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Tytuł:
Blood lead determinants and the prevalence of neuropsychiatric symptoms in firearm users in Mexico
Autorzy:
Aguilar Madrid, Guadalupe
Téllez-Cárdenas, Liliana
Juárez-Pérez, Cuauhtémoc A.
Haro-García, Luis C.
Mercado-García, Adriana
Gopar-Nieto, Rodrigo
Cabello-López, Alejandro
Powiązania:
https://bibliotekanauki.pl/articles/2177065.pdf
Data publikacji:
2015-11-12
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
neuropsychiatric symptoms
occupational exposure
lead exposure
blood lead
firearms
heavy metal toxicity
Opis:
Objectives To identify blood lead predictors and the prevalence of neuropsychiatric symptoms in firearm users of public security in Mexico. Material and Methods A cross-sectional study was performed on 65 males. We obtained socio-occupational data and determined venous blood lead (blood (B), lead (Pb) – BPb), as well as neuropsychiatric symptoms using the Q-16 questionnaire. A multiple linear regression model was constructed to assess determinants of BPb. Results The mean age in the study group was 34.8 years (standard deviation (SD) = 6.9, range: 21–60); the mean number of years spent in the company amounted to 14 years (SD = 8.5, range: 1–48). Twenty percent of the respondents (N = 13) used leaded glazed clay pottery (lead (Pb), glazed (G), and clay pottery (C) – PbGC) in the kitchen. During practice they fired a mean of 72 shots (SD = 60, range: 20–250), and during their whole duration of employment 5483 shots (SD = 8322.5, range: 200–50 000). The mean BPb was 7.6 μg/dl (SD = 6.8, range: 2.7–51.7). Two caretakers from the firing range had 29.6 μg/dl and 51.7 μg/dl BPb. The subjects who had shooting practice sessions ≥ 12 times a year reported a greater percentage of miscarriages in their partners (24% vs. 0%). Twelve percent of the respondents showed an increase in neuropsychiatric symptoms. The BPb multiple linear regression model explained R² = 44.15%, as follows: those who had ≥ 12 practice sessions per year – β = 0.5339 and those who used PbGC – β = 0.3651. Conclusions Using firearms and PbGC contributes to the increased BPb in the studied personnel. The determinants of BPb were: shooting practices >12 times a year and using PbGC. Blood lead concentrations reported in the study, despite being low, are a health risk, as evidenced by the prevalence of neuropsychiatric symptoms.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2016, 29, 2; 219-228
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The role of probiotic intervention in regulating gut microbiota, short-chain fatty acids and depression-like behavior in lead-exposed rats
Autorzy:
Chen, Xiaojun
Meng, Shujuan
Yu, Yongli
Li, Shuang
Wu, Lei
Zhang, Yanshu
Powiązania:
https://bibliotekanauki.pl/articles/2085714.pdf
Data publikacji:
2022-02-15
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
depression
lead exposure
probiotic
gut microbiota
SCFAs
neurobehavioral tests
Opis:
ObjectivesThe aim of this study was to observe the depression-like behavior changes of rats exposed to lead with or without probiotic intervention, and to investigate changes in the gut microbiota and fecal short-chain fatty acids (SCFAs) levels after lead exposure, and the possible functions of probiotics in this process.Material and MethodsAdult male Sprague Dawley rats were exposed to a 300 mg/l lead acetate solution for 24 weeks, with or without probiotic (freeze-dried powder containing Lactobacillus and Bifidobacterium: 6 billion live bacteria/2 g) intervention in weeks 17–24. The sucrose preference test (SPT), the forced swim test (FST), and the tail suspension test (TST) were preformed to study the depression-like behaviors of these rats. The alteration of rat gut microbiota induced by lead exposure was analyzed by 16S rRNA sequencing, and the levels of fecal SCFAs were detected using gas chromatography.ResultsNeurobehavioral tests showed that lead exposure induced depression-like behavior in rats, including reduced sucrose preference in the SPT, and increased immobility times in the FST and the TST. Sequencing and gas chromatography showed that lead exposure changed the structure and the phylogenetic diversity of the gut microbiota, as well as significantly altered the levels of SCFAs. Moreover, the depression-like behaviors, and the changes in both gut microbiota and SCFAs, could be mitigated by probiotic intervention.ConclusionsLead exposure not only changes the structure and diversity of the gut microbiome but also affects metabolic function. Probiotic intervention may be a novel initiative for the prevention and treatment of neurological damage following lead exposure. Health. 2022;35(1):95–106
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2022, 35, 1; 95-106
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Lead Exposure in Trader Communities in Industrial Area of the Battery Recycling Plant: Tangerang, Indonesia
Autorzy:
Oginawati, Katharina
Sidhi, Rifan
Susetyo, Septian Hadi
Powiązania:
https://bibliotekanauki.pl/articles/123452.pdf
Data publikacji:
2020
Wydawca:
Polskie Towarzystwo Inżynierii Ekologicznej
Tematy:
lead exposure
urine lead
risk assessment
heavy metal
battery recycling plant
Opis:
The aim of this study was to look at the risk of community around the battery recycling plant in terms of the exposure to lead dust. The number of respondents amounted to 60 people from an industrial area and a residential area. The sample of the industrial area included 30 respondents with a composition of 15 men and 15 women. The same number of respondents was also examined in the residential area as a control area, located 5 km from the industrial area. Respirable dust was measured using a personal dust sampler, the concentration of lead in dust was measured using GF-AAS, while as a biomarker of exposure, the lead content in urine was measured using GF-AAS. The average values for respirable lead in industrial and residential areas are 0.92 μg/m3 and 0.92–1.34 μg/m3. The analysis of the lead content in urine for the industrial and residential areas produced an average value of 119 ppb and 123 ppb. The average value of HI for the lead exposure on the industrial and residential areas are in danger (HI > 1) which is 3.6 ± 1.94 and 2.18 ± 1.49. The OR values for the respondents in the industrial area compared to the residential areas amounting to 1.17 for the category of HI lead exposure and 1.22 for the category of lead in urine.
