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    Wyświetlanie 1-15 z 15
    Tytuł:
    Properties of bilayer gelatin/polycaprolactone scaffolds
    Autorzy:
    Rajzer, I.
    Powiązania:
    https://bibliotekanauki.pl/articles/283923.pdf
    Data publikacji:
    2011
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    scaffolds
    composites
    tissue engineering
    Opis:
    In this study, nanofibrous composite scaffolds have been fabricated in order to mimic the physical architecture of native extracellular matrix. Gelatin is a good candidate to mimic the chemical composition of natural collagen. It has many integrin-binding sites for cell adhesion and differentiation, which are found in collagen. However, electrospun scaffold made of gelatin had very poor mechanical properties. Therefore, in this study, bilayer nanofibrous scaffolds made of gelatin and poly(caprolactone) were produced by sequential electrospinning. The microscopic morphology, mechanical properties and porosity of electrospun bilayer gelatin/polycaprolactone scaffold were investigated.
    Źródło:
    Engineering of Biomaterials; 2011, 14, 104; 2-4
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of PCL and PCL/HAp scaffolds processed by electrospinning and porogen leaching techniques
    Autorzy:
    Rajzer, I.
    Powiązania:
    https://bibliotekanauki.pl/articles/283996.pdf
    Data publikacji:
    2011
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    scaffolds
    electrospinning
    leaching
    Opis:
    In order to improve the pore size of the polycapro-lactone (PCL) and polycaprolactone/hydroxyapatite (PCL/HAp) nanofibrous scaffolds, salt-leaching technique together with electrospinning method were applied. Salt particles were incorporated within the polymer nanofibrous matrix and then were leached out to generate some macropores. Microstructure, pore size distribution and average fibre diameter of the scaffold were investigated by scanning electron microscopy and PMI capillary flow porometer. Mechanical properties were determined by means of tensile test. Presence of hydroxyapatite and chemical characterization of the scaffold were done by FTIR analysis.
    Źródło:
    Engineering of Biomaterials; 2011, 14, 103; 4-7
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A tubular polycaprolactone/hyaluronic acid scaffolds for nasal cartilage tissue engineering
    Autorzy:
    Jatteau, S.
    Kurowska, A.
    Ziąbka, M.
    Rajzer, I.
    Powiązania:
    https://bibliotekanauki.pl/articles/285184.pdf
    Data publikacji:
    2017
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    electrospinning
    tissue engineering scaffolds
    nasal cartilages
    hyaluronic acid
    PCL
    Opis:
    In this preliminary study, 3D nanofibrous porous scaffolds in the form of spiral tubes for future application as nasal cartilages implants were fabricated by combining polycaprolactone electrospun fibers with drug modified hyaluronic acid gel. It is expected that the spiral form of the scaffold with open geometries, large surface area, and distance between the scaffold walls will be helpful for improving future cell penetration into the scaffolds, nutrient transport and metabolic waste removal, which are otherwise limited in conventional electrospun tissue-engineered scaffolds. The tubular scaffolds structure, its porosity and fibers’ diameter were assessed via scanning electron microscopy, and biological properties of the scaffolds were evaluated in an in vitro study using Simulated Body Fluid (SBF). SEM results showed that apatite formed within a short period on tubular scaffolds after its immersion in SBF, demonstrating high in vitro bioactivity of the scaffolds.
    Źródło:
    Engineering of Biomaterials; 2017, 20, 141; 8-12
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of PCL and PCL/n-HAp fibres processed by melt spinning
    Autorzy:
    Rajzer, I.
    Fabia, J.
    Graczyk, T.
    Piekarczyk, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/283872.pdf
    Data publikacji:
    2013
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    PCL fibres
    melt spinning
    scaffolds
    bone
    tissue engineering
    Opis:
    In this work the process for the manufacture of polycaprolactone fibres containing hydroxyapatite nanoparticles by melt spinning method was developed. The effect of nanohydroxyapatite content on the fibre structure and properties was investigated with FTIR, SEM, DSC, TGA methods. The mechanical properties of obtained fibres enable further processing to scaffolds by nonwoven technologies.
    Źródło:
    Engineering of Biomaterials; 2013, 16, 118; 2-4
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Mineralization and degradation of poly(ε -caprolactone) / hydroxyapatite electrospun membranes
    Autorzy:
    Rajzer, I.
    Kwiatkowski, R.
    Sarna, E.
