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Wyświetlanie 1-15 z 37
Tytuł:
A Fluorescence, 1H NMR spectroscopy and molecular dynamics study of the influence of rotamer population on fluorescence decay of tyrosine, phenylalanine and their derivatives
Autorzy:
Ganzynkowicz, R.
Liwo, A.
Wiczk, W.
Powiązania:
https://bibliotekanauki.pl/articles/1965825.pdf
Data publikacji:
2001
Wydawca:
Politechnika Gdańska
Tematy:
tyrosine
phenylalanine
rotamers
fluorescence
molecular dynamics
NMR spectroscopy
Opis:
Molecular dynamics simulations were carried out on tyrosine and phenylalanine and their derivatives with various terminal groups to determine the populations of side-chain rotamers. The obtained populations were compared with those calculated from fluorescence-decay lifetime distributions and NMR studies. It was found that theoretically calculated populations do not match the experimental ones, which suggests that the static rotamer model is inadequate to explain the dynamics of tyrosine and phenylalanine side chain in fluorescence and NMR experiments.
Źródło:
TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk; 2001, 5, 3; 311-316
1428-6394
Pojawia się w:
TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Activity of selected aromatic amino acids in biological systems
Autorzy:
Krzyściak, Wirginia
Powiązania:
https://bibliotekanauki.pl/articles/1039824.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
tyrosine
reactive oxygen species
kynurenic acid
Opis:
Besides the structural function in proteins, aromatic amino acids are precursors of many important biological compounds essential for normal functioning of the human organism. Many of these compounds may be used as markers for identification of specific pathological states. Comprehensive knowledge about the metabolism of aromatic amino acids and mechanisms of action of their metabolites made it possible to develop effective treatments for many disorders. However, it should not be forgotten that in some pathological conditions, these compounds could not only be involved in the pathogenesis of many disease entities but could also be used as an important tool in prediction of many diseases. This paper contains a review of published literature on aromatic amino acids in the context of physiological processes of the human body and chosen social disorders, such as cancers; psychiatric disorders: depression, anxiety states, schizophrenia, bipolar affective disorders; neurodegenerative, and cardiovascular diseases; chronic kidney insufficiency or diabetes.
Źródło:
Acta Biochimica Polonica; 2011, 58, 4; 461-466
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Aspergillus niger, a dominant phylloplane coloniser, influences the activity of defense enzymes in Solanum lycopersicum
Autorzy:
Goswami, S.
Paul, P.K.
Sharma, P.D.
Powiązania:
https://bibliotekanauki.pl/articles/2084798.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Aspergillus niger
phylloplane
peroxidase
phenylalanine ammonia lyase
polyphenol oxidase
Solanum lycopersicum
tyrosine ammonia lyase
Opis:
Phylloplane microbes have been studied as strategic tools in management against plant pathogens. Non-pathogenic bacteria and fungi have been applied as crop protectants against various plant diseases. The present study aimed at evaluating the potentiality of Aspergillus niger spores in altering the activity of four key enzymes related to defense in tomato. The experiment was designed such that two groups of 50 tomato plants were considered: group 1 – sprayed with autoclaved distilled water (control) and group 2 – sprayed with A. niger spores. Spraying was carried out under aseptic conditions. The experimental parameters included analysis of the activity of peroxidase (POX), polyphenol oxidase (PPO), phenylalanine ammonia lyase (PAL) and tyrosine ammonia lyase (TAL) as well as expression of POX and PPO isoforms. The results demonstrated an inductive effect of A. niger on the activity of POX, PPO, PAL and TAL. Enhanced expression of POX and PPO isoforms was also observed. The results indicated that A. niger can be considered probiotic for the management of tomato against its phytopathogens.
Źródło:
Journal of Plant Protection Research; 2019, 59, 4; 512-518
1427-4345
Pojawia się w:
Journal of Plant Protection Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Beyond sequence similarity – the curious case of GW/WG protein domain
Autorzy:
Karlowski, W.M.
