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Tytuł:
Artificial immune system in planning deliveries in a short time
Autorzy:
Mrówczyńska, B.
Król, A.
Czech, P.
Powiązania:
https://bibliotekanauki.pl/articles/200739.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
artificial immune system
genetic algorithm
simulated annealing
open vehicle routing problem
on-time delivery
Taguchi method
Opis:
In the calculations presented in the article, an artificial immune system (AIS) was used to plan the routes of the fleet of delivery vehicles supplying food products to customers waiting for the delivery within a specified, short time, in such a manner so as to avoid delays and minimize the number of delivery vehicles. This type of task is classified as an open vehicle routing problem with time windows (OVRPWT). It comes down to the task of a traveling salesman, which belongs to NP-hard problems. The use of the AIS to solve this problem proved effective. The paper compares the results of AIS with two other varieties of artificial intelligence: genetic algorithms (GA) and simulated annealing (SA). The presented methods are controlled by sets of parameters, which were adjusted using the Taguchi method. Finally, the results were compared, which allowed for the evaluation of all these methods. The results obtained using AIS proved to be the best.
Źródło:
Bulletin of the Polish Academy of Sciences. Technical Sciences; 2019, 67, 5; 969-980
0239-7528
Pojawia się w:
Bulletin of the Polish Academy of Sciences. Technical Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Gas outflow from an underground site – numerical simulations into baric tendency and airflow rate relationship
Emisja gazów z górotworu – symulacje numeryczne wpływu tendencji barycznej na intensywność przepływu gazów
Autorzy:
Wrona, P.
Król, A.
Król, M.
Powiązania:
https://bibliotekanauki.pl/articles/219607.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
symulacja CFD
emisja CO2
ANSYS Fluent
oddziaływanie na środowisko
zagrożenie gazowe
CFD simulation
CO2 leak
Ansys Fluent
environmental impact
gas hazard
Opis:
Gas emissions from underground sites to the atmosphere depend on many factors. Pressure drops are considered to be the most important. However, emissions can also be observed during the initial phase of the pressure rise, following a previous drop in pressure. On the other hand, gas emissions may not be detected when the pressure drops, especially when a previous pressure rise has taken place. The aim of the research was to determine the role of variations in baric tendency on airflow rate and its direction. To solve this problem a numerical model was built utilizing the Ansys Fluent software package. Subsequently, three scenarios of baric tendency variations were tested: a) rise – drop, b) drop – drop, c) drop – rise. The results showed inert behavior of gases. Under scenario (c), 1 hour after the change in tendency gases still were flowing out to the atmosphere. Considering scenario (a), it was proved that even during a pressure drop gas emissions do not take place, which can be crucial for further determination of the gas hazard at the surface or for assessment of the rate of gas emissions from a particular gas emitter. Scenario (b) merely gave an overview of the process and was mainly used for validation purposes. It gave a maximal CO2 concentration of 2.18%vol (comparable to measurements) and a CO2 mass flow rate 0.15kg/s. Taking into account greenhouse gas emissions this amounted to 514 kg CO2/h.
