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    Wyświetlanie 1-13 z 13
    Tytuł:
    Iterative methods for efficient sampling-based optimal motion planning of nonlinear systems
    Autorzy:
    Ha, J. S.
    Choi, H. L.
    Jeon, J. H.
    Powiązania:
    https://bibliotekanauki.pl/articles/330028.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Zielonogórski. Oficyna Wydawnicza
    Tematy:
    optimal motion planning
    sampling based algorithm
    nonlinear dynamics
    planowanie ruchu
    algorytm próbkowania
    dynamika nieliniowa
    Opis:
    This paper extends the RRT* algorithm, a recently developed but widely used sampling based optimal motion planner, in order to effectively handle nonlinear kinodynamic constraints. Nonlinearity in kinodynamic differential constraints often leads to difficulties in choosing an appropriate distance metric and in computing optimized trajectory segments in tree construction. To tackle these two difficulties, this work adopts the affine quadratic regulator-based pseudo-metric as the distance measure and utilizes iterative two-point boundary value problem solvers to compute the optimized segments. The proposed extension then preserves the inherent asymptotic optimality of the RRT* framework, while efficiently handling a variety of kinodynamic constraints. Three numerical case studies validate the applicability of the proposed method.
    Źródło:
    International Journal of Applied Mathematics and Computer Science; 2018, 28, 1; 155-168
    1641-876X
    2083-8492
    Pojawia się w:
    International Journal of Applied Mathematics and Computer Science
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Magnetic Properties of YBCO-PST Composites
    Autorzy:
    Andrzejewski, B.
    Kaczmarek, A.
    Stankowski, J.
    Hilczer, B.
    Marfaing, J.
    Régnier, S.
    Caranoni, C.
    Powiązania:
    https://bibliotekanauki.pl/articles/2014556.pdf
    Data publikacji:
    2000-12
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    74.80.Bj
    74.25.Ha
    76.30.Fc
    Opis:
    The magnetic properties of granular superconductor-insulator composites were investigated. The composites were random composition of the YBa$\text{}_{2}$Cu$\text{}_{3}$O$\text{}_{7-δ}$ (YBCO) high-temperature superconductor and Pb(Sc$\text{}_{0.5}$Ta$\text{}_{0.5}$)O$\text{}_{3}$ (PST) ferroelectric insulator. The composites exhibited lower superconducting volume ratio than the YBCO content. For samples with YBCO content low enough no global (the whole sample) and local (separated grains) superconductivity was observed. The observed decay of the superconductivity, lowering of the critical temperature, and the increase in number of paramagnetic centres as PST content increases are explained assuming reaction among YBCO and PST phases and possible formation of an additional ones, which did not exist in the initial powders.
    Źródło:
    Acta Physica Polonica A; 2000, 98, 6; 739-746
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Spin Glass-Like Transition in Orthorhombic T-Phase Al-Pd(Fe)-Mn Complex Metallic Alloys
    Autorzy:
    Slanovec, J.
    Jagličic, Z.
    Jagodić, M.
    Heggen, M.
    Feuerbacher, M.
    Balanetskyy, S.
    Dolinšek, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/1813510.pdf
    Data publikacji:
    2008-01
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    75.10.Nr
    74.25.Ha
    71.23.Ft
    Opis:
    Magnetic properties of orthorhombic T-phase Al-Pd(Fe)-Mn - members of complex metallic alloys - with different Pd(Fe)/Mn atomic ratios were studied experimentally. The measured zero field cooling-field cooling splitting, the frequency dependent AC susceptibility and slow thermoremanent magnetization time decay indicate that the samples possess built-in frustration-like properties similar to those in spin glasses.
    Źródło:
    Acta Physica Polonica A; 2008, 113, 1; 19-22
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Superconductivity, Weak Itinerant Ferromagnetism and Electronic Band Structure of Y$\text{}_{9}$Co$\text{}_{7}$
    Autorzy:
    Kołodziejczyk, A.
    Wiendlocha, B.
    Zalecki, R.
    Toboła, J.
