Temat: throat cancer - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Serum and saliva levels of matrix metalloproteinase 3 and 9 in pharynx and larynx cancer
Autorzy:: Polz-Dacewicz, Małgorzata
Maciąg, Paweł
Kliszczewska, Ewa
Rolniak, Łukasz
Powiązania:: https://bibliotekanauki.pl/articles/972529.pdf
Data publikacji:: 2017
Wydawca:: Instytut Medycyny Wsi
Tematy:: matrix metalloproteinases
larynx cancer
throat cancer
head and neck cancer
Opis:: Introduction and objective. Matrix metalloproteinases (MMPs) are proteolytic enzymes responsible for the decomposition of extracellular matrix elements. They play an important role during embryogenesis, wound healing, endometrial epithelial exfoliation, the formation of new blood vessels, and also during cancer development. Throat and larynx tumours are included in a large group of head and neck cancers. These tumours are characterized by a poor prognosis. Despite advances in medical science, cancer treatment is difficult and often ineffective. The aim of the study was to evaluate the level of MMP-3 and MMP-9 in the serum and saliva of patients with pharynx and larynx tumours. Materials and method. Samples of saliva and serum were collected from 60 patients with larynx or throat cancer. Twenty patients without cancer comprised the control group. MMPs in saliva and serum were determined by the ELISA method. Results. In the study group, concentrations of MMP-3 in saliva were from 0.2 – 77.6 ng/ml. Patients with malignant tumours had higher saliva MMP-3 levels than healthy subjects. The concentration of MMP-3 in the serum of the study group ranged from 10.9 – 200.00 ng/ml, which was also higher than in the control group. There were no statistically significant difference in the MMP-9 level between the study and control groups (both in serum and saliva). Conclusions. This study is another element that shows the phenomena taking place at the cellular level during oncological disease. In serum and saliva samples, higher values of MMP3 were found in patients with cancer. The increase in the concentration of this enzyme in the risk group may be used for early detection of tumour transformation and evaluation of treatment.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2017, 11, 2; 106-110
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Difficulties associated with the diagnosis of mycosis of the oral cavity and throat in chronic lymphocytic leukemia (CLL)
Autorzy:: Kaczmarczyk, D.
Morawiec-Sztandera, A.
Niedźwiecka, I.
Kurnatowski, P.
Powiązania:: https://bibliotekanauki.pl/articles/2143364.pdf
Data publikacji:: 2011
Wydawca:: Polskie Towarzystwo Parazytologiczne
Tematy:: diagnosis
mycosis
oral cavity
throat
chronic lymphocytic leukemia
fungal infection
disease risk
fungi
cancer formation
neoplastic process
treatment
human disease
disease symptom
immunodeficiency
prevalence
Opis:: Cases of fungal infections are being encountered more often in clinical practice. The factors associated with a high risk of mycoses include, among others, corticosteroidotherapy, the administration antibiotics with wide spectrum of antibacterial properties, neutropenia, neoplasms. Fungi may play a role in cancer formation, may act as a complication in the course of treatment, and may mimic a neoplastic process by giving a similar clinical picture. In the case of fungal throat infection, patients complain of increased body temperature, a general feeling of weakness, malaise, headache, spontaneous pain intensifying during swallowing, a feeling of an obstacle in the throat or a cough. A physical examination may reveal congestion of the mucosa followed by a unilateral crater ulceration often covered with fat, as well as a thick coating, which is accompanied by foetor ex ore. The submandibular and neck lymph nodes are often greatly enlarged and painful. These symptoms may resemble those associated with the neoplastic process and changes in the course of systemic diseases (agranulocytosis). A correct diagnosis in these cases is necessary for adequate therapy. Chronic lymphocytic leukemia (CLL) is the most common type of leukemia among adults in Europe and North America. It is estimated that in Poland, CLL affects approximately 1,400 people per year. In this paper, a case of 62-years old patient with CLL with fungal infection of oral cavity and throat is presented.
Źródło:: Wiadomości Parazytologiczne; 2011, 57, 3; 155-158
0043-5163
Pojawia się w:: Wiadomości Parazytologiczne
Dostawca treści:: Biblioteka Nauki