Powiązania:
https://bibliotekanauki.pl/articles/79861.pdf
Data publikacji:
2011
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
RNA silencing
gene expression
protein domain
amino acid sequence
Arabidopsis thaliana
Vitis vinifera
cysteine
phenylalanine
histidine
methionine
tyrosine
sequence similarity
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2011, 92, 4
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Carbon isotope effects in the studies of the mechanism of action of tyrosine phenol-lyase
Autorzy:
Augustyniak, W.
Kański, R.
Kańska, M.
Powiązania:
https://bibliotekanauki.pl/articles/148527.pdf
Data publikacji:
2006
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
12C/14C kinetic isotope effects
tyrosine phenol-lyase
Opis:
12C/14C kinetic isotope effects on the hydrolytic cleavage of tyrosine to phenol and ammonium pyruvate catalyzed by Citrobacter freundii tyrosine phenol-lyase have been determined in positions 2, 3 and ring-1' of L-tyrosine. The competitive method with dual-label approach was applied with 3',5'-ring 3H as remote label. The results revealed the change of the effect on carbon atom in position 2 during the reaction course from the high normal values to low inverse values. On the other hand, the effect values on 3 and ring-1' position remained constant during the reaction course. The discussion of these results regarding the reaction mechanism is presented.
Źródło:
Nukleonika; 2006, 51,suppl.2; 7-11
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Characterization of dual specificity protein kinase from maize seedlings.
Autorzy:
Trojanek, Joanna
Klimecka, Maria
Fraser, Anna
Dobrowolska, Grażyna
Muszyńska, Grażyna
Powiązania:
https://bibliotekanauki.pl/articles/1041540.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
dual specificity kinase
tyrosine phosphorylation
maize
Opis:
A protein kinase of 57 kDa, able to phosphorylate tyrosine in synthetic substrates pol(Glu4,Tyr1) and a fragment of Src tyrosine kinase, was isolated and partly purified from maize seedlings (Zea mays). The protein kinase was able to phosphorylate exogenous proteins: enolase, caseins, histones and myelin basic protein. Amino acid analysis of phosphorylated casein and enolase, as well as of phosphorylated endogenous proteins, showed that both Tyr and Ser residues were phosphorylated. Phosphotyrosine was also immunodetected in the 57 kDa protein fraction. In the protein fraction there are present 57 kDa protein kinase and enolase. This co-purification suggests that enolase can be an endogenous substrate of the kinase. The two proteins could be resolved by two-dimensional electrophoresis. Specific inhibitors of typical protein-tyrosine kinases had essentially no effect on the activity of the maize enzyme. Staurosporine, a nonspecific inhibitor of protein kinases, effectively inhibited the 57 kDa protein kinase. Also, poly L-lysine and heparin inhibited tyrosine phosphorylation by 57 kDa maize protein kinase. The substrate and inhibitor specificities of the 57 kDa maize protein kinase phosphorylating tyrosine indicate that it is a novel plant dual-specificity protein kinase.
