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Tytuł:
Deteriorations of pulmonary function, elevated carbon monoxide levels and increased oxidative stress amongst water-pipe smokers
Autorzy:
Yalcin, Funda K.
Er, Mukremin
Hasanoglu, H. Canan
Kilic, Hatice
Senturk, Aysegul
Karalezli, Aysegul
Ergin, Merve
Erel, Ozcan
Powiązania:
https://bibliotekanauki.pl/articles/2161884.pdf
Data publikacji:
2017-07-14
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
Oxidative stress
carbon monoxide
cigarette smoking
pulmonary function tests
antioxidant status
water-pipe smoking
Opis:
Objectives A water pipe (hookah) is a tobacco smoking tool which is thought to be more harmless than a cigarette, and there are no adequate studies about its hazards to health. Water-pipe smoking is threatening health of the youth in the world today. The objective of this study has been to investigate the carbon monoxide (CO) levels in breath, examine the changes in pulmonary function tests (PFT) and to assess the change of the oxidative stress parameters in blood after smoking a water pipe. Material and Methods This study is a cross-sectional analytical study that has included 50 volunteers who smoke a water pipe and the control group of 50 volunteers who smoke neither a cigarette nor a water pipe. Carbon monoxide levels were measured in the breath and pulmonary function tests (PFTs) were performed before and after smoking a water pipe. Blood samples were taken from either the volunteer control group or water-pipe smokers group after smoking a water pipe for the purpose of evaluation of the parameters of oxidative stress. Results Carbon monoxide values were measured to be 8.08±7.4 ppm and 28.08±16.5 ppm before and after smoking a water pipe, respectively. This increment was found statistically significant. There were also significant reductions in PFTs after smoking a water pipe. Total oxidative status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) were found prominently higher after smoking a water pipe for the group of water-pipe smokers than for the control group. Conclusions This study has shown that water-pipe smoking leads to deterioration in pulmonary function and increases oxidative stress. To the best of our knowledge this study is the only one that has shown the effect of water-pipe smoking on oxidative stress. More studies must be planned to show the side effects of water-pipe habit and protective policies should be planned especially for young people in Europe. Int J Occup Med Environ Health 2017;30(5):731–742
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2017, 30, 5; 731-742
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of Cu²⁺ Ion Irradiation on Microstructure of Er₂O₃ Coating Layer Formed by MOCVD Method
Autorzy:
Tanaka, M.
Takezawa, M.
Hishinuma, Y.
Tanaka, T.
Muroga, T.
Ikeno, S.
Lee, S.
Matsuda, K.
Powiązania:
https://bibliotekanauki.pl/articles/1032912.pdf
Data publikacji:
2017-05
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
nuclear fusion
coating
Er2O3
thin film
TEM
SEM and XRD
Opis:
Erbium oxide (Er₂O₃) coating is one of the promising methods to restrict tritium permeation and the magneto hydrodynamic pressure drop for advanced breeding blanket systems. Er₂O₃ coating layer on large interior surface area of metal pipe is deposited by using metal organic chemical vapor deposition process. In this work, the influence of Cu²⁺ ion irradiation on microstructure of Er₂O₃ coating layer on stainless steel 316 (SUS 316) substrate by metal organic chemical vapor deposition methods was investigated using scanning electron microscopy, transmission electron microscopy observation and X-ray diffraction analysis. Microstructure observation of Er₂O₃ coating was carried out after 0.00-1.50 dpa Cu²⁺ ion irradiation at 298 K and 773 K. Scanning electron microscopy observation of the surface area on Er₂O₃ thin film revealed the crack generation on surface after Cu²⁺ ion irradiation. X-ray diffraction peaks were identified in Er₂O₃ after Cu²⁺ ion irradiation transmission electron microscopy observations, the formation of interlayer between Er₂O₃ coating and SUS substrate was confirmed. According to transmission electron microscopy-energy dispersive spectroscopy, the interlayer includes Fe and Cr.
Źródło:
Acta Physica Polonica A; 2017, 131, 5; 1351-1352
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Photoactivation Analysis of Mineral Trioxide Aggregate: Preliminary Results
Autorzy:
Eke, C.