    Kaprzyk, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/2047310.pdf
    Data publikacji:
    2007-04
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    74.25.Jb
    74.25.Ha
    74.20.Mn
    Opis:
    The paper presents experimental results for the intermetallic compound Y$\text{}_{9}$Co$\text{}_{7}$ which is the first very weak itinerant ferromagnetic superconductor. The measurements of electrical resistivity, susceptibility, magnetization, specific heat, nuclear magnetic resonance, and other properties show the magnetic transition at T$\text{}_{C}$≈ 4.5 K and the onset of superconductivity at about T$\text{}_{S}$≈ 2.5 K, revealing the coexistence state within a temperature interval below T$\text{}_{S}$. A few of the results are shortly reviewed and discussed. We focus attention on our recent ultraviolet photoemission spectroscopy and their comparison with our band structure calculations. Interpretations are considered which take into account the characteristic structure of the compound and different possible types of magnetic ordering.
    Źródło:
    Acta Physica Polonica A; 2007, 111, 4; 513-526
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Magnetization, Susceptibility and Critical Currents of $(Tl_{2-x}Re_{x})Ba_{2}CaCu_{2}O_{y}$ Thin Films
    Autorzy:
    Woch, W.
    Dujavová, A.
    Przewoźnik, J.
    Zalecki, R.
    Kołodziejczyk, A.
    Sojková, M.
    Chromik, Š.
    Powiązania:
    https://bibliotekanauki.pl/articles/1431480.pdf
    Data publikacji:
    2012-04
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    70.72.Gr
    74.25.Ha
    Opis:
    The magnetization and the AC susceptibility vs. the temperature as well as the applied magnetic field of the thin film $(Tl_{2-x}Re_{x})Ba_{2}CaCu_{2}O_{y}$ with x=0 and 0.15 on R-plane sapphire substrate with $CeO_{2}$ buffer layer were measured and analyzed. XRD measurements show c-axis as well as a-b plane oriented Tl-1212 and superconducting pure phase. The zero critical temperature of the Tl-Re sample is 99.9 K and is practically the same as the critical temperature of the rhenium free sample: 99.5 K. The Tl-Re superconductor exhibits two peaks of the absorption part of AC susceptibility in the vicinity of the critical temperature in contrary to the rhenium free sample. The first peak placed in higher temperature is related to intragranular properties while the second peak is connected with the intergranular one. The critical current densities versus temperature were calculated from AC susceptibility as well as from the magnetization loops measurements using the Bean's critical state model. The Tl-Re film exhibits the higher critical current in comparison to the rhenium free thallium based film.
    Źródło:
    Acta Physica Polonica A; 2012, 121, 4; 845-849
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Magnetic Properties of YBa$\text{}_{2}$Cu$\text{}_{3}$O$\text{}_{7-δ}$ Melt Textured Samples Prepared by Powder Melting Process and Quench and Melt Growth Techniques
    Autorzy:
    Plesch, G.
    Cígaň, A.
    Maňka, J.
    Bučkuliaková, A.
    Hanic, F.
    Buchta, Š.
    Andrzejewski, B.
    Stankowski, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/2014193.pdf
    Data publikacji:
    2000-10
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    74.25.Ha
    74.80.Bj
    Opis:
    The microstructure and magnetic properties of the melt textured YBa$\text{}_{2}$Cu$\text{}_{3}$O$\text{}_{7-δ}$ samples prepared by the powder melting process, in which Y$\text{}_{2}$Cu$\text{}_{2}$O$\text{}_{5}$ and BaCuO$\text{}_{2}$ were used as precursors, and those prepared by the quench and melt growth method are described and compared. The lattice parameters and T$\text{}_{c}$ values for the samples prepared by the both techniques were similar. The penetration and the spatial distribution of the magnetic flux in the superconducting samples was imaged by means of a field-mapping device using a Hall probe. In the range of low magnetic fields up to 820Am$\text{}^{-1}$ no significant differences in penetration of magnetic flux between the samples prepared by the powder melting process and the quench and melt growth were observed. The mapping could not resolve any grain boundaries, single grains and structural defects. By the ac and virgin volume magnetisation characteristics, which were measured in the zero-field cooled condition by a 2nd order SQUID gradiometer, no weak links were identified. Better magnetic properties of the quench and melt growth samples in high magnetic fields can be explained by the differences in microstructure and/or by the risen content of the finely dispersed 211 and Pt containing phases. The increase factor in magnetisation is about 2.5. Some aspects of the Bean model for textured YBa$\text{}_{2}$Cu$\text{}_{3}$O$\text{}_{7-δ}$ samples are discussed.
    Źródło:
    Acta Physica Polonica A; 2000, 98, 4; 327-334
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Growth of NdBa$\text{}_{2}$Cu$\text{}_{3}$O$\text{}_{7-δ}$ Superconducting Thin Films on SrTiO$\text{}_{3}$(100) and LaSrGaO$\text{}_{4}$(100) Substrates
    Autorzy:
    Park, J.-C.
