Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Yкраїнський (UK)
Przejdź do strony domowej biblioteki Centralna Biblioteka Wojskowa Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaCentralna Biblioteka Wojskowa

Wyszukujesz frazę "cell adhesion" wg kryterium: Wszystkie pola

  Lista filtrów
Wyrównaj
Wyświetlanie 1-15 z 31
Tytuł:
Vascular smooth muscle cells in cultures on low density polyethylene modified with plasma discharge and biofunctionalization
Autorzy:
Parizek, M.
Kasalkova, N.
Bacakova, L.
Kolarova, K.
Lisa, V.
Svorcik, V.
Powiązania:
https://bibliotekanauki.pl/articles/285087.pdf
Data publikacji:
2009
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
Ar plasma discharge
biomaterials
low-density polyethylene
cell adhesion
cell proliferation
grafting
tissue engineering
vascular smooth muscle cells
Opis:
Low density polyethylene (LDPE) was modified by an Ar plasma discharge and then grafted with glycine (Gly), bovine serum albumin (BSA) or polyethylene glykol (PEG). Some plasma-treated samples and samples grafted with BSA were exposed to a suspension of colloidal carbon particles (C, BSA+C). Pristine LDPE and tissue culture polystyrene dishes (PSC) were used as control samples. The materials were seeded with rat aortic smooth muscle cells and incubated in a medium DMEM with 10% of fetal bovine serum. On day 1 after seeding, the cells on LDPE modified with plasma only, Gly, BSA and BSA+C adhered in similar numbers as on PSC, while the values on non-modified and PEG-modified samples were significantly lower. On day 5, the highest cell numbers were found again on LDPE with Gly, BSA and BSA+C. On day 7, the highest number of cells was found on LDPE modified only with plasma. The latter cells also dis-played the largest cell spreading area. The increased cell colonization was probably due to the formation of oxygen-containing chemical functional groups after plasma irradiation, and also due to positive effects of grafted Gly, BSA and BSA in combination with colloidal C particles.
Źródło:
Engineering of Biomaterials; 2009, 12, no. 89-91; 25-28
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ultrasound conditioning of Streptococcus thermophilus CNRZ 447: growth, biofilm formation, exopolysaccharide production, and cell membrane permeability
Autorzy:
Khadem, H.
Tirtouil, A.M.
Drabo, M.S.
Boubakeur, B.
Powiązania:
https://bibliotekanauki.pl/articles/2096999.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Streptococcus thermophilus
ultrasound conditioning
bacterial adhesion
biofilm
exopolysaccharides
Opis:
Sonication is one of the new and innovative approaches that is being increasingly used in food industry to control fermentation processes and to eradicate spoiling. Recently, this approach has seen new industrial applications such as enhancing microbial productivity. The present study aimed to assess the effects of ultrasound conditioning on the metabolism and extracellular matrix production of Streptococcus thermophilus. Bacterial suspensions were treated in ultrasonic bath (35 kHz, 240/60 W peak/nominal power, 1.8 l capacity) for different time periods (5, 10, 15, 20, 30, 45, and 65 min), and the growth improvement, adhesion ability, biofilm formation, and exopolysaccharide production of the bacterial strain were measured. The bacterial strain exhibited resistance to the treatment, and the conditioning improved the growth, adhesion, membrane permeability, biofilm formation, and exopolysaccharide production ability. An optimal treatment was obtained for 30 minutes of conditioning. An excellent yield of desirable exopolysaccharides (1788 mg glucose equivalent/l) was achieved. Ultrasound conditioning may be used as a potential approach to enhance certain biotechnological properties of industrial microorganisms.
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2020, 101, 2; 159-165
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
TSD1 (TUMORUS SHOOT DEVELOPMENT1) and TSD2 genes related with cell wall function are involved in somatic embryogenesis induced in vitro in Arabidopsis
Autorzy:
Kudelko, K.
Grzybkowska, D.
Gaj, M.D.
Powiązania:
https://bibliotekanauki.pl/articles/80111.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
TSD1 gene
TSD2 gene
cell wall
somatic embryogenesis
Arabidopsis
cellulose biosynthesis
methyltransferase
cell adhesion
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The viability and intestinal epithelial cell adhesion of probiotic strain combination - in vitro study
Autorzy:
Piatek, J.
Gibas-Dorna, M.
Olejnik, A.
Krauss, H.
Wierzbicki, K.