Emisja gazów z górotworu do atmosfery zależy od wielu czynników, z których jako najważniejszy uznawane są spadki ciśnienia atmosferycznego. Jednakże podczas prowadzonych badań wypływ gazów został także odnotowany podczas początkowego okresu zwyżki barycznej, poprzedzonego zniżką. Wystąpiło także zjawisko braku wypływu gazów mimo występującej zniżki barycznej, w szczególności po okresie wzrostu ciśnienia. Dlatego celem przeprowadzonych badań było określenie wpływu zmian ciśnienia atmosferycznego (rodzaju tendencji barycznej) na natężenie przepływu gazów pomiędzy górotworem a atmosferą oraz wyznaczenie jego kierunku. Do badań stworzono model numeryczny zjawiska w programie Ansys Fluent. Założono trzy warianty zmian ciśnienia: a) zwyżka – zniżka, b) zniżka – zniżka, c) zniżka – zwyżka. Otrzymane wyniki potwierdziły występującą bezwładność badanego procesu. W przypadku scenariusza (c), 1 gazy wypływały do atmosfery przez okres godziny po zmianie tendencji barycznej ze zniżki na zwyżkę. Rozpatrując scenariusz (a), dowiedziono, że emisja gazów może nie wystąpić mimo zachodzącej zniżki ciśnienia atmosferycznego. Może to mieć kluczowe znaczenie przy określaniu zagrożenia gazowego na powierzchni terenu lub wyznaczaniu intensywności emisji gazów z górotworu. Scenariusz (b) był scenariuszem porównawczym i służył do walidacji modelu. Dla tego scenariusza otrzymano maksymalne stężenie CO2 wynoszące 2.18%vol (wartość porównywalna ze stwierdzoną podczas pomiarów) oraz natężenie emisji CO2 równe 0.15kg/s. W przeliczeniu na emisję godzinną jest to 514kg CO2/h. Wartość ta ma znaczenie pod kątem emisji gazów cieplarnianych do atmosfery.
Źródło:
Archives of Mining Sciences; 2018, 63, 2; 251-268
0860-7001
Pojawia się w:
Archives of Mining Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Reproduction of Phantom Sources Improves with Separation of Direct and Reflected Sounds
Autorzy:
Kleczkowski, P.
Król, A.
Małecki, P.
Powiązania:
https://bibliotekanauki.pl/articles/177770.pdf
Data publikacji:
2015
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
spatial audio
multichannel sound reproduction
phantom sources
auralization
ambisonics abbreviations
IR (impulse response)
SIR (spatial impulse response)
RT (reverberation time)
ANOVA (analysis of variance)
DS – direct sound
RSs – reflected sounds
Opis:
In virtual acoustics or artificial reverberation, impulse responses can be split so that direct and reflected components of the sound field are reproduced via separate loudspeakers. The authors had investigated the perceptual effect of angular separation of those components in commonly used 5.0 and 7.0 multichannel systems, with one and three sound sources respectively (Kleczkowski et al. (2015b). In that work, each of the front channels of the 7.0 system was fed with only one sound source. In this work a similar experiment is reported, but with phantom sound sources between the front loudspeakers. The perceptual advantage of separation was found to be more consistent than in the condition of discrete sound sources. The results were analysed both for pooled listeners and in three groups, according to experience. The advantage of separation was the highest in the group of experienced listeners.
Źródło:
Archives of Acoustics; 2015, 40, 4; 575-584
0137-5075
Pojawia się w:
Archives of Acoustics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The Effect of Sonication on Acoustic Properties of Biogenic Ferroparticle Suspension
Autorzy:
Józefczak, A.
Hornowski, T.
Król, A.
Molčan, M.
Leszczyński, B.
Timko, M.
Powiązania:
https://bibliotekanauki.pl/articles/176978.pdf
Data publikacji:
2016
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
magnetosomes
sonication
ultrasonic properties
Opis:
Superparamagnetic iron oxide nanoparticles (SPION) synthesised chemically usually need the modification of the particle surface. Other natural sources of magnetic particles are various magnetotactic bacteria. Magnetosomes isolated from magnetotactic bacteria are organelles consisting of magnetite (Fe3O4) or greigite (Fe3S4) crystals enclosed by a biological membrane. Magnetotactic bacteria produce their magnetic particles in chains. The process of isolation of magnetosome chains from the body of bacteria consists of a series of cycles of centrifugation and magnetic decantation. Using a high-energy ultrasound it is possible to break the magnetosome chains into individual nanoparticles – magnetosomes. This study presents the effect of sonication of magnetosome suspension on their acoustic properties, that is speed and attenuation of the sound. Acoustic propagation parameters are measured using ultrasonic spectroscopy based on FFT spectral analysis of the received pulses. The speed and attenuation of ultrasonic waves in magnetosome suspensions are analysed as a function of frequency, temperature, magnetic field intensity, and the angle between the direction of the wave and the direction of the field.
