Temat: synthase activity - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Histochemical study of the nitric oxide synthase activity in experimental trichinellosis
Autorzy:: Hadas, E.
Gustowska, L.
Boczon, K.
Janczewska, D.
Powiązania:: https://bibliotekanauki.pl/articles/837102.pdf
Data publikacji:: 1998
Wydawca:: Polskie Towarzystwo Parazytologiczne
Tematy:: parasite
nitric oxide synthase
mouse
mice
trichinellosis
enzyme
nitric oxide
Trichinella spiralis
synthase activity
Źródło:: Annals of Parasitology; 1998, 44, 3
0043-5163
Pojawia się w:: Annals of Parasitology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: The relationship between -C344/T aldosterone synthase (CYP11B2) gene polymorphism, enzyme activity level and increased risk of nonvalvular atrial fibrillation
Autorzy:: Yatskevich, Karsiaryna
Snezhitskiy, Viktor
Kurbat, Mikhail
Stepuro, Tatiana
Powiązania:: https://bibliotekanauki.pl/articles/552139.pdf
Data publikacji:: 2015
Wydawca:: Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:: atrial fibrillation, -C344/T aldosteronsynthase (CYP11B2) gene polymorphism
aldosterone synthase activity
Źródło:: Family Medicine & Primary Care Review; 2015, 2; 136-139
1734-3402
Pojawia się w:: Family Medicine & Primary Care Review
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Histochemical study of the nitric oxide synthase activity in experimental trichinellosis
Autorzy:: Hadaś, E.
Gustowska, L.
Boczoń, K.
Janczewska, D.
Powiązania:: https://bibliotekanauki.pl/articles/2148736.pdf
Data publikacji:: 1999
Wydawca:: Polskie Towarzystwo Parazytologiczne
Tematy:: toxic property
trichinellosis
nitric oxide
morphological transformation
parasitology
muscle cell
signalling property
infectious disease
physiological function
synthase activity
histochemistry
Opis:: Nitric oxide plays a critical role in a variety of biological acfivities. It has been nicknamed a ,,killer'' and ,,mediator" due to its toxic and signalling properties. Apart from its regular physiological function, nitric oxide indirectly participates in infectious diseases. Our report seems to be first presentation of the nitric oxide synthase participation in the host biochemical defence mechanisms and in morphological transformation of muscle cells in trichinellosis.
Źródło:: Wiadomości Parazytologiczne; 1999, 45, 1; 63-68
0043-5163
Pojawia się w:: Wiadomości Parazytologiczne
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Histochemical study of the nitric oxide synthase activity in experimental trichinellosis
Autorzy:: Hadas, E
Gustowska, L.
Boczon, K.
Janczewska, D.
Powiązania:: https://bibliotekanauki.pl/articles/839127.pdf
Data publikacji:: 1999
Wydawca:: Polskie Towarzystwo Parazytologiczne
Tematy:: toxic property
trichinellosis
nitric oxide
morphological transformation
parasitology
muscle cell
signalling property
infectious disease
physiological function
synthase activity
histochemistry
Opis:: Nitric oxide plays a critical role in a variety of biological acfivities. It has been nicknamed a ,,killer'' and ,,mediator" due to its toxic and signalling properties. Apart from its regular physiological function, nitric oxide indirectly participates in infectious diseases. Our report seems to be first presentation of the nitric oxide synthase participation in the host biochemical defence mechanisms and in morphological transformation of muscle cells in trichinellosis.
