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    Wyświetlanie 1-13 z 13
    Tytuł:
    Tissue distribution of a menthyl-conjugated oligodeoxyribonucleotide antisense to PAI-1 mRNA
    Autorzy:
    Szemraj, Janusz
    Al-Nedawi, Khalid
    Chabielska, Ewa
    Buczko, Wlodzimierz
    Pawlowska, Zofia
    Powiązania:
    https://bibliotekanauki.pl/articles/1041329.pdf
    Data publikacji:
    2005
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    PAI-1
    antisense oligonucleotides
    tissue distribution
    Opis:
    The inhibitory effect of numerous analogues of PO-16, an hexadecadeoxyribonucleotide antisense to sequences -22 to -17 of PAI-1 mRNA coding for a fragment of the signal peptide, on the expression of PAI-1 in endothelial cells, and physiological consequences of the subsequently reduced PAI-1 activity tested in vitro and in vivo, were described in our previous studies. Of particular interest was PO-16 5'-O-conjugated with menthyl phosphorothioate (MPO-16R). In this work, tissue localisation of MPO-16R labelled with [35S] phosphorothioate at the 3'-end, was determined. [35S]MPO-16R and control [35S]MPO-16R-SENSE oligonucleotides were administered intravenously into 22 rats and organ distribution of the labelled bioconjugates was assessed after 24 and 48 h. For this purpose, tissue sections were subjected to autoradiography, and quantitated by liquid scintillation after solubilisation. Overall clearance of radioactivity was already seen after 24 h, with the radioactivity recovered mainly in the kidney and liver. A smaller fraction of radioactivity was also retained in the spleen and heart. The kidney concentration of the labelled probe was higher than that of liver by 50%. The distribution of PAI-1 mRNA in untreated rat kidney, liver, spleen and heart established by two independent techniques: Ribonuclease Protection Assay and Real-Time PCR, shows the same pattern as that observed for [35S]MPO-16R antisense.
    Źródło:
    Acta Biochimica Polonica; 2005, 52, 4; 849-855
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Expression level of Ubc9 protein in rat tissues.
    Autorzy:
    Gołębiowski, Filip
    Szulc, Aneta
    Sakowicz, Monika
    Szutowicz, Andrzej
    Pawełczyk, Tadeusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1043384.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Ubc9
    rat
    recombinant protein
    tissue distribution
    Opis:
    Ubc9 is a homologue of the E2 ubiquitin conjugating enzyme and participates in the covalent linking of SUMO-1 molecule to the target protein. In this report we describe a simple and efficient method for obtaining pure human recombinant Ubc9 protein. The purified Ubc9 retained its native structure and was fully active in an in vitro sumoylation assay with the promyelocytic leukaemia (PML) peptide as a substrate. In order to better understand the physiology of Ubc9 protein we examined its levels in several rat tissues. Immunoblot analyses performed on tissue extracts revealed quantitative and qualitative differences in the expression pattern of Ubc9. The Ubc9 protein was present at a high level in spleen and lung. Moderate level of Ubc9 was detected in kidney and liver. Low amount of Ubc9 was observed in brain, whereas the 18 kDa band of Ubc9 was barely visible or absent in heart and skeletal muscle. In heart and muscle extracts the Ubc9 antibodies recognized a 38 kDa protein band. This band was not visible in extracts of other rat tissues. A comparison of the relative levels of Ubc9 mRNA and protein indicated that the overall expression level of Ubc9 was the highest in spleen and lung. In spleen, lung, kidney, brain, liver and heart there was a good correlation between the 18 kDa protein and Ubc9 mRNA levels. In skeletal muscle the Ubc9 mRNA level was unproportionally high comparing to the level of the 18 kDa protein. The presented data indicate that in the rat the expression of the Ubc9 protein appears to have some degree of tissue specificity.
    Źródło:
    Acta Biochimica Polonica; 2003, 50, 4; 1064-1073
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Body composition and fatty tissue distribution in women with various menstrual status
    Autorzy:
    Dmitruk, A.
    Czeczelewski, J.
    Czeczelewska, E.