Źródło:
Acta Biochimica Polonica; 2004, 51, 3; 635-647
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Chlorination of N-acetyltyrosine with HOCl, chloramines, and myeloperoxidase-hydrogen peroxide-chloride system
Autorzy:
Drabik, Grażyna
Naskalski, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1044197.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
chlorination
hypochlorite
N-acetyltyrosine
tyrosine chloroderivatives
Opis:
N-acetyl-L-tyrosine (N-acTyr), with the alpha amine residue blocked by acetylation, can mimic the reactivity of exposed tyrosyl residues incorporated into polypeptides. In this study chlorination of N-acTyr residue at positions 3 and 5 in reactions with NaOCl, chloramines and the myeloperoxidase (MPO)-H2O2-Cl- chlorinating system were invesigated. The reaction of N-acTyr with HOCl/OCl- depends on the reactant concentration ratio employed. At the OCl-/N-acTyr (molar) ratio 1:4 and pH 5.0 the chlorination reaction yield is about 96% and 3-chlorotyrosine is the predominant reaction product. At the OCl-/ N-acTyr molar ratio 1:1.1 both 3-chlorotyrosine and 3,5-dichlorotyrosine are formed. The yield of tyrosine chlorination depends also on pH, amounting to 100% at pH 5.5, 91% at pH 4.5 and 66% at pH 3.0. Replacing HOCl/OCl- by leucine/chloramine or alanine/chloramine in the reaction system, at pH 4.5 and 7.4, produces trace amount of 3-chlorotyrosine with the reaction yield of about 2% only. Employing the MPO-H2O2-Cl- chlorinating system at pH 5.4, production of a small amount of N-acTyr 3-chloroderivative was observed, but the reaction yield was low due to the rapid inactivation of MPO in the reaction system. The study results indicate that direct chlorination of tyrosyl residues which are not incorporated into the polypeptide structure occurs with excess HOCl/OCl- in acidic media. Due to the inability of the myeloperoxidase-H2O2-Cl- system to produce high enough HOCl concentrations, the MPO-mediated tyrosyl residue chlorination is not effective. Semistable amino-acid chloramines also appeared not effective as chlorine donors in direct tyrosyl chlorination.
Źródło:
Acta Biochimica Polonica; 2001, 48, 1; 271-275
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Czynniki wirulencji bakterii - białkowe fosfatazy tyrozynowe : jako cel terapeutyczny w odpowiedzi na rozwijającą się antybiotykooporność
Protein tyrosine phosphatases - factors of bacterial virulence : as a therapeutic target in response to increasing antibiotic resistance
Autorzy:
Kostrzewa, Tomasz
Styszko, Joanna
Przychodzeń, Paulina
Kamm, Anna
Górska-Ponikowska, Magdalena
Kuban-Jankowska, Alicja
Powiązania:
https://bibliotekanauki.pl/articles/171488.pdf
Data publikacji:
2019
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
antybiotykooporność
czynniki wirulencji bakterii
białkowe fosfatazy tyrozynowe
inhibitory PTPs
antibiotic resistance
virulence factors
protein tyrosine phosphatases
PTPs inhibitors
Opis:
Microbial virulence is the ability of pathogen to penetrate, replicate, multiplícate and, as a consequence, damage the cells of the infected organism. In recent years, rapid progress in bacterial genome sequencing has led to the discovery and characterization of many new virulence factors. One of the many mechanisms of bacterial virulence is the activity of bacterial kinases and phosphatases. These enzymes phosphorylate and dephosphorylate various amino acid residues in proteins, most commonly serine, tyrosine and threonine. Reversible phosphorylation and dephosphorylation can control the activity of target proteins, either directly, by inducing conformational changes in proteins, or indirectly, by regulating protein-protein interactions. Due to the increasing antibiotic resistance, new substances that could be used to treat diseases caused by resistant bacterial strains are sought. One of the possibilities seems to be the inhibition of bacterial tyrosine phosphatases. Phosphorylation of proteins containing tyrosine residues is a key post-translational modification that controls the numerous cellular functions in bacteria. So far, many tyrosine phosphatases have been found to be responsible for the virulence of various bacterial strains. Many bacterial species use protein tyrosine phosphatases activity in host-pathogen interaction, by affecting signalling pathways and subsequent induction of the infection process. Many studies are devoted to the search for tyrosine phosphatases inhibitors in the context of possible support of the current antibacterial treatment. This article presents a review of reports on bacterial virulence factors-protein tyrosine phosphatases as potential therapeutic targets.
