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    Wyświetlanie 1-3 z 3
    Tytuł:
    Influence of Adriblastin and Bleomycin on Wistar rat mothers and fetus development
    Autorzy:
    Sęk-Mastej, Anna
    Galiniak, Sabina
    Krawczyk-Marć, Izabela
    Balawender, Krzysztof
    Szymczak, Artur
    Kaniewski, Maciej
    Leksa, Natalia
    Biesiadecki, Marek
    Orkisz, Stanisław
    Powiązania:
    https://bibliotekanauki.pl/articles/454733.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    pregnancy
    foetus
    congenital defect
    teratogen
    Opis:
    Introduction. Gestation is a very sensitive time both to mother and child. Any substance, factor, or environmental condition disturbing homeostasis may cause congenital defects, anomalies or even death. Teratology evaluates those potential factors and their influence. Also, medicinal products used during pregnancy may be teratogenic. Adriblastin, also known as Doxorubicin, and Bleomycin are widely used cytostatic drugs in oncology. Aim. Aim of this study was to evaluate the embryotoxic effects of Doxorubicin and Bleomycin in an animal model. Materials and methods. Fertilised Wistar rat females were given each drug intraperitoneally between the 8th and 15th gestation day, and compared to control group receiving placebo (distilled water, 0.9% NaCl). Another group received acetyl salicylic acid, as a model, well known teratogen. Changes in mothers’ weight from baseline, implantation of embryos, any discrepancies in mothers wombs and health as well as defects in fetuses were evaluated and compared. Fetus skeletons were stained by Dowson’s method to visualise bone defects. Results and conclusion. Both Adriblastin and Bleomycin were teratogenic, producing significantly more embryo absorptions, and fetal defects compared to placebo. The effects of the two cytostatics were similar to the model teratogen acetyl salicylic acid.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 2; 85-91
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Developmental abnormalities in chicken embryos after injection proteolysis inhibitors from Ascaris suum
    Autorzy:
    Błaszkowska, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/2147678.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    Ascaris suum
    teratogen
    proteolysis inhibitor
    developmental abnormality
    inhibitor
    chicken embryo
    injection
    Opis:
    It bas been found that trypsin and α-chymotrypsin inhibitors isolated from Ascaris suum act embryotoxically and teratogenically on White Leghorn clucken embryos. Mortatity rate for the chicken embryos on day 15 of incubation was 45.0 ± 3.5% after injection of trypsin inbibitor and 44.0 ± 3.5% after adminstration α-chymotrypsin inbibitor. Gross examination of surviving embryos and their dissection revealed pathological changes (abdominal dropsy, umbilical hernia, subcutaneous oedema, hemoperitoneum, hemopericardium), symptoms indicating retardation in growth (lack of down, retarded ossification of long bones, decreased mean body weight) as well as malformations (schistocelia, micrognathia, cyclopia, crossed beak, cranial deformities) after injection of inhibitors from Ascaris. The highest incidence of embryos with pathological changes and malformations was found after administralion of α-chymotrypsin inbibitor. The most commonly occurring abnormality was schistocelia (21.4 ± 3.88%). Growth malformations were not found in the control groups. The trypsin and α-chymotrypsin inhibitors present in Ascaris homogenate have a significant disturbing effect on the development of the chicken embryo.
    Źródło:
    Wiadomości Parazytologiczne; 2002, 48, 1; 55-64
    0043-5163
    Pojawia się w:
    Wiadomości Parazytologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Developmental abnormalities in chicken embryos after injection proteolysis inhibitors from Ascaris suum
    Autorzy:
    Blaszkowska, J
    Powiązania:
    https://bibliotekanauki.pl/articles/840466.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    Ascaris suum
    teratogen
    proteolysis inhibitor
    developmental abnormality
    inhibitor
    chicken embryo
    injection
    Opis:
    It bas been found that trypsin and α-chymotrypsin inhibitors isolated from Ascaris suum act embryotoxically and teratogenically on White Leghorn clucken embryos. Mortatity rate for the chicken embryos on day 15 of incubation was 45.0 ± 3.5% after injection of trypsin inbibitor and 44.0 ± 3.5% after adminstration α-chymotrypsin inbibitor. Gross examination of surviving embryos and their dissection revealed pathological changes (abdominal dropsy, umbilical hernia, subcutaneous oedema, hemoperitoneum, hemopericardium), symptoms indicating retardation in growth (lack of down, retarded ossification of long bones, decreased mean body weight) as well as malformations (schistocelia, micrognathia, cyclopia, crossed beak, cranial deformities) after injection of inhibitors from Ascaris. The highest incidence of embryos with pathological changes and malformations was found after administralion of α-chymotrypsin inbibitor. The most commonly occurring abnormality was schistocelia (21.4 ± 3.88%). Growth malformations were not found in the control groups. The trypsin and α-chymotrypsin inhibitors present in Ascaris homogenate have a significant disturbing effect on the development of the chicken embryo.
    Źródło:
    Annals of Parasitology; 2002, 48, 1
    0043-5163
    Pojawia się w:
    Annals of Parasitology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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