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Wyświetlanie 1-15 z 35
Tytuł:
MGF360-12L of ASFV-SY18 is an immune-evasion protein that inhibits host type I IFN, NF-κB, and JAK/STAT pathways
Autorzy:
Chen, Q.
Wang, X.X.
Jiang, S.W.
Gao, X.T.
Huang, S.Y.
Liang, Y.
Jia, H.
Zhu, H.F.
Powiązania:
https://bibliotekanauki.pl/articles/16647496.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
African swine fever virus
MGF360-12L
type I IFN
NF-κB
JAK/STAT
Opis:
African swine fever virus (ASFV) causes feverous and hemorrhagic disease of domestic pigs and European wild boars with high mortality, yet no commercial vaccine is currently available. Several ASFV strains with natural deletion or gene-targeted knockout of multiple MGF360 and MGF505 genes are attenuated in vitro and in vivo, and can offer full protection against homologous challenge. However, the mechanisms underlying the protection are not fully understood. This study aims to investigate the effects of MGF360-12L of ASFV-SY18 on the cGAS-STING signaling pathway and explore the potential mechanisms. We identified that ASFV-SY18 MGF360-12L could inhibit cGAS-STING, TBK1, or IRF3-5D-stimulated IFN-β expression and ISRE activation. Specifically, MGF360-12L inhibits both the activation of PRD(III-I) in a dose-dependent manner, and suppresses the exogenous expression of TBK1 and IRF3-5D. MGF360-12L could block NF-κB activation induced by overexpression of cGAS-STING, TBK1, IKKβ. Downstream of the IFN-β signaling, MGF360-12L blocks the ISRE promoter activation by reducing total protein level of IRF9. Moreover, MGF360-12L protein can inhibit IFN-β-mediated antiviral effects. In conclusion, our findings suggest that MGF360-12L is a multifunctional immune-evasion protein that inhibits both the expression and effect of IFN-β, which could partially explain the attenuation of relevant gene-deleted ASFV strains, and shed light on the development of efficient ASFV live attenuated vaccines in the future.
Źródło:
Polish Journal of Veterinary Sciences; 2023, 26, 1; 119-130
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antibacterial spectrum of four compounds from yeasts in koumiss
Autorzy:
Chen, Y.J.
Du, C.G.
Guo, Y.Q.
Zhao, Y.F.
Aorigele, C.
Wang, C.J.
Simujide, H.
Aqima, W.
Zhang, X.Y.
Powiązania:
https://bibliotekanauki.pl/articles/2087160.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Kluyveromyces marxianus
Saccharomyces cerevisiae
Escherichia coli
minimum inhibition concentration
minimum bactericidal concentration
Źródło:
Polish Journal of Veterinary Sciences; 2021, 24, 2; 167-173
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The Bending, Impact Fracture Behavior and Characteristics of Stainless Steel Clad Plates with Different Rolling Temperature
Autorzy:
An, Q.
Fan, K. Y.
Ge, Y. F.
Liu, B. X.
He, J.
Wang, S.
Chen, C. X.
Ji, P. G.
Tolochko, O.
Powiązania:
https://bibliotekanauki.pl/articles/2049433.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
stainless steel clad plate
interface characteristics
bending behavior
impact morphologies
delamination crack
Opis:
The interface characteristics, bending and impact behavior, as well as fracture characteristics of stainless steel clad plates fabricated by vacuum hot rolling at different rolling temperatures of 1100°C, 1200°C and 1300°C are investigated in detail. The interface bonding strength is gradually increased with the increasing rolling temperature due to the sufficient diffusion behavior of alloy element. The bending toughness and impact toughness are gradually decreased, while the bending strength increase with the increase of the rolling temperature, which is attributed to mechanisms of matrix softening and interface strengthening at high rolling temperature. Due to the weak interface at 1100°C, the bending and impact crack propagation path was displaced by delamination cracks, which in turn lead to reduction in stress intensity of the main crack, playing an effective role in toughening the stainless steel clad plates. Moreover, the impact fracture morphologies of clad plates show a typical ductile-brittle transition phenomenon, which is attributed to the matrix softening behavior with the increasing rolling temperature.