    Golach, J.
    Parnicka, U.
    Powiązania:
    https://bibliotekanauki.pl/articles/875162.pdf
    Data publikacji:
    2018
    Wydawca:
    Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
    Tematy:
    body composition
    fatty tissue
    tissue distribution
    woman
    menstrual cycle
    Opis:
    Background. Menopause, also referred to as climacterium, is a period of multiple changes in the structure and functions of a woman organism. Objective. Determination of differences in body composition and fatty tissue distribution in women from groups discriminated based on their menstrual status. Material and Methods. The survey covered 312 women aged 38-75 years. Menstrual status of the surveyed women was established according to WHO guidelines based on answers to a questionnaire, and three groups were discriminated: women in the premenopausal period (group 1), in the perimenopausal period (group 2), and in the postmenopausal period (group 3). The following anthropomological measurements were taken: body height, body mass, waist and hip circumference, and thickness of 6 skinfolds. Their results enabled evaluating the somatic built of women in the separated groups. Fatty tissue distribution was determined based on TER distribution index calculated as a ratio of the sum of trunk skinfolds (TSS) to the sum of extremity skinfolds (ESS). Body composition of the women, including percentage of body fat, lean body mass, soft tissue mass, and total body water, was assessed using an IOI 353 analyzer by JAWON MEDICAL. In addition, percentages of women with underweight, normal content of fatty tissue, and these with overweight and obesity were calculated. The WHR index was computed in the case of obese women. Results. The highest values of body mass, hip circumference and most of the skinfolds were determined in the perimenopausal group, whereas the postmenopausal women were characterized by the highest percentage of body fat (PBF) and by the lowest contents of lean tissue, soft tissue, and total water content in the body. The highest percentage of obese women was found in the postmenopausal group, including 40% of them having visceral type obesity. The occurrence of the menopause contributed to changes in fatty tissue distribution, causing its shift from extremities toward the trunk. Conclusions. The study showed differences in the somatic built and body composition in groups of women distinguished based on their menstrual status.
    Wprowadzenie. Menopauza, zwana inaczej przekwitaniem, to okres licznych zmian w budowie i funkcjonowaniu organizmu kobiety. Cel. Określenie wielkości różnic w składzie ciała i rozmieszczeniu tkanki tłuszczowej u kobiet w grupach wydzielonych na podstawie statusu menstruacyjnego. Materiał i metody. Badaniom poddano 312 kobiet w wieku 38-75 lat. Na podstawie odpowiedzi udzielonych na pytania ankiety określono status menstruacyjny badanych kobiet zgodnie z zaleceniami WHO. Wydzielono trzy grupy kobiet będących w okresie premenopauzalnym (grupa 1- 69 kobiet ), perimenopauzalnym (grupa 2 – 45 kobiet) i postmenopauzalnym (grupa 3- 198 kobiet). Wykonano pomiary antropologiczne: wysokości ciała, masy ciała, obwodu pasa i bioder oraz grubości 6 fałdów skórno-tłuszczowych w celu oceny budowy somatycznej kobiet w wydzielonych grupach. W celu określenia dystrybucji tkanki tłuszczowej obliczono wskaźnik dystrybucji TER, będący stosunkiem sumy fałdów skórno-tłuszczowych na tułowiu (TSS) do sumy fałdów skórno-tłuszczowych na kończynach (ESS). Skład ciała oceniono przy pomocy analizatora składu ciała IOI 353 z oprogramowaniem JAWON MEDICAL. Pozwoliło to na określenie m.in. procentowej zawartości tkanki tłuszczowej, beztłuszczowej masy ciała, masy tkanek miękkich oraz całkowitej zawartości wody. Obliczono również odsetek osób z niedowagą, prawidłową zawartością tkanki tłuszczowej oraz z nadwagą i otyłością. U otyłych kobiet obliczono wskaźnik WHR. Wyniki. Najwyższe wartości masy ciała, obwodu bioder i większości fałdów skórno-tłuszczowych wystąpiły w grupie perimenopauzalnej, a w grupie postmenopauzalnej – najwyższe wartości całkowitej zawartości tkanki tłuszczowej (PBF), przy równoczesnym najniższym poziomie tkanki beztłuszczowej, tkanek miękkich i całkowitej zawartości wody w organizmie. Najwyższy odsetek otyłych kobiet wystąpił w grupie postmenopauzalnej, przy czym u 40% badanych z tej grupy była to otyłość wisceralna. Wystąpienie menopauzy przyczyniło się do zmian w rozmieszczeniu tkanki tłuszczowej, powodując przesunięcie jej z kończyn w kierunku tułowia. Wnioski. Stwierdzono występowanie różnic w budowie somatycznej i składzie ciała kobiet w grupach wydzielonych na podstawie statusu menstruacyjnego.