Źródło:
Journal of Ecological Engineering; 2020, 21, 4; 264-270
2299-8993
Pojawia się w:
Journal of Ecological Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Exposure to lead and cadmium released from ceramics and glassware intended to come into contact with food
Autorzy:
Rebeniak, M.
Wojciechowska-Mazurek, M.
Mania, M.
Szynal, T.
Strzelecka, A.
Starska, K.
Powiązania:
https://bibliotekanauki.pl/articles/876754.pdf
Data publikacji:
2014
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:
lead exposure
cadmium exposure
ceramics
glass
contact with food
food contact surface
lead migration
cadmium migration
risk assessment
health hazard
human health
kitchenware
Opis:
Background. The dietary intake of harmful elements, particularly lead and cadmium constitutes a health threat and essential measures should be undertaken to reduce consumer exposure. The latest risk assessments by the European Food Safety Authority (EFSA) and Joint FAO/WHO Expert Committee on Food Additives (JECFA) have indicated that the Provisional Tolerable Weekly Intake (PTWI) for lead and cadmium do not ensure health safety and their review had to be undertaken. Migration from ceramics and glassware intended for food contact is an important source of lead and cadmium intake. Objectives. To study the release of lead and cadmium from ceramics and glassware (including decorated products) intended for food contact that are available on the Polish market and to assess the resulting health risk to the consumer. Materials and Methods. Ceramics and glassware (mainly decorated) were sampled from the Polish market during 2010- 2012 throughout the country by staff of the Sanitary-Epidemiological Stations in accordance with monitoring procedures and guidelines designed by the National Institute of Public Health-National Institute of Hygiene. Migration of lead and cadmium was measured by incubating the samples with 4% acetic acid for 24 hours at a temperature of 22±2ºC in the dark. Flame Atomic Absorption Spectrometry (FAAS) was used to measure these elements in food simulant according to a validated and accredited method (PN-EN ISO/IEC 17025). Results. 1273 samples of ceramics and glass wares were analysed in 2010-2012. Lead and cadmium release were usually found to be below analytical detection limits. Permissible migration limits (as prescribed by the legislation) of these metals were rarely exceeded and were reported mainly in articles imported from outside the EU. Two imported and decorated ceramic flat plates released lead at 0.9 and 11.9 mg/dm2 (limit 0.8 mg/dm2) and 5 imported deep plates gave migration values of 4.7 mg/L, 4.9 mg/L, 5.6 mg/L, 6.1 mg/L, 8.6 mg/L (limit 4.0 mg/L). Lead migrations from ceramic ware rims above the 2.0 mg per product limit (as established in Polish Standard PN-B-13210:1997 [16]) were observed in 4 samples, at 2.1, 3.7, 4.2 and 14.4 mg per product, respectively. Migrations of cadmium from the ceramic samples’ rims were within permissible limits. Majority of high migration results were obtained for decorated rims of glass vessels for beverages. The highest migration from the rim of an imported glass mug was reported at 163.8 mg/product for lead and at 8.96 mg/product for cadmium. Risk assessment indicated that exposures to lead and cadmium released from ceramic wares based on the migration limits set by the EU legislation lead to human intake close to, or exceeding reference doses. For a 20 kg b.w. child the lead BMDL01 value could thus be exceeded by over 30-fold and the cadmium TWI value 4-fold. Conclusions. Review of EU legislation applicable to lead and cadmium migration limits from ceramics is necessary with an intention to lower such limits. The limits applied to the rims of ceramics and glassware intended for beverages should be included. The release of lead and cadmium at the maximum permissible levels for ceramics may lead to uptakes becoming hazardous to human health. Appropriate measures are thus necessary to reduce sources of exposure.
