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Wyświetlanie 1-10 z 18
Tytuł:
Medicinal value of animal venom for treatment of Cancer in Humans - A Review
Autorzy:
Pal, Partha
Roy, Spandita
Chattopadhyay, Swagata
Pal, Tapan Kumar
Powiązania:
https://bibliotekanauki.pl/articles/1193921.pdf
Data publikacji:
2015
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Cancer
animal venom
anticancer drug
medicinal value
Opis:
Since cancer is one of the leading causes death worldwide and there is an urgent need to find better treatment. In recent years remarkable progress has been made towards the understanding of proposed hallmarks of cancer development and treatment. Anticancer drug developments from natural resources are ventured throughout the world. Venoms of several animal species including snake, scorpion, frog, spider etc. and their active components in the form of peptides, enzymes etc. have shown promising therapeutic potential against cancer. In the present review, the anticancer potential of venoms as well as their biochemical derivatives from some vertebrates like snake or frog or some venomous arthropods like scorpion, honey bee, wasps, beetles, caterpillars, ants, centipedes and spiders has been discussed. Some of these molecules are in the clinical trials and may find their way towards anticancer drug development in the near future. The recognition that cancer is fundamentally a genetic disease has opened enormous opportunities for preventing and treating the disease and most of the molecular biological based treatment are cost effective. The search for alternative economical and natural sources for cancer medicines is of utmost need for the future in combating this dreadful disease that is spreading at fast rate in the present era.
Źródło:
World Scientific News; 2015, 22; 91-107
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Psychospołeczne funkcjonowanie osób chorych na anoreksję
Psychosocial functioning of people with anorexia
Autorzy:
Mysior, Ryszard
Synowiec, Izabela
Powiązania:
https://bibliotekanauki.pl/articles/498513.pdf
Data publikacji:
2018-12-31
Wydawca:
Małopolska Wyższa Szkoła Ekonomiczna w Tarnowie
Tematy:
anoreksja
jadłowstręt
zaburzenia odżywiania
anorexia
venom
nutrition disorders
Opis:
Anoreksja określana jest jako schorzenie o podłożu psychicznym, którego istotą jest świadome, rygorystyczne ograniczanie ilości przyjmowanych pokarmów, silne koncentrowanie się na wyglądzie i masie ciała powiązane z panicznym lękiem przed przybraniem na wadze. Jest to wyjątkowo podstępna i zdradliwa choroba, której skutki anorektyczki odczuwają przez całe życie. Celem artykułu jest poznanie psychospołecznego funkcjonowania kobiet, które chorują lub chorowały na anoreksję. W pierwszej części artykułu przybliżono teoretyczne informacje z zakresu zaburzeń odżywiania. Wyjaśniono pojęcia związane z zaburzeniem odżywiania i przyczyny powstawania choroby oraz metody i techniki leczenia. W części drugiej artykułu przedstawiono informacje dotyczące metodologicznego aspektu przeprowadzonych badań. W ostatniej części zaprezentowano dane pozyskane w trakcie wywiadów przeprowadzonych wśród młodych kobiet, które chorowały lub chorują na anoreksję.
Anorexia is an exceptionally insidious and treacherous disease, the effects of which are felt by the cured anorectic patients throughout their lives. The aim of this article is to get to know the psychosocial functioning of women who suffer from or have suffered from anorexia. The first part of the article presents theoretical information on eating disorders. The notions related to eating disorders and the causes of the disease, as well as methods and techniques of treatment are explained. The second part of the article presents information on the methodological aspect of the conducted research. The last part of the article presents information obtained as a result of interviews conducted among young women who were ill or still suffer from anorexia.
Źródło:
Problemy Współczesnej Pedagogiki; 2018, 4, 1; 43-55
2450-8101
Pojawia się w:
Problemy Współczesnej Pedagogiki
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Isolation and partial purification of anticoagulant fractions from the venom of the Iranian snake Echis carinatus
Autorzy:
Babaie, Mahdi
Zolfagharian, Hossein
Salmanizadeh, Hossein
Mirakabadi, Abbas
Alizadeh, Hafezeh
Powiązania:
https://bibliotekanauki.pl/articles/1039597.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
anticoagulant factor
snake venom
Iranian Echis carinatus
chromatography
Opis:
Many snake venoms comprise different factors, which can either promote or inhibit the blood coagulation pathway. Coagulation disorders and hemorrhage belong to the most prominent features of bites of the many vipers. A number of these factors interact with components of the human blood coagulation. This study is focused on the effect of Echis carinatus snake venom on blood coagulation pathway. Anticoagulant factors were purified from the Iranian Echis carinatus venom by two steps: gel filtration (Sephadex G-75) and ion-exchange (DEAE-Sephadex) chromatography, in order to study the anticoagulant effect of crude venom and their fractions. The prothrombin time was estimated on human plasma for each fraction. Our results showed that protrombin time value was increase from 13.4 s to 170 s for F2C and to 280 s for F2D. Our study showed that these fractions of the venom delay the prothrombine time and thus can be considered as anticoagulant factors. They were shown to exhibit proteolytic activity. The molecular weights of these anticoagulants (F2C, F2D) were estimated by SDS/PAGE electrophoresis. F2C comprises two protein bands with molecular weights of 50 and 79 kDa and F2D a single band with a molecular weight of 42 kDa.