    Źródło:
    Roczniki Państwowego Zakładu Higieny; 2018, 69, 1
    0035-7715
    Pojawia się w:
    Roczniki Państwowego Zakładu Higieny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Expression level of adenosine kinase in rat tissues. Lack of phosphate effect on the enzyme activity.
    Autorzy:
    Sakowicz, Monika
    Grdeń, Marzena
    Pawełczyk, Tadeusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1044105.pdf
    Data publikacji:
    2001
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    rat
    recombinant protein
    phosphate
    tissue distribution
    adenosine kinase
    Opis:
    In this report we describe cloning and expression of rat adenosine kinase (AK) in Esccherichaia coli cells as a fusion protein with 6xHis. The recombinant protein was purified and polyclonal antibodies to AK were generated in rabbits. Immunoblot analysis of extracts obtained from various rat tissues revealed two protein bands reactive with anti-AK IgG. The apparent molecular mass of these bands was 48 and 38 kDa in rat kidney, liver, spleen, brain, and lung. In heart and muscle the proteins that react with AK antibodies have the molecular masses of 48 and 40.5 kDa. In order to assess the relative AK mRNA level in rat tissues we used the multiplex PCR technique with β-actin mRNA as a reference. We found the highest level of AK mRNA in the liver, which decreased in the order kidney >spleen >lung >heart >brain >muscle. Measurement of AK activity in cytosolic fractions of rat tissues showed the highest activity in the liver (0.58 U/g), which decreased in the order kidney >spleen >lung >brain >heart >skeletal muscle. Kinetic studies on recombinant AK as well as on AK in the cytosolic fraction of various rat tissues showed that this enzyme is not affected by phosphate ions. The data presented indicate that in the rat tissues investigated at least two isoforms of adenosine kinase are expressed, and that the expression of the AK gene appears to have some degree of tissue specificity.
    Źródło:
    Acta Biochimica Polonica; 2001, 48, 3; 745-754
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Isolation and characterization of pigeon breast muscle cytosolic 5´-nucleotidase-I (cN-I)
    Autorzy:
    Tkacz-Stachowska, Kinga
    Lechward, Katarzyna
    Skladanowski, Andrzej
    Powiązania:
    https://bibliotekanauki.pl/articles/1041318.pdf
    Data publikacji:
    2005
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    skeletal muscle
    pigeon
    enzyme purification
    tissue distribution
    5´-nucleotidase
    Opis:
    5´-Nucleotidase specific towards dCMP and AMP was isolated from avian breast muscle and characterized. It was found to be similar to a type-I form (cN-I) identified earlier as the AMP-selective 5´-nucleotidase responsible for adenosine formation during ATP breakdown in transfected COS-7 cells. Expression pattern of the cN-I gene in pigeon tissues indicated breast muscle as a rich source of the transcript. We purified the enzyme from this source using two-step chromatography and obtained an active homogenous preparation, free of ecto-5´-nucleotidase activity. The tissue content of the activity was calculated at 0.09 U/g wet weight. The specific activity of the enzyme preparation was 4.33 U/mg protein and it preferred dCMP and AMP to dAMP and IMP as a substrate. Its kinetic properties were very similar to those of the enzyme purified earlier from heart tissue. It was strongly activated by ADP. Inhibition by inorganic phosphate was more pronounced than in heart-isolated cN-I. Despite this difference, a similar physiological function is suggested for cN-I in both types of muscle.