Er, K.
Segebade, C.
Boztosun, I.
Powiązania:
https://bibliotekanauki.pl/articles/1031466.pdf
Data publikacji:
2017-09
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
25.20.-x
29.20.Ej
Opis:
The purpose of this study is to qualitatively analyse the elemental components of a mineral trioxide aggregate material using photoactivation. The material was irradiated for two hours using bremsstrahlung photons with an end-point energy of 18 MeV from a clinical electron linear accelerator. After irradiation the gamma-ray emission of the sample was counted by gamma spectrometry using a high-purity germanium (HPGe) detector. The gamma-ray spectra were analyzed by computer software. Major and trace elements were detected.
Źródło:
Acta Physica Polonica A; 2017, 132, 3; 869-871
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Time Calibration of the J-PET Detector
Autorzy:
Skurzok, M.
Silarski, M.
Alfs, D.
Białas, P.
Shivani, S.
Curceanu, C.
Czerwiński, E.
Dulski, K.
Gajos, A.
Głowacz, B.
Gorgol, M.
Hiesmayr, B.
Jasińska, B.
Kisielewska-Kamińska, D.
Korcyl, G.
Kowalski, P.
Kozik, T.
Krawczyk, N.
Krzemień, W.
Kubicz, E.
Mohammed, Muhsin
Pawlik-Niedźwiecka, M.
Niedźwiecki, S.
Pałka, M.
Raczyński, L.
Raj, J.
Rudy, Z.
Sharma, N.
Sharma, S.
Shopa, R.
Wieczorek, A.
Wiślicki, W.
Zgardzińska, B.
Zieliński, M.
Moskal, P.
Powiązania:
https://bibliotekanauki.pl/articles/1033283.pdf
Data publikacji:
2017-11
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
06.20.fb
36.10.Dr
11.30.Er
24.80.+y
Opis:
The Jagiellonian positron emission tomograph project carried out in the Institute of Physics of the Jagiellonian University is focused on construction and tests of the first prototype of PET scanner for medical diagnostic which allows for the simultaneous 3D imaging of the whole human body using organic scintillators. The J-PET prototype consists of 192 scintillator strips forming three cylindrical layers which are optimized for the detection of photons from the electron-positron annihilation with high time-and high angular resolutions. In this article we present time calibration and synchronization of the whole J-PET detection system by irradiating each single detection module with a ²²Na source and a small detector providing common reference time for synchronization of all the modules.
Źródło:
Acta Physica Polonica A; 2017, 132, 5; 1641-1644
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wpływ preparatu białkowo-ksantofilowego PX z lucerny (Medicago sativa L.) na aktywność wybranych enzymów w komórkach wątroby tuczników
The effect of protein-xanthophyll concentrate (PX) from alfalfa (Medicago sativa L.) on the activity of selected enzymes in the liver cells of fattening pigs
Autorzy:
Abramowicz, K.
Krauze, M.
Grela, E.R.