Zukiewicz-Sobczak, W.
Glowacki, M.
Powiązania:
https://bibliotekanauki.pl/articles/52041.pdf
Data publikacji:
2012
Wydawca:
Instytut Medycyny Wsi
Opis:
To be effective, probiotic bacteria must exhibit a number of functional characteristics, including the resistance to gastric acidity and the ability to adhere to the intestinal epithelium. In this study, we examined in vitro the viability of lactic acid bacteria (LAB) combination after exposure to low pH, and the adhesion of LAB to Caco-2 cells during coincubation of 9 bacterial strains. To test bacterial viability, 6 commercially available products were incubated in 0.1 N HCl at pH 1.2 for 60 min. The greatest growth inhibition was noted for the non-capsulated product containing the Lactobacillus rhamnosus strain (log reduction of CFU = 6.4), and the best survival observed for the product containing 9 bacterial strains, equipped with a modern capsule made according to the Multi-Resistant Encapsulation technology (log reduction of CFU = 0.1). In the adhesion experiment, the combination of 9 bacterial strains was added to 17-day-old Caco-2 cell culture for 90 min. The greatest efficiency of adhesion was observed for the inoculum containing 5.5 × 108 CFU/mL/9.6 cm2 of Caco-2 and the dose of probiotic bacteria of 190 cells per one Caco-2 cell. As a result, approximately 157 bacterial cells adhered to one Caco-2 cell. The results indicate that the combination of 9 bacterial strains in the examined product is characterized as highly adhesive.
Źródło:
Annals of Agricultural and Environmental Medicine; 2012, 19, 1
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The role of cell adhesion molecule in cancer progression and its application in cancer therapy.
Autorzy:
Okegawa, Takatsugu
Pong, Rey-Chen
Li, Yingming
Hsieh, Jer-Tsong
Powiązania:
https://bibliotekanauki.pl/articles/1043281.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cancer gene therapy
gene
cell adhesion molecules
tumor progression
tumor suppressor
Opis:
Multiple and diverse cell adhesion molecules take part in intercellular and cell-extracellular matrix interactions of cancer. Cancer progression is a multi-step process in which some adhesion molecules play a pivotal role in the development of recurrent, invasive, and distant metastasis. A growing body of evidence indicates that alterations in the adhesion properties of neoplastic cells play a pivotal role in the development and progression of cancer. Loss of intercellular adhesion and the desquamation of cells from the underlying lamina propria allows malignant cells to escape from their site of origin, degrade the extracellular matrix, acquire a more motile and invasion phenotype, and finally, invade and metastasize. In addition to participating in tumor invasiveness and metastasis, adhesion molecules regulate or significantly contribute to a variety of functions including signal transduction, cell growth, differentiation, site-specific gene expression, morphogenesis, immunologic function, cell motility, wound healing, and inflammation. Cell adhesion molecule (CAM), a diverse system of transmembrane glycoproteins has been identified that mediates the cell-cell and cell-extracellular matrix adhesion and also serves as the receptor for different kinds of virus. We summarize recent progress regarding the role of CAM, particularly, immunoglobulin-CAMs and cadherins in the progression of cancer and discuss the potential application of CAMs in the development of cancer therapy mainly on urogenital cancer.
Źródło:
Acta Biochimica Polonica; 2004, 51, 2; 445-457
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of titanium alloy modified with a-C:N:H and a-SiCxNY(H) coatings on adhesion and immune response of human osteoblast-like MG-63 cells
Autorzy:
Ścisłowska-Czarnecka, A.
Menaszek, E.
Kołaczkowska, E.
Januś, M.
Stypuła, B.
Powiązania:
https://bibliotekanauki.pl/articles/284995.pdf
Data publikacji:
2008
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
titanium alloy
a-C:N:H and a-SiCxNy(H) coatings
osteoblast-like MG-63 cells
cell adhesion
cytokines
Opis:
The study was conducted in order to determine the effects of modified titanium alloy (Ti-6Al-4V) surfaces on the biological response of a human osteoblast-like cell line. MG-63 cells were cultured on disk-shaped Ti-alloys: unmodified, and covered with a-C:N:H or a-SiCxNy(H) layers. Interactions between materials and cells were examined through determination of cells adhesion and secretion of cytokines involved in the development of immune response.
Źródło:
Engineering of Biomaterials; 2008, 11, no. 81-84; 126-128
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The adhesion and growth of vascular smooth muscle cells in cultures on carboranethiol-modified gold films
Autorzy:
Parizek, M.