    Źródło:
    Acta Biochimica Polonica; 2005, 52, 4; 789-796
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Recent advances in studies on biochemical and structural properties of equilibrative and concentrative nucleoside transporters
    Autorzy:
    Podgorska, Marzena
    Kocbuch, Katarzyna
    Pawelczyk, Tadeusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1041310.pdf
    Data publikacji:
    2005
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    nucleoside transporters
    structure
    gene locus
    substrate specificity
    tissue distribution
    adenosine
    Opis:
    Nucleoside transporters (NT) facilitate the movement of nucleosides and nucleobases across cell membranes. NT-mediated transport is vital for the synthesis of nucleic acids in cells that lack de novo purine synthesis. Some nucleosides display biological activity and act as signalling molecules. For example, adenosine exerts a potent action on many physiological processes including vasodilatation, hormone and neurotransmitter release, platelet aggregation, and lipolysis. Therefore, carrier-mediated transport of this nucleoside plays an important role in modulating cell function, because the efficiency of the transport processes determines adenosine availability to its receptors or to metabolizing enzymes. Nucleoside transporters are also key elements in anticancer and antiviral therapy with the use of nucleoside analogues. Mammalian cells possess two major nucleoside transporter families: equilibrative (ENT) and concentrative (CNT) Na+-dependent ones. This review characterizes gene loci, substrate specificity, tissue distribution, membrane topology and structure of ENT and CNT proteins. Regulation of nucleoside transporters by various factors is also presented.
    Źródło:
    Acta Biochimica Polonica; 2005, 52, 4; 749-758
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Polybrominated diphenyl ethers (PBDEs) in sediment and fish tissues from Lake Chaohu, central eastern China
    Autorzy:
    Yang, S.
    Fu, Q.
    Teng, M.
    Yang, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/205368.pdf
    Data publikacji:
    2015
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    polybrominated diphenyl ethers
    exposure level
    sediment
    tissue distribution
    Lake Chaohu
    Opis:
    Polybrominated diphenyl ethers (PBDEs) levels in environmental media have increased over the last 20-25 years in the world. In aquatic environments PBDEs were found to be accumulated along food chain and Endocrine disruptors toxicity. In this study PBDEs were investigated in sediment and fish tissues from Lake Chaohu in central eastern China. There were 10 PBDEs congeners detected out of all 41 PBDEs. BDE-47 was of the highest with 5.17 ng/g in sediment and 58.47 ng/g in fish. PBDEs were evenly distributed across the surface sediment in the whole lake. It implied that the main source of PBDEs may not be an inflow river like Nanfei. Tissue distribution patterns of PBDEs in four fish species were in the order of BDE-47 > BDE-99 > BDE-100 > BDE-66 > BDE-138 > BDE-183 > BDE-154 > BDE-153. Octa- and deca-BDEs were below the detection limit. The concentrations of all PBDE congeners were higher in gills, livers, and kidneys than those in muscles and adipose tissue. Furthermore, PBDEs in different tissues had some different distribution patterns with fish size. Those discrepancies appeared to be correlated with the PBDEs pollution fluxes varying with the change of the year and their metabolism divergences in fish tissues.
    Źródło:
    Archives of Environmental Protection; 2015, 41, 2; 12-20
    2083-4772
    2083-4810
    Pojawia się w:
    Archives of Environmental Protection
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Iron-superoxide dismutase from pepper: biochemical characterization, cell localization and tissue distribution
    Autorzy:
    Rodriguez-Ruiz, M.
    Alvarez de Morales, P.
    del Rio, L.
    Corpas, F.