    Janicki, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/285016.pdf
    Data publikacji:
    2011
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    degradation
    mineralization
    electrospinning
    simulated body fluid
    Opis:
    The aim of this work was to study mineralization and degradation behavior of poly(ε-caprolactone) membranes modified with hydroxyapatite. The membranes have been obtained by electrospinning method. In vitro mineralization and degradation processes were carried out in simulated body fluid (SBF) as the release medium. The weight loss of the samples, water uptakes, pH and calcium, potassium, sodium ions concentrations of the solutions were determined. The chemistry and microstructure of the membranes after different times of incubation in SBF were characterized using SEM, FTIR, and XRD methods. The results of in vitro study in SBF indicate that incorporation of n-HAp strongly activates precipitation of the apatite like materials on the surface of nanofibers.
    Źródło:
    Engineering of Biomaterials; 2011, 14, no. 106-108; 5-9
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Needle-punched fibrous polycaprolactone scaffold for bone tissue engineering
    Autorzy:
    Rajzer, I.
    Grzybowska-Pietras, J.
    Fabia, J.
    Sarna, E.
    Powiązania:
    https://bibliotekanauki.pl/articles/284522.pdf
    Data publikacji:
    2013
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    needle-punched nonwovens
    scaffold
    hydroxyapatite
    poly(ε-caprolactone)
    Opis:
    In the present work a three dimensional composite scaffolds for bone tissue engineering were created by a carding and needle-punch processes. Highly porous nonwoven fabrics were obtained from PCL and PCL/n-HAp cut fibers without the use of any chemicals during the manufacturing process. The properties of nonwoven scaffolds were examined by SEM, FTIR, DSC and TGA methods. The average pore diameter as well as the pore size distribution of nonwoven fabrics were measured by a capillary flow porometry. The obtained results suggest that needle-punching method can be used to produce highly porous microstructures with an interconnected pore network.
    Źródło:
    Engineering of Biomaterials; 2013, 16, 121; 2-5
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Mechanical properties of carbon/hydroxyapatite nonwovens for bone tissue engineering
    Autorzy:
    Rajzer, I.
    Piekarczyk, W.
    Grzybowska-Pietras, J.
    Janicki, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/285172.pdf
    Data publikacji:
    2010
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    nonwovens
    bone tissue
    bone tissue engineering
    hydroxyapatite
    Źródło:
    Engineering of Biomaterials; 2010, 13, 93; 6-9
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Ca-deficient hydroxyapatite scaffolds from injectable calcium phosphate/chitosan cements
    Autorzy:
    Rajzer, I.
    Castano, O.
    Engel, E.
    Planell, J. A.
    Powiązania:
    https://bibliotekanauki.pl/articles/283850.pdf
    Data publikacji:
    2010
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    calcium phosphate cement
    injectability
    chitosan
    Opis:
    Calcium phosphate cement (CPC) has been success-fully used in bone tissue regeneration for many years. However, poor mechanical properties and low biodegradation rate limit any further applications. R-cement has a higher solubility than conventional CPC and its reaction products (CDHA) are similar to the mineral phase of bone. In this work we have developed new CPC composition which consists of a mix of cement R, glycerol as a liquid phase carrier and a biodegradable hydrogel (chitosan) which acts as a binder and was incorporated into R-cement to strengthen this biomaterial. The cement past was found to be stable in a syringe (even after two month of storage in the freezer) and hardened only after being exposed to biological fluids.
    Źródło:
    Engineering of Biomaterials; 2010, 13, 92; 2-4
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    3D printed poly L-lactic acid (PLLA) scaffolds for nasal cartilage engineering
    Autorzy:
    Jabłoński, A.
    Kopeć, J.
    Jatteau, S.
    Ziąbka, M.
    Rajzer, I.
    Powiązania:
    https://bibliotekanauki.pl/articles/970900.pdf
    Data publikacji:
    2018
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    3D printing
    PLLA
    nasal cartilages
    scaffolds
    tissue engineering
    Opis:
    In this study the scaffolds for nasal cartilages replacement were designed using a software called Rhino 3D v5.0. The software parameters considered for the design of scaffolds were chosen and the scaffolds were fabricated using Fused Deposition Modeling (FDM), a rapid prototyping technology, using poly(L-lactic acid) (PLLA) filament. The topographical properties of the scaffolds were calculated through 3D model simulation. The morphology of obtained scaffold was observed by Scanning Electron Microscopy (SEM). The biological properties, i.e. bioactivity of the scaffolds, were assessed in Simulated Body Fluid. On the basis of natural cartilages images the external shape of the scaffold was designed using the 3D modeling software. The FDM is a useful method in fabrication of 3D bioactive implants for cartilage tissue engineering. Thanks to the use of 3D modeling software, it is possible to prepare and manufacture artificial cartilage in a controlled manner. Artificial scaffold made of PLLA polymeric matrix may mimic natural one by shape, topography, geometry, pore size, and their distribution. In addition, it is possible to guarantee appropriately selected biological properties such as biocompatibility and high bioactivity of scaffolds, which was proved using scanning electron microscopy (SEM) analysis. The surface observation of the 3D printed scaffolds showed in vitro formation of apatite after immersion in the SBF. What is more, it is possible to match the scaffold not only to the large cavity but also individually to each patient.