Wprowadzenie. Pobranie pierwiastków szkodliwych dla zdrowia, szczególnie ołowiu i kadmu z żywnością stwarza zagrożenie dla zdrowia i niezbędne jest podejmowanie działań mających na celu obniżenie narażenia konsumentów. Najnowsze oceny ryzyka dokonane przez Europejski Urząd ds. Bezpieczeństwa Żywności (EFSA) i Połączony Komitet Ekspertów FAO/WHO ds. Dodatków do Żywności (JECFA) wykazały, że wartości tymczasowego tolerowanego tygodniowego pobrania (PTWI) ołowiu i kadmu nie zapewniały bezpieczeństwa zdrowotnego i doprowadziły do ich weryfikacji. Jednym z istotnych źródeł pobrania ołowiu i kadmu z żywnością jest ich migracja z wyrobów ceramicznych i szklanych przeznaczonych do kontaktu z żywnością. Cel. Zbadanie uwalniania ołowiu i kadmu z wyrobów ceramicznych i szklanych w tym dekorowanych przeznaczonych do kontaktu z żywnością dostępnych w obrocie w Polsce oraz ocena ryzyka dla zdrowia konsumenta. Materiał i metody. Materiał do badań stanowiły wyroby ceramiczne i szklane, głównie dekorowane, pobierane z obrotu handlowego w latach 2010-2012 na terenie całego kraju przez przedstawicieli Stacji Sanitarno-Epidemiologicznych w ramach monitoringu, zgodnie z planem i wytycznymi opracowanymi przez Zakład Bezpieczeństwa Żywności Narodowego Instytutu Zdrowia Publicznego – Państwowego Zakładu Higieny. Migrację ołowiu i kadmu z próbek wyrobów ceramicznych i szklanych przeprowadzano do 4% kwasu octowego przez 24 godziny w temperaturze 22±2ºC (w ciemności). Zawartość ołowiu i kadmu w płynie modelowym po migracji oznaczano metodą płomieniowej atomowej spektrometrii absorpcyjnej (FAAS), zwalidowaną i akredytowaną zgodnie z PN-EN ISO/IEC 17025. Wyniki. W latach 2010-2012 zbadano 1273 próbki wyrobów ceramicznych i szklanych. Uwalnianie ołowiu i kadmu z naczyń ceramicznych i szklanych było przeważnie poniżej granic wykrywalności stosowanych metod analitycznych. Przekroczenia limitów migracji tych metali z naczyń ceramicznych określonych w ustawodawstwie stwierdzano rzadko, głównie z wyrobów z importu (spoza UE). Z 2 naczyń ceramicznych płaskich zdobionych (z importu) ilości uwalnianego ołowiu wynosiły 0,9 mg/dm2 i 11,9 mg/dm2 (limit 0,8 mg/dm2). Z 5 naczyń ceramicznych głębokich (z importu) migracja ołowiu powyżej limitu (4,0 mg/L) wynosiła: 4,7 mg/L; 4,9 mg/L; 5,6 mg/L; 6,1 mg/L; 8,6 mg/L. Migrację ołowiu z obrzeży naczyń ceramicznych w ilościach przekraczających limit (2,0 mg/wyrób), podany w polskiej normie PN-B-13210:1997 [16], stwierdzono z 4 wyrobów i wynosiła ona: 2,1 mg/wyrób 3,7 mg/wyrób, 4,2 mg/wyrób, 14,4 mg/wyrób. Nie stwierdzono migracji kadmu z obrzeży badanych naczyń ceramicznych w ilości przekraczającej limit. Największą migrację ołowiu wynoszącą 163,8 mg/wyrób i kadmu 8,96 mg/wyrób stwierdzono z obrzeża kubka szklanego, z importu. Ocena narażenia na ołów i kadm wykazała, że uwalnianie ołowiu i kadmu na poziomie najwyższych dopuszczalnych ilości, podanych w przepisach UE, prowadzi do pobrania tych metali bliskiego bądź przekraczającego dawki referencyjne. W przypadku dziecka o masie ciała 20 kg przekroczenie dawki BMDL01 dla ołowiu może być ponad 30-krotne, a przekroczenie TWI dla kadmu ponad 4-krotne. Wnioski. Konieczne jest obniżenie obowiązujących w UE limitów migracji ołowiu i kadmu z naczyń ceramicznych oraz wprowadzenie limitów dla obrzeży naczyń ceramicznych przeznaczonych do napojów, a także dla wyrobów szklanych. Uwalnianie ołowiu i kadmu na poziomie najwyższych dopuszczalnych ilości zgodnych z aktualnymi przepisami dla wyrobów ceramicznych może prowadzić do pobrania tych metali zagrażającego zdrowiu. Niezbędne jest podjęcie działań eliminujących źródła zagrożenia.