Źródło:
Archives of Metallurgy and Materials; 2021, 66, 1; 229-239
1733-3490
Pojawia się w:
Archives of Metallurgy and Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Urinary concentrations and determinants of pyrethroid metabolites in pregnant women from non-rural areas of Yunnan, China
Autorzy:
Xu, Q.
Song, X.
Li, Y.
Jian, X.
Chen, S.
Chen, Y.
Powiązania:
https://bibliotekanauki.pl/articles/28762713.pdf
Data publikacji:
2021
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2021, 28, 4; 627-632
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Temporal patterns of pollen shedding for longleaf pine (Pinus palustris) at the Escambia Experimental Forest in Alabama, USA
Autorzy:
Chen, X.
Brockway, D.G.
Guo, Q.
Powiązania:
https://bibliotekanauki.pl/articles/2078205.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Instytut Dendrologii PAN
Tematy:
accumulated air temperature
accumulated pollen density
peak pollen shedding
pollen phenology
power-law
Opis:
Longleaf pine is an important tree species in the southeastern United States and studying the temporal patterns of pollen shedding is crucial to a better understanding of its phenology and seed production. In this study, field observation data on the timing of pollen shedding from 1958 to 2013 were analyzed with reference to local weather conditions. Our results indicated that the time of peak pollen shedding after January 1 (TPPS) ranged from 53 days (about February 22) to 95 days (around April 5). There was no significant trend of decreasing TPPS. The number of days with the maximum air temperature above 0 °C was close to the TPPS. The accumulated maximum daily air temperature for the TPPS approximated an average of 1,342 °C. The TPPS declined with an increase in the average air temperature during winters. The time of 80% accumulated pollen density (TAPD) varied from 5 to 32 days, with an average of 13 days. Taylor’s power-law was evident in the TAPD data, with the time group of 10–15 days having an interval time of 2 years. Winter weather was not correlated with the TAPD. These results provide new information concerning the pollen phenology for longleaf pine trees
Źródło:
Dendrobiology; 2020, 84; 30-38
1641-1307
Pojawia się w:
Dendrobiology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Isolation and sequence analysis of the complete VP2 gene of canine parvovirus from Chinese domestic pets and determination of the pathogenesis of these circulating strains in beagles
Autorzy:
Chen, M.R.
Guo, X.Y.
Wang, Z.Y.
Jiang, Y.T.
Yuan, W.F.
Xin, T.
Hou, S.H.
Song, T.Q.
Lin, W.D.
Zhu, H.F.
Jia, H.
Powiązania:
https://bibliotekanauki.pl/articles/2087542.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
canine parvovirus
molecular epidemiology
phylogenetic analysis
pathogenesis
Źródło:
Polish Journal of Veterinary Sciences; 2019, 2; 287-296
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pharmacokinetics of the recombinant ovine interferon-tau in lambs
Autorzy:
Zhao, J.
Yu, H.Y.
Zhao, Y.
Li, S.Q.
Fu, X.L.
Zhou, W.
Xia, B.B.
Wang, M.L.
Chen, J.
Powiązania:
https://bibliotekanauki.pl/articles/2087588.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
bioavailability
ovine interferon-τ
cytopathic effect inhibition assay
pharmacokinetic study
Źródło:
Polish Journal of Veterinary Sciences; 2019, 1; 75-82
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
pUC18-CpG stimulates RAW 264.7 via TBK1-mediated pathway and presents adjuvanticity in mice
Autorzy:
Wu, J.
Chen, Q.
Xin, T.
Sun, Y.
Jia, H.
Hou, S.H.
Guo, X.Y.
Powiązania:
https://bibliotekanauki.pl/articles/2087554.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
adjuvant
CpG DNA
Echinococcus granulosus
TBK1
type I interferons
Źródło:
Polish Journal of Veterinary Sciences; 2019, 2; 195-201
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Biomechanical evaluation of tendon connection with novel suture techniques
Autorzy:
Chen, Z.
Wang, J.
Wei, J.- S.
Hou, Z.-Y.
Li, M.