Powiązania:
https://bibliotekanauki.pl/articles/843823.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Zootechniczne
Tematy:
trzoda chlewna
zywienie zwierzat
dodatki paszowe
lucerna
koncentrat bialkowo-ksantofilowy
watroba
enzymy
dehydrogenaza mleczanowa
dehydrogenaza jablczanowa
dehydrogenaza bursztynianowa
hydrolaza glukozo-6-fosforanowa
aktywnosc enzymatyczna
Opis:
W dostępnej literaturze krajowej i zagranicznej prezentowane są nieliczne doniesienia na temat aktywności enzymów wskaźnikowych, zwłaszcza markerowych, charakteryzujących pracę konkretnych organelli komórkowych. Ubogie są również informacje na temat zmian aktywności enzymów, jakie zachodzą pod wpływem żywieniowych czynników doświadczalnych. W doświadczeniu założono, że koncentrat białkowo-ksantofilowy PX z lucerny pozytywnie wpłynie na metabolizm, czego efektem będzie poprawa wskaźników produkcyjnych u tuczników. Celem badań było zatem sprawdzenie możliwości wykorzystania niestosowanych dotąd enzymów w ocenie poprawności zachodzących procesów biochemicznych po podaniu PX. Oceniano aktywność enzymów związanych z kluczowymi przemianami biochemicznymi zachodzącymi w komórce, co pozwala na ocenę poprawności zachodzących procesów, jak i reakcji ustroju na czynniki zewnętrzne. Doświadczenie przeprowadzono na 288 tucznikach (loszkach i wieprzkach) mieszańcach (wbp x Neckar), podzielonych na 4 grupy, zróżnicowane pod względem dawki i okresu podawania koncentratu białkowo-ksantofilowego PX z lucerny (Medicago sativa L.). Koncentrat z lucerny wprowadzono do mieszanki paszowej w miejsce poekstrakcyjnej śruty sojowej. Analizowano aktywność wybranych enzymów markerowych: dehydrogenazy mleczanowej (LDH), jabłczanowej (MDH), bursztynianowej (SDH) oraz hydrolazy glukozo-6-fosforanowej (G6PC). Wykazano obniżenie aktywności analizowanych enzymów w komórkach wątroby u zwierząt otrzymujących dodatek koncentratu PX w porównaniu do zwierząt z grupy kontrolnej, co sugeruje korzystny wpływ zastosowanego preparatu na przemiany metaboliczne u badanych zwierząt. Wyniki doświadczenia potwierdzają celowość stosowania w żywieniu świń koncentratu białkowo-ksantofilowego PX z lucerny, zwłaszcza w dawce 3% podawanej w sposób ciągły.
The available Polish and foreign literature contains few reports on the activity of indicator enzymes, especially marker enzymes, which characterize the work of specific cell organelles. Information on enzyme changes induced by experimental dietary factors is also scarce. We postulated that proteinxanthophyll PX alfalfa concentrate would have a positive effect on metabolism in fattening pigs, resulting in improved performance parameters. Therefore the aim of the study was to test the possibility of using enzymes that have not previously been used to assess the biochemical processes taking place following administration of PX. We evaluated the activity of enzymes associated with key biological transformations taking place in the cell, as this makes it possible to assess whether these processes are proceeding normally and to evaluate the response of the body to external factors. The experiment was conducted on 288 finishers (gilts and barrows), all of which were crossbreds (Polish Large White x Neckar), divided into 4 groups according to the dosage and duration of administration of proteinxanthophyll PX concentrate from alfalfa (Medicago sativa L.). The alfalfa concentrate was introduced to the compound feed in place of soybean extraction meal. We analysed the activity of selected marker enzymes: lactate dehydrogenase (LDH), malate dehydrogenase (MDH), succinate hydrolase (SDH), and glucose-6-phosphate hydrolase (G6PC). We found a decrease in the activity of the enzymes in the liver cells of the pigs receiving the PX concentrate as compared to the control, which suggests that the product had a favourable effect on their metabolism. The results confirm the benefit of using proteinxanthophyll PX in pig feed, particularly at a continuous dose of 3%.
Źródło:
Roczniki Naukowe Polskiego Towarzystwa Zootechnicznego; 2017, 13, 2
1733-7305
Pojawia się w:
Roczniki Naukowe Polskiego Towarzystwa Zootechnicznego
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A Study of Importance of Solar Calculations for "Two Colored Rainbow System" in Istanbul
Autorzy:
Er, Z.
Powiązania:
https://bibliotekanauki.pl/articles/1402524.pdf
Data publikacji:
2015-08
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
96.60.Ub
96.60.Q
89.60.-k
89.30.Cc
Opis:
The sun radiation is the largest renewable energy source on the planet which can be used in technology by means of thermal, photovoltaic and concentrated solar power systems. In this study, two types of solar collectors, called the "Two Colored Rainbow System", were used as a source for water heating at the Faculty of Science and Letters, at Istanbul Technical University. The performance of solar water heating system was experimentally investigated. In the experimental study, the temperature of hot water storage tank versus time of the day was investigated. The average daily solar radiation at a location is often sufficient for a basic system analysis. The radiation of sun varies according to the location, date, time and conditions of climate. The change of sun radiation was computed using a determined set of parameters. This study was aimed to offer optimization of design parameters taking into account possible interferences during the operation of the system. Additionally, hourly solar radiation on tilted surfaces is measured in Istanbul. Data of solar radiation intensity were also collected using a standard solarimeter (pyrometer) via a data logger.
