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    Wyświetlanie 1-6 z 6
    Tytuł:
    FACTORS ASSOCIATED WITH ESTIMATE OF HIGH TERATOGENIC RISK IN FEMALES EXPOSED TO ANTI-INFECTIVE AND ANTI-INFLAMMATORY DRUGS DURING PREGNANCY
    Autorzy:
    Grubor, Iva
    Nikolić, Ljiljana
    Ružić Zečević, Dejana
    Milovanović, Dragan
    Folić, Marko
    Rosić, Nikola
    Radonjić, Vesela
    Janković, Slobodan M.
    Powiązania:
    https://bibliotekanauki.pl/articles/895244.pdf
    Data publikacji:
    2018-12-31
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    pregnancy
    drugs
    risk of teratogenicity
    risk estimate
    Opis:
    ABSTRACT Introduction. Considering that small number of drugs are completely safe for use during pregnancy, right choice and adequate risk assessment is extremely important. Objective. The aim of this study was to analyze factors associated with estimate of high teratogenic risk (as judged by clinical pharmacologist) in pregnant females who were prescribed anti-infective drugs or mild analgesics. Methods. A cross-sectional study included 284 pregnant women who came for an advice about teratogenic risk to clinical pharmacologist in Clinical Centre Kragujevac, Serbia during the period from 1997 to 2012. All of included pregnant women were prescribed mild analgesics and/or anti-infective drugs during the first 3 months of pregnancy. The data were collected from patient files and by phone interviews. Results. Clinical pharmacologists estimated the risk of teratogenicity as “high” in pregnant females who were using tetracyclines or propionic acid derivatives. Disorders of development reported by mothers during phone interviews were associated with cephalosporin use during first 3 months of pregnancy, while miscarriages or abortions happened more often in women who used a tetracycline. Conclusions. Estimate of risk from congenital anomalies after use of drugs during pregnancy, which make clinical pharmacologists as part of their routine healthcare services, depends on amount of published data about previous experiences with specific drugs during the first 3 months of pregnancy. Key Words: pregnancy; drugs; risk of teratogenicity; risk estimate
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 6; 1439-1445
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The overview of current evidence on the reproductive toxicity of dibutyl phthalate
    Autorzy:
    Czubacka, Ewelina
    Czerczak, Sławomir
    Kupczewska-Dobecka, Małgorzata M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2086165.pdf
    Data publikacji:
    2021-01-07
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    reprotoxicity
    toxicology
    dibutyl phthalate
    endocrine disruptor
    embryotoxicity
    teratogenicity
    Opis:
    Over the past years, many legitimate concerns have been raised about the effects of dibutyl phthalate (DBP) as an endocrine disruptor, especially on reproduction. The aim of this publication is to critically review the literature related to the developmental and reproductive toxicity of DBP in animals. Several electronic databases were systematically searched until 2019. Studies were qualified for the review if they: linked exposure to DPB with reproduction, were published in English after 1990, and were conducted on animals. In the studies of the testicular effects of DBP on experimental animals, the most common effects of exposure included reduced fertility, atrophic changes in male gonads, degenerative changes in the epididymis, as well as a reduction in sperm count and motility, cryptorchidism, hypospadias, poor sperm quality and other genital defects (decreased testicular weight, delayed spermatogenesis, Leydig cell aggregation, impaired Sertoli cell maturation, and significant inhibitions of testicular enzymes). The embryotoxic effects of DBP on laboratory animals included mainly an increase in fetal resorption and a decrease in live births. The teratogenic effects of DBP also manifest as skeletal malformations in fetuses, malformations of male gonads and other genital effects. On the basis of the literature data, it is clearly demonstrated that DBP shows anti-androgenic effects; however, there are also reports confirming its weak estrogenic effect. Additionally, lower doses cause more adverse effects than the highest dose, which is an important fact because of the widespread environmental exposure to DBP. The studies clearly confirm that DBP is an endocrine disruptor.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2021, 34, 1; 15-37
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Disturbances of mouse pregnancy after injection of Ascaris homogenate during early organogenesis
    ZABURZENIA PRZEBIEGU CIĄŻY U MYSZY PO INIEKCJI HOMOGENATU Z ASCARIS W CZASIE WCZESNEJ ORGANOGENEZY
    Autorzy:
    Blaszkowska, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/2148586.pdf
    Data publikacji:
    2000
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    tegumental homogenate
    mouse
    mice
    Ascaris
    Ascaris suum
    organogenesis
    homogenate
    embryotoxicity
    pregnancy
    teratogenicity
    Opis:
    Administration of the Ascaris tegumental homogenate (0.6-1.2 g of Ascaris proteins/kg/day) at a early stage of organogenesis (5-9 days of pregnancy) had a harmful effect upon the developing mouse fetuses. It has been found that injection of the homogenate did not delay or prevent implantation, but causes a high rate of intrauterine deaths. The Ascaris homogenate significantly decreased the number of live fetuses per litter, increased the frequency of litter resorption, produced a delay in bone formation and induced pathological changes of fetal organs and tissues. The congenital malformations were noted in fetuses after injection of higher doses of Ascaris homogenate (exencephaly, craniomeningocele and intemal hydrocephalus). No malformations were noted in control groups and after injection of minimum dose of the homogenate. The symptoms that occurred after administration of the tegumental homogenate to pregnant mice included: decreased body weight gain (p<0.001) as compared to controls, vaginal hemorrhage, intrauterine resorption of litter and mortality. These signs suggest that the Ascaris homogenate causes matemal toxicity.