Base, T.
Londesborough, M. G. S.
Lisa, V.
Bacakova, L.
Powiązania:
https://bibliotekanauki.pl/articles/285409.pdf
Data publikacji:
2008
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
metal coating
gold film
carboranethiol
cell adhesion
cell spreading
cell proliferation
biomaterials
tissue engineering
surgical implants
Opis:
Metal surfaces have become important over the last decade for potential surgical implants, and within this context we present here a study of the cell growth on modified gold surfaces. Gold films, deposited on glass plates and annealed with a hydrogen flame, were modified with four different carboranethiol derivatives: 1-(HS)-1,2-C2B10H11 (A), 1,2-(HS)2-1,2-C2B10H10 (B), 9,12-(HS)2-1,2-C2B10H10 (C) and 1,12-(HS)2-1,12- C2B10H10 (D). The materials engendered from these modifications were used to investigate the adhesion and growth of rat aortic smooth muscle cells cultured on these surfaces in a DMEM medium with 10% of fetal bovine serum. One day after seeding, the highest number of initially adhered cells was found on the surface of a bare gold film. However, three days after seeding, the number of cells on carboranethiol-modified gold samples B, C and D was significantly higher than the number on a bare gold film. After seven days, the number of cells on a bare gold film and on gold films modified with derivatives A, B and D was very similar, but the surface of a gold film modified with derivative C exhibited a significantly smaller number of cells. This may be explained by the exposure of the CH vertices of the carborane cluster, which are more acidic than the BH vertices exposed toward the cells in either A or B.
Źródło:
Engineering of Biomaterials; 2008, 11, no. 81-84; 117-119
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The adhesion and growth of vascular smooth muscle cells in cultures on carboranethiol-modified gold films
Autorzy:
Parizek, M.
Base, T.
Londesborough, M. G. S.
Lisa, V.
Bacakova, L.
Powiązania:
https://bibliotekanauki.pl/articles/286249.pdf
Data publikacji:
2008
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
implanty chirurgiczne
biomateriały
powłoki metalowe
inżynieria materiałowa
metal coatings
gold film
carboranethiol
cell adhesion
cell spreading
cell proliferation
biomaterials
tissue engineering
surgical implants
Opis:
Metal surfaces have become important over the last decade for potential surgical implants, and within this context we present here a study of the cell growth on modified gold surfaces. Gold films, deposited on glass plates and annealed with a hydrogen flame, were modified with four different carboranethiol derivatives: 1-(HS)-1,2-C2 B10H11(A), 1,2-(HS)2-1,2-C2B10H10(B), 9,12-(HS)2-1,2-C2B10H10(C) and 1,12-(HS)2-1,12- C2B10H10(D). The materials engendered from these modifications were used to investigate the adhesion and growth of rat aortic smooth muscle cells cultured on these surfaces in a DMEM medium with 10% of fetal bovine serum. One day after seeding, the highest number of initially adhered cells was found on the surface of a bare gold film. However, three days after seeding, the number of cells on carboranethiol-modified gold samples B, C and D was significantly higher than the number on a bare gold film. After seven days, the number of cells on a bare gold film and on gold films modified with derivatives A, B and D was very similar, but the surface of a gold film modified with derivative C exhibited a significantly smaller number of cells. This may be explained by the exposure of the CH vertices of the carborane cluster, which are more acidic than the BH vertices exposed toward the cells in either A or B.
Źródło:
Engineering of Biomaterials; 2008, 11, 75; 6-8
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Surface properties of neutral components in copper column bioleaching of black shale samples
Autorzy:
Sadowski, Z.
Baranska, J.
Pawlowska, A.
Powiązania:
https://bibliotekanauki.pl/articles/110261.pdf
Data publikacji:
2018
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
adhesion
surface energy
glass beads
biohydrometallurgy
column bioleaching
bacteria cell
polyethylene pellets
Opis:
The behaviour of glass beads and polyethylene pellets as the extra bacteria support in the fine black shale ore in the column bed bioreactor was compared. Capillary rise experiments enabled the calculation of the contact angle and the surface free energy of glass beads and polyethylene pellets. The results showed that the support material made up of polyethylene pellets yielded a higher copper extraction, which could be explained by conditions favourable to cell adhesion on the polyethylene surface.