Źródło:
Archives of Acoustics; 2016, 41, 1; 161-168
0137-5075
Pojawia się w:
Archives of Acoustics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Lombard Effect in Polish Speech and its Comparison in English Speech
Autorzy:
Kleczkowski, P.
Żak, A.
Król-Nowak, A.
Powiązania:
https://bibliotekanauki.pl/articles/177703.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
lombard effect
speech production
Polish speech
speech level
fundamental frequency of speech
spectral tilt
Opis:
The first extensive investigation on the Lombard effect with Polish speech has been performed. Characteristic parameters of Lombard speech were measured: intensity, fundamental frequency, spectral tilt, duration of words, duration of pauses and duration of vowels. The effect was investigated in a task involving real communication – solving a Sudoku puzzle. The speakers produced speech in quiet and in three different backgrounds: competing speech, speech-shaped noise and speech-modulated noise. The experimental conditions were held as close as possible to those in the study by Cooke and Lu (2010) so that conclusions could be drawn whether differences between the Lombard effect in Polish speech and English speech existed. Most of the findings on the Lombard effect known from the literature have been confirmed with Polish speech. In three parameters, Polish speakers were more sensitive to modulated backgrounds while English speakers were more sensitive to a stationary background. In both languages, the modulated backgrounds induced speakers to extend pauses in the communication tasks.
Źródło:
Archives of Acoustics; 2017, 42, 4; 561-569
0137-5075
Pojawia się w:
Archives of Acoustics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Król gniewny czy król szalony? Herodotowy portret Kambizesa
AN ANGRY KING OR A MADMAN? HERODOTUS PORTRAIT OF CAMBYSES
Autorzy:
Marchewka, Anna
Powiązania:
https://bibliotekanauki.pl/articles/702719.pdf
Data publikacji:
2008
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Herodotus
Cambyses
Opis:
Delineating various characters in his Histories, Herodotus is influenced by his theories on national character. This is why he presents Cambyses as a cruel barbarian despot. Many of the king’s deeds result from anger which the historian tries to justify. Other crimes, such as cruel treatment of his family and friends, and profanation of Persian and foreign religious cults, Herodotus seems to treat as signs of madness. In this article, it is shown that some of these actions could have stemmed from cultural misunderstandings: the king did not know enough about foreign religions and customs.
Źródło:
Meander; 2008, 63, 1-4; 76-88
0025-6285
Pojawia się w:
Meander
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of age and stage of lactation on whey protein content in milk of cows of different breeds
Autorzy:
Krol, J.
Brodziak, A.
Litwinczuk, Z.
Litwinczuk, A.
Powiązania:
https://bibliotekanauki.pl/articles/30979.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
The aim of the study was to determine the effect of age of cows, i.e. subsequent lactation and stage of lactation, on bioactive whey protein content in milk of dairy cows of six primary breeds kept in Poland. In all cases the significant correlations between lactoferrin concentration in milk and stage of lactation was stated. Its content gradually increased with the course of lactation but the changes in the content of this protein were highly dependent on breed of cows, what was indicated also by high interactions between breed and stage of lactation.
Źródło:
Polish Journal of Veterinary Sciences; 2013, 16, 2
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Canine mammary carcinoma cell line are resistant to chemosensitizers: verapamil and cyclosporin A
Autorzy:
Krol, M.
Pawlowski, K.M.
Majchrzak, K.
Mucha, J.
Motyl, T.