    Źródło:
    Wiadomości Parazytologiczne; 2000, 46, 3; 369-378
    0043-5163
    Pojawia się w:
    Wiadomości Parazytologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Ameloriate Effect of Glucose Monohydrate on Nicotine Sulfate-induced Toxicity and Teratogenicity in Xenopus embryos: an Experimental Study
    Autorzy:
    Pekmezekmek, Ayper Boga
    Emre, Mustafa
    Tunç, Erdal
    Sertdemir, Yasar
    Powiązania:
    https://bibliotekanauki.pl/articles/27322949.pdf
    Data publikacji:
    2023
    Wydawca:
    Politechnika Koszalińska. Wydawnictwo Uczelniane
    Tematy:
    D(+) glucose monohydrate
    embryo-teratogenicity
    FETAX
    nicotine sulfate
    Xenopus laevis
    Opis:
    It is well documented that nicotine causes low birth weight, preterm birth, pregnancy difficulties, lower fertility, inhibition of spermatogenesis, and decreased steroidogenesis and potassium channels conductance of Xenopus oocytes. Lung cancer is the most well-known adverse impact of nicotine. This work used a 96-hour FETAX test to examine how concurrent administration of glucose monohydrate modifies the effects of exposure to nicotine, nicotine sulfate, and/or glucose on ion channels and membrane potential in Xenopus leavis embryos at an early stage of development. In-vitro fertilised embryos were treated with nicotine and glucose alone or in combination for this aim, and the effects of those treatments were then assessed for potential teratogenic effects. At the conclusion of the FETAX technique, the ratios of healthy, abnormal, and dead embryos were calculated, and the length of embryos in each treatment group was assessed. The ratios of abnormal and dead embryos were considerably higher with nicotine treatment alone compared to controls. Compared to the results of the nicotine-alone treatment group, the ratio of aberrant embryos was marginally reduced by concurrent glucose and nicotine therapy. In contrast, the ratio of normal embryos was raised. Additionally, treatments with glucose, nicotine, and Nic+Glu significantly altered the resting membrane potentials of fertilised oocytes (p < 0.001). Our findings indicated that the simultaneous treatment groups that also received glucose had a protective impact on embryos. Such structured, more sophisticated research is required to confirm these findings.
    Źródło:
    Rocznik Ochrona Środowiska; 2023, 25; 265--273
    1506-218X
    Pojawia się w:
    Rocznik Ochrona Środowiska
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Disturbances of mouse pregnancy after injection of Ascaris homogenate during early organogenesis
    Autorzy:
    Blaszkowska, J
    Powiązania:
    https://bibliotekanauki.pl/articles/838767.pdf
    Data publikacji:
    2000
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    pregnancy
    teratogenicity
    tegumental homogenate
    mouse
    mice
    Ascaris
    Ascaris suum
    organogenesis
    homogenate
    embryotoxicity
    Opis:
    Administration of the Ascaris tegumental homogenate (0.6-1.2 g of Ascaris proteins/kg/day) at a early stage of organogenesis (5-9 days of pregnancy) had a harmful effect upon the developing mouse fetuses. It has been found that injection of the homogenate did not delay or prevent implantation, but causes a high rate of intrauterine deaths. The Ascaris homogenate significantly decreased the number of live fetuses per litter, increased the frequency of litter resorption, produced a delay in bone formation and induced pathological changes of fetal organs and tissues. The congenital malformations were noted in fetuses after injection of higher doses of Ascaris homogenate (exencephaly, craniomeningocele and intemal hydrocephalus). No malformations were noted in control groups and after injection of minimum dose of the homogenate. The symptoms that occurred after administration of the tegumental homogenate to pregnant mice included: decreased body weight gain (p<0.001) as compared to controls, vaginal hemorrhage, intrauterine resorption of litter and mortality. These signs suggest that the Ascaris homogenate causes matemal toxicity.