Źródło:
Wiadomości Chemiczne; 2019, 73, 11-12; 679-699
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Deep molecular response (MR4.5) as a target of therapy with tyrosine kinase inhibitors. MR4.5 – goal of CML treatment
Autorzy:
Sacha, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/1065835.pdf
Data publikacji:
2014
Wydawca:
Medical Education
Tematy:
chronic myeloid leukemia
possibility cure
therapy targets
tyrosine kinase inhibitors
Opis:
Chronic myeloid leukemia (CML) accounts for 15% of diagnosed leukemias. The annual incidence in two Polish regions has been calculated for 0.7/100,000 of general population. Introduction of tyrosine kinase inhibitors (TKIs) have substantially improved not only the prognosis of CML, but also changed the treatment goals, and the expectations of patients and physicians. The goals of CML therapy include: to prevent the progression towards accelerated phase and blastic phase, to eliminate the risk of death from leukemia, to prolong the length of survival to comparable of healthy population and to attain a quality of life comparable to healthy people. Patients treated up-front with second generation TKIs (2GTKI) have a better chance to achieve faster and deeper response to therapy. Most of patients receiving 2GTKI in first line or e.g. nilotinib after initial phase of imatinib therapy can achieve very deep molecular response (MR4.5), which is a key criterion for discontinuation studies. The results of stop-trials suggest that substantial proportion of patient could achieve sustained treatment-free survival, and that the disease could be controlled despite of persistence of minimal residual disease, which does not require a clinical intervention. Patients group that could benefit most from discontinuation study include younger people, those who have achieved MR4.5 and patients reporting TKI – associated side effects. Achievement of MR4.5 could be considered as a target of CML therapy for considerable proportion of patients. The question of safe TKI dose reduction or therapy cessation should be addressed in the future planned clinical trials.
Źródło:
OncoReview; 2014, 4, 1; A27-32
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Design, synthesis and biological evaluation of some novel substituted quinazoline derivatives as antitumor agents.
Autorzy:
Ahmed, Marwa
Magdy, Naja
Powiązania:
https://bibliotekanauki.pl/articles/895417.pdf
Data publikacji:
2018-06-30
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
cytotoxicity
quinazoline
Tyrosine kinases
Opis:
New series of 6,8-dibromo-2-(4-chlorophenyl)quinazolin-4-yloxy derivatives were synthesized and their cytotoxic activity on MCF7, HEPG2 and HCT116 cell lines were evaluated. Compound XI and XIIIb were two times more active than doxorubicin on MCF7 cancer cell line. Compound VIIIa was 3 times more active than doxorubicin on HEPG2 cancer cell line. While compounds XII, XIIIa and XIIIb were more potent than doxorubicin on HCT116 cancer cell line. IC50 of all newly synthesized compounds were evaluated in vitro for thier inhibition to EGFR tyrosine kinase. All compound show good inhibitory activity on EGFR tyrosine kinase with IC50 range (6.19-19.87) µM.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 3
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dual regulation of cytosolic ascorbate peroxide (APX) by tyrosine nitration and S-nitrosylation
Autorzy:
Begara-Morales, J.
Sanchez-Calvo, B.
Chaki, M.
Valderrama, R.
Mata-Perez, C.
Lopez-Jaramillo, J.
Carreras, A.
Padilla, M.
Corpas, F.
Barroso, J.
Powiązania:
https://bibliotekanauki.pl/articles/80378.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
post-translational modification
nitric oxide
target protein
ascorbate peroxidase
tyrosine nitration
S-nitrosylation
salinity stress
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of Drechslera graminea on total soluble proteins and defense enzymes of barley
Autorzy:
Goel, N.
Jaiswal, G.
Srivastava, A.K.
Paul, P.K.
Goel, A.
Powiązania:
https://bibliotekanauki.pl/articles/66670.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
barley
Hordeum vulgare
defense enzyme
Drechslera graminea
peroxidase
phenylalanine lyase
polyphenol oxidase
protein
soluble protein
tyrosine ammonia lyase
Opis:
Barley phylloplane is seriously colonized by Drechslera graminea, the causal agent of leaf stripe disease in the hos. The present study involved the elucidation of alterations induced in the protein content of the host due to Drechslera infection. Naturally growing barley plants were obtained from fields and Drechslera graminea was isolated and identified from diseased plants’ leaves. After identification and preparation of the pure culture, the pathogen was inoculated on plants grown under aseptic and controlled laboratory conditions. Changes in the total soluble cytoplasmic proteins and defense enzymes of the host such as polyphenol oxidase (PPO), peroxidase (POX), phenylalanine lyase (PAL) and tyrosine ammonia lyase (TAL) were observed up to 5 h after inoculation. The results demonstrated a significant effect of the pathogen on the cytoplasmic protein expression of the host as well as in its defense system.