Źródło:
Roczniki Państwowego Zakładu Higieny; 2014, 65, 4
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Acute lead poisoning in an indoor firing range
Autorzy:
Štěpánek, Ladislav
Nakládalová, Marie
Klementa, Viktor
Ferenčíková, Veronika
Powiązania:
https://bibliotekanauki.pl/articles/2085522.pdf
Data publikacji:
2020-05-15
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
lead poisoning
blood lead level
occupational exposure to lead
urine lead level
anemia
chelation therapy
Opis:
The presented case demonstrates that acute lead poisoning may occur due to just short-term exposure to a mixture of lead-containing dust and ammunition. Such exposure may result in high blood lead levels persisting for years in the absence of any symptoms. A middle-aged male with a history of an approximately 7-day cleanup of an old recreational firing range with large ammunition and dust deposits presented to an emergency department with abdominal pain, dyspnea, fatigue and impaired cognitive function. Given his occupational history, specific tests were performed that showed high lead concentrations in both blood and urine. The patient was diagnosed with acute lead poisoning. He was started on chelation therapy that improved both clinical and laboratory parameters. Over a subsequent nearly 3-year follow-up, the patient’s blood lead levels fluctuated and continued to be increased. Given the absence of other sources of lead exposure, these were likely due to the formation of bone deposits. Med Pr. 2020;71(3):375–9
Źródło:
Medycyna Pracy; 2020, 71, 3; 375-379
0465-5893
2353-1339
Pojawia się w:
Medycyna Pracy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Low-level environmental lead exposure and intellectual impairment in children — The current concepts of risk assessment
Autorzy:
Jakubowski, Marek
Powiązania:
https://bibliotekanauki.pl/articles/2185480.pdf
Data publikacji:
2011-03-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
lead
children
risk assessment
environmental exposure
Opis:
Lead is an environmental contaminant. The majority of epidemiological research on the health effects of lead has been focused on children, because they are more vulnerable to lead than adults. In children, an elevated blood lead (B-Pb) is associated with reduced Intelligence Quotient (IQ) score. This paper summarizes the current opinions on the assessment of the health risk connected with the children’s environmental exposure to lead. The B-Pb level of concern of 100 μg/l proposed by the US Centers of Disease Control in 1991 was for a long time accepted as the guideline value. In the meantime there has been a significant worldwide decrease of B-Pb levels in children and present geometric mean values in the European countries range from 20 to 30 μg/l. The recent analyses of the association of intelligence test scores and B-Pb levels have revealed that the steepest declines in IQ occur at blood levels < 100 μg/l and that no threshold below which lead does not cause neurodevelopmental toxicity can be defended. European Food Safety Authority (EFSA) concluded in 2010, on the basis of results of Benchmark Dose (BMD) analysis, that an increase in B-Pb of 12 μg/l (BMDL₀₁) could decrease the IQ score by one point. It seems that this value can be used as a “unit risk” to calculate the possible decrease of IQ and, consequently, influence of the low-level exposure to lead (< 100 μg/l) on the health and socioeconomic status of the exposed population.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2011, 24, 1; 1-7
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Studies on battery repair and recycling workers occupationally exposed to lead in Karachi
Autorzy:
Haider, M.J.
Qureshi, N.
Powiązania:
https://bibliotekanauki.pl/articles/874438.pdf
Data publikacji:
2013
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:
battery repair
recycling
worker
occupational exposure
lead
human exposure
blood lead level
hematological parameter
Karachi city
Opis:
Objective. The present study was carried out to investigate the effects of occupational lead exposure on the hematological and biochemical parameters in occupationally exposed and non exposed inhabitants of Karachi. Material and methods. In 100 lead exposed subjects recruited from automobile workshops, lead battery repair and recycling units located in Karachi and in 100 control subjects the general health status, hematological parameters and exposure markers for lead were measured. Results. Results indicated that the mean values of blood lead level and δ-aminolevulinic acid were significantly higher (P<0.05) while the activity of δ-aminolevulinic acid dehydratase were significantly decreased (P<0.05) among battery repair and recycling workers as compared to controls. The abnormalities in the blood lead level, δ-aminolevulinic acid and δ-aminolevulinic acid dehydratase were more frequent in lead exposed battery repair workers when compared with control subjects. The blood lead levels and δ-aminolevulinic acid were positively correlated while δ-aminolevulinic acid dehydratase was found to be negatively correlated with age, years of exposure and years of employment. Blood lead level was positively correlated with hemoglobin and RBC count while δ-aminolevulinic acid dehydratase was negatively correlated with hemoglobin concentration. The work related symptoms, droopiness, nasal symptoms and muscular pain were more frequent among battery repair workers as compared to control group. The findings of present study confirmed that occupational exposure to lead is associated with deviation in important hematological parameters and biological markers of exposure to lead among lead exposed workers, and also confirms the impact of lead exposure in the development of adverse effects among lead exposed workers. Conclusions. The study provides the data for risk assessment in lead battery repair workers of Karachi and suggests the need for preventive measures for battery repair workers and improvements to reduce occupational lead exposures to protect them from lead toxicity. It is suggested that hematological and physical examinations of lead exposed workers should be carried out periodically to prevent future health hazards.