    Źródło:
    Annals of Parasitology; 2000, 46, 3
    0043-5163
    Pojawia się w:
    Annals of Parasitology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    2-(2-Metoksyetoksy)etanol. Dokumentacja dopuszczalnych wielkości narażenia zawodowego
    2-(2-Methoxyethoxy)ethanol. Documentation
    Autorzy:
    Starek, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/137956.pdf
    Data publikacji:
    2006
    Wydawca:
    Centralny Instytut Ochrony Pracy
    Tematy:
    2-(2-metoksyetoksy)etanol
    embriotoksyczność
    fetotoksyczność
    teratogeneza
    NDS
    2-(2methoxyethoxy)ethanol
    embriotoxicity
    fetotoxicity
    teratogenicity
    MAC value
    Opis:
    2-(2-Metoksyetoksy)etanol (MEE) jest rozpuszczalnikiem organicznym bejc m.in. do: drewna, lakierów, tuszów czy farb tekstylnych. Jest stosowany w: fotografice, przemyśle tworzyw sztucznych i farbiarstwie. W dostępnym piśmiennictwie nie ma danych na temat toksyczności tego związku dla ludzi. Medialna dawka śmiertelna 2-(2-metoksyetoksy)etanolu u szczurów po podaniu dożołądkowym jest bardzo duża (9210 mg/kg m.c.). Po jednorazowym lub wielokrotnym podaniu tego związku dożołądkowo szczurom obserwowano: wzrost aktywności enzymów wskaźnikowych w surowicy krwi, spadek masy ciała i zmianę względnej masy narządów. Podobne objawy, łącznie z hemolizą krwinek, obserwowano w warunkach narażenia powtarzanego na ten związek. Dotychczas nie przeprowadzono badań nad genotoksycznym i rakotwórczym działaniem 2-(2-metoksyetoksy)etanolu. U myszy i szczurów związek ten działał embriotoksycznie, fetotoksycznie i teratogennie. Do obliczenia wartości najwyższego dopuszczalnego stężenia (NDS) 2-(2-metoksyetoksy)etanolu wykorzystano wyniki doświadczenia przeprowadzonego na zwierzętach, w którym szczury narażano na pary 2-(2-metoksyetoksy)etanolu w zakresie stężeń 0 ÷ 1060 mg/m3 przez 13 tygodni. Stężenie 1060 mg/m3 2-(2-metoksyetoksy)etanolu przyjęto za wartość NOAEL w tym doświadczeniu. Stosując odpowiednie współczynniki niepewności, obliczono wartość NDS wynoszącą 133 mg/m3. Zaproponowano przyjęcie stężenia 50 mg/m3 2-(2-metoksyetoksy)etanolu za wartość NDS, zgodnie z projektem dyrektywy Unii Europejskiej. Dodatkowo zalecono oznakowanie substancji literami „Ft” i „Sk” symbolizującymi substancję fetotoksyczną i substancję wchłaniającą się przez skórę. Obecnie nie ma merytorycznych podstaw do zaproponowania wartości najwyższego dopuszczalnego stężenia chwilowego (NDSCh) i dopuszczalnego stężenia w materiale biologicznym (DSB) 2-(2-metoksyetoksy)etanolu.
    2-(2-Methoxyethoxy)ethanol (DEGME) is a colorless liquid with pleasant odour.It is used in variety of industrial applications including the manufacture of plastics, as bases for inks, dyes and cleaners and as deicing agent, and also as diluent for hydraulic brake fluid, and in water-base paints. There are no data available on toxicity of DEGME in humans. In rats treated with this chemical the decrease of body weight and relative organ weights, and also elevated indicator enzyme activities in serum and intravascular hemolysis were observed. There are no available literature data on DEGME genotoxic and carcinogenic activities. This compound exerts embryotoxic, fetotoxic and teratogenic effects. Based on the LOAEL value (1050 mg/m3) obtained in a subchronic experiment in rats and the relevant uncertainty factors, a MAC (TWA) value was calculated at 133 mg/m3. In accordance with project of European Commission Directions the MAC (TWA) value at 50 mg/m3 was suggested. Because DEGME has been shown to penetrate the skin in amounts sufficient to induce systemic toxicity and exerts reproductive toxicity, a skin (“Sk”) and fetotoxic (“Ft”) notations are considered appropriate. No MAC (STEL) value has been established.
    Źródło:
    Podstawy i Metody Oceny Środowiska Pracy; 2006, 1 (47); 171-183
    1231-868X
    Pojawia się w:
    Podstawy i Metody Oceny Środowiska Pracy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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