Źródło:
Acta Physica Polonica A; 2015, 128, 2B; B-477-B-478
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of dietary supplementation with alfalfa protein-xanthophyll concentrate (PX) on ewe milk performance
Wpływ stosowania koncentratu białkowo-ksantofilowego z lucerny (PX) w żywieniu owiec matek na ich mleczność i wzrost potomstwa
Autorzy:
Szymanowska, A.
Patkowski, K.
Gruszecki, T.M.
Szymanowski, M.
Grela, E.R.
Miroslaw, M.
Powiązania:
https://bibliotekanauki.pl/articles/843984.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Zootechniczne
Źródło:
Roczniki Naukowe Polskiego Towarzystwa Zootechnicznego; 2015, 11, 4
1733-7305
Pojawia się w:
Roczniki Naukowe Polskiego Towarzystwa Zootechnicznego
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of humic-plant feed preparations on biochemical blood parameters of laying hens in deep litter housing system
Autorzy:
Bubel, F.
Dobrzanski, Z.
Gawel, A.
Pogoda-Sewerniak, K.
Grela, E.R.
Powiązania:
https://bibliotekanauki.pl/articles/30300.pdf
Data publikacji:
2015
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
An influence of various humic-plant feed additives based on some herbs (nettle, chamomile, yarrow, perforatum), lucerne and humic materials on biochemical indices of Lohmann Brown (LB) layers blood plasma was estimated. Hens were housed in deep litter system, 20 birds in a group. Four groups were formed: control (C - standard feeding), and experimental, supplemented with preparations: E-1 herbal-humic, E-2 humic-herbal and E-3 - humic-lucerne. Hens were placed in the pens on the 16th week of life, addition of preparations with standard food mixture started at the 22nd wk and lasted until 66th wk of life. Blood for analyses was collected four times in the following periods: 27, 37, 54 and 65th wk of life. The applied humic-plant preparations to a limited degree affected the values of examined biochemical parameters in serum: total protein (TP), albumins (Albs), glucose (Glu), urea, triacylglycerols (TAG), total cholesterol (TCh), alanine aminotransferase (ALT), aspartate aminot-ransferase (AST) and alkaline phosphatase (ALP). It is difficult to determine based on these study, which preparation is one the most active biologically, however is seems that humic-lucerne preparation affected the examined blood parameters to the highest degree. The reference values ranges in hens blood serum LB hens were proposed for: TP (43-65 g/l), Albs (15-22 g/l), urea (0.5-1.2 mmol/l), Glu 10-15 mmol/l), TCh (2.2-4.5 mmol/l), TAG (10-24 mmol/l), AST (4-12 U/l), ALT (150-280 mmol/l) and ALP (190-350 U/l).
Źródło:
Polish Journal of Veterinary Sciences; 2015, 18, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wpływ dodatku preparatu białkowego z lucerny (APC) w mieszankach dla loch i prosiąt na strawność podstawowych składników pokarmowych i frakcji włókna detergentowego
The effect of alfalfa protein concentrate (APC) addition in mixtures for sows and piglets on the total tract digestibility of the basic nutrients and detergent fiber fractions
Autorzy:
Pietrzak, K.
Grela, E.R.