Źródło:
Acta Biochimica Polonica; 2013, 60, 1; 17-20
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Biochemical and electrophoretic analyses of saliva from the predatory reduviid species Rhynocoris marginatus (Fab.)
Autorzy:
Kitherian, Sahayaraj
Muthukumar, Subramanium
Rivers, David
Powiązania:
https://bibliotekanauki.pl/articles/1039616.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
enzymes
Biochemical characterization
venom proteins
saliva
reduviid predator
paralysis
Opis:
The saliva of Rhynocoris marginatus consists of amylase, invertase, trehalase, protease, acid phosphatase, alkaline phosphatase, phospholipase, lipase, trypsin, hyaluronidase, and esterase. All enzyme activities were significantly higher in the saliva of female R. marginatus when compared to the saliva of male individuals. The saliva was analyzed by tricine SDS/PAGE, sephadex column chromatography, FT-IR, and MALDI-TOF. The pH of the saliva was slightly alkali. The SDS/PAGE revealed a few proteins with molecular masses greater than 29.5 and 36.2 kDa for male and female predator saliva respectively. The FT-IR spectrum confirmed the acidic, proteinaceous, enzymatic, and aromatic nature of the saliva. The MALDI-TOF-MS revealed the presence of enzymes, proteins, peptides, and other biomolecules. The most prominent peptides were named as RmIT-1 (3.79kDa), RmIT-2 (9.7kDa), and RmIT-3 (10.94kDa) (Rhynocoris marginatus Insect Toxin). Further studies are underway to isolate and identify these biomolecules.
Źródło:
Acta Biochimica Polonica; 2013, 60, 1; 91-97
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Anti-Snake venom Activities of the leaf extracts of Asystasia gangetica (L) and Newbouldia leavis (p. Beauv)
Autorzy:
Enenebeaku, C. K.
Umerie, S. C.
Nwankwo, M. U.
Enenebeaku, U. E.
Powiązania:
https://bibliotekanauki.pl/articles/1112887.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Asystasia gangetica
Medicinal plants
Naja melanoleuca
Newbouldia leavis
Snake Venom
Opis:
The leaf extracts of two medicinal plants Asystasia gangetica (L) and Newboulia leavis (p. Beauv) were assessed for anti-snake venom activity in vivo using mice. The result of the phytochemical analysis revealed that the two plants contain flavonoids, glycosides, saponins, tannins and alkaloids. The methanolic extracts of the two plants A. gangetica (L) and N. leavis (p. Beauv) significantly (p< 0.05) neutralized the Naja melanoleuca venom-induced lethality activity in the mice. The extracts (flavonoids, tannins and saponins) of the two plants also showed significant (p<0.05) neutralization of the venom–induced lethality activity in mice. The work confirmed that Asystasia gangetica and Newbouldia leavis possess significant anti-venom activity and can therefore be used in the treatment of snake bites.
Źródło:
World News of Natural Sciences; 2018, 16; 33-41
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of hymenoptera venom immunotherapy on neutrophils, interleukin 8 (IL-8) and interleukin 17 (IL-17)
Autorzy:
Pałgan, Krzysztof
Żbikowska-Gotz, Magdalena
Zacniewski, Robert
Bartuzi, Zbigniew
Powiązania:
https://bibliotekanauki.pl/articles/2116499.pdf
Data publikacji:
2020-10-20
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
bee
IL-8
IL-17A
venom immunotherapy
wasp
neutrophils
Opis:
ObjectivesVenom immunotherapy (VIT) is an effective treatment method and is addressed to patients with a history of an anaphylactic reaction to Hymenoptera stings. However, the immunological mechanisms of protection have not been explained yet. The objective of this study was to analyze neutrophils, interleukin 8 (IL-8) and interleukin 17 (IL-17) before and after the initial phase of the immunotherapy.Material and MethodsOverall, 40 individuals, including 20 wasp venom sensitized and 20 bee venom sensitized patients, were included in the study. The patients had had a history of severe allergic reactions type III and IV according to Mueller’s classification. An ultra-rush VIT protocol was used in this study. The concentration of serum IL-8 and IL-17A was determined using the ELISA enzymatic method.ResultsThe authors demonstrated a significant rise in the IL-8 level after the immunotherapy, compared to baseline (14.9 vs. 24.7, p < 0.05). The rise in the neutrophils level was also noticeable but proved to be barely out of the range of statistical significance (4.3 vs. 5.0, p = 0.06). The shift in IL-17A was negligent and not statistically significant in the paired samples t-test (1.6 vs. 1.5, p = 0.34)ConclusionsVenom immunotherapy induces neutrophils and IL-8 activity after 2 days. After the desensitization, the level of IL-17A did not change.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2020, 33, 6; 811-817
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Is coagulopathy a common consequence of a Vipera berus bite? A retrospective single centre study
Autorzy:
Dylag-Trojanowska, K.E.