Cel. Badania przeprowadzono w celu określenia wpływu zawodowego narażenia na ołów na hematologiczne i biochemiczne parametry u zawodowo narażonych w porównaniu do nienarażonych mieszkańców Karaczi. Materiał i metody. U 100 osób narażanych na ołów spośród pracowników zatrudnionych w zakładach naprawy i przetwarzania akumulatorów w Karaczi i u 100 osób kontrolnych badano ogólny stan zdrowia, parametry hematologiczne i markery narażenia na ołów. Wyniki. Wyniki wskazują, że średnie poziomy ołowiu i kwasu δ-aminolewulinowego we krwi były znacząco wyższe (P<0.05), podczas gdy aktywność dehydratazy kwasu δ-aminolewulinowego była znacząco niższa (P<0.05) u zatrudnionych przy naprawie i przetwarzaniu akumulatorów w porównaniu do osób z grupy kontrolnej. Poziomy ołowiu we krwi i kwasu δ-aminolewulinowego były skorelowane pozytywnie podczas gdy w przypadku aktywności dehydratazy kwasu δ-aminolewulinowego stwierdzono negatywną korelację do wieku i mierzonego w latach czasu narażenia. Stężenie ołowiu we krwi było pozytywnie skorelowane z hemoglobiną i liczbą erytrocytów a aktywność dehydratazy kwasu δ-aminolewulinowego była negatywnie skorelowana ze stężeniem hemoglobiny. Objawy związane z wykonywaną pracą, takie jak osłabienie, objawy ze strony nosa i bóle mięśniowe częściej występowały u osób narażonych niż z grupy kontrolnej. Wyniki przeprowadzonych badań potwierdziły, że zawodowe narażenie na ołów wiąże się ze zmianami istotnych parametrów hematologicznych i występowaniem markerów narażenia na ołów u narażonych pracowników, a także występowaniem szkodliwych skutków zdrowotnych. Wnioski. Wyniki badań dostarczają danych do oceny ryzyka u pracowników naprawy i recyklingu akumulatorów i sugerują potrzebę zastosowania środków zaradczych w celu obniżenia zawodowego narażenia na ołów u tej grupy pracowników i ochrony przed toksycznym oddziaływaniem ołowiu. Sugeruje się, że badania parametrów hematologicznych i medycznych u pracowników narażonych na ołów powinny być wykonywane okresowo w celu zapobieżenia przyszłym zagrożeniom zdrowia.
Źródło:
Roczniki Państwowego Zakładu Higieny; 2013, 64, 1
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The determinants of lead and cadmium blood levels for preschool children from industrially contaminated sites in Poland
Autorzy:
Kowalska, Małgorzata
Kulka, Elżbieta
Jarosz, Wanda
Kowalski, Michał
Powiązania:
https://bibliotekanauki.pl/articles/2159917.pdf
Data publikacji:
2017-12-21
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
exposure
cadmium
lead
preschool children
ICS
parental questionnaire
Opis:
Objectives Industrially contaminated sites (ICS) represent an important public health issue in European countries. The Silesian Voivodeship, the region located in the southern part of Poland, the historical center of industry, has many sites that meet ICS criteria. Most of them are landfills containing lead, cadmium and zinc. Material and Methods The aim of the study has been to evaluate determinants of lead and cadmium blood levels for preschool children living in the vicinity of selected environmental hazards in Piekary Śląskie, the city located in the region of Silesia. Data about exposure was obtained from the parental questionnaire and was verified by levels of biomarkers in children’s blood. Finally, 678 preschool children were studied. Results Obtained results have confirmed that the statistically significant higher level of lead in blood has been revealed in the case of younger children whose fathers have a higher level of education and whose mothers smoke cigarettes at home, as well as for those living in the vicinity of any environmental hazard. In the case of cadmium, a higher level of the biomarker has been reported for older children who rather do not live close to any environmental hazard. We have recognized 30% of children with blood lead level (PbB) exceeding 2 μg/dl and 0.8% of children with blood cadmium level (CdB) exceeding the reference value (0.5 μg/l). Conclusions Own observation has confirmed that preschool children living in Piekary Śląskie are still exposed to heavy metals existing in environment. The source of the higher level in blood is not only the hazardous vicinity in the place of residence but also well-known factors associated with the age of children, parental life style and educational background. The parental questionnaire could be useful to identify potential determinants of exposure to lead and cadmium, however exposure must be verified by measurement of a proper biomarker. Int J Occup Med Environ Health 2018;31(3):351–359
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2018, 31, 3; 351-359
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Association between occupational lead exposure and plasma levels of selected oxidative stress related parameters in Jordanian automobile workers
Autorzy:
Shraideh, Ziad
Badran, Darwish
Hunaiti, Abdelrahim
Battah, Abdelkader
Powiązania:
https://bibliotekanauki.pl/articles/2160039.pdf
Data publikacji:
2018-07-04
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
cytotoxicity
biomarkers
Oxidative stress
exposure
lead
occupational health
Opis:
