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Wyszukujesz frazę "tumor therapy" wg kryterium: Temat

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    Wyświetlanie 1-12 z 12
    Tytuł:
    An overview of the preclinical and clinical studies of the effects of tumor treating fields on malignant glioma cells
    Autorzy:
    Bądziul, Dorota
    Banaś-Ząbczyk, Agnieszka
    Tabarkiewicz, Jacek
    Powiązania:
    https://bibliotekanauki.pl/articles/454690.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    anaplastic astrocytoma
    glioblastoma multiforme
    brain tumor
    tumor treating fields
    tumor therapy
    Opis:
    Anaplastic astrocytoma (AA, WHO grade III) and glioblastoma multiforme (GBM, WHO grade IV) are malignant tumors of the brain. The average survival time of patients with GMB is approximately one year and two years in the case of anaplastic astrocytoma with standard therapy based on surgical tumor resection followed by chemotherapy or radiotherapy. High invasiveness of gliomas, the ability of rapid division and so-called diffusive infiltration of tumor cells into normal brain tissue, which prevents complete surgical removal, are hallmarks of theses tumors. Therefore, new specific therapies for eliminating cancer cells are needed to treat this tumors. Recently, it has been demonstrated that alternating electric field, also known as tumor treating fields (TTFields) has a unique mechanism of destroying glioma cells. TTFields applies electromagnetic energy frequency-dependent and intensitydependent and disrupts cancer cell replication as they undergo mitosis. Futhermore, TTFields turn out to act comparably to conventional chemotherapeutics, lacking numerous side adverse associated with chemotherapy. The authors provide an up-todate review of the mechanism of action as well as preclinical and clinical data on TTFields.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 2; 141-144
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Combined delivery of an antiangiogenic protein (angiostatin) and an immunomodulatory gene (interleukin-12) in the treatment of murine cancer.
    Autorzy:
    Wilczyńska, Urszula
    Kucharska, Anna
    Szary, Jarosław
    Szala, Stanisław
    Powiązania:
    https://bibliotekanauki.pl/articles/1044050.pdf
    Data publikacji:
    2001
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    angiogenesis
    IL-12 gene
    tumor gene therapy
    angiostatin
    Opis:
    We investigated the feasibility of a novel therapeutic approach to treat neoplastic diseases in mice. This novel strategy consists in delivering a protein (angiostatin) with strong antiangiogenic properties, followed by administration of the interleukin 12 gene that is strongly immunomodulatory and has also some antiangiogenic effects. When angiostatin-mediated antiangiogenic therapy was used in combination with intratumor delivery of the IL-12 gene (a strategy much safer than IL-12 protein administration), this produced a synergistic therapeutic effect.
    Źródło:
    Acta Biochimica Polonica; 2001, 48, 4; 1077-1084
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Direct transfer of IL-12 gene into growing Renca tumors.
    Autorzy:
    Budryk, Magdalena
    Wilczyńska, Urszula
    Szary, Jarosław
    Szala, Stanisław
    Powiązania:
    https://bibliotekanauki.pl/articles/1044365.pdf
    Data publikacji:
    2000
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    IL-12 gene
    tumor gene therapy
    naked DNA
    Opis:
    We investigated the feasibility of transferring naked plasmid DNA containing a therapeutic gene (IL-12) into mice harboring growing Renca tumors. We found that naked DNA transferred into growing Renca and B16(F10) tumors gives higher expression level of reporter gene than complexes of DNA with DDAB/ DOPE or DC-Chol/DOPE. Transfer of naked DNA carrying the IL-12 gene into growing Renca tumors causes a distinct therapeutic effect that depends on the time span between inoculation of mice with cancer cells and the beginning of the therapy. Therapy started on day 3 resulted in total cure (100%) of mice.
    Źródło:
    Acta Biochimica Polonica; 2000, 47, 2; 385-391
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A recently developed approach in tumor therapy using Salmonella
    Autorzy:
    Gharbavi, M.
    Karimkhanlooei, G.
    Amani, J.
    Kashiazari, P.