    Palma, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/80920.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    iron-superoxide dismutase
    pepper
    Capsicum annuum
    biochemical characteristics
    tissue distribution
    stress condition
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Propagation of Gaussian Schell-model vortex beams in biological tissues
    Autorzy:
    Duan, Meiling
    Tian, Yannan
    Li, Jinhong
    Powiązania:
    https://bibliotekanauki.pl/articles/173473.pdf
    Data publikacji:
    2019
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    GSM vortex beams
    intensity distribution
    spectral degree of coherence
    biological tissue
    Opis:
    The dependence of changes in the relative intensity and the spectral degree of coherence on the refractive-index Cn2 of biological tissues, space correlation length σ0 and wavelength λ of the Gaussian Schell-model (GSM) vortex and non-vortex beams in biological tissues has been studied. It is shown that the intensity distribution of GSM vortex beams passing through the biological tissues undergoes several stages. The bigger Cn2 is, and the smaller σ0 is, the quicker the intensity evolution is. The attenuation of intensity for GSM vortex beams is much slower than that of non-vortex beams, thus the beam quality of the former is better than the latter. When propagating through the biological tissue, the phase singularities of GSM vortex beams will appear. As the propagation distance increases, the position of the phase singularities will shift, and these points will disappear where the changes in the spectral degree of coherence of GSM vortex beams are consistent with those of GSM non-vortex beams. At the same propagation distance, the bigger Cn2 is, and the smaller σ0 and λ are, the shorter the distance between the phase singularities and the z axis is, when the propagation distance z is in the range of 0–50 μm.
    Źródło:
    Optica Applicata; 2019, 49, 2; 203-215
    0078-5466
    1899-7015
    Pojawia się w:
    Optica Applicata
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Badanie pól temperaturowych w procesie spawania tkanek laserem półprzewodnikowym
    Measurements of tissue temperatures during laser welding process
    Autorzy:
    Polakowski, H.
    Zając, A.
    Kubik, E.
    Powiązania:
    https://bibliotekanauki.pl/articles/154640.pdf
    Data publikacji:
    2011
    Wydawca:
    Stowarzyszenie Inżynierów i Techników Mechaników Polskich
    Tematy:
    laserowe łączenie tkanek
    wizualizacja rozkładów temperatury
    laser tissue welding
    visualization of temperature distribution
    Opis:
    W ostatnich latach prowadzone są intensywne prace związane z zastosowania promieniowania laserowego do spawania tkanek biologicznych. Absorpcja promieniowania w tkance prowadzi do jej ogrzewania i po przekroczeniu przez nagrzewany obszar określonej, charakterystycznej dla danej tkanki temperatury progowej prowadzi do jej koagulacji. Skuteczny przebieg łączenia wymaga dobrania odpowiednich parametrów wiązki promieniowania. W pracy przeprowadzono badania efektu koagulacji tkanki biologicznej przy naświetlaniu promieniowaniem lasera półprzewodnikowego pracującego w reżimie pracy ciągłej oraz impulsowej.
    In recent years the extensive works on laser tissue welding have been performed. Trough the years the application of various types of lasers for selected medical procedures have been considered and analyzed [1, 2, 3]. Recently there have been efforts to widely implement laser tissue welding [3]. Pulse Nd:YAG lasers are most commonly used for that task. The development of high energy semiconductor lasers makes it possible to use such lasers in the aforementioned procedures. Absorption of laser radiation causes the local temperature rise inside the tissue. During the process, the temperature reaches the coagulation temperature, which is from 65°C to 95°C, depending on the kind of tissue [5]. During the research the effect of coagulation of biological tissues caused by pulsed and continuous wave (CW) laser illumination was investigated. The tests were conducted on a stand shown in Fig. 2. The applied laser diode LIMO90-F200-DL980 emitted a constant laser beam of the wavelength ? = 970 nm, with the power output up to 100W. The beam could be modulated with the frequency up to a few hundred Hz. The thermal camera ThermaCam P640 was used to visualize the process and record the temperature distribution. It was found that most of available semiconductor lasers met the requirements necessary for tissue welding. Better coagulation results were obtained for lasers operating in CW mode.
    Źródło:
    Pomiary Automatyka Kontrola; 2011, R. 57, nr 10, 10; 1173-1176
    0032-4140
    Pojawia się w:
    Pomiary Automatyka Kontrola
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Determination of bone volume porosity based on histograms of the mCT scans
    Autorzy:
    Gadzała, P.