Źródło:
Journal of Plant Protection Research; 2018, 58, 3
1427-4345
Pojawia się w:
Journal of Plant Protection Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Efficacy of crizotinib therapy for a patient with non-small cell lung cancer with ALK gene rearrangement – case report and review of current therapeutic options
Autorzy:
Bargiel, J.B.
Cabaj, J.
Chmielewska, I.
Milanowski, J.
Powiązania:
https://bibliotekanauki.pl/articles/2098542.pdf
Data publikacji:
2021
Wydawca:
Instytut Medycyny Wsi
Tematy:
non-small cell lung cancer
crizotinib
therapy
gene rearrangement
tyrosine kinase inhibitor
patient
Opis:
Introduction. Currently, nearly 23,000 cases of lung cancer are diagnosed in Poland annually, of which 5% are cases with rearrangements in the ALK gene. In recent years, tremendous progress has been made in understanding the genetic makeup of this type of cancer, which has enabled the use of new therapies, in particular, molecularly targeted drugs. Crizotinib is the first oral small molecule inhibitor of ALK, MET and ROS1 receptor tyrosine Kinases approved by the European Medicines Agency(EMA). Case report. The paper presents the case of a 62-year-old patient diagnosed with non-small cell lung cancer with rearrangement in the ALK gene in stage IV of the disease. The patient was qualified for treatment with crizotinib under the B6 drug programme. Treatment started in May 2019. During treatment, assessment was made at 3 control points, where the first and second showed a partial response according to the RECIST 1.1 scale; in the next assessment, the response was maintained in the form of disease stabilization.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2021, 15, 3; 151-154
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Enzymatic reductive amination of p-hydroxy- and phenylpyruvic acids as a method of synthesis of L-tyrosine and L-phenylalanine labelled with deuterium and tritium
Autorzy:
Pałka, K.
Kańska, M.
Powiązania:
https://bibliotekanauki.pl/articles/146609.pdf
Data publikacji:
2012
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
deuterium
enzyme
L-phenylalanine
tritium
L-tyrosine
Opis:
We report the synthesis of isotopomers of L-phenylalanine and L-tyrosine selectively labelled with hydrogen isotopes in the 2-position of the side chain. The deuterium or tritium label was introduced using reductive amination activity of enzyme L-phenylalanine dehydrogenase (EC 1.4.1.20). This way p-phenylpyruvic acid was converted into [2-2H]-, [2-3H]-, and doubly labelled [2-2H/3H]-isotopomers of L-phenylalanine, using deuteriated, tritiated, and mixed (DTO) incubation media, respectively. Similarly, p-hydroxyphenylpyruvic acid was converted into [2-2H]-, [2-3H]-, and [2-2H/3H]-L-tyrosine. Deuterium labelled isotopomers of L-phenylalanine and --tyrosine can be used as markers in the investigation of abnormal metabolism of these amino acids observed in patients with inborn genetic diseases such as phenylketonuria and tyrosinemia.
Źródło:
Nukleonika; 2012, 57, 3; 383-387
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fengycin or plipastatin? A confusing question in Bacilli
Autorzy:
Hussein, W.
Powiązania:
https://bibliotekanauki.pl/articles/79895.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
fengycin
plipastatin
L-tyrosine
Bacillus subtilis
Bacillus amyloliquefaciens
Bacillus atrophaeus
epimerization
nonribosomal peptide system
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2019, 100, 1
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 37

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