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Wyszukujesz frazę "Shah, H." wg kryterium: Autor


Tytuł:
Modeling computational studies of modified drug molecules binding to the LRRK2 protein in the treatment of Parkinson’s disease
Autorzy:
Shah, H.
Darsey, J. A.
Powiązania:
https://bibliotekanauki.pl/articles/284742.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
LRRK2 proteins
Parkinson
Computational Modeling
IC50
Density Functional Theory
DFT
Opis:
Parkinson’s disease is a neurodegenerative and progressive disease of the central nervous system. It affects more than 10 million patients worldwide and the symptoms allow for little to no control for movement. These symptoms appear because the chemical messenger dopamine is being made in small quantities from impaired cells. However, the disease often forms when there is a mutation in the LRRK2 gene, as the functions of the protein become abnormal. The IC50 value is essential information about molecules because it measures their effectiveness. The goal of this research was to design molecules with a lower IC50 value. This was first done by modeling molecules on the molecular modeling program, Gaussian 09. Modifications were made to molecules that were said to bind to the LRRK2 protein. Modifications ranged from adding a single atom or replacing atoms with groups. After running these molecules on the program, the total energy was found. Using the equation found from the correlation between 1/IC50 and the total energy, the IC50 value was predicted for each of the modified molecules. Many of the modified molecules portrayed a positive percent difference between the original IC50 value and the new one. This saves both time and money because the molecules with lower IC50 values can be made, preserving the resources. After creating the molecule with a low IC50 value, further experimental procedures can be taken; this is a large step in assisting researchers to reach a potential treatment because it is more efficient.
Źródło:
Engineering of Biomaterials; 2018, 21, 145; 2-7
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Music Playlist Generation using Facial Expression Analysis and Task Extraction
Autorzy:
Sen, A.
Popat, D.
Shah, H.
Kuwor, P.
Johri, E.
Powiązania:
https://bibliotekanauki.pl/articles/908868.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Marii Curie-Skłodowskiej. Wydawnictwo Uniwersytetu Marii Curie-Skłodowskiej
Tematy:
facial expression analysis
emotion recognition
feature extraction
viola jones face detection
gabor filter
adaboost
k-NN algorithm
task extraction
music classification
playlist generation
Opis:
In day to day stressful environment of IT Industry, there is a truancy for the appropriate relaxation time for all working professionals. To keep a person stress free, various technical or non-technical stress releasing methods are now being adopted. We can categorize the people working on computers as administrators, programmers, etc. each of whom require varied ways in order to ease themselves. The work pressure and the vexation of any kind for a person can be depicted by their emotions. Facial expressions are the key to analyze the current psychology of the person. In this paper, we discuss a user intuitive smart music player. This player will capture the facial expressions of a person working on the computer and identify the current emotion. Intuitively the music will be played for the user to relax them. The music player will take into account the foreground processes which the person is executing on the computer. Since various sort of music is available to boost one's enthusiasm, taking into consideration the tasks executed on the system by the user and the current emotions they carry, an ideal playlist of songs will be created and played for the person. The person can browse the playlist and modify it to make the system more flexible. This music player will thus allow the working professionals to stay relaxed in spite of their workloads.
Źródło:
Annales Universitatis Mariae Curie-Skłodowska. Sectio AI, Informatica; 2016, 16, 2; 1-6
1732-1360
2083-3628
Pojawia się w:
Annales Universitatis Mariae Curie-Skłodowska. Sectio AI, Informatica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Coordinated production, ordering, shipment and pricing model for supplier-retailer inventory system under trade credit
Autorzy:
Shah, Nita H.
Naik, Monika K.
Powiązania:
https://bibliotekanauki.pl/articles/406551.pdf
Data publikacji:
2019
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
defective item
production inventory system
supply chain of two players
time-price
credit
dependent demand
element uszkodzony
system inwentaryzacji produkcji
łańcuch dostaw
kredyt
popyt zależny
Opis:
The objective of this article is to maximize the joint profit for supplier and retailer by constructing a combined supplier–retailer inventory model wherein supplier and retailer both have implemented trade credit policies, and some defective items are received by the retailer. The customer’s demand is expressed as a function of time, price and credit period, which is appropriate for the products for which demand increases initially and after some time it starts to decrease. Production, directly proportional to the customer’s demand rate, is considered as one of the decision variables for the purpose of reducing the holding cost of the supplier. The article estimates the optimum replenishment cycle, customer’s credit period, retail selling price by a classical optimization technique. For validation of the derived model, various numerical examples are demonstrated. Finally, implementing sensitivity analysis on the decision variables by varying the inventory parameters, effective managerial insights are generated which is beneficial for the players of supply chain by practically gaining the maximum joint profit through advising to opt for the case N ≤ M ≤ T , i.e., when the customer’s trade credit period offered by the retailer is lesser than the retailer’s trade credit period offered by the supplier and which is lesser than the replenishment cycle length.