    Ha, D. H.
    Kim, I.-S.
    Park, Y.K.
    Powiązania:
    https://bibliotekanauki.pl/articles/1964239.pdf
    Data publikacji:
    1997-07
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    74.76.Bz
    Opis:
    NdBa$\text{}_{2}$Cu$\text{}_{3}$O$\text{}_{7-δ}$ superconducting thin films were grown on SrTiO$\text{}_{3}$(100) and LaSrGaO$\text{}_{4}$(100) substrates by off-axis rf sputtering and pulsed laser deposition. The effects of several deposition parameters, e.g. gas pressure, substrate temperature and energy density were studied. Thin films grown by off-axis rf sputtering were highly c-axis oriented, but those by pulsed laser deposition were predominantly a-axis oriented under our deposition conditions. However, the c-axis oriented portion for the films grown by pulsed laser deposition was increased by increasing the temperature above 800°C. T$\text{}_{c(zero)}$ was 87 K and 83 K for the c- and a-axis oriented films respectively. The critical current density of c-axis oriented films was 10$\text{}^{6}$-10$\text{}^{7}$ A/cm$\text{}^{2}$ below 60 K.
    Źródło:
    Acta Physica Polonica A; 1997, 92, 1; 105-114
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The effect of Sm addition on the microstructure and superconducting properties of YBCO bulk superconductors
    Autorzy:
    Volochová, D.
    Diko, P.
    Piovarči, S.
    Antal, V.
    Kováč, J.
    Jirsa, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1054772.pdf
    Data publikacji:
    2017-04
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    74.72.-h
    74.62.Dh
    81.10.Fq
    61.72.-y
    74.25.Ha
    74.25.Sv
    Opis:
    The effect of Sm addition on the microstructure and superconducting properties of Y-Ba-Cu-O (YBCO) bulk superconductors has been studied. Nominal composition: 1 mol YBa₂Cu₃O_{7-δ} + 0.25 mol Y₂O₃ + 1 wt% CeO₂ was enriched with different amounts of SmBa₂Cu₃O_y powder with the aim to increase critical current density, J_c, especially in higher magnetic fields by introducing additional pinning centers. Single grain YBCO bulk superconductors with SmBa₂Cu₃O_y (Y123-Sm) addition were prepared by the optimized top seeded melt growth process. Microstructure analysis, performed by polarized light microscope, revealed that SmBa₂Cu₃O_y addition leads to a higher amount of slightly coarser Y₂BaCuO₅ particles, which is related to lower critical current densities (J_c ≈ 6×10⁴ A/cm²) of the YBCO samples with SmBa₂Cu₃O_y addition in low magnetic fields. On the other hand, an enhancement of critical current density, J_c, in higher magnetic fields was observed for Y123-Sm samples. Moreover, a maximum trapped magnetic field, B_{tmax}, of 564 mT at 77 K in Y123-Sm, x=0.0025 sample (Ø 17.2 mm) was 43% higher than that for YBCO sample without any addition.
    Źródło:
    Acta Physica Polonica A; 2017, 131, 4; 1009-1011
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Influence of Sm and Yb Pollution on Superconducting Properties of YBCO Bulk Superconductors
    Autorzy:
    Volochová, D.
    Jurek, K.
    Radušovská, M.
    Piovarči, S.
    Antal, V.
    Kováč, J.
    Jirsa, M.
    Diko, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/1371573.pdf
    Data publikacji:
    2014-07
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    74.60.Bf
    74.72.-h
    81.40.Rs
    74.25.Ha
    74.81.Bd
    74.25.Op
    Opis:
    $YBa_{2}Cu_{3}O_{7-δ }$ (YBCO, Y-123) bulk superconductors with a nominal composition $Y_{1.5}Ba_{2}Cu_{3}O_{x}$ and 1 wt% $CeO_{2}$ addition were prepared by the Top Seeded Melt Growth (TSMG) process. Small single-crystalline pieces, cut from the $SmBa_{2}Cu_{3}O_{y}$ (Sm-123) bulk, were used for seeding of epitaxial growth. Wavelength-dispersive spectrometry (WDS) confirmed the presence of 0.1 wt% Sm from the seed and 0.25 wt% Yb from the substrate, practically in the whole sample volume. The influence of this Sm and Yb contamination on superconducting properties of grown bulk materials is reported.
