Temat: verapamil - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Importance of early intervention in verapamil overdose – Case report and antidotes review
Autorzy:: Marzeda, P.
Drozd, M.
Tchorz, M.
Kisiel, K.
Powiązania:: https://bibliotekanauki.pl/articles/2098544.pdf
Data publikacji:: 2021
Wydawca:: Instytut Medycyny Wsi
Tematy:: verapamil
overdose
calcium channel blocker
lipid emulsion
antidote potential
Opis:: Introduction. Verapamil is a widely used cardiac drug. It belongs to the non-dihydropiridine subgroup of calcium channel blockers (CCBs), and is used mainly for the treatment of atrial dysrhythmias, hypertension or angina. In this article, we describe a case of poisoning with verapamil mixed with ethanol and review current treatment options. A 54-year-old female was admitted to the Toxicology Clinic by emergency medical services after ingesting sustained-release CCBs and ethanol in a suicidal attempt. The patient was successfully treated by administration of catecholamines and calcium, and the introduction of a high-dose insulin infusion (HDI). Conclusions. This case report emphasizes that even in severe poisoning, early and proper intervention may prevent circulatory breakdown. It also summarizes treatment options in patients after verapamil overdose. Along with decontamination, administration of catecholamines and correcting electrolyte abnormalities, the main options are HDI and lipid emulsion therapy (LET).
Źródło:: Journal of Pre-Clinical and Clinical Research; 2021, 15, 3; 142-147
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: The effect of co-processed dry binder with microcrystalline cellulose on release of verapamil hydrochloride from hydrophilic matrix tablets
Autorzy:: Komersová, Alena
Lochař, Václav
Myslíková, Kateřina
Mužíková, Jitka
Bartoš, Martin
Powiązania:: https://bibliotekanauki.pl/articles/895631.pdf
Data publikacji:: 2018-10-31
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Tematy:: matrix tablets
Dissolution kinetics
Verapamil hydrochloride
hypromellose
Comprecel® 102
MicroceLac®100
Opis:: The aim of this study was to evaluate the use of co-processed dry binder MicroceLac®100 (lactose and microcrystalline cellulose in ratio 3:1) and Comprecel® 102 (pure microcrystalline cellulose) in formulations for the extended release of verapamil hydrochloride. Hydrophilic matrix tablets containing verapamil hydrochloride, hypromellose and dry binder were prepared by the direct compression method. Hypromelloses MethocelTM K4M Premium CR or MethocelTM K100M Premium CR were used as controlled release agents. Using scanning electron microscopy regular distribution of the active substance in the prepared tablets was confirmed. Release of verapamil hydrochloride from the prepared formulations was studied by the dissolution test method. The dissolution profiles were fitted to the first-order kinetic model, Higuchi diffusion model, Korsmeyer-Peppas and Weibull model and kinetic parameters as the first order release rate constant (k1), release exponent (n) from Korsmeyer-Peppas model, Higuchi constant (KH) and parameters of Weibull model (b, λ) were determined. Based on results of non-linear regression analysis, the higher release rate constants were found for formulations containing co-processed dry binder MicroceLac®100 in comparison with formulations containing pure microcrystalline cellulose (Comprecel® 102). In addition, tablets swelling, erosion and disintegration during the dissolution test were monitored photographically.
Źródło:: Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 5; 1223-1231
0001-6837
2353-5288
Pojawia się w:: Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Wolne rodniki w sterylizowanym termicznie verapamilu
Free radicals in thermally sterilized verapamil
Autorzy:: Ramos, P.
Pepliński, P.
Pilawa, B.
Powiązania:: https://bibliotekanauki.pl/articles/285536.pdf
Data publikacji:: 2009
Wydawca:: Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:: werapamil
sterylizacja termiczna
wolne rodniki
spektroskopia EPR
verapamil
thermal sterilization
free radicals
EPR spectroscopy
Opis:: Zbadano generowanie wolnych rodników w werapamilu podczas sterylizacji termiczne w temperaturze 180 stopni C. Koncentrację i właściwości wolnych rodników analizowano z zastosowaniem spektroskopii elektronowego rezonansu paramagnetycznego (EPR) na pasmo X (9.3 GHz). Wykazano, że w procesie sterylizacji termicznej powstają w werapamilu stabilne wolne rodniki. Wolne procesy relaksacji spin-sieć oraz silne oddziaływania dipolowe występują w werapamilu. Badania metodą EPR wykazały, że sterylizacja wysokotemperaturowa nie jest zalecana dla werapamilu.
Free radical formation in verapamil during thermal sterilization at temperature 180 degrees of C was studied. Concentration and properties of free radicals were examined by the use of electron paramagnetic resonance (EPR) spectroscopy at X-band (9.3GHz). It was stated that stable free radicals are formed during thermal sterilization of verapamil. Slow spin-lattice relaxation processes and strong dipolar interactions exist in verapamil.EPR studies showed that sterilization at high temperature is not recommended for verapamil.
Źródło:: Engineering of Biomaterials; 2009, 12, no. 89-91; 163-165
1429-7248
Pojawia się w:: Engineering of Biomaterials
Dostawca treści:: Biblioteka Nauki

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