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Wyszukujesz frazę "succinoyl chitosan nanoparticles" wg kryterium: Temat


Wyświetlanie 1-2 z 2
Tytuł:
Biodistribution of doxorubicin-loaded succinoyl chitosan nanoparticles in mice injected via intravenous or intranasal routes
Autorzy:
Zubareva, Anastasia
Shcherbinina, Tatyana
Varlamov, Valery P.
Svirshchevskaya, Elena
Powiązania:
https://bibliotekanauki.pl/articles/1035197.pdf
Data publikacji:
2014
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
biodistribution
doxorubicin
succinoyl chitosan nanoparticles
Opis:
Chitosan (Chi) is an extremely promising natural biopolymer with remarkable potency for the development of drug and vaccine delivery nanosystems. Various Chi derivatives are used to form nanoparticles (NPs) with unique properties. However, the efficacy of the therapy delivered by Chi NPs depends significantly on NP biodistribution in the body. The aim of this study was the analysis of biodistribution of NPs formed by succinoyl Chi and loaded with doxorubicin (SCNPDOX). We compared the distribution of free DOX and SCNP-DOX after intravenous (i.v.) and intranasal (i.n.) delivery into tumour-bearing mice. Distribution of DOX and SCNP-DOX was comparable after i.v. injection while they differed significantly after i.n. instillation.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 145-154
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Formation and characterization of succinoyl chitosan particles loaded with warnerin
Autorzy:
Shagdarova, Balzhima Ts
Ilyina, Alla V.
Lopatin, Sergey A.
Korobov, Vladimir P.
Lemkina, Larisa M.
Varlamov, Valery P.
Powiązania:
https://bibliotekanauki.pl/articles/1034836.pdf
Data publikacji:
2015
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
chitosan nanoparticles
coacervation method
succinoyl chitosan
warnerin
Opis:
This study aims to obtain nanoparticles based on succinoyl chitosan loaded with Warnerin (War-SCNPs), low molecular weight cationic peptide. The nanoparticles of succinoyl chitosan (SCNPs) were prepared by salt coacervation method, and Warnerin loading efficiency on SCNPs was reached 75% in the optimum conditions, particularly, ration (SCNPs : peptide) was equal to (1.75 : 1, μg / ml ). Formed War-SCNPs were stable, had a weak electric charge from (-4.4) to (-14,6) mV. Determining of SCNPs size showed that a main fraction of SCNPs had the size of 160 nm, and after the peptide sorption War-SCNPs size increased up to 330 nm. The experimental data of this study will likely impact War-SCNPs use as therapeutic delivery systems of the peptide to be administered parenteral.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2015, 20; 246-253
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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