    Źródło:
    Acta Physica Polonica A; 2014, 126, 1; 358-359
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Porównanie powłok HA otrzymanych w metodzie hydrotermalnej z roztworu zawierającego EDTA-Ca2+-PO43-lub roztworu Hanka na czystym Ti i Ti implantowanym jonami Ca
    Comparison of HA coatings obtained by hydrothermal method using EDTA-Ca2+-PO43-solution or Hank’s solution on pure Ti and on Ti implanted with Ca ions
    Autorzy:
    Strzała, A.
    Petelenz, B.
    Kwiatkowska, J.
    Rajchel, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/285041.pdf
    Data publikacji:
    2010
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    hydroksyapatyty
    synteza hydrotermalna
    mikrospektroskopia Ramana
    implantacja jonowa Ca
    hydroxyapatite
    hydrothermal synthesis
    Raman micro-spectrometry
    Ca ion implantation
    Opis:
    W celu otrzymania biozgodnej i bioaktywnej warstwy, która poprawi integrację protezy stawu biodrowego z kością, przy użyciu metody hydrotermalnej formowano hydroksyapatyt Ca10(PO4)6(OH)2, HA na podłożach z czystego tytanu oraz tytanu implantowanego jonami Ca. Do syntezy HA użyto dwóch różnych roztworów: jednego zawierającego EDTA, jony wapnia i fosforu oraz drugiego, którym był roztwór Hanka, którego skład i stężenie soli są podobne do składu i stężenia soli osocza krwi ludzkiej. Budowę cząsteczkową tak otrzymanych warstw określono przy użyciu mikrospektroskopii ramanowskiej.W artykule dyskutowana jest efektywność formowania HA w tych roztworach przy użyciu metody hydrotermalnej i wpływ stanu podłoża na procesy osadzania HA.
    In order to obtain a biocompatible and bioactive coating that improves hip joint endoprosthesis integration with bone, hydroxyapatite Ca10(PO4)6(OH)2, HA, was formed on pure titanium and Ca ions implanted titanium substrates using hydrothermal method. To synthesize HA two different solutions were used: one containing EDTA, calcium and phosphorus ions, and the other which was Hank’s solution whose salt composition is similar to the human blood plasma. The molecular composition of as deposited coatings was investigated by means of Raman micro-spectroscopy. The effectiveness of the solutions in HA forming by the hydrothermal method and the influence of the substrate condition are discussed.
    Źródło:
    Engineering of Biomaterials; 2010, 13, 92; 24-29
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Warm Tensile Deformation Behavior and Constitutive Equation of Supersaturated Solid-Solutionized Al-9Mg Extruded Alloy
    Autorzy:
    Yang, Seung Y.
    Kim, Bong H.
    Lee, Da B.
    Choi, Kweon H.
    Kim, Nam S.
    Ha, Seong H.
    Yoon, Young O.
    Lim, Hyun K.
    Kim, Shae
    Kim, Young J.
    Powiązania:
    https://bibliotekanauki.pl/articles/2048882.pdf
    Data publikacji:
    2021
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    aluminum alloy
    Al-9Mg alloy
    tensile test
    constitutive equation
    Opis:
    In this paper, as a purpose to apply the supersaturated solid-solutionized Al-9Mg alloy to the structural sheet parts of automotive, tensile tests were conducted under the various conditions and a constitutive equation was derived from the tensile test results. Al-9Mg alloy was produced using a special Mg master alloy containing Al2Ca during the casting process and extruded into the sheet. In order to study the deformation behavior of Al-9Mg alloy in warm temperature forming environments, tensile tests were conducted under the temperature of 373 K-573 K and the strain rate of 0.001/s~0.1/s. in addition, by using the raw data obtained from tensile tests, a constitutive equation of the Al-9Mg alloy was derived for predicting the optimized condition of the hot stamping process. Al-9Mg alloy showed uncommon deformation behavior at the 373 K and 473 K temperature conditions. The calculated curves from the constitutive equation well-matched with the measured curves from the experiments particularly under the low temperature and high strain rate conditions.
    Źródło:
    Archives of Metallurgy and Materials; 2021, 66, 4; 1013-1018
    1733-3490
    Pojawia się w:
    Archives of Metallurgy and Materials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Nanostructural Superconducting Materials for Fault Current Limiters and Cryogenic Electrical Machines
    Autorzy:
    Prikhna, T.
    Gawalek, W.
    Savchuk, Ya.