Powiązania:
https://bibliotekanauki.pl/articles/2196815.pdf
Data publikacji:
2015
Wydawca:
Uniwersytet Przyrodniczy w Lublinie. Wydawnictwo Uniwersytetu Przyrodniczego w Lublinie
Tematy:
lucerna
preparaty bialkowe
preparat bialkowy z lucerny
dodatki paszowe
mieszanki paszowe
skladniki pokarmowe
wlokno detergentowe
strawnosc
zywienie zwierzat
lochy
prosieta
Źródło:
Annales Universitatis Mariae Curie-Skłodowska. Sectio EE: Zootechnica; 2015, 33, 1; 17-25
0239-4243
2083-7399
Pojawia się w:
Annales Universitatis Mariae Curie-Skłodowska. Sectio EE: Zootechnica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Koncepcje kształtowania bezpieczeństwa ruchu drogowego. Cz. 2, Możliwości zastosowania koncepcji trzech er w Polsce
Concepts of road safety development. Part 2. The possibility of the three eras concept implementation in Poland
Autorzy:
Jamroz, K.
Powiązania:
https://bibliotekanauki.pl/articles/144860.pdf
Data publikacji:
2013
Wydawca:
Stowarzyszenie Inżynierów i Techników Komunikacji Rzeczpospolitej Polskiej
Tematy:
drogi
bezpieczeństwo ruchu drogowego
kształtowanie bezpieczeństwa
koncepcja trzech er
roads
road safety
developing safety
three eras concepts
Opis:
Odpowiadając na zalecenia ONZ i Unii Europejskiej, Polska przystąpiła do opracowania strategicznego programu brd na lata 2013-2020. Jednym z podejść do opracowania tego programu powinna być koncepcja trzech er. W artykule przedstawiono propozycję praktycznego wdrożenia koncepcji trzech er na sieci dróg w Polsce.
In response to the recommendations of the United Nations and the European Union, Poland has acceded to develop a strategic road safety program for the years 2013 to 2020. One of the approaches to the development of this program should be the concept of three eras. This article describes a practical implementation of the concept of the three eras of the road network in Poland.
Źródło:
Drogownictwo; 2013, 1; 15-19
0012-6357
Pojawia się w:
Drogownictwo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of protein-xanthophyll concentrate of alfalfa on growth performance and carcass value of growing-finishing pigs
Wpływ dodatku koncentratu białkowo-ksantofilowego z lucerny na efekty produkcyjne i wartość rzeźną tusz tuczników
Autorzy:
Pietrzak, K.
Grela, E.R.
Powiązania:
https://bibliotekanauki.pl/articles/2196927.pdf
Data publikacji:
2013
Wydawca:
Uniwersytet Przyrodniczy w Lublinie. Wydawnictwo Uniwersytetu Przyrodniczego w Lublinie
Tematy:
protein-xanthophyll concentrate
alfalfa
Medicago sativa
protein content
growth performance
carcass value
growing-finishing pig
slaughter trait
Źródło:
Annales Universitatis Mariae Curie-Skłodowska. Sectio EE: Zootechnica; 2013, 31, 3; 10-17
0239-4243
2083-7399
Pojawia się w:
Annales Universitatis Mariae Curie-Skłodowska. Sectio EE: Zootechnica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of supplementing organic diets with fish meal and premix on the performance of pigs and some meat and blood characteristics
Autorzy:
Grela, E.R.
Matras, J.
Pisarski, R.K.
Sobolewska, S.
Powiązania:
https://bibliotekanauki.pl/articles/30373.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
The aim of this study was to determine the effect of fish meal and mineral-vitamin premix, supplementing organic diets, on the performance of pigs and some meat and blood characteristics. The experiment was conducted on an organic pig fattening farm. The study involved 120 pigs with an approximate 25 kg body weight. Animals were divided into 3 groups, kept in pens, 10 animals each. Group I (control) animals were fed with plant feedstuffs of organic origin. Diets for group II and III were enriched with fish meal or fish meal and vitamin-mineral premix, respectively. The experiment was carried out till pigs reached a weight of 115 kg. Feed samples were subjected to laboratory analyses. Body weight (3 times) and feed intake were recorded. Blood samples were collected (2 times) to determine hematological and biochemical indices. Some parameters in meat samples were also determined. The fish meal addition improved (P ≤ 0.05) the average daily gains as well as feed conversion ratio during fattening period and mineral-vitamin premix significantly (P ≤ 0.05) fortified fish meal influence. Fish meal supplement improved (P ≤ 0.05) also some carcass characteristics. Supplementation of the diet with premix additionally decreased (P ≤ 0.05) backfat thickness and increased share of meat in carcass. Fish meal improved (P ≤ 0.05) some meat characteristics and elevated content of some polyunsaturated fatty acids. An increase in hemoglobin, red blood cell, white blood cell and cholesterol level in blood of animals from both experimental groups were also found. The results obtained proved the usefulness of fish meal and mineral-vitamin premix in the fatteners nutrition based on organic diets.