    Szczepański, Z.
    Zych, G.
    Powiązania:
    https://bibliotekanauki.pl/articles/115459.pdf
    Data publikacji:
    2010
    Wydawca:
    Fundacja na Rzecz Młodych Naukowców
    Tematy:
    volume porosity
    bone tissue
    computed microtomography
    mCT
    histogram
    probability distribution
    voxels
    thresholding
    microscopic
    Opis:
    The new method is proposed in the paper for determination of volume porosity of bone tissue based on histograms of 3D mCT scans and also precise defi nition of the threshold value of relative density preserving calculated volume porosity during the reconstruction of the binary image of sample. In this method the normed histogram is considered as a probability distribution of relative mass density in the bone sample. It was shown that the normed histograms of increasing 3D sample are convergent to the limit curve which can be interpreted as a representative histogram of given sample. The limit histograms have been used to determine: the distributions of relative densities in the sets of voxels of pore and skeleton type and their characteristics, the volume porosities of both samples and thresholds values of their binarisation.
    Źródło:
    Challenges of Modern Technology; 2010, 1, 1; 88-89
    2082-2863
    2353-4419
    Pojawia się w:
    Challenges of Modern Technology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Stress distribution in cell wall – inferring stress anisotropy from the pattern of buckling in the innermost cell wall layer
    Autorzy:
    Borowska-Wykret, D.
    Powiązania:
    https://bibliotekanauki.pl/articles/79982.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    stress distribution
    cell wall
    anisotropy
    tensile stress
    hyperosmotic condition
    epidermis cell
    tissue stress
    cellulose microfibril
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Wpływ zmienności właściwości fizycznych tkanki na rozkład temperatury w tkance przy terapeutycznym oddziaływaniu ultradźwięków
    The influence of the physical parameters of tissue on the temperature distribution during ultrasound interaction
    Autorzy:
    Kruglenko, E.
    Powiązania:
    https://bibliotekanauki.pl/articles/261178.pdf
    Data publikacji:
    2012
    Wydawca:
    Politechnika Wrocławska. Wydział Podstawowych Problemów Techniki. Katedra Inżynierii Biomedycznej
    Tematy:
    ultradźwięki
    rozkład temperatury
    tkanka miękka
    przewodność cieplna
    ciepło właściwe
    infrasounds
    temperature distribution
    soft tissue
    thermal conductivity
    heat capacity
    Opis:
    Artykuł dotyczy numerycznego wyznaczania in vivo przestrzennego i czasowego rozkładu temperatury po oddziaływaniu na tkankę zogniskowaną wiązką ultradźwiękową małej mocy. Celem pracy jest analiza wpływu parametrów fizycznych tkanki na rozkład temperatury oraz przedstawienie wyników obliczeń dla modelu wątroby szczura, w którym uwzględniono zależność parametrów fizycznych tkanki od temperatury. Wykazano, że przewidywana temperatura tkanki po 20-minutowym oddziaływaniu w większym stopniu zależy od zmiany przewodnictwa cieplnego tkanki niż od jej ciepła właściwego. Parametry materiałowe wody i tkanki wątroby przyjęto na podstawie danych z literatury. Założono, że geometria modelu numerycznego odpowiada rzeczywistemu położeniu obszaru oddziaływania względem głowicy emitującej zogniskowaną wiązkę ultradźwiękową.
    The paper concerns the numerical calculation of the spatiotemporal distribution of the temperature field induced by a low power focused ultrasound beam within tissues in vivo. The aim of the study was to analyze the influence of various tissue parameters on the temperature distribution and to present the results of calculations for the rat liver model, taking into account the dependence of physical parameters on the temperature. It was shown that the predicted tissue temperature after 20 minutes of interaction depends more on the tissue thermal conductivity than its heat capacity. The material parameters of water and liver tissue were taken from the literature, and the geometry of numerical model corresponds to the actual location of the interaction area of the transducer emitting highly focused ultrasound beam.
    Źródło:
    Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna; 2012, 18, 4; 250-254
    1234-5563
    Pojawia się w:
    Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-13 z 13

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