    Sharafi, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/2097086.pdf
    Data publikacji:
    2020
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    cancer therapy
    combination therapy
    Salmonella
    tumor targeting
    Opis:
    There are three main approaches in cancer treatment: surgery, chemotherapy, and radiotherapy. Recently, the use of bioengineered bacteria as therapeutic agents has been shown to have some valuable properties in the treatment of cancer, which do not exist in conventional approaches. Bacteria in particular can target tumors, and they can preferentially proliferate and accumulate within tumors and inhibit the growth of cancer cells by inducing cytotoxicity. Thus, bacteria can be easily detected in tumor sites. Moreover, bacteria-derived factors exert an immunostimulatory effect. Over the past decade, Salmonella, Clostridium, and other bacterial genera have been shown to inhibit tumor growth and promote the survival rate in animal models. Clinical trials for cancer treatment with bacteria have shown improved results by combination with other therapeutic methods such as chemotherapy or radioactive agents. This review is an effort to introduce the use of healthy bacteria in tumor therapy. We specifically focus on Salmonella, which has been extensively used in tumor therapy. Therefore, in this review study, we discuss the merits, mechanisms, and attenuated strains of a combination therapy compared to other therapeutic approaches in Salmonella-mediated cancer therapy.
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2020, 101, 3; 253-267
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Direct tumor damage mechanisms of photodynamic therapy.
    Autorzy:
    Nowis, Dominika
    Makowski, Marcin
    Stokłosa, Tomasz
    Legat, Magdalena
    Issat, Tadeusz
    Gołąb, Jakub
    Powiązania:
    https://bibliotekanauki.pl/articles/1041411.pdf
    Data publikacji:
    2005
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    photosensitizer
    tumor
    photodynamic therapy
    apoptosis
    Opis:
    Photodynamic therapy (PDT) is a clinically approved and rapidly developing cancer treatment regimen. It is a minimally invasive two-stage procedure that requires administration of a photosensitizing agent followed by illumination of the tumor with visible light usually generated by laser sources. A third component of PDT is molecular oxygen which is required for the most effective antitumor effects. In the presence of the latter, light of an appropriate wavelength excites the photosensitizer thereby producing cytotoxic intermediates that damage cellular structures. PDT has been approved in many countries for the treatment of lung, esophageal, bladder, skin and head and neck cancers. The antitumor effects of this treatment result from the combination of direct tumor cell photodamage, destruction of tumor vasculature and activation of an immune response. The mechanisms of the direct photodamage of tumor cells, the signaling pathways that lead to apoptosis or survival of sublethaly damaged cells, and potential novel strategies of improving the antitumor efficacy of PDT are discussed.
    Źródło:
    Acta Biochimica Polonica; 2005, 52, 2; 339-352
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    PRRT as an alternative method of treatment in patient with glucagonoma syndrome: A case report
    Autorzy:
    Popławska-Kita, A.
    Szyszkowska, A.
    Brelska, P.
    Kowalczuk, M.
    Szostek, A.
    Popławski, Ł.
    Siewko, K.
    Szelachowska, M.
    Kamiński, G.
    Werel, D.
    Górska, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1917699.pdf
    Data publikacji:
    2016
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Glucagonoma
    tumor
    peptide receptor radionuclide therapy
    Opis:
    Introduction: Glucagonoma is a rare pancreatic neuroendocrine tumor derived from alpha-cells of the islet of Langerhans. Due to oversecretion of glucagon it is associated with a characteristic paraneoplastic phenomenon, called glucagonoma syndrome, which consists of necrolytic migratory erythema (NME), weight loss, diabetes mellitus, diarrhea, normochromic normocytic anemia, deep vein thrombosis or pulmonary embolism and neuropsychiatric disturbances. Treatment modalities include surgical removal of tumor, somatostatin analogs and peptide receptor radionuclide therapy (PRRT). Case report: We present a case of 61-year-old woman diagnosed with glucagonoma in April 2012. Initially, body-caudal pancreatomy and resection of regional lymph nodes were performed. Five months after surgery, a PET-CT scan detected pathological mass with expression of somatostatin receptors in pancreatic body and metastases to regional lymph nodes. What is more, since April 2014 the patient had complained about persistent pruritus of the entire body. At present, due to the nonsurgical pancreatic mass and metastases she is treated with somatostatin analogs and PRRT. During this therapy the pruritus had decreased and currently there is no sign of cutaneous disease. Moreover, reduction of tumor size was obtained. Conclusions: PRRT may reduce tumor size and by reducing bothersome symptoms substantially improve the quality of life in patients with SSTR-positive tumors
    Źródło:
    Progress in Health Sciences; 2016, 6(1); 209-214
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The role of cell adhesion molecule in cancer progression and its application in cancer therapy.