Objectives: To study any possible correlation between blood lead levels and some oxidative stress parameters of selected groups of lead-exposed automobile occupational Jordanian workers. Material and Methods: Blood lead levels were determined for a total of 90 male automobile workers aged within the range of 25–45 years old along with the group of 20 agematched healthy males control. To get an idea about the antioxidant status of controls and lead-exposed workers, and to estimate the oxidative stress caused by exposure to lead, we measured the hydrogen peroxide (H2O2) concentration, superoxide dismutase (SOD) activity, lipid peroxidation as malondialdehyde (MDA) and total antioxidant capacity of controls and workers. Results: The study showed that lead levels in the case of workers were approximately 4–5 times as high as in controls 14.5–21 μg×dl–1 vs. 4.3 μg×dl–1, respectively. There was a significant decrease (16–25%) in the level of plasma reduced glutathione and 21–33% decrease in total antioxidant capacity (TAOC) in all worker groups, as compared to controls. The results showed that the concentration of malondialdehyde (MDA) in plasma was higher (120–333%) in the case of workers than controls being the highest in automobile electronics and the lowest – in mechanics. Furthermore, there was 149–221% increase in hydrogen peroxide (H2O2) concentration, and 26–38% increase in SOD activity in the case of workers compared to the control group. Conclusions: There is a strong evidence for the associations between occupational lead exposure and various markers of oxidative stress in Jordanian automobile occupational workers. Thus, there is an urgent need to raise awareness and to initiate suitable protection guidelines for workers. Int J Occup Med Environ Health 2018;31(4):517–525
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2018, 31, 4; 517-525
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Assessment of infant exposure to lead and cadmium content in infant formulas
Ocena stopnia narazenia niemowlat na pobieranie olowiu i kadmu w preparatach mleka w proszku
Autorzy:
Winiarska-Mieczan, A
Powiązania:
https://bibliotekanauki.pl/articles/14982.pdf
Data publikacji:
2009
Wydawca:
Uniwersytet Warmińsko-Mazurski w Olsztynie / Polskie Towarzystwo Magnezologiczne im. Prof. Juliana Aleksandrowicza
Tematy:
child
infant formula
cadmium
lead
infant milk formula
infant exposure
cadmium content
lead content
Opis:
Infants and little children are the highest risk group as far as the exposition to toxic metals is concerned. Newly born babies do not have effectively functioning regulatory mechanisms and the absorption of mineral elements, including toxic ones, is higher than in older children and adults. Separate, more rigorous requirements have been determined for food products for infant nutrition. Special attention is required in the case of toxic metals, including lead and cadmium, which are regarded as particularly harmful to the organism. The objective of the present work was to establish the content of lead and cadmium in powdered milk used in the nutrition of infants in the first months of their lives. Moreover, on the basis of surveys, the popularity of using milk replacement formulas was determined, as well as factors affecting this situation. All the examined preparations were labelled as “a special nutrition product”. They had been purchased in different groceries in Lublin in October 2007, all before their use-by date. The shares of Pb and Cd were marked in the samples. It was demonstrated that only two preparations did not comply with the recommendations regarding the content of cadmium, while in the other samples the maximum value was not exceeded. It was also noted that the analysed preparations were not safe for babies as far as the content of lead was concerned. At the same time, it was observed that as many as 87% babies were breast-fed, which is a positive phenomenon, whereas 40% women used combined nutrition for their children (breast feeding alternately with powdered milk). The choice of a particular preparation resulted in the first place from the doctor’s recommendations, and next from babies’ preferences and friends’ opinions.
Niemowlęta oraz małe dzieci to grupa populacji o najwyższym ryzyku narażenia na toksyczne działanie metali. U noworodków zaraz po urodzeniu brak jest sprawnie działających mechanizmów regulacyjnych, a wchłanianie składników mineralnych, w tym także pierwiastków toksycznych, jest większe niż u dzieci starszych i osób dorosłych. Ustalono odrębne, bardziej rygorystyczne wymagania dla produktów spożywczych przeznaczonych do żywienia niemowląt. Szczególnej uwagi wymagają metale szkodliwe, do których zalicza się m.in. ołów i kadm, uznawane za szczególnie niebezpieczne dla organizmu. Celem pracy było ustalenie zawartości ołowiu i kadmu w mleku w proszku stosowanym w żywieniu niemowląt w pierwszych miesiącach życia. Ponadto na podstawie badań ankietowych określono popularność stosowania preparatów mlekozastępczych oraz czynniki wpływające na ten stan. Materiał do badań stanowiły preparaty uznanych marek, przeznaczone do żywienia niemowląt w pierwszych miesiącach życia. Wszystkie badane preparaty miały adnotację „produkt specjalnego przeznaczenia żywieniowego”. Produkty zakupiono w sklepach spożywczych na terenie Lublina w październiku 2007 r., w okresie ich przydatności do spożycia. W pobranych próbach oznaczono zawartość Pb i Cd. Jedynie dwa preparaty nie spełniały wymagań odnośnie do zawartości kadmu, w pozostałych wartość dopuszczalna nie została przekroczona. Ponadto stwierdzono, że analizowane preparaty nie są bezpieczne dla niemowląt pod względem zawartości ołowiu. Jednocześnie stwierdzono, że aż 87% dzieci było karmionych piersią, co jest zjawiskiem pozytywnym, przy czym 40% kobiet stosowało żywienie mieszane (karmienie piersią naprzemiennie z mlekiem w proszku). Największy wpływ na zakup danego preparatu miała porada lekarza, następnie upodobania dziecka oraz opinia znajomych.