Źródło:
Physicochemical Problems of Mineral Processing; 2018, 54, 4; 1146-1151
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Surface modifications of biomaterial with different cold plasma reactors to improve cell adhesion
Autorzy:
Terebun, Piotr
Kwiatkowski, Michał
Zarzeczny, Dawid
Pawłat, Joanna
Wójcik, Michał
Trzaskowska, Marta
Kazimierczak, Paulina
Przekora, Agata
Powiązania:
https://bibliotekanauki.pl/articles/2172008.pdf
Data publikacji:
2022
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
curdlan
agarose
gliding arc discharge reactor
dielectric barrier discharge plasma jet
dielectric barrier discharge surface reactor
surface modification
Opis:
There is a growing trend in the engineering of biomaterials, focusing on surface modifications of biomaterials to improve their mechanical strength, corrosion resistance, and biological properties. Cold plasma treatment may improve biological properties of biomaterials for biomedical applications by enhancing their integration with host tissue. This study investigated the influence of different cold plasma treatments on the surface properties of a polysaccharides- -based biomaterial to improve cell adhesion to its surface. The samples were subjected to plasma treatment using three different reactors operating at atmospheric pressure: gliding arc discharge (GAD) reactor, dielectric barrier discharge (DBD) plasma jet, and DBD surface reactor. Next, surface chemistry of the biomaterial after plasma treatment was determined by ATR-FTIR analysis. Furthermore, a cell adhesion assay on the samples was carried out using normal human skin fibroblasts (BJ cell line). The attenuated total reflection Fourier transform infrared analysis (ATR- -FTIR) showed that new potential functional groups could be formed on the material surface after plasma treatment. However, plasma treatment of the samples did not enhance cell adhesion to the surface of the polysaccharides-based biomaterial. Thus, the obtained results indicate that plasma treatment using GAD reactor, DBD plasma jet, and DBD surface reactor was not effective for surface modification and cell responses.
Źródło:
Engineering of Biomaterials; 2022, 25, 165; 2--6
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Shape memory process in resorbable polymers: effect on surface properties and cell adhesion
Autorzy:
Costa, A. M.
Ferreira, A. S.
Posadowska, U.
Krok, M.
Smola, A.
Dobrzyński, P.
Pamuła, E.
Powiązania:
https://bibliotekanauki.pl/articles/286068.pdf
Data publikacji:
2012
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
shape memory
PLGA
tissue regeneration
foil
Opis:
The objectives of this study were to confirm the shape memory behavior of two new bioresorbable terpolymers (L-lactide, glycolide, and trimethylene carbonate: L-PLGTMC and B-PLGTMC), to follow the influence of the shape memory process on their surface properties and to test their cytocompatibility using osteoblast-like cells. For this purpose, foils of both terpolymers were prepared. The terpolymers' ability to recover up to 92-93% of the memorized shape within 10 seconds was obtained. The influence of shape memory process on the surface properties was assessed by water contact angle (WCA) measurement and atomic force microscopy (AFM) and the results suggested that both terpolymers preserved the hydrophilicity after recovery and also that B-PLGTMC polymer was rougher than L-PLGTMC (about 9 folds more). The AFM pictures showed the presence of spherical shape hills on the B-PLGTMC foil surface which after the stretching procedure became oriented toward the direction of the applied load. The terpolymers were seeded on both sides (Top and Bottom faces) with human MG63 osteoblast-like cells. Cell viability was assessed after 1, 3 and 7 days, using MTT assay. Results revealed an increasing number of metabolically active cells with the incubation time, suggesting, together with nitric oxide (NO) level determination, the cytocompatibility of both terpolymers. Cell spreading and morphology were investigated by H&E staining and obtained results corresponded well with ones of MTT and NO.
Źródło:
Engineering of Biomaterials; 2012, 15, 114; 8-11
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ruch pod mikroskopem - współczesne techniki badania adhezji i ruchliwości komórek
Motion under the microscope - modern techniques for studying cell adhesion and motility
Autorzy:
Pomorski, Paweł
Powiązania:
https://bibliotekanauki.pl/articles/1192766.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Przyrodników im. Kopernika
Opis:
Ruch komórek jest jedną z ich fundamentalnych cech. To dzięki niemu organizm może się rozwijać, układ odpornościowy działać, organy regenerować, a rany goić się. Badanie mechanizmów ruchu jest jednak jedną z trudniejszych metodycznie dziedzin biologii komórki. Procesy biochemicznie zachodzą bowiem w ruchliwych komórkach niesynchronicznie, a często takich komórek jest niewiele. Niniejszy artykuł poświęcono metodom mikroskopowym stworzonym by rozwiązać ten problem. Omawiane są metody pomiaru parametrów ruchu i adhezji do podłoża. Omawiane są również podstawy zastosowania klasycznych metod mikroskopowych do badania procesów ruchowych. Pokrótce wspominamy też o wykorzystaniu sond molekularnych do badania procesów sygnalizacji w komórkach ruchliwych, a także o mikroskopowych metodach eksperymentalnych, umożliwiających doświadczenia na pojedynczych komórkach.