Chen, Q.-X
Powiązania:
https://bibliotekanauki.pl/articles/306902.pdf
Data publikacji:
2018
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
ścięgno Achillesa
IFLL
biomechanika
internal fixation with limited loop
Achilles tendon
biomechanics
Opis:
Achilles tendon rupture is a severe injury with poor curative effect due to its anatomical characteristic and mechanical peculiarity. Internal fixation of limited loop (IFLL) with steel-wire has been applied on patients with tendon rupture to fix the broken ends before physical rehabilitation. The purpose of this study is to investigate the biomechanical property and radiological characteristic of such suture technique for the repairment of tendon rupture. Methods: Tendons of pigs’ hint feet were separated for the biomechanical study. Suture surgery was performed according to the protocol of IFLL. Biomechanical Testing Machine was adopted to conduct the biomechanical tensile load examination. The maximal load, elastic modulus and tendon stiffness of the stitched tendons with or without reinforcement were examined. Results: The maximum tensile load of the stitched tendons using IFLL reached 1/4 of the uninjured tendon’s maximum tensile load, indicating that such suture technique is capable of providing enough tension for the ruptured tendon. Surprisingly, tendons fixed with titanium wire showed the highest load tension, which was comparable to the undamaged tendon. Therefore, we found the biomechanical basis of using IFLL in effectively connecting the rupture ends of tendons. Conclusions: In conclusion, we provide biomechanical evidence for the use of IFLL in treatment of Achilles tendon rupture, by providing enough strength for the ankle function. Such suture technique could help the patients with better rehabilitation and reduced in-hospital stay after Achilles tendon injury.
Źródło:
Acta of Bioengineering and Biomechanics; 2018, 20, 1; 135-141
1509-409X
2450-6303
Pojawia się w:
Acta of Bioengineering and Biomechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Experiment on pressure characteristics of submerged floating tunnel with different section types under wave condition
Autorzy:
Li, Q.
Jiang, S.
Chen, X.
Powiązania:
https://bibliotekanauki.pl/articles/260098.pdf
Data publikacji:
2018
Wydawca:
Politechnika Gdańska. Wydział Inżynierii Mechanicznej i Okrętownictwa
Tematy:
submerged floating tunnel
section type
irregular waves
pressure characteristics
physical test
Opis:
Submerged floating tunnel (SFT for short) is a special underwater traffic structure, and wave load is one of the main environmental loads of SFT structure. In this paper, the 1:60 physical model test of three kinds of SFT in a two-dimensional wave flume is tested. The effects of random irregular waves on the SFT structure under different wave heights and periods are discussed. The study shows that: (1) Compared with circular and polygonal sections, there are multiple local peaks in the elliptical section during the period. with the increase of wave height, the number of local peaks also increases. It suggests that the rotational moment plays an important role in the elliptical section which has a relatively small depth-width ratio. (2) The position of the maximum and minimum pressure in the three kinds of SFT sections is consistent. Their vertical wave forces are all larger than their horizontal wave forces. The increase of vertical wave force relative to horizontal wave force in polygon section is larger than that in elliptical section, and the difference in the circular section is the smallest. (3) Under the same traffic condition, the wave force of the elliptical and polygon section is smaller, but they are more sensitive to the change of wave height, and the increase is obvious. The distribution of wave force in the circular section is more uniform.
Źródło:
Polish Maritime Research; 2018, S 3; 54-60
1233-2585
Pojawia się w:
Polish Maritime Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Leaching of heavy metals from MSWI fly ash : experiments vs. simulation
Autorzy:
Qiu, Q
Jiang, X.
Chen, Z.
Lu, S.
Ni, M.
Powiązania:
https://bibliotekanauki.pl/articles/205253.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
simulation
MSWI fly ash
microwave
hydrothermal treatment
Visual MINTEQ
Opis:
In this work, pH-dependence experiments and leaching modeling using Visual MINTEQ were performed to evaluate the stability and simulate the leaching characteristics of heavy metals in municipal solid waste incineration (MSWI) fly ash. Modeling the equilibrium concentration of Cd, Cu, Cr, Ni, Pb and Zn in raw and treated fly ash was the main target and was conducted over a pH range of 0.5–14. In addition, simulation of the leaching behavior of MSWI fly ash with different additives was also conducted. The treated fly ash was solidified by a microwave-assisted hydrothermal process with added phosphate. The initial elemental concentrations of MSWI fly ash, including raw and treated fly ash, were detected by a microwave apparatus and inductively coupled plasma atomic emission spectroscopy (ICP-AES). The ICP-AES analysis showed that most leaching concentrations of treated fly ash decreased considerably compared to the raw fly ash. The simulation results indicated that the dissolution/precipitation simulation models of Zn, Cu and Pb were broadly consistent with the experimental results, while the leaching behaviors of Ni, Cr and Cd were determined by both dissolution/precipitation and surface complexation mechanisms. In addition, the models of reagent solidification revealed that the stabilization effect of Na2S was better than that of Na2CO3. This model will be useful in the evaluation of the leaching concentrations of heavy metals in fly ash.
