- Tytuł:
-
Zastosowanie związków kompleksowych platyny, palladu i kobaltu w medycynie. Cz. 1
Application of coordination compounds of platinum, palladium and cobalt in medicine. Part 1 - Autorzy:
-
Pawlak, Marta
Drzeżdżon, Joanna
Jacewicz, Dagmara - Powiązania:
- https://bibliotekanauki.pl/articles/1409835.pdf
- Data publikacji:
- 2020
- Wydawca:
- Polskie Towarzystwo Chemiczne
- Tematy:
-
związki kompleksowe platyny
związki kompleksowe palladu
związki kompleksowe kobaltu
leki przeciwnowotworowe
coordination compounds of platinum
coordination compounds of palladium
coordination compounds of cobalt
anticancer drugs - Opis:
- The complex compounds containing metal ions are a group of compounds widely used in medicine. More and more metals are also being used to create cancer drugs or to help with other very serious diseases. Anticancer drugs are a particular use of complex compounds. Many thousands of platinum(II) compounds have been synthesized in cancer therapy, but only six of them have found use in the treatment of cancer. The most popular and the most commonly used compound is cisplatin, it has become the basis for the treatment of bladder, cervical, head, esophagus and many cancers occurring in children. The mechanism of action of platinum(II) and platinum(IV) compounds against cancer cells is to inhibit DNA replication, then RNA transcription and stop the G2 phase of the cell cycle and lead to programmed cell death or apoptosis. Coordination compounds containing more than one metal ion in their composition open new possibilities in the fight against cancer. Pt-DNA connections created by compounds containing at least two metal atoms are different from those formed by cisplatin. The basic dinuclear structure allows for great flexibility in forming DNA-DNA or DNA-protein bonds. The cobalt(III) complexes began to be used to image areas of hypoxia in cancer cells. It is believed, that cobalt(III) complexes undergo bioreduction, which leads to the release of the labile cobalt(II) complex and one or more bioactive ligands. Studies on nitro-Co(III) complexes containing acetylacetone and a nitrogen mustard ligand have shown that it is a particularly effective anti-cancer drug. Due to the fact that many people have cancer new effective anti-cancer drugs with low toxicity and no side effects are still being sought.
- Źródło:
-
Wiadomości Chemiczne; 2020, 74, 11-12; 797-822
0043-5104
2300-0295 - Pojawia się w:
- Wiadomości Chemiczne
- Dostawca treści:
- Biblioteka Nauki
Artykuł