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Wyszukujesz frazę "thallium-201" wg kryterium: Temat

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    Tytuł:
    Preparation and biodistribution of [201Tl](III)vancomycin complex in normal rats
    Autorzy:
    Jalilian, A.
    Hosseini, M.
    Karimian, A.
    Saddadi, F.
    Sadeghi, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/146167.pdf
    Data publikacji:
    2006
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    thallium-201
    vancomycin
    labeling
    SPECT
    radiopharmaceuticals
    infection
    Opis:
    Thallium-201 (T1/2 = 3.04 days) in Tl+ form was converted to Tl3+ cation in presence of O3 in 6 M HCl controlled by RTLC/gel electrophoresis methods. The final evaporated activity was reacted with vancomycin (VAN) in water to yield [201Tl](III)VAN. The best results were obtained at room temperature in water after 30 min with a radiochemical yield > 99%, after mixing the reactants followed by SPE purification using Si Sep-Pak. The studies showed that thallic ion is mostly incorporated into vancomycin with a radiochemical purity of more than 98 š 1% by RTLC. A specific activity of about 4.14 x 1010 Bq/mmol was obtained. Radiochemical purity and stability of 201Tl-VAN in the preparation and in presence of human serum was determined up to 5.5 days. Biodistribution study of 201Tl(III)-vancomycin in normal rats was performed up to 52 h.
    Źródło:
    Nukleonika; 2006, 51, 4; 203-208
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Computer simulation of temperature distribution on a solid target for 201Tl production
    Autorzy:
    Aboudzadeh Rovais, M. R.
    Yousefi, K.
    Ardaneh, K.
    Mirzaii, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/147613.pdf
    Data publikacji:
    2011
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    heat transfer
    computer simulation
    solid target
    thallium-201
    Opis:
    Thallium-201 is of great interest in nuclear medicine for diagnostic purposes. It is produced by the 203Tl(p,3n)201Pb nuclear reaction. Since the target for 201Tl production is a solid target and the maximum beam current for the irradiation has a direct relation with its temperature surface, therefore, the control of temperature during the irradiation is essential. Designing a proper cooling system is one of the important and determining parameters in radionuclide production efficiency. Non-controlled temperature would cause melting and consequently loss of target materials that could be very costly especially when an isotopically enriched material is used. In this study, the heat transfer and temperature distribution on the target has been simulated based on a computational fluid dynamics (CDF) code for the thermal behavior of the target during the irradiation and under the different beam currents, cooling flow rates and target designing. The results on the routinely used target for the production of 201Tl in AMIRS, showed that there was a good linearity between proton beam currents (in the range of 100–350 mi A) and maximum temperature on the thallium target (345–458 K). The results also showed that the flow rate of the cooling water can be brought down (from routinely used 45 L/min) to 15 L/min without any risk of melting of target material.
    Źródło:
    Nukleonika; 2011, 56, 4; 283-289
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Właściwości biologiczne i fizyko-chemiczne talu
    Biological and physico-chemical properties of thallium
    Autorzy:
    MUSZYŃSKA, Bożena
    ROJOWSKI, Jacek
    DOBOSZ, Konrad
    OPOKA, Włodzimierz
    Powiązania:
    https://bibliotekanauki.pl/articles/1033799.pdf
    Data publikacji:
    2015
    Wydawca:
    Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
    Tematy:
    "201Tl"
    "Thallium"
    "elements"
    "toxicity of Thallium"
    Opis:
    Thallium is a toxic and quite common element in the environment, but it is poorly examined, despite the known toxic activity of this metal. The ionic radius of the element is similar to the ionic radius of potassium, and at the same valence (K+,Tl+) allows substitution of this element in the nervous system and muscle, which results in its toxic activity. Thallium interferes with many enzymes and also has a strong affinity to the group – SH. The most dangerous symptoms of poisoning come from central nervous system. This element is easily cumulated by many living organisms, which poses a serious threat. In the past, it was used in rodenticides, and despite the risks, in many countries is still used for this purpose due to its low production costs. Contamination of this element of industrial areas is associated with the steel industry and cement production, while residents of these areas are often not aware of the threat and grow in these area vegetables that can absorb thallium, and in particular here talking about the Brassicaceae family. This element in the environment should be constantly monitored. Its isotope such as 201Tl (Thallium-201) has some significance in medicine, as radiopharmaceutical.
    Źródło:
    Medicina Internacia Revuo; 2015, 26, 105; 180-185
    0465-5435
    Pojawia się w:
    Medicina Internacia Revuo
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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