Hodorowicz-Zaniewska, D.
Zybaczyńska, J.
Szczepanik, A.M.
Powiązania:
https://bibliotekanauki.pl/articles/2081944.pdf
Data publikacji:
2018
Wydawca:
Instytut Medycyny Wsi
Tematy:
Polska
thrombocytopenia
coagulopathy
venom
antivenom
envenomation
Vipera berus bite
snake
snakebite
Opis:
Introduction. The Vipera berus (common viper) is the only species of venomous snake found in Poland. The aim of this study was to determine to what extent coagulopathy has occurred as a post-bite complication. Materials and method. The medical records of 138 adult patients in the Sucha Beskidzka hospital with the diagnosis of snake bite between 2001–2014 were retrospectively analyzed. Demographic, clinical and laboratory data were collected. Antivenom was given to all patients, except one, with snake bites, but laboratory test were taken prior to administration of antivenom. Obtained results were compared to those of the control group, composed of 176 adults hospitalized in the same period for an elective laparoscopic cholecystectomy. Results. The mean platelet count in the study group was 239.94×109/L (SD=56.56) and 248.77×109/L (SD=57.82) in the control group. In 98% of the study group and 100% of the control group the platelet value (PLT) fell within laboratory norms (130 to 420×109/L), 2 patients after snake bites had a PLT lower than normal, and thrombocytosis was not observed in either group. A reference range of 0.85–1.3 INR below normal was found in 2 patients in the study group and 15 from the control group, while values above the normal range were found in 8 patients (6.7%) from the snake bite group and no patients from the control group. In the study group, the INR ranged from 0.78–1.43 with a mean of 1.046 (SD=0.14), while in the control group the range was from 0.79–1.28, with a mean of 0.95 (SD=0.08). There was a significant difference in INR between the study and control groups (p<0.0001). Conclusions. The bite from V. berus does not result in severe thrombocytopenia, with only a moderate increase in INR values observed in about 7% of patients.
Źródło:
Annals of Agricultural and Environmental Medicine; 2018, 25, 4; 630-634
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of Bee Venom on Activity and Expression of 15-Lipoxygenase-1 in Human HT29 Colon Cancer
Autorzy:
soukhtanloo, Mohammad
Zare, Maryam
Khayatzadeh, Jina
Sadegh Nia, Hamidreza
Mojarad, Majid
Baghbani, Fatemeh
Sargolzaei, Javad
Sadeghian, Hamid
Sisakhti, Mohsen
Powiązania:
https://bibliotekanauki.pl/articles/895438.pdf
Data publikacji:
2019-02-28
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
apoptosis
HPLC
15-lipoxygenase-1
Bee Venom
HT-29
Colerectal Cancer
Opis:
Colorectal cancer has a high incidence rate with significant mortality and morbidity. The 15-lipoxygenase-1 (15-LOX-1) is a crucial enzyme as well as a tumor suppressor, especially in colon cancer. Bee venom, by the induction of apoptosis, is a promising new anti-cancer agent. Thus, the effects of bee venom on the expression of 15-LOX-1 m-RNA and its activities in the HT-29 cell line have been investigated in the current study. Human HT-29 colon cancer cells were treated with increasing concentrations of bee venom (1.87-30 µg/mL), and cisplatin (5 µg/mL) as the positive control for 24- and 48-hours. Then, cell viability and apoptosis were measured using the MMT assay and flow cytometry, respectively. Enzyme activity and expression was assayed using the kinetic method and real-time PCR, respectively. The results showed that the main content of bee venom was melittin with a retention time of 60 minutes. The IC50 values of bee venom at 24- and 48-hours were 6.01 µg/mL and 4.44 µg/mL, respectively. Expression of 15-LOX-1 in cancer cells treated with bee venom increased (p < 0.0005), as well as the activity of the enzyme in the presence of bee venom (p < 0.01). The current study revealed the apoptotic and cytotoxic effects of bee venom against the human colon cancer HT-29 cell line that was not seen in fibroblast cells. Findings suggest that bee venom may have therapeutic effects against the HT-29 colon cancer cell through the induction of the15-LOX-1 pathway. However, further studies are needed in this regard.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 1; 75-82
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Quality of life in parents of children and adolescents after systemic sting reactions
Autorzy:
Cichocka-Jarosz, E.