Powiązania:
https://bibliotekanauki.pl/articles/32199.pdf
Data publikacji:
2014
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
Cancer chemotherapy can fail in many ways. One of the most significant is the development of multiple drug resistance (MDR), which constitutes a serious clinical problem. The development of MDR relates to the expression of a major membrane pump, P-glycoprotein (P-gp). Thus, currently one of the goals of experimental and clinical oncology is to decrease its activity. So far, many different P-gp inhibitors are available, but their efficacy is still questionable and requires further study. The aim of our study was to assess an impact of classical P-gp inhibitors (verapamil and cyclosporin A) in the reversion of multidrug resistance in canine mammary cancer cells. We used two cell lines isolated from mammary tumors and two cell lines isolated from their lung metastases. All of them showed P-gp over-expression confirmed using Real-time rt-PCR, Skan^R screening station and confocal microscopy. The FACS analysis showed that in three of the examined cell lines, treatment with verpamil/cyclosporin A was ineffective to reverse cancer chemoresistance. However, more studies in this field are required.
Źródło:
Polish Journal of Veterinary Sciences; 2014, 17, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of the Mechanical Properties of the Titanium Layer Obtained by the Mold Cavity Preparation Method
Autorzy:
Dulska, A.
Szajnar, J.
Król, M.
Powiązania:
https://bibliotekanauki.pl/articles/2049618.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
modular insert
titanium layer
cast iron
SLM
Opis:
The article presents the technology of layered casting with the use of 3D printing to make a frame insert. The insert was made of powdered titanium and then filled with liquid cast iron. The paper presents the results of research, including structure observation and hardness measurements, as well as abrasion resistance tests. The results indicate the possibility of creating a local reinforcement using a frame insert. The resulting casting is characterized by a local increase in hardness and, in addition, an increase in abrasion resistance of the entire surface layer. The quality of the obtained connection depends strongly on the casting parameters.
Źródło:
Archives of Metallurgy and Materials; 2021, 66, 1; 51-56
1733-3490
Pojawia się w:
Archives of Metallurgy and Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Structure and properties investigation of MCMgAl12Zn1 magnesium alloy
Autorzy:
Dobrzański, L. A.
Król, M.
Powiązania:
https://bibliotekanauki.pl/articles/380517.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
thermal analysis
microstructure
mechanical properties
magnesium alloy
analiza termiczna
mikrostruktura
właściwości mechaniczne
stop magnezu
Opis:
This work presents an influence of cooling rate on crystallization process, structure and mechanical properties of MCMgAl12Zn1 cast magnesium alloy. The experiments were performed using the novel Universal Metallurgical Simulator and Analyzer Platform. The apparatus enabled recording the temperature during refrigerate magnesium alloy with three different cooling rates, i.e. 0.6, 1.2 and 2.4ºC/s and calculate a first derivative. Based on first derivative results, nucleation temperature, beginning of nucleation of eutectic and solidus temperature were described. It was fund that the formation temperatures of various thermal parameters, mechanical properties (hardness and ultimate compressive strength) and grain size are shifting with an increasing cooling rate.
Źródło:
Archives of Foundry Engineering; 2013, 13, 1; 9-14
1897-3310
2299-2944
Pojawia się w:
Archives of Foundry Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A role of ghrelin in cancerogenesis
Autorzy:
Majchrzak, K.
Szyszko, K.
Pawlowski, K.M.
Motyl, T.
Krol, M.
Powiązania:
https://bibliotekanauki.pl/articles/31726.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
ghrelin
cancerogenesis
growth hormone secretagogue receptor
cancer
mammary cancer
veterinary oncology
oncology
dog
animal disease
Opis:
Ghrelin is a 28 amino-acid multi-functional peptide hormone, which was identified as a natural ligand of the growth hormone secretagogue receptor (GHS-R). Pituitary growth hormone-releasing activity in both animals and humans has been well documented. It has various biological functions, including regulation of appetite and body weight, control of energy homeostasis, modulation of cardiovascular and gastrointestinal system and anti-inflammatory effect. However, both ghrelin and its receptor (GHS-R) are widely distributed in various tumors, which strongly implies their role in neoplastic cell growth trough autocrine/paracrine mechanism. Multiple studies have demonstrated the role of ghrelin in cancer cells proliferation, differentiation, invasiveness and apoptosis inhibition. The ghrelin axis is more complex than it was originally thought and consist of several compounds that might interact with each other and affect ghrelin activities. Here, we provide an overview of the ghrelin and its receptor role in tumor progression.