Źródło:
Archives of Environmental Protection; 2018, 44, 2; 55-61
2083-4772
2083-4810
Pojawia się w:
Archives of Environmental Protection
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Optimal expression and purification of sapelovirus A structural protein VP1, and its immunogenicity in mice
Autorzy:
Zhao, T.T.
Cui, L.
Chen, L.
Li, J.J.
Liang, Q.L.
Wu, P.J.
Yu, X.Q.
Zhang, Z.H.
Hua, X.G.
Powiązania:
https://bibliotekanauki.pl/articles/2087686.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
sapelovirus A
prokaryotic expression
purification
Źródło:
Polish Journal of Veterinary Sciences; 2018, 21, 3; 573-579
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stability of air nucleus in liquid water and cavitation inception on marine engineering
Autorzy:
Fu, Q.
Chen, M.
Wang, X.
Zhu, R.
Zhang, G.
Powiązania:
https://bibliotekanauki.pl/articles/260137.pdf
Data publikacji:
2018
Wydawca:
Politechnika Gdańska. Wydział Inżynierii Mechanicznej i Okrętownictwa
Tematy:
air nuclei
water
molecular dynamics
stability
surface tension
Opis:
The micro air nucleus widely distributed in the ocean is a necessary condition for the cavitation of hydraulic machinery in seawater. In order to study the stability of air nucleus in seawater and cavitation inception, the computational domain of water molecules with air nucleus was studied using the method of molecular dynamics simulation, and the transient characteristics of air nucleus in liquid water were obtained. The key factors influencing nuclei stability were analyzed. The results showed that air nucleus with a certain mass could maintain the dynamic equilibrium in liquid water. The internal density of air nuclei had a critical value that allowed the nuclei to stably exist in water. The air nuclei mass was the decisive factor in its equilibrium volume in water, and the two were positively correlated. The internal density of air nuclei was negatively correlated with the nuclei radius when the nuclei was stable in water. Liquid surface tension was an important factor affecting the stability of the air nuclei. The larger the initial radius of nuclei, the smaller the water pressure, and the more likely the cavitation occurs.
Źródło:
Polish Maritime Research; 2018, S 3; 111-119
1233-2585
Pojawia się w:
Polish Maritime Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The DC-side active filter with dual-buck full-bridge inverter for wind generators
Autorzy:
Chen, X-Q.
Zhao, S-W.
Wang, Y.
Powiązania:
https://bibliotekanauki.pl/articles/141358.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
multi-pulse ac-dc converter
auto-transformer
harmonic suppression
DC-side active filter
dual-buck full-bridge inverter
Opis:
This paper proposes a new dc-side active filter for wind generators that combines 12-pulse polygon auto-transformer rectifier with dc-side current injection method and dual-buck full-bridge inverter having not the “shoot-through” problem in conventional bridge-type inverters, and therefore this system with the character low harmonic distortion and high reliability. The proposed dc-side active filter is realized by using dual-buck full bridge converter, which directly injects compensation current at dc-side of two six-pulse diode bridges rectifiers. Compared with the conventional three-phase active power filter at ac-side, the system with the dc-side active filter draws nearly sinusoidal current by shaping the diode bridges output current to be triangular without using the instantaneous reactive power compensation technology, only using simple hysteretic current control, even though under load variation and unbalanced voltage disturbances, and while an acceptable linear approximation to the accurate waveform of injection current is recommended. The performance of the system was simulated using MATLAB/Simulink, and the possibility of the dc-side active filter eliminating current harmonics was confirmed in steady and transient states. The simulation results indicate, the system has a total harmonic distortion of current reduced closely to 1%, and a high power factor on the wind generator side.
Źródło:
Archives of Electrical Engineering; 2018, 67, 2; 263--277
1427-4221
2300-2506
Pojawia się w:
Archives of Electrical Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 35

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