Źródło:
Journal of Elementology; 2009, 14, 3; 573-581
1644-2296
Pojawia się w:
Journal of Elementology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Usefulness of biomarkers as intermediate endpoints in health risks posed by occupational lead exposure
Autorzy:
Borghini, Andrea
Gianicolo, Emilio Antonio
Andreassi, Maria Grazia
Powiązania:
https://bibliotekanauki.pl/articles/2177066.pdf
Data publikacji:
2015-10-16
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
biomarkers
occupational exposure
lead
individual susceptibility
genotoxic effects
health risk
Opis:
The article concerns potential harmful effects of exposure to lead. Although the occurrence of severe lead poisoning has receded in several countries, occupational exposure resulting in moderate and clinically symptomatic toxicity is still common. An earlier and precise characterization of an individual response is obligatory in order to assess the possible risks for human health. Biomarkers may fill important gaps in the path from exposure to a disease. Specifically speaking, emerging (DNA double strand breaks and telomeric DNA erosion) and validated (micronuclei induction and chromosomal aberrations) biomarkers of genotoxicity seem to provide evidence for the assessment of molecular and cellular damage. Moreover, identification of genetic variability with a key role in modulating genotoxic damage may help minimize risks for susceptible subjects. Further investigations are naturally needed to properly define their diagnostic and/or prognostic value as “early warning” signs of a long-term risk for a subsequent clinically overt disease.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2016, 29, 2; 167-178
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The content of lead, cadmium, arsenic, mercury and tin in fruit and their products based on monitoring studies – exposure assessment
Autorzy:
Mania, M.
Rebeniak, M.
Chabros, E.
Orshulyak, O.
Postupolski, J.
Powiązania:
https://bibliotekanauki.pl/articles/2082840.pdf
Data publikacji:
2021
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:
food
fruit
monitoring
lead
cadmium
mercury
arsenic
tin
exposure assessment
Opis:
Background. Fruit and fruit products are important part of our daily diet. In addition to the ingredients necessary for the proper functioning of the body, these products can also be a source of intake elements harmful to human health. Objective. Analysis of the results of monitoring studies conducted in Poland in 2015 concerning contamination of lead (Pb), cadmium (Cd), arsenic (As), mercury (Hg) and tin (Sn) in fruit and fruit products and exposure assessment. Material and methods. Approximately 600 samples of fresh, frozen, dried fruits, fruit preserves and canned fruits were tested. The laboratories of State Sanitary Inspection were involved in testing. Accredited and validated analytical methods were used. The test samples were prepared in accordance with the standard PN-EN 13804:2013. The contents of lead, cadmium and tin were determined by using flame atomic absorption spectrometry (FAAS) or flameless with electrothermal atomization spectrometry (GFAAS); arsenic by using hydride generation atomic absorption spectrometry method (HGAAS) and mercury the "cold vapor" atomic absorption spectrometry (CVAAS) method. Results. Contamination of investigated samples with elements harmful to human health (Pb, Ca, As, Hg and Sn does not rise concern to human health and was in most cases comparable with contamination reported in other European Union countries. The estimated average exposure of adults and children to lead intake with fruit and fruit products ranged from 0.5% to 14.6% of the respective Benchmark Dose Lower Confidence Limit (BMDL) established by the European Food Safety Authority (EFSA). The mean intake of cadmium with these groups of foodstuffs was in the range 0.3 - 8.5% of the TWI value (Tolerable Weekly Intake) established by EFSA for adults and children (0.1 - 3.6% of the PTMI (Provisional Tolerable Monthly Intake) established by JECFA. In case of arsenic mean intake was in the range 0.5 - 1.6% BMDL whilst for mercury (inorganic form) intake represented 0.5 - 1.4% of TWI value established by JECFA and then confirmed by EFSA. Conclusions. Based on the obtained results, it was found that content of Pb, Cd, As, Hg and Sn in the tested samples of fruit and their products does not pose a risk to consumer health. Estimated exposure of consumers does not exceed tolerable doses established by EFSA and JECFA for these elements.
Źródło:
Roczniki Państwowego Zakładu Higieny; 2021, 72, 4; 353-360
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Health risk assessment and dietary exposure of polycyclic aromatic hydrocarbons (PAHs), lead and cadmium from bread consumed in Nigeria
Autorzy:
Udowelle, N.A.
Igweze, Z.N.
Asomugha, R.N.
Orisakwe, O.E.