Źródło:
Polish Journal of Veterinary Sciences; 2012, 15, 2
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of Carbon on Spin Reorientation Processes in $Er_{2-x}R_xFe_{14}C$ (R~=~Gd, Pr) - Mössbauer and Magnetometric Studies
Autorzy:
Pędziwiatr, A.
Krawiec, K.
Bogacz, B.
Kapusta, Cz.
Przewoźnik, J.
Kaczorowski, D.
Talik, E.
Powiązania:
https://bibliotekanauki.pl/articles/1506592.pdf
Data publikacji:
2011-01
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
76.80.+y
75.25.-j
75.50.-y
75.50.Bb
Opis:
The $Er_{2-x}R_{x}Fe_{14}C$ (R=Gd, Pr) polycrystalline compounds have been synthesized and investigated with $\text{}^{57}Fe$ Mössbauer spectroscopy and magnetic measurements. The spin reorientation phenomena were studied extensively by narrow step temperature scanning in the neighborhood of the spin reorientation temperature. Obtained Mössbauer spectra were analyzed using a procedure of simultaneous fitting and the transmission integral approach. Consistent description of Mössbauer spectra were obtained, temperature and composition dependencies of hyperfine interaction parameters and subspectra contributions were derived from fits and the transition temperatures were determined for all the compounds studied. Initial magnetization versus temperature measurements (in zero and non-zero external field) for $Er_{2-x}Gd_{x}Fe_{14}C$ compounds allowed to establish the temperature regions of reorientation, change of magnetization value during the transition process. The results obtained with different methods were analyzed and the spin arrangement diagrams were constructed. Data obtained for $Er_{2-x}Gd_{x}Fe_{14}C$ were compared with those for $Er_{2-x}Gd_{x}Fe_{14}B$ series.
Źródło:
Acta Physica Polonica A; 2011, 119, 1; 48-51
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preliminary evaluation of ER- and AhR-mediated gene expression patterns in rainbow trout (Oncorhynchus mykiss) liver after short-term exposure to zearalenone in binary mixtures
Autorzy:
Woźny, M.
Brzuzan, P.
Wolińska, L.
Góra, M.
Łuczyński, M. K.
Powiązania:
https://bibliotekanauki.pl/articles/363144.pdf
Data publikacji:
2010
Wydawca:
Uniwersytet Warmińsko-Mazurski w Olsztynie
Tematy:
receptor AhR
benzo(a)piren
ścieżka sygnałowa
17beta-estradiol
receptor estrogenowy
zearalenone
aryl hydrocarbon receptor
benzo(a)pyrene
crosstalk
estrogen receptor
Opis:
While estrogenic properties of mycotoxin zearalenone (ZEA) has been an extensively studied issue, little is known about molecular background of its biological responses that cannot be simply explained by the estrogenic potential. The present study describes effects of ZEA (10mg*kg-1 body weight) in binary mixtures either with benzo[a]pyrene (B[a]P), or with 17β-estradiol (E2) on ER- and AhR-dependent gene expression in juvenile rainbow trout liver, evaluated using Real-Time qPCR. The study revealed dual nature of ZEA, as the treatment with this compound alone increased mRNA levels of both ER- and AhR-mediated gene expression. However, our results did not show any synergistic or additive effect of ZEA in binary mixures with E2 or B[a]P on studied gene expression levels. Whether the intriguing potential of ZEA to elicit distinct signals was a result of binding affinity to AhR or/and ER and AhR mutual receptor interactions, should be investigated in further experiments.
Źródło:
Environmental Biotechnology; 2010, 6, 1; 16-23
1734-4964
Pojawia się w:
Environmental Biotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł

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