Źródło:
Operations Research and Decisions; 2019, 29, 2; 55-76
2081-8858
2391-6060
Pojawia się w:
Operations Research and Decisions
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
An efficient one-pot multicomponent synthesis and characterization of 5-cyano-1,2,3,4-tetrahydropyrimidine derivatives
Autorzy:
Vaghasiya, R. G.
Shah, V. H.
Powiązania:
https://bibliotekanauki.pl/articles/411702.pdf
Data publikacji:
2015
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
substituted pyrazole-4-carbaldehyde
5-cyano-1,2,3,4-tetrahydropyrimidine derivatives
multi component reaction
non-chromatographic method
Opis:
A series of pyrimidine-5-carbonitrile derivatives was efficiently synthesized via one-pot, multi component reaction (MCRs) of 1,3-bifunctional synthon (ethylcyano acetate), substituted pyrazole-4-carbaldehyde, and thiourea/urea in the presence of basic catalyst. The key advantages of this process are high yields, shorter reaction times, easy work-up, and purification of products by non-chromatographic method.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2015, 40; 51-60
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Inventory models and trade credit: a review
Autorzy:
Soni, H.
Shah, N. H.
Jaggi, C. K.
Powiązania:
https://bibliotekanauki.pl/articles/969900.pdf
Data publikacji:
2010
Wydawca:
Polska Akademia Nauk. Instytut Badań Systemowych PAN
Tematy:
lot-size model
trade credit
deterioration
probabilistic demand
Opis:
This article reviews the literature on quantitatively oriented approaches for determining the optimal lot-size when supplier offers credit period to the retailer to settle their account. An attempt is made to provide an up-to-date review of existing literature, concentrating on descriptions of the types of problems that have been solved and important structural results.
Źródło:
Control and Cybernetics; 2010, 39, 3; 867-882
0324-8569
Pojawia się w:
Control and Cybernetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Optimal credit period and ordering quantity for credit dependent trended demand and deteriorating items with maximum lifetime
Autorzy:
Shah, N. H.
Shah, D. B.
Patel, D. G.
Powiązania:
https://bibliotekanauki.pl/articles/970075.pdf
Data publikacji:
2015
Wydawca:
Polska Akademia Nauk. Instytut Badań Systemowych PAN
Tematy:
inventory
trended demand
trade credit
default risk
deterioration
maximum lifetime
Opis:
In this paper, an inventory system is analyzed regarding a trended demand. The seller offers its buyer a credit period for settling the account, which attracts more buyers and enhances market demand. However, the offer of credit period leads to default risk for the supplier. The units in inventory are deteriorating continuously and also have definite maximum lifetime. The aim is to maximize the profit of the retailer. Numerical examples are given to validate the developed mathematical model. Sensitivity analysis is performed to obtain the critical inventory parameters and deduce the managerial strategies.
Źródło:
Control and Cybernetics; 2015, 44, 2; 311-320
0324-8569
Pojawia się w:
Control and Cybernetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
An EOQ model with time dependent deterioration under discounted cash flow approach when supplier credits are linked to order quantity
Autorzy:
Shah, B. J.
Shah, N. H.
Shah, Y. K.
Powiązania:
https://bibliotekanauki.pl/articles/970398.pdf
Data publikacji:
2007
Wydawca:
Polska Akademia Nauk. Instytut Badań Systemowych PAN
Tematy:
time dependent deterioration
discounted cashflows (DCF) approach
supplier credit linked to order quantity
Opis:
This article deals with an inventory model under a situation in which the supplier offers the purchaser some credit period if the purchaser orders a large quantity. Shortages are not allowed. The effects of the inflation rate on purchase price, ordering price and inventory holding price, time dependent deterioration of units and permissible delay in payment are discussed. A mathematical model is developed when units in inventory are subject to time dependent deterioration under inflation when the supplier offers a permissible delay to the purchaser if the order quantity is greater than or equal to a pre-specified quantity. Optimal solution is obtained and algorithm is given to find the optimal order quantity and replenishment time, which minimizes the total cost of an inventory system in different scenarios. The paper concludes with a numerical example to illustrate the theoretical results and interdependence of parameters is studied for the optimal solutions.
Źródło:
Control and Cybernetics; 2007, 36, 2; 405-423
0324-8569
Pojawia się w:
Control and Cybernetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A rapid, convient and diversified-multicomponent synthesis and characterization of pyrano[2,3-b]indoles
Autorzy:
Ghodasara, H. B.
Singala, P. M.
Shah, V. H.
