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    Wyświetlanie 1-4 z 4
    Tytuł:
    Identification of miRNAs and their potential targets in halophyte plant Thellungiella halophila
    Autorzy:
    Panahi, B.
    Mohammadi, S.A.
    Ebrahimie, E.
    Powiązania:
    https://bibliotekanauki.pl/articles/81192.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    microRNA
    gene expression
    halophytic plant
    Thellungiella halophila
    Expressed Sequence Tag programme
    target protein
    gene identification
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Dual regulation of cytosolic ascorbate peroxide (APX) by tyrosine nitration and S-nitrosylation
    Autorzy:
    Begara-Morales, J.
    Sanchez-Calvo, B.
    Chaki, M.
    Valderrama, R.
    Mata-Perez, C.
    Lopez-Jaramillo, J.
    Carreras, A.
    Padilla, M.
    Corpas, F.
    Barroso, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/80378.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    post-translational modification
    nitric oxide
    target protein
    ascorbate peroxidase
    tyrosine nitration
    S-nitrosylation
    salinity stress
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The importance of grain legumes for a domestic protein security
    Autorzy:
    Święcicki, Wojciech
    Szukała, Jerzy
    Rutkowski, Andrzej
    Jerzak, Michał
    Mikulski, Wojciech
    Górynowicz, Barbara
    Powiązania:
    https://bibliotekanauki.pl/articles/2147937.pdf
    Data publikacji:
    2020-09
    Wydawca:
    Instytut Uprawy Nawożenia i Gleboznawstwa – Państwowy Instytut Badawczy
    Tematy:
    feed protein
    soya meal
    domestic protein sources
    indicator target
    Opis:
    Soya meal is the main high protein source in feeding pigs and poultry. Taking into account the annual value of domestic import, limited soya seed producers (USA, Argentina, Brasil) and China as the main soya seed importer (66 percent of the world import), a use of alternative protein sources (grain legumes, rape meal, DDGS) seems to be justified. An additional reason for a so called protein security in Poland are the feed regulations prohibiting a usage of GM products in feeding. Polish Government launched research projects for two periods (2011–2015 and 2016–2020) to solve main problems related to increased production and usage of domestic protein sources in animals feeding. Main strategies and research results of four areas – grain legume genetics and breeding, cropping technologies, pigs and poultry feeding and economic aspects of production, market infrastructure and turnover of domestic protein crops – are presented in the paper. Satisfactory is an increase of acreage under grain legumes in Poland – from 100 thousand ha in 2011 to 300 thousand ha in 2019. At present, given the availability of domestic grain legumes and rape meal it is possible to decrease soya meal imports up to 60–50 percent. Over the past decade, a strong increase of poultry meat production (about 120 percent) with a rather small increase of soya meal imports (about 18 percent) is also as optimistic tendency. A lasting solution may be achieved by setting a national/ European indicator target that would put the mandatory share of domestic protein sources in feed mixes at 10–20%, and creation of Polish feed companies, competitive to foreign, both large and mobile feed mixing plants, using the farmer’s raw materials.
    Źródło:
    Polish Journal of Agronomy; 2020, 42; 46-50
    2081-2787
    Pojawia się w:
    Polish Journal of Agronomy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Prioritizing and modelling of putative drug target proteins of Candida albicans by systems biology approach
    Autorzy:
    Ismail, Tariq
    Fatima, Nighat
    Muhammad, Syed
    Zaidi, Syed
    Rehman, Nisar
    Hussain, Izhar
    Tariq, Najam us
    Amirzada, Imran
    Mannan, Abdul
    Powiązania:
    https://bibliotekanauki.pl/articles/1038391.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Candida albicans
    drug target identification
    protein modeling
    Opis:
    Candida albicans (Candida albicans) is one of the major sources of nosocomial infections in humans which may prove fatal in 30% of cases. The hospital acquired infection is very difficult to treat affectively due to the presence of drug resistant pathogenic strains, therefore there is a need to find alternative drug targets to cure this infection. In silico and computational level frame work was used to prioritize and establish antifungal drug targets of Candida albicans. The identification of putative drug targets was based on acquiring 5090 completely annotated genes of Candida albicans from available databases which were categorized into essential and non-essential genes. The result indicated that 9% of proteins were essential and could become potential candidates for intervention which might result in pathogen eradication. We studied cluster of orthologs and the subtractive genomic analysis of these essential proteins against human genome was made as a reference to minimize the side effects. It was seen that 14% of Candida albicans proteins were evolutionary related to the human proteins while 86% are non-human homologs. In the next step of compatible drug target selections, the non-human homologs were sequentially compared to the human microbiome data to minimize the potential effects against gut flora which accumulated to 38% of the essential genome. The sub-cellular localization of these candidate proteins in fungal cellular systems indicated that 80% of them are cytoplasmic, 10% are mitochondrial and the remaining 10% are associated with the cell wall. The role of these non-human and non-gut flora putative target proteins in Candida albicans biological pathways was studied. Due to their integrated and critical role in Candida albicans replication cycle, four proteins were selected for molecular modeling. For drug designing and development, four high quality and reliable protein models with more than 70% sequence identity were constructed. These proteins are used for the docking studies of the known and new ligands (unpublished data). Our study will be an effective framework for drug target identifications of pathogenic microbial strains and development of new therapies against the infections they cause.
    Źródło:
    Acta Biochimica Polonica; 2018, 65, 2; 209-218
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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