    Sergienko, N.
    Moshchil, V.
    Sokolovsky, V.
    Vajda, J.
    Tkach, V.
    Karau, F.
    Weber, H.
    Eisterer, M.
    Joulain, A.
    Rabier, J.
    Chaud, X.
    Wendt, M.
    Dellith, J.
    Danilenko, N.
    Habisreuther, T.
    Dub, S.
    Meerovich, V.
    Litzkendorf, D.
    Nagorny, P.
    Kovalev, L.
    Schmidt, Ch.
    Melnikov, V.
    Shapovalov, A.
    Kozyrev, A.
    Sverdun, V.
    Kosa, J.
    Vlasenko, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/1549637.pdf
    Data publikacji:
    2010-01
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    74.25.Sv
    74.81.Bd
    74.70.Ad
    74.78.Na
    74.62.Fj
    74.25.Ld
    74.62.Dh
    74.25.Ha
    Opis:
    Materials of the Y-Ba-Cu-O (melt-textured $YBa_{2}Cu_{3}O_{7-δ}$-based materials or MT-YBCO) and Mg-B-O ($MgB_{2}$-based materials) systems with high superconducting performance, which can be attained due to the formation of regularly distributed nanostructural defects and inhomogeneities in their structure can be effectively used in cryogenic technique, in particular in fault current limiters and electrical machines (electromotors, generators, pumps for liquid gases, etc.). The developed processes of high-temperature (900-800°C) oxygenation under elevated pressure (16 MPa) of MT-YBCO and high-pressure (2 GPa) synthesis of $MgB_{2}$-based materials allowed us to attain high superconductive (critical current densities, upper critical fields, fields of irreversibility, trapped magnetic fields) and mechanical (hardness, fracture toughness, Young modulus) characteristics. It has been shown that the effect of materials properties improvement in the case of MT-YBCO was attained due to the formation of high twin density (20-22 $μm^{-1}$), prevention of macrocracking and reduction (by a factor of 4.5) of microcrack density, and in the case of $MgB_{2}$-based materials due to the formation of oxygen-enriched as compared to the matrix phase fine-dispersed Mg-B-O inhomogeneities as well as inclusions of higher borides with near-$MgB_{12}$ stoichiometry in the Mg-B-O matrix (with 15-37 nm average grain sizes). The possibility is shown to obtain the rather high $T_{c}$ (37 K) and critical current densities in materials with $MgB_{12}$ matrix (with 95% of shielding fraction as calculated from the resistant curve).
    Źródło:
    Acta Physica Polonica A; 2010, 117, 1; 7-14
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Anticonvulsant potency of 10 various p-isopropoxyphenylsuccinimide derivatives in the maximal electroshock-induced seizure threshold model in mice
    Przeciwdrgawkowe działanie 10 różnych pochodnych p-izopropoksyfenylobursztynimidów w modelu progu maksymalnego wstrząsu elektrycznego u myszy
    Autorzy:
    Kocharov, S.L.
    Panosyan, H.A.
    Marzeda, P.
    Wroblewska-Łuczka, P.
    Kochman, E.
    Wlaź, A.
    Łuszczki, J.J.
