the polymer chains were anchored to the particles and entangled to form a network [7]. Used synthetic clay has got the same type structure and but better sorption properties to montmorillonite but it has got serious advantage - as a synthetic compound shows low heavy metal content. The initial results indicate that the incorporation of clay improved the swelling behavior in contrast to the pure chitosan beads. There also had been revealed significant disproportion of viscosity received hydrogels according to different type of LA or different concentration. Increasing content causes telling rise of viscosity, especially reported in higher content of used crosslinker. The aim of research is to develop a bioactive system biopolymer/layered silicate intelligent nanocomposite based on chitosan and synthetic clay by a cross-linking reaction using sodium tripolyphosphate as the gel factor. The resultant composite were characterized by Fourier transform infrared spectroscopy, scanning electronic microscope and X-ray diffraction analysis. The bioactivity in physiological pH solution (SBF pH=7.40) [8], drug encapsulation efficiency and controlled release behaviour were also investigated by using the model drug to reveal the effects of introduced LA.
Źródło:
Engineering of Biomaterials; 2013, 16, no. 122-123 spec. iss.; 1-2
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of shear direction on gelation ability of colloidal chitosan solutions
Autorzy:
Rył, Anna
Owczarz, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/185096.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
sol-gel phase transition
chitosan hydrogels
rheometry measurements
oscillatory shear
rotational shear
hydrożel chitozanowy
pomiar reometrii
ścinanie oscylacyjne
ścinanie rotacyjne
Opis:
This paper discusses the influence of the direction of applied deformation on the ability to gelation of thermosensitive chitosan hydrogels. The application of the shear rate equal in value to the classically performed oscillatory measurements leads to significantly different shapes of experimental curves. It was found that the type of mechanically applied deformation has a significant impact on the gelation ability of colloidal chitosan solutions and conditions of sol-gel phase transition. Simple shear leads to a phase transition at a lower temperature or in a shorter time compared to oscillatory tests. Moreover, based on the final values of dynamic viscosity in rotational measurements, it was found that stronger crosslinking of the polymer structure was observed.
Źródło:
Chemical and Process Engineering; 2019, 40, 2; 207--212
0208-6425
2300-1925
Pojawia się w:
Chemical and Process Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Double crosslinking of chitosan/vanillin hydrogels as a basis for mechanically strong gradient scaffolds for tissue engineering
Autorzy:
Hunger, Martyna
Domalik-Pyzik, Patrycja
Reczyńska, Katarzyna
Chłopek, Jan
Powiązania:
https://bibliotekanauki.pl/articles/1844976.pdf
Data publikacji:
2020
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
hydrogel
chitosan
vanillin
tripolyphosphate
tissue engineering
Opis:
Polysaccharides, such as chitosan (CS), are widely used in many biomedical applications. However, they require crosslinking agents to achieve chemical stability and appropriate mechanical properties. In this work, chitosan-based hydrogels were crosslinked using vanillin and/or sodium tripolyphosphate, as chemical and physical crosslinking agents, respectively. Microstructural (digital microscope, SEM), structural (FTIR-ATR), mechanical (static compression test), and in vitro biological (chemical stability and swelling ratio in PBS, cytotoxicity) properties of the obtained materials were evaluated to assess materials potential as biomedical scaffolds. The optimal ratio of vanillin to chitosan (DD = 89%) to crosslink the polymer was found to be 1.2:1. Moreover, the double crosslinking with vanillin caused a two-time increase in the compression strength of the samples and led to the slower biodegradability. Cytotoxicity studies showed that the cells prefer double vanillin crosslinked hydrogels over those treated with TPP. Further studies, such as bioactivity are required to determine the specific functionality of the hydrogels and the specific tissue which may be treated with the tested materials. The optimal material was chosen to the next step of the study, which may be obtaining composite hydrogels with hydroxyapatite and/or graphene oxide to tailor or improve properties towards specific tissue regeneration.