    Autorzy:
    Okegawa, Takatsugu
    Pong, Rey-Chen
    Li, Yingming
    Hsieh, Jer-Tsong
    Powiązania:
    https://bibliotekanauki.pl/articles/1043281.pdf
    Data publikacji:
    2004
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    cancer gene therapy
    gene
    cell adhesion molecules
    tumor progression
    tumor suppressor
    Opis:
    Multiple and diverse cell adhesion molecules take part in intercellular and cell-extracellular matrix interactions of cancer. Cancer progression is a multi-step process in which some adhesion molecules play a pivotal role in the development of recurrent, invasive, and distant metastasis. A growing body of evidence indicates that alterations in the adhesion properties of neoplastic cells play a pivotal role in the development and progression of cancer. Loss of intercellular adhesion and the desquamation of cells from the underlying lamina propria allows malignant cells to escape from their site of origin, degrade the extracellular matrix, acquire a more motile and invasion phenotype, and finally, invade and metastasize. In addition to participating in tumor invasiveness and metastasis, adhesion molecules regulate or significantly contribute to a variety of functions including signal transduction, cell growth, differentiation, site-specific gene expression, morphogenesis, immunologic function, cell motility, wound healing, and inflammation. Cell adhesion molecule (CAM), a diverse system of transmembrane glycoproteins has been identified that mediates the cell-cell and cell-extracellular matrix adhesion and also serves as the receptor for different kinds of virus. We summarize recent progress regarding the role of CAM, particularly, immunoglobulin-CAMs and cadherins in the progression of cancer and discuss the potential application of CAMs in the development of cancer therapy mainly on urogenital cancer.
    Źródło:
    Acta Biochimica Polonica; 2004, 51, 2; 445-457
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    New integrative PDT method of cancer treatment by means of laser, magnetic therapy and herbal ferromagnetics
    Autorzy:
    Arakelyan, Hayk S.
    Powiązania:
    https://bibliotekanauki.pl/articles/773493.pdf
    Data publikacji:
    2014
    Wydawca:
    Medical Education
    Tematy:
    cancer
    integrative photodynamic therapy
    tumor’s cell
    Opis:
    Integrative photodynamic therapy (IPDT) of tumors consists of combined use of different curable factors that extremely increase the effectiveness of IPDT. The leading curable effect of PDT is determined by developing of aggressive photochemical reactions in the tumor. The main destructive factor of these reactions is the generation of free radicals that kill tumor’s cells. For PDT efficacy increasing it is necessary to solve the following problems and assure: easiness of production or synthesis; accumulation high selectivity regarding tumor tissue; low toxicity in light and darkness; singled oxygen generation high quant output; promptly elimination from the organism after the treatment procedure; good absorption in spectral intervals most transparent for tissues (red and infrared intervals); optimal interconversion between quant output and fluorescence quant output. PDT effectiveness may be significantly increased by means of: increasing of photosentisizer selectivity and accumulation in tumor tissue; increasing of tumor tissue photochemical destruction caused by photosensitizer. Realization of integrative PDT using Cyber Laser may increase tumor therapy effectiveness to 94–96% and at the same time will establish a new direction in PDT.
    Źródło:
    OncoReview; 2014, 4, 4; A171-A174
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Bleeding liver tumor in a patient on anticoagulation therapy – case report
    Autorzy:
    Migdalski, Łukasz
    Kuzdak, Krzysztof
    Powiązania:
    https://bibliotekanauki.pl/articles/1394244.pdf
    Data publikacji:
    2015
    Wydawca:
    Index Copernicus International
    Tematy:
    liver tumor
    intraabdominal bleeding
    hepatocellular carcinoma (HCC)
    acenocumarolum
    anticoagulant therapy
    Opis:
    Intraabdominal bleeding is a serious surgical problem, particularly in elderly patients following an anticoagulant therapy. It occurs, that abdominal haemorrhage is the first symptom of hepatocellular carcinoma, mostly in Asians and Africans, occasionally in Europeans. The article's author shows a case of an elderly man, treated by Acenocumarolum, in a haemorrhagic shock. During an operation a bleeding liver tumor was revealed. The surgical team performed an effectual tumor resection and stoped the bleeding.