Ability to move is one of the fundamental functions of the living cells. It is due to the motility that organism develops, immune system can work, organs are able to regenerate and wound heal. In the same time motility studies are among methodologically most difficult ones. Biochemical processes underlying motility are notoriously unsynchronized and motile cells are usually not very numerous. Current paper reviews microscope techniques developed to solve those problems. We discuss basic measurements, parameterizing motility and substratum adhesion. Classical, structural microscopy used for motility studies are also sketched shortly. We describe also use of molecular probes for signaling studies in motile cells as well as we mention about microscopic experimental techniques, allowing experiments on single cells.
Źródło:
Kosmos; 2013, 62, 2; 181-192
0023-4249
Pojawia się w:
Kosmos
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pro-angiogenic effects of X-rays on murine endothelial cells
Autorzy:
Lisiak, E.
Dziekiewicz, M.
Meineke, V.
Bilski, M.
Janiak, M.
Powiązania:
https://bibliotekanauki.pl/articles/147804.pdf
Data publikacji:
2005
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
angiogenesis
ionizing radiation
cell adhesion
integrins
Opis:
Recently, significant attention has been paid to the possibility of thwarting cancer progression by inhibition of neoangiogenesis (formation of new blood vessels) in growing tumors. Although general mechanisms of angiogenesis have been elucidated, virtually nothing is known about the effects of low doses of ionizing radiation on pro-angiogenic properties of endothelial cells. In the present study, we evaluated the effects of a low (0.2 Gy), intermediate (1 Gy), and high (4 Gy) doses of X-rays on a few angiogenesis-related parameters of isolated murine endothelial cells. We show here that 24 to 48 hours after irradiation with 0.2 Gy the cell proliferation was inhibited to a similar extent as after the exposure to 1 Gy. Also, adhesion of the 0.2 Gy-irradiated cells to both gelatin and MatrigelŽ was inhibited 24 hours post-exposure, whereas irradiation with 1 or 4 Gy resulted in the increased adhesion of the cells to these substrata. Similar effects were observed during the "wound" migration assay. Finally, 24 hours after exposure of the cells to 0.2 Gy of X-rays, the surface expression of the â3 integrin subunit was down-regulated, whereas irradiations with 1 and 4 Gy of X-rays resulted in the significantly elevated expression of this subunit. These results indicate that proliferating endothelial cells are sensitive in vitro to relatively low doses of ionizing radiation
Źródło:
Nukleonika; 2005, 50,suppl.2; 17-20
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polish Artificial Heart - new coatings, technology, diagnostics
Autorzy:
Sarna, J.
Kustosz, R.
Major, R.
Lackner, J.
Major, B.
Powiązania:
https://bibliotekanauki.pl/articles/200025.pdf
Data publikacji:
2010
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
pulsed laser deposition
microstructure
cell adhesion
Opis:
Since 1991, the Foundation for Cardiac Surgery Development in Zabrze has been implementing research on the artificial heart. In 1995, an artificial ventricle, POLVAD, was implanted to a patient, and in 1998, the prototype of a clinical controller, POLPDU-401, was created. A further development of the studies on an implantable artificial heart requires an integrated approach and an application of advanced methods of materials sciences in order to develop new materials suitable for the contact with blood, as well as to apply a multilateral biomedical diagnostics in hydrodynamic conditions. The estimation of the cell–material interaction plays an important role in the biomaterial design. An analysis of the influence of the carbon content in titanium nitride on the biological and biophysical properties of biomaterial coatings was studied. The cell-material reactions were considered in dynamic and static conditions. Three groups of materials were under examinations – titanium nitride (TiN), as well as titanium carbonitride with a low and high carbon content – of which the best properties were observed for TiN. We found a strong influence of the stoichiometry of TiN (atomic ratio of Ti/N) on the biocompatibility. A non-stoichiometric TiN could have a negative influence on the surrounding tissue.