    Źródło:
    Engineering of Biomaterials; 2018, 21, 144; 15-19
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Hyaluronic Acid-Coated Carbon Nonwoven Fabrics as Potential Material for Repair of Osteochondral Defects for medical applications
    Włókniny węglowe modyfikowane kwasem hialuronowym jako potencjalne podłoża w leczeniu ubytków kostno-chrzęstnych
    Autorzy:
    Rajzer, I.
    Menaszek, E.
    Bacakova, L.
    Orzelski, M.
    Błażewicz, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/231613.pdf
    Data publikacji:
    2013
    Wydawca:
    Sieć Badawcza Łukasiewicz - Instytut Biopolimerów i Włókien Chemicznych
    Tematy:
    cartilage
    carbon fibres
    nonwoven scaffolds
    hyaluronic acid
    biomaterials
    chrząstki
    włókna węglowe
    modyfikacja włóknin
    kwas hialuronowy
    biomateriały
    Opis:
    Damaged articular cartilage is known to have poor capacity for regeneration. Carbon fibres (CFs) have been widely investigated as cellular growth supports in cartilage tissue engineering. However, the long duration of the process of cartilage restoration limits the applicability of CFs implants in the treatment of cartilage tissue defects. Hyaluronic acid (HA) plays a key role in cartilage tissue development, repair and function. In the present study we focused on the in vitro and in vivo evaluation of two types of carbon nonwoven fabrics: HA modified and non-modified carbon nonwovens. The results of in vitro studies showed that cells attached well and retained their good viability in the carbon nonwoven matrix. The incorporation of hyaluronic acid resulted in the enhancement of cell proliferation. The results of in vivo studies showed a faster process of tissue regeneration in the case of HA modified carbon nonwovens. The results presented indicated that HA-modified carbon materials seem to be a suitable material for the treatment of osteochondral defects.
    Uszkodzona chrząstka stawowa posiada słabą zdolność do regeneracji. Od lat prowadzone są badania nad zastosowaniem włókien węglowych w inżynierii tkankowej chrząstki, jako podłoży podtrzymujących wzrost komórek. Niestety długi proces odbudowy chrząstki w obrębie implantu węglowego ogranicza możliwość zastosowania włóknin węglowych w leczeniu ubytków chrzęstnych. Kwas hialuronowy (HA) jest składnikiem chrząstki odpowiedzialnym za jej właściwy rozwój oraz proces regeneracji. Modyfikacja włóknin kwasem hialuronowym może w korzystny sposób wpłynąć na własności biologiczne implantów węglowych. W pracy przedstawiono wyniki badań in vitro oraz in vivo nad włókninami węglowymi modyfikowanymi kwasem hialuronowym oraz nad włókninami niemodyfikowanymi. Z przeprowadzonych badań in vitro wynika, że modyfikacja włóknin węglowych kwasem hialuronowym powoduje wzrost proliferacji komórek hodowanych na tych materiałach. Natomiast wyniki badań in vivo wykazały, że proces regeneracji tkanki następuje szybciej w przypadku włóknin węglowych modyfikowanych kwasem hialuronowym niż w przypadku włóknin niemodyfikowanych. Przeprowadzone badania wskazują, że włóknina węglowa modyfikowana kwasem hialuronowym może być rozważana jako potencjalny materiał w leczeniu ubytków kostno-chrzęstnych.
    Źródło:
    Fibres & Textiles in Eastern Europe; 2013, 3 (99); 102-107
    1230-3666
    2300-7354
    Pojawia się w:
    Fibres & Textiles in Eastern Europe
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Electrospun biomimetic resorbable scaffold
    Autorzy:
    Rajzer, I.
    Piekarczyk, W.
    Kwiatkowski, R.
