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    Wyświetlanie 1-2 z 2
    Tytuł:
    ALLIUM URSINUM L. LEAVES COMPONENTS MODIFIED THE PHYSICO-CHEMICAL PROPERTIES OF RED BLOOD CELLS PROTECTING THEM FROM THE EFFECTS OF OXIDATIVE STRESS
    Autorzy:
    Cyboran-Mikołajczyk, Sylwia M.
    Kleszczyńska, Halina
    Oszmiański, Jan
    Pasławski, Robert
    Powiązania:
    https://bibliotekanauki.pl/articles/895386.pdf
    Data publikacji:
    2019-06-28
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    erythrocytes
    fluidity
    transmembrane potential
    bear garlic extract
    AAPH oxidation
    biological membrane
    Opis:
    The aim of the study is to determine the antioxidant activity and influence of Allium ursinum L. leaf extract on physicochemical and electrical properties of erythrocytes in order to help clarify its capacity to alleviate oxidative stress. The phenolic compounds were isolated from the leaves of bear garlic. The composition of the extract is well documented and was earlier analyzed quantitatively and qualitatively by UPLC methods. The impact of the extract constituents on the erythrocyte membrane properties was determined on the basis of its osmotic fragility, fluidity, organization of the hydrophilic area and transmembrane potential with spectrophotometric and fluorimetric methods. Furthermore, the effect of the extract on the level of membrane lipid oxidation and also on the extent of hemolysis of erythrocytes subjected to oxidation induced by AAPH compound was determined. The study showed that the extract at 40 µg/mL lowers the level of erythrocyte hemolysis caused by 76.8% oxidation. In addition, the extract protects lipid membranes against hemolysis better than ascorbic acid. The extract, in examined range of concentrations, did not induce hemolysis of erythrocytes, caused small decrease in their electric potential and osmotic fragility, and increased disorder of the polar heads of membrane lipids. The high antioxidant efficiency and determined effects of the interaction of bear garlic leaf extract with the erythrocyte membrane suggest that its constituents may not only protect cells against free radicals but also mitigate the effects of oxidative stress.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 3; 483-491
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cytotoxicity of PP(Arg)2- and PP(Ala)2(Arg)2-based photodynamic therapy and early stage of apoptosis induction in human breast cancers in vitro
    Autorzy:
    Nowak-Stępniowska, Agata
    Wiktorska, Katarzyna
    Małecki, Maciej
    Milczarek, Małgorzata
    Lubelska, Katarzyna
    Padzik-Graczyk, Alfreda
    Powiązania:
    https://bibliotekanauki.pl/articles/1039664.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    photodynamic therapy
    breast cancer
    transmembrane mitochondrial potential
    Opis:
    Mitochondria are cell energetic centers where ATP is produced. They also play a very important role in the PDT as intracellular sites of photosensitizer localization. Photosensitizers gathering in mitochondria (like porphyrin derivatives used in this work) are more effective in tumor cell destruction. Moreover, it was assumed that di-amino acid substituents attached to porphyrin ring will strengthen the effectivity of interaction with membrane receptors of examined cells. MTT assay was performed to investigate the influence of PP(Arg)2 and PP(Ala)2(Arg)2-based PDT on breast cancer cell viability for 24 h, 48 h and 120 h after cell irradiation. Then the influence of PP(Ala)2(Arg)2- and PP(Arg)2-mediated PDT on early mitochondrial apoptosis induction via measurements of the transmembrane mitochondrial potential changes was examined. Results showed that lower energy doses and maximal nontoxic photosensitizer doses of PP(Ala)2(Arg)2 and PP(Arg)2 applied in PDT can imply apoptotic cell death. It was confirmed that modification of the protoporphyrin IX by attaching two alanine substituents raised the efficiency of photodynamic therapy.
    Źródło:
    Acta Biochimica Polonica; 2012, 59, 4; 603-611
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-2 z 2

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