    Powiązania:
    https://bibliotekanauki.pl/articles/2052722.pdf
    Data publikacji:
    2017
    Wydawca:
    Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej
    Tematy:
    p-isopropoxyphenylsuccinimide
    electroshock
    maximal electroshock-induced
    seizure threshold
    threshold increasing dose by 20%
    p-izopropoksyfenylobursztynimid
    wstrząs elektryczny
    próg maksymalnego
    wstrząsu elektrycznego
    dawka zwiększająca próg o 20%
    Opis:
    Background. To compare the anticonvulsant potency of 10 various p-isopropoxyphenylsuccinimide (IPPS) derivatives [i.e., IPPS (IPPS); N-(morpholinomethyl)-IPPS (MM-IPPS); N-(anilinomethyl)-IPPS (AM-IPPS); N-hydroxymethyl-IPPS (HM-IPPS); N-(p-acetylphenyl)-IPPS (AP-IPPS); N-(p-ethoxycarbonylphenylmethyl)-IPPS (ECPM-IPPS); N-(m-bromoanilinomethyl)-IPPS (BAM-IPPS); N-(o-carboxyanilinomethyl)-IPPS (o-CAMIPPS); N-(m-carboxyanilinomethyl)-IPPS (m-CAM-IPPS); N-(p-carboxyanilinomethyl)-IPPS (p-CAM-IPPS)] in the maximal electroshock-induced seizure threshold (MEST) test in mice. Material and methods. Linear regression analysis of doses of IPPS derivatives and their threshold increases in the MEST test in mice allowed to calculate TID20 values i.e., doses of the tested IPPS derivatives that elevate by 20% the seizure threshold in IPPS-treated mice over the threshold in control animals. Results. A ll t he studied IPPS derivatives (i.e., IPPS, MMIPPS, HM-IPPS, AP-IPPS, AM-IPPS, ECPM-IPPS, o-CAM-IPPS, m-CAM-IPPS, p-CAM-IPPS and BAM-IPPS) increased in a dose dependent manner the threshold for maximal electroshockinduced seizures in mice. The TID20 values in the MEST test for IPPS, AP-IPPS, AM-IPPS, BAMIPPS, o-CAM-IPPS, m-CAM-IPPS, p-CAM-IPPS, ECPM-IPPS, HM-IPPS, and MM-IPPS were 60.44 mg/kg, 86.30 mg/kg, 44.69 mg/kg, 103.34 mg/kg, 22.43 mg/kg, 52.84 mg/kg, 80.85 mg/kg, 109.75 mg/kg, 32.62 mg/kg and 53.50 mg/kg, respectively. Conclusions. The studied IPPS derivatives with respect to their anticonvulsant potency in the MEST test can be arranged as follows: o-CAM-IPPS > HM-IPPS > AM-IPPS > m-CAM-IPPS > MM-IPPS > IPPS > p-CAM-IPPS >AP-IPPS > BAM-IPPS > ECPM-IPPS.
    Wprowadzenie. Porównać siłę przeciwdrgawkowego działania 10 różnych pochodnych p-izopropoksyfenylobursztynimidów (IPPS) [tj. (IPPS); N-(morfolinometylo)-IPPS (MM-IPPS); N-(anilinometylo)-IPPS (AM-IPPS); N-hydroksymetylo-IPPS (HM-IPPS); N-(p-acetylofenylo)-IPPS (AP-IPPS); N-(p-etoksykarbonylofenylometylo)-IPPS (ECPM-IPPS); N-(m-bromoanilinometylo)-IPPS (BAM-IPPS); N-(o-karboksyanilinometylo)-IPPS (o-CAM-IPPS); N-(m-karboksyanilinometylo)-IPPS (m-CAM-IPPS); N-(p-karboksyanilinometylo)-IPPS (p-CAM-IPPS)] w teście progu maksymalnego wstrząsu elektrycznego (MEST) u myszy. Materiał i metody. Analiza regresji liniowej dawek pochodnych IPPS i ich wzrostów progu w teście MEST u myszy pozwoliła policzyć wartości TID20 tj. dawki badanych pochodnych IPPS, które podnoszą o 20% próg drgawkowy u myszy, którym podano IPPS, ponad próg u zwierząt kontrolnych. Wyniki. Wszystkie badane pochodne IPPS (tj. IPPS, MM-IPPS, HM-IPPS, AP-IPPS, AM-IPPS, ECPM-IPPS, o-CAM-IPPS, m-CAM-IPPS, p-CAM-IPPS and BAM-IPPS) zwiększały w sposób zależny od dawki próg maksymalnego wstrząsu elektrycznego u myszy. Wartości TID20 w teście MEST dla IPPS, AP-IPPS, AM-IPPS, BAM-IPPS, o-CAM-IPPS, m-CAM-IPPS, p-CAM-IPPS, ECPM-IPPS, HM-IPPS i MM-IPPS wynosiły odpowiednio: 60,44 mg/kg, 86,30 mg/kg, 44,69 mg/kg, 103,34 mg/kg, 22,43 mg/kg, 52,84 mg/kg, 80,85 mg/kg, 109,75 mg/kg, 32,62 mg/kg i 53,50 mg/kg. Wnioski. Badane pochodne IPPS w odniesieniu do ich siły przeciwdrgawkowego działania można uporządkować następująco: o-CAM-IPPS > HM-IPPS > AM-IPPS > m-CAM-IPPS > MM-IPPS > IPPS > p-CAM-IPPS > AP-IPPS > BAM-IPPS > ECPM-IPPS.
    Źródło:
    Health Problems of Civilization; 2017, 11, 3; 195-201
    2353-6942
    2354-0265
    Pojawia się w:
    Health Problems of Civilization
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-13 z 13

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