    Źródło:
    Polish Journal of Surgery; 2015, 87, 12; 641-643
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Vasostatin increases oxygenation of B16-F10 melanoma tumors and raises therapeutic efficacy of cyclophosphamide
    Autorzy:
    Cichoń, Tomasz
    Jarosz, Magdalena
    Smolarczyk, Ryszard
    Ogórek, Barbara
    Matuszczak, Sybilla
    Wagner, Marek
    Mitrus, Iwona
    Sochanik, Aleksander
    Jazowiecka-Rakus, Joanna
    Szala, Stanisław
    Powiązania:
    https://bibliotekanauki.pl/articles/1039715.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    oxygenation
    vasostatin
    normalization of tumor blood vessels
    cyclophosphamide
    anticancer therapy
    Opis:
    One of the preconditions of effective anticancer therapy is efficient transfer of the therapeutic agent (chemotherapeutic) to tumor cells. Fundamental barriers making drug delivery and action difficult include underoxygenation, elevated interstitial pressure, poor and abnormal tumor blood vascular network and acidic tumor milieu. In this study we aimed at developing an optimized scheme of administering a combination of an angiogenesis-inhibiting drug (vasostatin) and a chemotherapeutic (cyclophosphamide) in the therapeutic treatment of mice bearing experimental B16-F10 melanoma tumors. We report that the strongest tumor growth inhibition was observed in mice that received two, three or four vasostatin doses in combination with one injection of cyclophosphamide (i.e., V2 + CTX, V3 + CTX or V4 + CTX schemes). Double administration of vasostatin increases oxygenation of B16-F10 tumors. On the other hand, its five-fold administration lowers tumor oxygenation, breaks down tumor vascular network (increasing hypoxia) and leads in consequence to death of cancer cells and appearance of necrotic areas in the tumor. A decreased cyclophosphamide dose in combination with two doses of vasostatin (V2 + CTX scheme) inhibits tumor growth similarly to a larger dose of cyclophosphamide alone.
    Źródło:
    Acta Biochimica Polonica; 2012, 59, 3; 377-381
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Salmonella and cancer: from pathogens to therapeutics
    Autorzy:
    Chorobik, Paulina
    Czaplicki, Dominik
    Ossysek, Karolina
    Bereta, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1039520.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    bacterial cancer therapy
    immunotherapy
    cancer vaccine
    tumor targeting
    Salmonella
    VNP20009
    Opis:
    Bacterial cancer therapy is a concept more than 100 years old - yet, all things considered, it is still in early development. While the use of many passive therapeutics is hindered by the complexity of tumor biology, bacteria offer unique features that can overcome these limitations. Microbial metabolism, motility and sensitivity can lead to site-specific treatment, highly focused on the tumor and safe to other tissues. Activation of tumor-specific immunity is another important mechanism of such therapies. Several bacterial strains have been evaluated as cancer therapeutics so far, Salmonella Typhimurium being one of the most promising. S. Typhimurium and its derivatives have been used both as direct tumoricidal agents and as cancer vaccine vectors. VNP20009, an attenuated mutant of S. Typhimurium, shows significant native toxicity against murine tumors and was studied in a first-in-man phase I clinical trial for toxicity and anticancer activity. While proved to be safe in cancer patients, insufficient tumor colonization of VNP20009 was identified as a major limitation for further clinical development. Antibody-fragment-based targeting of cancer cells is one of the few approaches proposed to overcome this drawback.
    Źródło:
    Acta Biochimica Polonica; 2013, 60, 3; 285-297
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Surface-modified SPION systems for cancer therapy
    Autorzy:
    Karewicz, Anna
    Karnas, Karolina
    Dulińska-Litewka, Joanna
    Kapusta, Czesław
    Lekka, Małgorzata
    Powiązania:
    https://bibliotekanauki.pl/articles/1844916.pdf
    Data publikacji:
    2020
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    SPION systems
    cancer therapy
    tumor cells
    system SPION
    terapia
    komórki rakowe
    Źródło:
    Engineering of Biomaterials; 2020, 23, 158 spec. iss.; 13
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-12 z 12

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