Powiązania:
https://bibliotekanauki.pl/articles/874134.pdf
Data publikacji:
2017
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:
health risk
risk assessment
dietary exposure
human nutrition
polycyclic aromatic hydrocarbon
lead
cadmium
bread
Nigeria
Opis:
Objective. A risk assessment and dietary exposure to polycyclic aromatic hydrocarbons (PAHs), lead and cadmium from bread, a common food consumed in Nigeria. Material and Methods. Sixty samples of bread were collected from different types of bakeries where the heat is generated by wood (42 samples) or by electricity (18 samples) from twenty bakeries located in Gusau Zamfara (B1- B14) and Port Harcourt Rivers States (B15-B20) in Nigeria. PAHs in bread were determined by gas chromatography. Lead and cadmium were determined using atomic absorption spectrophotometry. Results. Non-carcinogenic PAHs pyrene (13.72 μg/kg) and genotoxic PAHs (PAH8), benzo[a]anthracene (9.13 μg/ kg) were at the highest concentrations. Total benzo[a]pyrene concentration of 6.7 μg/kg was detected in 100% of tested samples. Dietary intake of total PAHs ranged between 0.004-0.063 μg/kg bw. day-1 (children), 0.002-0.028 μg/kg day-1 (adolescents), 0.01-0.017 μg/kg day-1 (male), 0.002-0.027 μg/kg day-1 (female), and 0.002-0.025 μg/kg day-1 (seniors). The Target Hazard Quotient (THQ) for Pb and Cd were below 1. Lead ranged from 0.01-0.071 mg/kg with 10.85 and 100% of bread samples violating the permissible limit set by USEPA, WHO and EU respectively. Cadmium ranged from 0.01-0.03 mg/kg, with all bread samples below the permissible limits as set by US EPA, JECFA and EU. The daily intake of Pb and Cd ranged from 0.03-0.23 μg/kg bw day-1 and 0.033-0.36 μg/kg bw day-1 respectively. Incremental lifetime cancer risk (ILCR) was 3.8 x 10-7. Conclusions. The levels of these contaminants in bread if not controlled might present a possible route of exposure to heavy metals and PAHs additional to the body burden from other sources.
Źródło:
Roczniki Państwowego Zakładu Higieny; 2017, 68, 3
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Level of DNA damage in lead-exposed workers
Autorzy:
Olewinska, E
Kasperczyk, A.
Kapka, L.
Kozlowska, A.
Pawlas, N.
Dobrakowski, M.
Birkner, E.
Kasperczyk, S.
Powiązania:
https://bibliotekanauki.pl/articles/51218.pdf
Data publikacji:
2010
Wydawca:
Instytut Medycyny Wsi
Tematy:
occupational exposure
occupational disease
human disease
lead
DNA damage
comet assay
worker
genotoxic effect
Polska
industry
heavy metal
Źródło:
Annals of Agricultural and Environmental Medicine; 2010, 17, 2; 231-236
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of the type of thermal stabilizer on the graying of poly(vinyl chloride) compositions under the action of UV light and moisture
Wpływ rodzaju stabilizatora termicznego na szarzenie kompozycji polichlorku winylu) pod wpływem działania promieniowania UV i wilgoci
Autorzy:
Bortel, K.
Kamińska-Bach, G.
Powiązania:
https://bibliotekanauki.pl/articles/278691.pdf
Data publikacji:
2015
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Inżynierii Materiałów Polimerowych i Barwników
Tematy:
poly(vinyl chloride)
titanium dioxide
lead stabilizer
graying
weathering
UV exposure
poli(chlorek winylu)
ditlenek tytanu
stabilizatory ołowiowe
szarzenie
starzenie naturalne
promieniowanie UV
Opis:
In some cases, in the initial stages of exposure to atmospheric conditions, gray discoloration appears on the surface of PVC products pigmented with titanium white. The aim of the study was to develop a simple method for determining the likelihood of discoloration of a PVC /thermal stabilizer / titanium white composition at the onset of exposure to UV radiation. Common thermal stabilizers were used to determine which of them, combined with a polymer and TiO2, can cause discoloration of the samples when exposed to UV radiation, especially in the presence of water. It has been shown that discoloration of a PVC composition surface exposed to UV radiation occurs only in the case of lead stabilizers. Discoloration did not occur when tin stabilizers and Ca/Zn were used in the PVC compositions. Only areas exposed to H2O during exposure to UV radiation were affected.
W niektórych przypadkach na powierzchni wyrobów z PVC pigmentowanych bielą tytanową w początkowym etapie ekspozycji w warunkach atmosferycznych, pojawiają się szare przebarwienia. Niniejsza praca miała na celu opracowanie prostej metody określenia prawdopodobieństwa wystąpienia szarzenia kompozycji PVC/stabilizator termiczny/biel tytanowa w początkowym etapie ekspozycji na działanie promieniowania UV. Wykazano, że szarzenie powierzchniowe kompozycji PVC pod wpływem działania promieniowania UV, występuje jedynie w przypadku zastosowania stabilizatorów ołowiowych. Zjawiska tego nie stwierdzono w przypadku stosowania w kompozycjach PVC stabilizatorów cynowych jak również Ca/Zn. Szarzeniu ulegają jedynie miejsca mające kontakt z H2O podczas napromienienia UV.
Źródło:
Przetwórstwo Tworzyw; 2015, T. 21, Nr 5 (167), 5 (167); 376-388
1429-0472
Pojawia się w:
Przetwórstwo Tworzyw
Dostawca treści:
Biblioteka Nauki
Artykuł
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