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    Wyświetlanie 1-3 z 3
    Tytuł:
    Oxidative stress and antioxidants markers in individuals with thyroid hormones dysfunction
    Autorzy:
    Omon, Emmanuel Akokhamen
    Ajay, Olawale David
    Powiązania:
    https://bibliotekanauki.pl/articles/29520465.pdf
    Data publikacji:
    2023-12-31
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    antioxidants
    dysfunction
    malondialdehyde
    oxidative stress
    thyroid hormone
    Opis:
    Introduction and aim. Thyroid hormone abnormalities have been associated with oxidative changes in human beings. The aim of the study was to evaluate the oxidative stress marker and antioxidants status in individuals with thyroid hormone dysfunction in Ekiti State. Material and methods. A total of eighty samples were recruited in this study comprising forty subjects with thyroid hormones dysfunction and forty apparently healthy controls. Malondialdehyde (MDA), reduced glutathione (GSH) and catalase were determined spectrophotometerically. Results. MDA was non-significantly higher (p>0.05) in subjects (4.33±0.84 nmol/mL) compared with control (4.12±0.63 nmol/mL), catalase was non-significantly higher (p>0.05) in subjects (199.36±20.21 µm/mL) compared with control (181.55±16.61 µm/mL), while GSH was significantly lower (p<0.05) in subjects (79.31±10.12 µmol/mL) compared with control (127.21±7.29 µmol/mL). Conclusion. It can be concluded that the increase in the reactive oxygen species accompanied with impairment of the antioxidant system occurs in patients with thyroid hormone dysfunction. Hypothyroidism and hyperthyroidism induces disequilibrium of the oxidative/anti-oxidative balance that can lead to subsequent development of inflammation and associated diseases.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2023, 4; 768-775
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Thyroid dysfunctions due to lithium treatment in bipolar disorder: changes in oxidative stress, trace elements, and hemorheological parameters
    Autorzy:
    Bahtiyar, N.
    Serinkan Cinemre, F.
    Cinemre, H.
    Kiziler, A.
    Atagun, M.
    Gulyasar, T.
    Aydemir, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/1192380.pdf
    Data publikacji:
    2020
    Wydawca:
    Uniwersytet Warmińsko-Mazurski w Olsztynie / Polskie Towarzystwo Magnezologiczne im. Prof. Juliana Aleksandrowicza
    Tematy:
    bipolar disorder
    lithium treatment
    thyroid dysfunction
    oxidative stress
    trace
    elements
    hemorheology
    Opis:
    Lithium is one of the most widely used medications for the treatment of bipolar disorder (BD). It also has some side effects on thyroid functions. We aimed to investigate the role of oxidative stress, trace elements, and hemorheological parameters on the pathophysiology of thyroid dysfunctions developed by lithium treatment in patients with BD. Patients with BD were divided into three groups: patients that non-lithium-treated, lithium-treated patients for 4-6 weeks, and lithium-treated patients for 40-68 weeks. Blood samples for analysis were taken before and after the treatment period. After analysis, patients were divided into six groups: non-treatment BD group (Group 1); short-term lithium-treatment group that did not develop thyroid dysfunctions (Group 2); short-term lithium-treatment group that developed hyperthyroidism (Group 3); longterm lithium treatment group that developed hypothyroidism (Group 4), long-term lithium-treatment group that developed hyperthyroidism (Group 5), and long-term lithium-treatment group that did not develop thyroid dysfunctions (Group 6). Plasma and whole blood viscosity levels were significantly increased in Groups 4 and 6 compared to Groups 1, 2, and 3. Hemoglobin levels were lower in Group 4 than in Groups 1, 2, and 5. Fibrinogen values were higher in Groups 4 and 5 than Group 1. Plasma and erythrocyte malondialdehyde levels were higher in Group 4 than In Groups 1, 2, 3, and 5. Also, they were increased in Group 6 in comparison with Groups 2 and 3. Erythrocyte glutathione levels were lower in Groups 4 and 6 than Groups 1, 2, 3 and 5. Plasma protein carbonyls levels were higher in Group 4 than in Group 1, or in Group 5 than in Groups 1, 2, and 3, as well as in Group 6 than Groups 1, and 2. Serum zinc levels were higher in Groups 2, 3 and 6 than in Group1. Serum copper levels increased in Groups 2, 4 and 6 in comparison with Group1. The results of this study indicate that oxidative stress increased with treatment time in lithium-induced thyroid dysfunctions. Also, whole blood viscosity, plasma viscosity, fibrinogen, zinc, and copper levels were affected by lithium treatment and treatment duration induced thyroid dysfunctions.
    Źródło:
    Journal of Elementology; 2020, 25, 3; 863-878
    1644-2296
    Pojawia się w:
    Journal of Elementology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Influence of brassica sprouts on short chain fatty acids concentration in stools of rats with thyroid dysfunction
    Autorzy:
    Dobrowolska-Iwanek, Justyna
    Zagrodzki, Paweł
    Prochownik, Ewelina
    Jarkiewicz, Aneta
    Paśko, Paweł
    Powiązania:
    https://bibliotekanauki.pl/articles/895296.pdf
    Data publikacji:
    2019-12-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    thyroid dysfunction
    short chain fatty acids
    broccoli sprouts
    stool samples
    Opis:
    The aim of the study was to investigate the influence of kohlrabi and broccoli sprouts added to diet on the concentrations of short-chain fatty acids in faeces samples of rats with thyroid dysfunction. Two models of hypothyroidism were used. First one was based on the diet with iodine deficiency and the second by sulfadimethoxine addition to the animal drinking water. In most cases the concentrations of acetic acid, propanoic acid and butanoic acid in stool samples obtained from rats with thyroid dysfunction were insignificantly lower than found in control group. Moreover, almost in all cases the diet enriched with brassica sprouts insignificantly increased the concentration of fatty acids in investigated material. Significant positive correlation between concentrations of butanoic and acetic acids was found in different groups of rats. In conclusion, the addition of brassica or kohlrabi sprouts in rat’s diet may slightly alleviate the decline of concentrations of some fatty acids in stool of animals with thyroid dysfunction. Long term effects of this phenomenon should be evaluated in future studies.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 6; 1005-1014
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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