Temat: tyrosine kinases - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Design, synthesis and biological evaluation of some novel substituted quinazoline derivatives as antitumor agents.
Autorzy:: Ahmed, Marwa
Magdy, Naja
Powiązania:: https://bibliotekanauki.pl/articles/895417.pdf
Data publikacji:: 2018-06-30
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Tematy:: cytotoxicity
quinazoline
Tyrosine kinases
Opis:: New series of 6,8-dibromo-2-(4-chlorophenyl)quinazolin-4-yloxy derivatives were synthesized and their cytotoxic activity on MCF7, HEPG2 and HCT116 cell lines were evaluated. Compound XI and XIIIb were two times more active than doxorubicin on MCF7 cancer cell line. Compound VIIIa was 3 times more active than doxorubicin on HEPG2 cancer cell line. While compounds XII, XIIIa and XIIIb were more potent than doxorubicin on HCT116 cancer cell line. IC50 of all newly synthesized compounds were evaluated in vitro for thier inhibition to EGFR tyrosine kinase. All compound show good inhibitory activity on EGFR tyrosine kinase with IC50 range (6.19-19.87) µM.
Źródło:: Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 3
0001-6837
2353-5288
Pojawia się w:: Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:: Biblioteka Nauki

Artykuł

Skocz do pozycji: 2.

Tytuł:: Synthetic derivatives of genistein, their properties and possible applications
Autorzy:: Rusin, Aleksandra
Krawczyk, Zdzisław
Grynkiewicz, Grzegorz
Gogler, Agnieszka
Zawisza-Puchałka, Jadwiga
Szeja, Wiesław
Powiązania:: https://bibliotekanauki.pl/articles/1040415.pdf
Data publikacji:: 2010
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: synthetic genistein derivatives
inhibition of cell proliferation
tyrosine kinases
selective estrogen receptor modulators
anticancer activity
antimicrobial activity
Opis:: Genistein, the principal isoflavone constituent of soybean, attracts much attention as a natural molecule with significant affinity towards targets of potential medicinal interest, but also as a food supplement or prospective chemopreventive agent. Since its physicochemical properties are considered suboptimal for drug development, much effort has been invested in designing its analogs and conjugates in hope to obtain compounds with improved efficacy and selectivity. The aim of this article is to summarize current knowledge about the properties of synthetic genistein derivatives and to discuss possible clinical application of selected novel compounds. Some basic information concerning chemical reactivity of genistein, relevant to the synthesis of its derivatives, is also presented.
Źródło:: Acta Biochimica Polonica; 2010, 57, 1; 23-34
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

Skocz do pozycji: 3.

Tytuł:: The first line therapy for intermediate/ high risk patients with advanced renal cell carcinoma according to therapeutic program B.10
Autorzy:: Żołnierek, Jakub
Powiązania:: https://bibliotekanauki.pl/articles/22792533.pdf
Data publikacji:: 2023-08-19
Wydawca:: Medical Education
Tematy:: renal cell carcinoma
intermediate risk group
unfavourable risk group
tyrosine kinases inhibitor
immune check-point inhibitor
Opis:: The purpose of this article is to discuss the use of therapeutic options for the first-line systemic treatment of patients with advanced renal cell carcinoma under the B.10 drug program effective in Poland as of May 2022 - with a focus on intermediate and high-risk patient populations according to the IMDC. The specific situation created by reimbursement conditions with the exclusion of regimens combined with a tyrosine kinase inhibitor and immune checkpoint inhibitors along with the marginalisation of the use of an mTOr inhibitor necessitates a choice between two-drug immunotherapy or an antian giogenic drug in monotherapy. In this context, choosing the right treatment in the context of specific clinical situations is a challenge.
Źródło:: OncoReview; 2023, 13, 2; 48-57
2450-6125
Pojawia się w:: OncoReview
Dostawca treści:: Biblioteka Nauki

Artykuł

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