Źródło:
Engineering of Biomaterials; 2020, 23, 155; 2-11
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Chitosan/poly(vinyl alcohol) hydrogels as controlled drug delivery systems
Autorzy:
Kocemba, Aleksandra
Mucha, Maria
Powiązania:
https://bibliotekanauki.pl/articles/1034608.pdf
Data publikacji:
2017
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
chitosan/PVA hydrogel
gentamicin
glutaraldehyde
release kinetics
swelling
Opis:
In order to achieve hydrogel and drug release profiles, a comprehensive knowledge of the types, properties and syntheses of hydrogel polymer networks are needed. For this reason, a natural biopolymer hydrogel based on chitosan was described. Chitosan has many advantages, which meet the requirements necessary for the preparation of medical materials; for example, wound dressings. This article focused on the biomedical use of a chitosan hydrogel: chitosan–poly(vinyl alcohol) (PVA). The method of preparation of hydrogels containing a drug as an active wound dressing was described. To obtain a hydrogel dressing to be applied in patients with burns or difficult curative wounds, gentamicin (an aminoglycoside antibiotic) was used as a medicament. The effect of the PVA concentration in hydrogels on the release rate of the antibiotic was examined. For this, the crosslinking agent of the hydrogel, glutaraldehyde, was used. The release process of gentamicin was described by using an equation of first order kinetics.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2017, 22; 97-105
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cytotoxicity of chitosan based thermo-sensitive hydrogels intended for nervous tissue engineering
Autorzy:
Nawrotek, Katarzyna
Modrzejewska, Zofia
Paluch, Danuta
Zarzycki, Roman
Rusak, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/1034899.pdf
Data publikacji:
2015
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
Chitosan
biomaterial
hydrogel
nervous tissue regeneration
Opis:
The damage to the central nervous system is one of the most difficult cases of trauma to treat. Over the last few years, increasing attention has been focused on the development of strategies based on biomaterials for regeneration and repair of the spinal cord injury. In particular, materials in the form of hydrogels based on chitosan are being actively investigated due to their intrinsic properties that are favorable in spinal cord tissue regeneration. The purpose of this study was to develop a thermo-gelling chitosan solution that will be prepared with the use of acids that naturally occur in the human nervous tissue. For this purpose, two types of chitosan gels were prepared based on chitosan glutamate and chitosan lactate. In order to reduce toxic action of the system obtained gels were conditioned in distilled water with pH 5.00. The changes in the structures of systems obtained were determined with the use of FTIR method. Biocompatibility was primarily evaluated through cytotoxicity testing by MTT assay with respect to mouse fibroblast cells.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2015, 20; 222-235
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mechanical properties of hydrogels in a chitosan/ silk/graphene system
Autorzy:
Boruchowski, Marcin
Gryń, Karol
Szaraniec, Barbara
Chłopek, Jan
Powiązania:
https://bibliotekanauki.pl/articles/1844939.pdf
Data publikacji:
2020
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
hydrogels
chitosan
mechanical properties
hydrożele
właściwości mechaniczne
Źródło:
Engineering of Biomaterials; 2020, 23, 158 spec. iss.; 45
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mechanical properties of hydrogels in a chitosan/ silk/graphene system
Autorzy:
Boruchowski, Marcin
Gryń, Karol
Szaraniec, Barbara
Chłopek, Jan
Powiązania:
https://bibliotekanauki.pl/articles/1844879.pdf
Data publikacji:
2020
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
hydrogels
chitosan
mechanical properties
hydrożele
chitozan
właściwości mechaniczne
Źródło:
Engineering of Biomaterials; 2020, 23, 158 spec. iss.; 45
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of substrate composition on the physicochemical properties of hydrogels with chitosan
Autorzy:
Szcześniak, Maria
Grimling, Bożena
Meler, Jan
Pluta, Janusz
Powiązania:
https://bibliotekanauki.pl/articles/1034687.pdf
Data publikacji:
2016
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
Carbopl 934P
PVP
chitosane
hydrogels
pharmaceutical availability
rheological parameters
Opis:
The aim of the study was to evaluate the effect of Carbopol 934 P and PVP K 90 on the rheological properties of chitosan gels. Hydrogels were prepared with hydrocortisone containing chitosan, Carbopl 934P, PVP, propylene glycol-1,2 or polyethyleneglycol 400 and glycerol. Addition of polymers had positive influence on the dispersion of hydrogels. The studied gels have thixotropic properties, their viscosity increases with the increase of the concentration of polymers. Increase of the content of polyvinylpyrrolidone K 90 and Carbopol 934 P increases the consistence, gels are more firm and cohesive. Gels with 5 % chitosane, 15% polyvinylpyrrolidone K 90 and Carbopol 934 P in the presence of additives have prolonged half release period of hydrocortisone.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 187-191
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-25 z 39

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