Źródło:
Bulletin of the Polish Academy of Sciences. Technical Sciences; 2010, 58, 2; 329-335
0239-7528
Pojawia się w:
Bulletin of the Polish Academy of Sciences. Technical Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Molekularne czynniki adhezyjne w szerzeniu się nabłonkowego raka jajnika
Role of molecular adhesion factors in the spread of epithelial ovarian cancer
Autorzy:
Waksmański, Bogdan
Olejek, Anita
Powiązania:
https://bibliotekanauki.pl/articles/908240.pdf
Data publikacji:
2006
Wydawca:
Medical Communications
Tematy:
FAK
cadherins
cell adhesion
epithelial ovarian carcinoma
Opis:
The process of spread of epithelial ovarian cancer is associated with molecular mechanisms including cellular surface receptors, basal membrane components, intercellular adhesion molecules and cell-derived signals. The key role in cellular adhesion and its motility is played by E-cadherin and catenins. Expression of the cadherin – catenin complex decreases in parallel with progressing clinical stage of ovarian cancer. At the same time, re-expression of this complex is associated with dissemination of the neoplasm over peritoneal surface. Changing expression or dysfunction of receptors for integrins and their association with molecules of extracellular matrix (ECM) is closely correlated with tumour progression and/or its metastatic potential. The lysophosphatidic acid mediates laminin-dependant migration of cells by the autocrine local mechanism. The first step in formation of metastases is degradation of collagen type IV, as well as activation of metalloproteinases and pro-angiogenic factors, whose increased expression is seen in ovarian cancer cells. Adhesion contact kinase (FAK) is crucial for migration of neoplastic cells, inversely dependant on growth factors and integrin receptors. Increased expression of this kinase is associated with statistically significant with higher clinical stage of the tumour, presence of metastases in lymph nodes and distant metastases. The basic prerequisite for formation of metastases is derangement of cell adhesion mechanism, inducing loss of adhesion between cells and between cells and extracellular matrix. This mechanism is crucial in the spread of ovarian cancer throughout the abdominal cavity.
Proces szerzenia się nabłonkowego raka jajnika jest związany z mechanizmami molekularnymi obejmującymi receptory powierzchni komórki, składnikami błony podstawnej, międzykomórkowymi cząsteczkami adhezyjnymi oraz sygnałami pochodzącymi od komórki. Podstawową rolę w adhezji komórki i jej ruchliwości pełnią E-kadheryna oraz kateniny. Ekspresja kompleksu kadheryna – kateniny zmniejsza się wraz z postępującym stopniem zaawansowania klinicznego raka jajnika. Jednocześnie występuje reekspresja tego układu w przypadku rozsiewu procesu nowotworowego na powierzchni otrzewnej. Zmieniająca się ekspresja lub nieprawidłowe działanie receptorów integryn i ich związek z cząsteczkami macierzy zewnątrzkomórkowej ECM wykazuje ścisłe połączenie z postępem rozwoju guza lub potencjałem przerzutu. Kwas lizofosfatydowy pośredniczy w zależnej od laminin migracji komórek w autokrynnym mechanizmie lokalnym. Pierwszym krokiem w procesie tworzenia przerzutów jest degradacja kolagenu typu IV z działaniem metaloproteinaz oraz czynników proangiogennych, których zwiększona ekspresja jest obserwowana w komórkach raka jajnika. Kinaza kontaktów adhezyjnych FAK pełni podstawową rolę w migracji komórek nowotworowych ujemnie zależnych od czynników wzrostu oraz receptorów integryn. Zwiększona ekspresja tej kinazy wiąże się istotnie statystycznie z wyższym stopniem zaawansowania klinicznego guza, obecnością przerzutów w węzłach chłonnych i obecnością odległych przerzutów. Podstawowym wstępnym warunkiem powstania przerzutu jest zaburzenie mechanizmu adhezji komórki, co w konsekwencji indukuje zmiany w przyleganiu między komórkami oraz komórkami a macierzą zewnątrzkomórkową. Mechanizm ten ma podstawowe znaczenie w szerzeniu się raka jajnika w obrębie jamy brzusznej.
Źródło:
Ginekologia Onkologiczna; 2006, 4, 3; 193-201
1731-5379
Pojawia się w:
Ginekologia Onkologiczna
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 31

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies