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Wyszukujesz frazę "HSCT" wg kryterium: Temat

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    Wyświetlanie 1-4 z 4
    Tytuł:
    Application of pixantrone in a III line of treatment as a bridge therapy to allotransplantation of stem cells
    Autorzy:
    Kwiatkowska-Pamuła, Anna
    Janeczek, Aleksandra
    Giebel, Sebastian
    Powiązania:
    https://bibliotekanauki.pl/articles/1035647.pdf
    Data publikacji:
    2020-06-30
    Wydawca:
    Medical Education
    Tematy:
    DLBCL lymphoma
    allo-HSCT
    cardiotoxicity
    chemotherapy
    pixantrone
    Opis:
    Diffuse large B-cell lymphomas are the most common group among all lymphomas. Despite the effectiveness of the I line therapy in 10–40% of patients, the possibility of relapse should be taken into account. The anthracycline antibiotics used in the II line therapy carry a high risk of cardiac complications. In patients with refractory or recurrent disease, emergency treatment is used, aiming for the transplantation of hematopoietic cells. If the II line therapy fails, the prognosis is bad. A new chance for patients with refractory or recurrent B-cell lymphoma is pixantrone dimaleate, a drug structurally related to anthracyclines with a significantly lower cardiotoxic potential. The paper presents a case of a 65-year-old patient with relapsing DLBCL lymphoma, after two treatment lines: R-CHOP and R-DHAP, and after autologous transplantation of stem cells, in which the use of pixantrone in the treatment of recurrence allowed to achieve remission and prepare the patient for the allo-HSCT procedure.
    Źródło:
    OncoReview; 2020, 10, 2; 57-61
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Severe vascular and neurological complications after hematopoietic stem cell transplantation with reduced intensity conditioning
    Autorzy:
    Czyżewski, Krzysztof
    Nierychlewska, Paulina
    Richert-Przygońska, Monika
    Cieściński, Jakub
    Styczyński, Jan
    Powiązania:
    https://bibliotekanauki.pl/articles/1035762.pdf
    Data publikacji:
    2019
    Wydawca:
    Medical Education
    Tematy:
    ALLO-HSCT
    PRES
    fludarabine
    neurotoxicity
    reduced intensity conditioning
    Opis:
    It is well established that the benefit of myeloablative ALLO-HSCT can be associated with a potential high risk of procedure-related toxicity. The objective of this report is the analysis of complications in a 17-year-old girl with AML previously treated for medulloblastoma and myelodysplastic syndrome. Thiotepa, fludarabine, treosulfan and thymoglobuline were used in conditioning regimen. During conditioning neurological complications have occurred. MRI and CT scan results revealed the coexistence of PRES with the left internal carotid artery thrombosis. The effect of fludarabine on endothelial cells could possibly contribute to irreversible CNS damage and death in presented case.
    Źródło:
    OncoReview; 2019, 9, 1; 27-30
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Multiplex real-time PCR to identify a possible reinfection with different strains of human cytomegalovirus in allogeneic hematopoietic stem cell transplant recipients
    Autorzy:
    Zawilinska, Barbara
    Szostek, Slawa
    Kopec, Jolanta
    Piatkowska-Jakubas, Beata
    Kosz-Vnenchak, Magdalena
    Powiązania:
    https://bibliotekanauki.pl/articles/1038859.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    HCMV gB genotypes
    multiple HCMV infections
    reactivation and reinfection
    allo-HSCT
    Opis:
    Human cytomegalovirus (HCMV) infection remains the leading cause of serious contagious complications after allogeneic hematopoietic stem cell transplantation. These infections in HCMV-seropositive recipients can be due to reactivation or reinfection. Different HCMV strains were identified by determining the genotypes isolated from repeatedly tested patients. The UL55 sequences encoding viral glycoprotein B (gB) have been chosen as the target gene. The region, in which the gB precursor protein is cleaved into two fragments by a cellular endoprotease, is characterized by genetic variability, and based on that HCMV is classified into four major genotypes: gB1, gB2, gB3 and gB4. Multiplex real-time PCR assay enabled both, HCMV gB genotyping, as well as simultaneous quantitative assessment of the detected genotypes. This study was carried out in 30 transplant recipients, from whom 105 isolates of HCMV DNA were genotyped. In 40% of recipients, a mixed infection with two or three genotypes was detected. Genotype gB1 dominated in general, and characteristically for mixed infections, the genotype gB3 or gB4 was always present. Although there were no significant differences in the load for each genotype, in case of multiple infections, the number of copies of gB1 genotype was significantly higher when compared to a single gB1 infection. In patients with mixed genotypes, chronic HCMV infections and graft versus host disease were observed more often, as well as antiviral treatment was less effective. It was assumed that these adverse effects can be related to the presence of gB3 and gB4 genotypes.
    Źródło:
    Acta Biochimica Polonica; 2016, 63, 1; 161-166
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Discovering diagnostic gene targets for early diagnosis of acute GVHD using methods of computational intelligence on gene expression data
    Autorzy:
    Fiasch'e, M.
    Morabito, F. C.
    Verma, A.
    Kasabov, N.
    Cuzzola, M.
    Iacopino, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/91634.pdf
    Data publikacji:
    2011
    Wydawca:
    Społeczna Akademia Nauk w Łodzi. Polskie Towarzystwo Sieci Neuronowych
    Tematy:
    acute graft-versus-host disease
    aGVHD
    haematopoietic stem cell transplantation
    HSCT
    immunologic attack
    diagnosis
    computational intelligence
    gene expression data
    Opis:
    This is an application paper of applying standard methods of computational intelligence to identify diagnostic gene targets and to use them for a successful diagnosis of a medical problem - acute graft-versus-host disease (aGVHD). This is the major complication after allogeneic haematopoietic stem cell transplantation (HSCT) in which functional immune cells of donor, recognize the recipient as ”foreign” and mount an immunologic attack. In this paper we analyzed gene-expression profiles of 47 genes associated with allo-reactivity in 59 patients submitted to HSCT. We have applied different dimensionality reduction techniques of the variable space, combined with different classifiers to detect the aGVHD at onset of clinical signs. This is a preliminary study which utilises both computational and biological evidence for the involvement of a limited number of genes for the diagnosis of aGVHD. Directions for further studies are also outlined in this paper.
    Źródło:
    Journal of Artificial Intelligence and Soft Computing Research; 2011, 1, 1; 81-89
    2083-2567
    2449-6499
    Pojawia się w:
    Journal of Artificial Intelligence and Soft Computing Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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