Powiązania:
https://bibliotekanauki.pl/articles/412134.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
1,3-bifunctional synthon
Pyrano[2,3-b]indoles
multi component reaction
non-chromatographic metod
Opis:
A series of pyrano[2,3-b]indoles, was efficiently synthesized via one-pot, multi component reaction (MCRs) of 1,3-bifunctional synthon(malononitrile/ethylcyano acetate), aromatic aldehydes and oxiindole in the presence of various basic catalyst. The key advantages of this process are high yields, shorter reaction times, easy work-up, and purification of products by non-chromatographic method.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 7; 69-76
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis, Characterization and Biological evaluation of 6-substituted-2-(substituted-phenyl)-quinoline derivatives bearing 4-amino-1,2,4-triazole-3-thiol ring at C-4 position
Autorzy:
Vaghasiya, R. G.
Ghodasara, H. B.
Vachharajani, P. R.
Shah, V. H.
Powiązania:
https://bibliotekanauki.pl/articles/412211.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Quinoline, 4-amino-1,2,4-triazole-3-thiol
therapeutic agents
antimicrobial assai
Opis:
Quinoline derivatives represent one of the most active classes of compounds possesses wide spectrum biodynamic activities and use as potent therapeutic agents. In this research work, a synthesis, characterization and biological evaluation of 6-substituted-2-(substituted-phenyl)-quinoline derivatives bearing 4-amino-1,2,4-triazole-3-thiol ring at C-4 position is described. The synthesis of quinoline derivatives is carried out by the reaction of substituted quinoline-4-carbohydrazides with a mixture of carbon disulphide and potassium hydroxide which further react with hydrazine hydrate to give final compounds. All of these compounds were screened for their in vitro antimicrobial assay against gram (+ve), gram (-ve) bacteria and fungi activity compared with standard drugs viz., Ampicilin, Chloramphenicol, Ciprofloxacin, Norfloxacin, Griseofulvin and Nystatin at different concentrations.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 8; 30-37
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Challenges and opportunities for the future of icampuses
Autorzy:
Thomas, A. M.
Shah, H.
Moore, P.
Evans, C.
Sharma, M.
Pham, H. V.
Osman, K.
Wilcox, A. J.
Rayson, P.
Chapman, C.
Chima, P.
Athwal, C.
While, D.
Powiązania:
https://bibliotekanauki.pl/articles/952933.pdf
Data publikacji:
2013
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydawnictwo AGH
Tematy:
education
icampus
sensors
context
Web 2.0
Opis:
Meeting the educational needs of students currently requires moving toward collaborative electronic and mobile learning systems that parallel the vision of Web 2.0. However, factors such as data freedom, brokerage, interconnectivity and the Internet of Things add to a vision for Web 3.0 that will require consideration in the development of future campus-based, distance and vocational study. So, education can, in future, be expected to require deeper technological connections between students and learning environments, based on significant use of sensors, mobile devices, cloud computing and rich-media visualization. Therefore, we discuss challenges associated with such a futuristic campus context, including how learning materials and environments may be enriched by it. As an additional novel element the potential for much of that enrichment to be realized through development by students, within the curriculum, is also considered. We will conclude that much of the technology required to embrace the vision of Web 3.0 in education already exists, but that further research in key areas is required for the concept to achieve its full potential.
Źródło:
Computer Science; 2013, 14 (1); 5-25
1508-2806
2300-7036
Pojawia się w:
Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis, Characterization and Biological evaluation of some newer 5-[6-chloro/fluoro/nitro-2-(p-chloro/ fluoro/ methyl phenyl)-quinolin-4-yl]-1,3,4-oxadiazole-2-thiols
Autorzy:
Faldu, V. J.
Talpara, P. K.
Bhuva, N. H.
Vachharajani, P. R.
Shah, V. H.
Powiązania:
https://bibliotekanauki.pl/articles/412197.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Quinolines
1,3,4-oxadiazole-2-thiols
therapeutic agents
antimicrobial assai
Opis:
Recent study shows that quinolines represent one of the most active classes of compounds possesses wide spectrum biodynamic activities and use as potent therapeutic agents. In present research work, 5-[6-chloro/fluoro/nitro-2-(p-chloro/fluoro/methyl phenyl)-quinolin-4-yl]-1,3,4-oxadiazole-2-thiols have been synthesized by condensation of substituted quinoline-4-carbohydrazides and mixture of carbon disulphide and potassium hydroxide. All of these compounds were screened for their in vitroanti microbial assay against gram (+ve), gram (-ve) bacteria and fungi activity compared with standard drugs viz., Ampicilin, Chloramphenicol, Ciprofloxacin, Norfloxacin, Griseofulvin and Nystatin at different concentrations.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 6; 26-32
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis of novel 2-mercapto-4-(p-aminophenyl sulphonylamino)-6-(aryl)-pyrimidine-5-carboxamide derivatives via the Biginelli reaction
Autorzy:
Bhuva, N. H.
Gothalia, V. K.
Singala, P. M.
Talpara, P. K.
Faldu, V. J.