    Biniaś, W.
    Janicki, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/285153.pdf
    Data publikacji:
    2010
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    bone tissue engineering
    scaffolds
    resorbable materials
    Źródło:
    Engineering of Biomaterials; 2010, 13, no. 99-101; 13-15
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Biomimetic fibrous composite membranes for bone tissue engineering
    Autorzy:
    Rajzer, I.
    Chrzanowski, W.
    Biniaś, W.
    Sarna, E.
    Janicki, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/284248.pdf
    Data publikacji:
    2010
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    tissue engineering
    biomaterials
    membranes
    Opis:
    One of the major challenges in biomaterials and tissue engineering is to guide the cell differentiation to the specific phenotype, therefore allow the formation of the tissue of certain type. This can be achieved by manipulating the structural, geometrical and chemical characteristics of the tissue engineering constructs. In our studies we concentrated on the chemical modifications of the polymer based materials for tissue engineering. The primary aim of our study was to incorporate nano size hydroxyapatite (n-HAp) crystals into the polymer fibres and form membranes, which are a core to the construction of novel scaffolds for tissue regeneration. We hypothesised that n-HAp will significantly improve the bioactivity of the polymer based membranes due to the presence of chemical cues. We developed a simple method to fabricate PLDL/n- HAp composite membranes using electrospinning process. The investigation showed that the incorporation of the n-HAp particles in the polymer spinning solution induced changes in the material surface morphology. FTIR analysis confirmed the presence of apatite on the surface of the membrane' fibers. The bioactivity analysis, which was based on SEM observation of the membranes surface, showed that after only 7 days immersion in SBF, the PLDL/n-HAp -membranes were completely covered by the apatite layer. This was not observed for pure PLDL membranes.
    Źródło:
    Engineering of Biomaterials; 2010, 13, 93; 2-5
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    An ultrasonic method for estimation of elastic properties of R-bone cement after immersion in Ringers solution
    Autorzy:
    Rajzer, I.
    Piekarczyk, J.
    Castano, O.
    Engel, E.
    Planell, J. A.
    Powiązania:
    https://bibliotekanauki.pl/articles/285794.pdf
    Data publikacji:
    2008
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    calcium phosphate cement
    elastic properties
    injectability
    ultrasonic method
    Opis:
    The aim of this investigation is to establish an improved non-destructive ultrasonic through-transmission technique to monitor the setting behaviour of calcium phosphate cement samples. On the basis of ultrasound techniques the elastic properties of cement paste after different soaking time in Ringer's solution were measured. Young's modulus, the rigidity modulus, and Poisson's ratio were calculated from measurements of density and ultrasonic longitudinal and shear wave velocities.
    Źródło:
    Engineering of Biomaterials; 2008, 11, no. 81-84; 113-116
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Modeling, fabrication and characterization of 3D PLLA scaffolds plotted with commercial printer
    Autorzy:
    Jablonski, A.
    Kopec, J.
    Jatteau, S.
    Śliwka, M.
    Ziąbka, M.
    Rajzer, I.
    Powiązania:
    https://bibliotekanauki.pl/articles/286129.pdf
    Data publikacji:
    2017
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    scaffolds
    medical implants
    PLLA
    Źródło:
    Engineering of Biomaterials; 2017, 20, no. 143 spec. iss.; 84
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of simulated body fluid on the microstructure of melt spun composite fibers
    Autorzy:
    Rajzer, I.
    Rom, M.
    Fabia, J.
    Sarna, E.
    Biniaś, D.
    Zima, A.
    Ślósarczyk, A.
    Janicki, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/283899.pdf
    Data publikacji:
    2009
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    composites fibers
    simulated body fluid
    polylactic acid
    hydroxyapatite
    bone tissue regeneration
    Opis:
    Polylactic acid (PLA) offers unique features of biodegradability and thermal processability, that offer potential applications in medicine. PLA can be transformed into fibers by spinning enabling then subsequent fabrication of desirable three dimensional fabrics which may be used as scaffolds for tissue engineering applications. Incorporation of synthetic nano-hydroxyapatite into the fibrous polymer matrix can enhance bioactive properties of the prospective scaffold. In the present work, the method of production of composite fibers based on polylactic acid (PLA) and nano-hydroxyapatite (n-HAp) is proposed. Obtained fibers have shown excellent apatite-forming ability when immersed in simulated body fluid.
    Źródło:
    Engineering of Biomaterials; 2009, 12, 88; 2-4
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-15 z 15

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