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    Wyświetlanie 1-3 z 3
    Tytuł:
    Analytical strategies for assessing occupational exposure to antineoplastic drugs in healthcare workplaces
    Autorzy:
    Dugheri, Stefano
    Bonari, Alessandro
    Pompilio, Ilenia
    Boccalon, Pierpaolo
    Tognoni, Daniela
    Cecchi, Michele
    Ughi, Massimo
    Mucci, Nicola
    Arcangeli, Giulio
    Powiązania:
    https://bibliotekanauki.pl/articles/2162575.pdf
    Data publikacji:
    2018-12-18
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    occupational exposure
    LC-MS/MS
    ICP-MS
    urine
    antineoplastic drugs
    wipe test
    Opis:
    Background Cytotoxic antineoplastic drugs (ADs), widely used in treating cancer, are considered hazardous in the workplace and thus require safe handling practices. An analytical protocol for environmental and biological AD monitoring in the healthcare environment has been developed, since Europe lacks clear guidelines and regulations for cytostatic preparation and handling. Material and Methods Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used for measuring contemporaneously 20 multi-class cytostatic compounds and urinary α-fluoro-β-alanine, whereas platinum was detected by inductively coupled plasma mass spectrometry (ICP-MS). Sampling procedures and analytical conditions were optimized and the assays were validated. Environmental AD monitoring data, collected in 2009–2017, for a total of 3749 wipe tests and 57 720 determinations, was evaluated. Results The proportion of positive samples gradually decreased from 11.7% in 2010 to 1% in 2017, however, 2266 determinations were positive. No urine sample had detectable concentrations of any of the 4 drugs considered (0/398 samples). Conclusions These improvements are so large that the key role played by the new, more stringent rules for preparing and administering ADs is evident. Hence, the analytical method involving multi-element determinations allows for a more thorough and complete investigation into the AD contamination of work environments. Med Pr 2018;69(6):589–604
    Źródło:
    Medycyna Pracy; 2018, 69, 6; 589-604
    0465-5893
    2353-1339
    Pojawia się w:
    Medycyna Pracy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Monitoring surface contamination for thirty antineoplastic drugs: a new proposal for surface exposure levels (SELs)
    Autorzy:
    Dugheri, Stefano
    Mucci, Nicola
    Bucaletti, Elisabetta
    Squillaci, Donato
    Cappelli, Giovanni
    Trevisani, Lucia
    Bonari, Alessandro
    Cecchi, Michele
    Mini, Enrico
    Ghiori, Andrea
    Tognoni, Daniela
    Berti, Nicola
    Alderighi, Francesca
    Li Vigni, Nicola
    Orlandi, Irene
    Arcangeli, Giulio
    Powiązania:
    https://bibliotekanauki.pl/articles/2152946.pdf
    Data publikacji:
    2022
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    health risk assessment
    antineoplastic drugs
    wipe test
    ultra-high performance liquid chromatography
    surface exposure level
    tandem mass spectrometry
    Opis:
    Background Chemotherapy drugs are widely used to treat cancer, but their active compounds represent a danger for workers who could be exposed to them. However, they aren’t yet included in directive CE No. 1272/2008 and the European Biosafety Network has only recommended a limit value of 100 pg/cm2 for surface contamination. Thus, it is crucial to assess surface contaminations in healthcare environments. Currently, the technique of choice is surface wipe test combined with liquid chromatography tandem mass spectrometry to achieve high sensibility. Material and Methods A campaign involving Careggi University Hospital (Florence, Italy) was performed from January 2020 to December 2021, collecting 1449 wipe samples between administration units, preparation unit, and personnel gloves. From the obtained data, the 90th percentile was calculated for 30 antiblastic drugs and proposed as surface exposure levels (SELs); while from data concerning personnel glove contamination, weekly contamination was estimated. Results In the 2-year period only 417 wipe samples were found positive (28.8%), the majority of which regard samples coming from administration unit bathrooms. The proposed SELs are almost all <100 pg/cm2, except for few drugs which produce higher contamination on bathroom surfaces. Also, the estimation of pharmacy personnel’s glove contamination highlighted very low results (ng/week). Conclusions Deeply established protocols and procedures for safe handling of ADs allow for obtaining excellent cleaning results and thus a safer work environment, however, the risk of cytostatic contaminations cannot be avoided in healthcare workplaces, and thus a harmonization of classification and labeling of chemotherapy drugs throughout the European Union should be done.
    Źródło:
    Medycyna Pracy; 2022, 73, 5; 383-396
    0465-5893
    2353-1339
    Pojawia się w:
    Medycyna Pracy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Occupational exposure to antineoplastic drugs in hospital environments: potential risk associated with contact with cyclophosphamide- and ifosfamide-contaminated surfaces
    Autorzy:
    Mucci, Nicola
    Dugheri, Stefano
    Farioli†, Andrea
    Garzaro, Giacomo
    Rapisarda, Venerando
    Campagna, Marcello
    Bonari, Alessandro
    Arcangeli, Giulio
    Powiązania:
    https://bibliotekanauki.pl/articles/2085717.pdf
    Data publikacji:
    2020-09-24
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    occupational exposure
    cyclophosphamide
    antineoplastic drugs
    ifosfamide
    wipe test
    surface contamination
    Opis:
    BackgroundCyclophosphamide (CP) and ifosfamide (IP) contaminations have been detected in hospital environments. This study was conducted to determine if there was any contamination in the spaces (floors and door handles) between the hospital exit and the antineoplastic drugs (ADs) preparation and administration units. At the same time, the authors proposed a new automation of the analytical procedure to considerably decrease the time needed for sample preparation and analysis.Material and MethodsTo evaluate the ADs contamination of surfaces, 829 wipe tests were performed in a campaign involving 3 hospitals located in Italy. Sampling was performed using an innovative kit. The levels of ADs were measured in each wipe sample using liquid chromatography/triple quadrupole.ResultsOn-line solid-phase extraction guarantees the construction of a robust and reproducible analytical method. The CP and IP recoveries from stainless steel, polycarbonate and polyvinyl chloride ranged >80%, and the wipe holders and the automation tested ensured desorption efficiencies close to 100% for both the ADs. Of the 552 wipes taken on the spaces between the hospital exit and the preparation, administration and pharmacy warehouse units, 22 were greater than or equal to the limit of quantification, all adjacent to the administration units.ConclusionsThis study provides an insight into the exposure situation against ADs residues. In order to improve environmental monitoring programs, the authors propose to evaluate the ADs contamination also outside the preparation, administration and pharmacy warehouse units.
    Źródło:
    Medycyna Pracy; 2020, 71, 5; 519-529
    0465-5893
    2353-1339
    Pojawia się w:
    Medycyna Pracy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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