Źródło:
Polish Journal of Veterinary Sciences; 2012, 15, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fusing the electromagnetic articulograph, high-speed video cameras and a 16-channel microphone array for speech analysis
Autorzy:
Mik, Ł.
Lorenc, A.
Król, D.
Wielgat, R.
Święciński, R.
Jędryka, R.
Powiązania:
https://bibliotekanauki.pl/articles/200263.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
electromagnetic articulography
microphone array
vision system
speech analysis
artykulograf elektromagnetyczny
system wizyjny
analiza mowy
Opis:
Electromagnetic articulography (EMA) is one of the instrumental phonetic research methods used for recording and assessing articulatory movements. Usually, articulographic data are analysed together with standard audio recordings. This paper, however, demonstrates how coupling the articulograph with devices providing other types of information may be used in more advanced speech research. A novel measurement system is presented that consists of the AG 500 electromagnetic articulograph, a 16-channel microphone array with a dedicated audio recorder and a video module consisting of 3 high-speed cameras. It is argued that synchronization of all these devices allows for comparative analyses of results obtained with the three components. To complement the description of the system, the article presents innovative data analysis techniques developed by the authors as well as preliminary results of the system’s accuracy.
Źródło:
Bulletin of the Polish Academy of Sciences. Technical Sciences; 2018, 66, 3; 257-266
0239-7528
Pojawia się w:
Bulletin of the Polish Academy of Sciences. Technical Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nanotechnology for biomedical applications - enhancement of photodynamic activity by nanomaterials
Autorzy:
Ulatowska-Jarża, A.
Pucińska, J.
Wysocka-Król, K.
Hołowacz, I.
Podbielska, H.
Powiązania:
https://bibliotekanauki.pl/articles/200175.pdf
Data publikacji:
2011
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
silver-doped nanomaterials
silica-titania (SiO2-TiO2) materials
photodynamic activity
fluorescence enhancement
Opis:
Over the last two decades nanotechnology has become one of the most dynamically evolving field of research. The unique properties of nanomaterials, not disclosing at microscale, are examined and exploited to extend our understanding of the interactions taking place at atomic or molecular level. Those findings affect research in many areas, like e.g. alternative energy sources, electronics, physics and medicine. In this paper, the possibility of using nanomaterials for the enhancement of photodynamic activity, is discussed. A brief review on drug-delivery facilitating nanomaterials, regarding their characteristic features, is presented. An exemplary application of silver-doped nanomaterials for enhancement of photodynamic properties of two photosensitizers: Photolon and Protoporphyrin IX, is described. Influence of silver-doped nanomaterials addition on the fluorescence intensity of photosensitizers immobilized in silica-titania (SiO2-TiO2) sol was examined via VIS spectroscopy. Influence of sonication on the fluorescence enhancement was also investigated. It was demonstrated that the fluorescence enhancement of photosensitizers depends on the concentration of both: photosensitizer and silver-doped nanoparticles.