Źródło:: Annals of Parasitology; 1999, 45, 1
0043-5163
Pojawia się w:: Annals of Parasitology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Allelic polymorphism of endothelial NO-synthase gene and its functional manifestations
Autorzy:: Dosenko, Victor
Zagoriy, Vyacheslav
Haytovich, Nikolay
Gordok, Olga
Moibenko, Alexey
Powiązania:: https://bibliotekanauki.pl/articles/1041240.pdf
Data publikacji:: 2006
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: activity of nitric oxide synthase
endothelial nitric oxide synthase
RNA expression
platelets
allelic polymorphism
Opis:: Investigation of the mechanisms of phenotypic realization of allelic polymorphism of the eNOS gene has shown that the level of eNOS mRNA and activity of this enzyme in platelets depends from genotype. We identified a T-786→C polymorphism in the promoter region, a variable number of tandem repeats (4a/4b) in intron 4 and the G894→T polymorphism in exon 7 of the eNOS gene in isolated human platelets. We measured eNOS mRNA in isolated platelets by reverse transcription-PCR and eNOS enzyme activity by fluorimetric detection system FCANOS-1 using diaminofluorescein diacetate (DAF-2A). It was shown that the level of eNOS mRNA is the lowest for the -786C/C promoter genotype. In exon 7 homozygotes (894T/T) the level of RNA is lower than in normal homozygotes (894G/G), but higher than in heterozygotes (894G/T). The eNOS activity in platelets is lower in carriers of the 786C/C promoter genotype than in normal homozygotes (2.1 × P=0.03), and lower comparing to heterozygotes (2.9 × P>0.05). The eNOS activity accompanying the 894T/T variant of exon 7 is also lower than in normal homozygotes (P>0.05). Regarding the polymorphism in intron 4 - the enzyme's activity is lower in carriers of the 4a/4a genotype comparing to normal homozygotes (1.7 × P>0.05) and lower than in heterozygotes (1.9 × P>0.05). These results allow one to conclude that the T-786→C polymorphism of the eNOS gene promoter most significantly affects the gene expression and eNOS activity.
Źródło:: Acta Biochimica Polonica; 2006, 53, 2; 299-302
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Farnesyl diphosphate synthase; regulation of product specificity.
Autorzy:: Szkopińska, Anna
Płochocka, Danuta
Powiązania:: https://bibliotekanauki.pl/articles/1041460.pdf
Data publikacji:: 2005
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: modulation of enzyme activity
dimer structure
gene family
FPP synthase
Opis:: Farnesyl diphosphate synthase (FPPS) is a key enzyme in isoprenoid biosynthesis which supplies sesquiterpene precursors for several classes of essential metabolites including sterols, dolichols, ubiquinones and carotenoids as well as substrates for farnesylation and geranylgeranylation of proteins. It catalyzes the sequential head-to-tail condensation of two molecules of isopentenyl diphosphate with dimethylallyl diphosphate. The enzyme is a homodimer of subunits, typically having two aspartate-rich motifs with two sets of substrate binding sites for an allylic diphosphate and isopentenyl diphosphate per homodimer. The synthase amino-acid residues at the 4th and 5th positions before the first aspartate rich motif mainly determine product specificity. Hypothetically, type I (eukaryotic) and type II (eubacterial) FPPSs evolved from archeal geranylgeranyl diphosphate synthase by substitutions in the chain length determination region. FPPS belongs to enzymes encoded by gene families. In plants this offers the possibility of differential regulation in response to environmental changes or to herbivore or pathogen attack.
Źródło:: Acta Biochimica Polonica; 2005, 52, 1; 45-55
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Facilitated diffusion of glucosamine-6-phosphate synthase inhibitors enhances their antifungal activity.
Autorzy:: Janiak, Agnieszka
Cybulska, Barbara
Szlinder-Richter, Joanna
Borowski, Edward
Milewski, Sławomir
Powiązania:: https://bibliotekanauki.pl/articles/1043810.pdf
Data publikacji:: 2002
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: diffusion
liposomes
antifungal activity
synergism
GlcN-6-P synthase
Opis:: N3-(4-Methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP) and 2-amino-2-deoxy-D-glucitol-6-phosphate (ADGP) are strong inhibitors of the essential fungal enzyme, glucosamine-6-phosphate synthase, but their antifungal activity is poor, due to slow penetration of these agents through the cytoplasmic membrane. In the present studies we have exploited the possibility of enhancement of ADGP and FMDP antifungal activity by improving their transport properties. It has been found that membrane-permeabilising polyene macrolides amphotericin B (AMB) and its N-methyl-N-fructosyl methyl ester derivative (MF-AME), at subinhibitory concentrations, facilitate diffusion of ADGP through the fungal cell membrane, thus allowing a decrease of its minimal inhibitory concentration (MIC). Synergistic effects have been observed for combinations of ADGP with AMB or MF-AME. Fractional inhibitory concentration (FIC) indexes, determined against a number of Candida spp., have been in the 0.18-0.81 range. Weak antifungal synergistic effects have been found for combinations of FMDP with AMB or MF-AME. ADGP can be easily encapsulated into unilamellar lipid vesicles. Liposomal preparations of ADGP demonstrated stronger antifungal activity against some fungal strains than free ADGP.
Źródło:: Acta Biochimica Polonica; 2002, 49, 1; 77-86
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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