- Tytuł:
- Pathways of tRNA turnover in eukaryotic cells
- Autorzy:
- Turowski, T. W.
- Powiązania:
- https://bibliotekanauki.pl/articles/115770.pdf
- Data publikacji:
- 2011
- Wydawca:
- Fundacja na Rzecz Młodych Naukowców
- Tematy:
-
tRNA turnover
rapid tRNA decay
polymerase III - Opis:
- Cell ability to control amount of a transfer RNA is one of the ways to regulate rate of protein synthesis. Because 80–90% dry mass of cells are proteins, the level of translation is determinant to the cell growth. Growth of cells is a key question in tumors therapy and biotechnology. tRNA turnover consist of a three pathways described in a last few years: exosome and TRAMP complex dependent pathway in nucleus, directed to hypomodified or affected tRNA; rapid tRNA decay pathway involving two 5’–3’ exonucleases Rat1 and Xrn1, proposed to occur in nucleus and cytoplasm; stress-activated endonucleolytic cleavage to tRNA halves pathway, founded in cytoplasm with a clear role to direct regulation of translation by tRNA half-molecules inhibition.
- Źródło:
-
Challenges of Modern Technology; 2011, 2, 2; 63-65
2082-2863
2353-4419 - Pojawia się w:
- Challenges of Modern Technology
- Dostawca treści:
- Biblioteka Nauki