Brzyski, P.
Tarczoń, I.
Jedynak-Wąsowicz, U.
Tomasik, T.
Lis, G.
Powiązania:
https://bibliotekanauki.pl/articles/2083218.pdf
Data publikacji:
2019
Wydawca:
Instytut Medycyny Wsi
Tematy:
quality of life
parents
insect sting
Hymenoptera venom allergy
cross-sectional study
Opis:
Introduction and objectives. The study aimed at evaluating the impact of Hymenoptera venom allergy (HVA) in children and adolescents, on their parents’ QoL, taking into account their socio-demographic characteristics. Materials and method. The study sample consisted of 101 parents of children and adolescents aged 9–17 years, with a history of systemic reaction after insect sting who were referred for consultations in the tertiary level allergology department. The mean age of the parents was 39 years (SD=8.1; range 25–65 years); the majority were mothers (68%) and rural inhabitants (62%). QoL in parents of HVA children and adolescents was measured with the Parents of Children with Hymenoptera Venom Allergy Quality of Life Scale, a questionnaire covering 5 dimensions: anxiety, caution, limitations and discomfort, support provided to the child and feeling of safety, each measured on the scale ranging from 1 to 5. Independent predictors of QoL were estimated using the Generalized Linear Model. Results. Parents of urban children and adolescents treated with venom immunotherapy (VIT) up to 3 years (B=-1.37, 95CI= (-2.22;-0.53); p=0.001) and of rural children treated for more than 3 years (B=-0.94, 95CI=(-1.55;-0.33); p=0.003) reported lower anxiety than parents studied at diagnosis. In urban parents, individuals studied at VIT beginning reported a lower feeling of safety (B=-0.63, 95CI=(-1.11;-0.15); p=0.010); those studied up to 3 years of treatment reported a higher feeling of safety (B=0.64, 95CI=(0.11;1.16); p=0.018) than those studied at diagnosis. Contrariwise, in rural parents, those studied at the beginning of immunotherapy reported a higher feeling of safety than those studied at diagnosis (B=0.51, 95CI=(0.13;0.88); p=0.008). Conclusions. The longest VIT duration in children and adolescents with HVA is related to the decreased anxiety of their parents. Parent’s feeling of safety depends on the stage of treatment and place of residence.
Źródło:
Annals of Agricultural and Environmental Medicine; 2019, 26, 2; 315-321
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of previous scorpion bite on the action of local anaesthetic agents: A case report
Autorzy:
Hariharan, Uma
Tripathi, Sonali
Powiązania:
https://bibliotekanauki.pl/articles/1065187.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Bromage Scale
Country-side
Local Anaesthetic Action
Neurotoxic Venom
Scorpion Bite
Subarachnoid block
Opis:
Scorpion bites are a relatively common phenomenon in the Indian subcontinent, especially in the countryside. Past history of scorpion bite, as a relevant and significant factor, during pre-anesthetic evaluation is infrequently taken, when patient comes for unrelated medical/surgical conditions. We hereby report a case of failure of subarachnoid block in an adult male, posted for lower limb orthopedic surgery. A 45-year-old, ASA grade 1 male patient was posted for elective right tibial nailing. Single-shot subarachnoid block was planned for the procedure, which failed. Sub-arachnoid block was repeated and again, there were no signs of sensory or motor blockade. At this point, on specific enquiry, the patient gave history of scorpion bite twice; first, at the age of 32 years, and the second time, about 10 months back. Thereafter, it was decided to give standard balanced general anaesthesia for the procedure. The surgery lasted for 90 min and was uneventful. Postoperatively, neurological examination of the lower limbs revealed incomplete sensory block by pin prick method and grade I motor block on Bromage scale (just able to flex/move knees). Scorpion venom may be responsible for the development of resistance to the action of local anesthetic agents. This case report discusses the possible correlations between scorpion bite and the failure of sub-arachnoid block.
Źródło:
World Scientific News; 2019, 120, 2; 291-295
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 18

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