Źródło:
Bulletin of the Polish Academy of Sciences. Technical Sciences; 2011, 59, 3; 253-261
0239-7528
Pojawia się w:
Bulletin of the Polish Academy of Sciences. Technical Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Studia nad niepełnosprawnością a wyobraźnia socjologiczna
Disability Studies and Sociological Imagination
Autorzy:
Kowalska, Beata
Król, Agnieszka
Migalska, Aleksandra
Warat, Marta
Powiązania:
https://bibliotekanauki.pl/articles/427139.pdf
Data publikacji:
2014
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
społeczny model niepełnosprawności
wyobraźnia socjologiczna
metodologia feministyczna
obywatelskość
social model of disability
sociological imagination
feminist methodology
citizenship
Opis:
Powołując się na wprowadzoną przez Wrighta Millsa kategorię wyobraźni socjologicznej autorki stawiają pytanie o obecność studiów nad niepełnosprawnością w socjologii. Przedstawienie teoretycznych modeli niepełnosprawności w naukach społecznych staje się punktem wyjścia rozważań metodologicznych, związanych z prowadzeniem badań wyznaczonych przez społeczny model niepełnosprawności. Refleksji poddano zarówno założenia, jak i praktykę prezentowanych badań jakościowych, dotyczących genderowego wymiaru niepełnosprawności. Są one analizowane w aspekcie komplementarności wymiarów badawczego i emancypacyjnego oraz jako splot perspektyw indywidualnych, strukturalnych i obywatelskich. Autorki, lokując swoje badania w perspektywie metodologii feministycznej i socjologii zaangażowanej, podkreślają: ich procesualny i wzmacniający charakter, przełamanie tradycyjnych relacji badacz/ka – osoba badana, unikanie narzucania siatki pojęciowej badaczki i uznanie kompetencji uczestniczek badań, jak również konieczność zapewnienia pełnej dostępności jako warunku podmiotowego traktowania uczestniczek.
Referring to the concept of sociological imagination introduced by Charles Wright Mills, the authors reflect on the place of disability studies in sociology. Presenting theoretical models of disability in social sciences becomes a starting point for a discussion of methodological insights concerning research based on the social model of disability. They are analyzed both from the point of view of complementarity between research and emancipatory dimension and as a combination of individual, structural and civic perspectives. The authors situate their research in the perspective of feminist methodology and public sociology. They stress its process aspect and empowering effects as well as the resulting breach of traditional relationship between the researcher and the subject. They also discuss the avoidance of imposing the researcher’s conceptual network and recognition of the participants’ competences as well as the necessity to provide for as full an accessibility as possible as a condition of subjective approach to the participants of research.
Źródło:
Studia Socjologiczne; 2014, 2(213); 225-250
0039-3371
Pojawia się w:
Studia Socjologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Gene expression pattern in canine mammary osteosarcoma
Autorzy:
Pawlowski, K.
Majewska, A.
Szyszko, K.
Dolka, I.
Motyl, T.
Krol, M.
Powiązania:
https://bibliotekanauki.pl/articles/32248.pdf
Data publikacji:
2011
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
bone tumour
canine mammary osteosarcoma
gene expression
mammary osteosarcoma
microarray
osteosarcoma
transcriptome
tumour
sarcoma
proliferation
aggressive tumour
gene list
Opis:
Canine mammary sarcomas are usually very aggressive and easily metastasize. Unfortunately the biology of this type of tumor is not well known because they are a very rare type of tumors. The aim of this study was to find differences in gene expression patterns in canine mammary osteosarcomas (malignant) versus osteomas (benign) using DNA microarrays. Our microarray experiment showed that 11 genes were up-regulated in osteosarcoma in comparison to osteoma whereas 36 genes were down-regulated. Among the up-regulated genes were: PDK1, EXT1, and EIF4H which are involved in AKT/PI3K and GLI/Hedgehog pathways. These genes play an important role in cell biology (cancer cell proliferation) and may be essential in osteosarcoma formation and development. Analyzing the down-regulated genes, the most interesting seemed to be HSPB8 and SEPP1. HSPB8 is a small heat shock protein that plays an important role in cell cycle regulation, apoptosis, and breast carcinogenesis. Also SEPP1 may play a role in carcinogenesis, as its down-regulation may induce oxidative stress possibly resulting in carcinogenesis. The preliminary results of the present study indicate that the up-regulation of three genes EXT1, EIF4H, and PDK1 may play an essential role in osteosarcoma formation, development and proliferation. In our opinion the cross-talk between GLI/Hedgehog and PI3K/AKT pathways may be a key factor to increase tumor proliferation and malignancy.
Źródło:
Polish Journal of Veterinary Sciences; 2011, 14, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 22

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