Shah, V. H.
Powiązania:
https://bibliotekanauki.pl/articles/412069.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
2-mercapto-4-(p-aminophenylsulphonylamino)-6-(aryl)-pyrimidine-5-carboxamide
Biginelli condensation
Opis:
Series of 2-mercapto-4-(p-aminophenylsulphonylamino)-6-(aryl)-pyrimidine-5-carboxamide Aa-h were synthesized via the biginelli condensation. 2-mercapto-4-amino-6-(aryl)-pyrimidine-5-carboxamide react with p-acetamidophenylsulphonylchloride in the presence of pyridine 2 to form 2-mercapto-4-(p-acetamidophenylsulphonylamino)-6-(aryl)-pyrimidine-5-carboxamide 3. It was treated with diluted HCl under reflux afforded 2-mercapto-4-(p-aminophenylsulphonylamino)-6-(aryl)-pyrimidine-5-carboxamide A a-h. The newly synthesized compounds were characterized by elemental analyses, infrared (IR), 1H NMR and 13 C NMR spectroscopic investigation.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 17, 2; 168-173
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Maximizing power output of a partially shaded total-cross-tied photovoltaic array
Autorzy:
Shah, N. S.
Patel, H. H.
Powiązania:
https://bibliotekanauki.pl/articles/136262.pdf
Data publikacji:
2017
Wydawca:
EEEIC International Barbara Leonowicz Szabłowska
Tematy:
current compensation
voltage equalization
MPPT
partial shading
TCT configuration
Opis:
Non-uniform conditions on the modules of the PV array, especially, partial shading reduces the output of the PV array to a large extent. The shaded module in a string limits the current of the entire string and hence, the output power of the string. The output power under such conditions is reported to be higher for total-cross-tied (TCT) configuration. This paper describes two different approaches, one based on current compensation (current equalization) and another based on voltage equalization, to extract higher power from the partially shaded total-cross-tied photovoltaic array. The TCT configuration is considered to minimize the number of converters, sensors, cost and complexity involved. The additional converters in the two distinct approaches evaluated here operate only when the partial shading occurs and are controlled to minimize the current and voltage miss-matches. The analysis and the control algorithm are presented. Simulation results obtained in MATLAB/Simulink are included to demonstrate the effectiveness of both methods and the relative merits and demerits of these approaches are highlighted.
Źródło:
Transactions on Environment and Electrical Engineering; 2017, 2, 1; 10-18
2450-5730
Pojawia się w:
Transactions on Environment and Electrical Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and antimicrobial screening of some new pyrimido[1,2-a]benzimidazole derivatives
Autorzy:
Shah, N. M.
Joshi, H. S.
Powiązania:
https://bibliotekanauki.pl/articles/411967.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
2-aminobenzimidazole
pyrimido[1,2-a]benzimidazole
chalcone
antimicrobial activity azoloazine
Opis:
Some new pyrimido[1,2-a]benzimidazole derivatives were synthesized by reacting 2-amino benzimidazole and chalcones in n-butanol at reflux temperature. In our present study we have used various heterocyclic chalcones derived from furfural and substituted acetophenones. All synthesized compounds were characterized by IR, 1H NMR and Mass spectroscopy. All synthesized compounds were screened for their antimicrobial activity against gram positive and gram negative bacteria which showed moderate to good activity.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 6; 56-60
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Novel s-Triazinyl Schiff Base/Chalcone Congeners: Rational, Synthesis, Antimicrobial and Anti-TB Evaluation
Autorzy:
Lakum, H. P.
Shah, D. R.
Chikhalia, K. H.
Powiązania:
https://bibliotekanauki.pl/articles/412603.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
antimicrobial
Anti-TB
s-Triazine
Schiff base
Chalcone
Opis:
The occurrence of Multi Drug Resistant (MDR) infectious microbial strains has been increased upto alarming level which affects the public health worldwide. To cure this problem, a library of s-triazinyl derivatives comprising schiff base or chalcone motif have been rationalized, synthesized and screened for their in vitro antibacterial activity against five bacterial strains (Staphylococcus aureus MTCC 96, Bacillus subtilis MTCC 441, Escherichia coli MTCC 739, Pseudomonas aeruginosa MTCC 741 and Klebsiella pneumoniae MTCC 109) and four fungal strains (Aspergillus niger MTCC 282, Aspergillus fumigates MTCC 343, Aspergillus clavatus MTCC 1323, Candida albicans MTCC 183) using broth dilution technique. All the newly synthesized scaffolds were further evaluated for their in vitro anti-TB efficacy against the tubercular strain (Mycobacterium tuberculosis H37Rv) using Lowenstein-Jensen MIC method. All the derivatives were well characterized by IR, 1H NMR, 13C NMR, elemental analysis as well as mass spectroscopy.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 19, 1; 56-73
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł

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