Temat: streptozotocin - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Ultrastructural haemomicrocircular channel links of rat testicle in streptozotocin-induced diabetes
Autorzy:: Kryvko, Y.
Mateshuk-Vatseba, L.
Savka, I.
Luszczewska-Sierakowska, I.
Wawrzyniak, A.
Radzikowska, E.
Maciejewski, R.
Powiązania:: https://bibliotekanauki.pl/articles/3590.pdf
Data publikacji:: 2014
Wydawca:: Instytut Medycyny Wsi
Tematy:: ultrastructure
hemomicrocircular channel
tissue
seminal duct
arteriole
rat
testicle
streptozotocin
diabetes
Opis:: Abstract The first changes in rat testicle haemomicrocircular channel links ultrastructural arrangement are noticed already in a 2-week run of streptozotocin-induced diabetes mellitus, and accumulate throughout next periods of the experiment. Angiopathy is a trigger mechanism for diabetic development of testicle structural changes. This finding is a basis for further morphologist and clinicist surveys for the purpose of new diabetic testicle pathology diagnostics, prevention, and elaboration of treatment techniques.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2014, 08, 2
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Efficacy of Lepidium Sativum to act as an anti-diabetic agent
Autorzy:: Mishra, N.
Mohammed, A.
Rizvi, S.I.
Powiązania:: https://bibliotekanauki.pl/articles/1918412.pdf
Data publikacji:: 2017
Wydawca:: Uniwersytet Medyczny w Białymstoku
Tematy:: Lepidium sativum
diabetes
insulin
streptozotocin
oxidative stress
cholesterol
Opis:: Objective: Lepidium sativum, commonly known as chandrashoor in India, has been used in the Indian traditional medicine system for the treatment of various diseases. The present study was undertaken to investigate the hypoglycemic effect of Lepidium sativum in normal and streptozotocin-induced diabetic rats. Materials and methods: Thirty (30) adult male Wistar rats weighing 157±51g were randomly assigned to five groups of six rats each as Normal control, Diabetic control, Diabetics supplemented with Lepidium sativum extract, Diabetics treated with insulin, and Normal rats supplemented with Lepidium sativum. All rats were fed with a normal laboratory diet, nutrient rich pellets, and had free access to drinking water. The rats were injected with streptozotocin at a dose of 45 mg/kg body weight intraperitoneally to induce diabetes. The extracts were then given orally to different groups of rats at a dose of 20mg/kg body weight for 16 days. Thereafter, the rats were sacrificed, and blood samples collected by cardiac puncture were used for the determination of Glucose, Creatinine, Alkaline Phosphatase, Cholesterol, Malondialdehyde level, % DPPH, and FRAP content. Results: Administration of lepidium extract showed a significant reduction in glucose, creatinine, and alkaline phosphatase levels. Elevated cholesterol level was restored approximately to normal; a significant decrease in malondialdehyde levels was also observed compared to diabetic controls. Conclusion: Lepidium sativum extract shows efficacy in the prevention and management of diabetes mellitus and its related complications.
Źródło:: Progress in Health Sciences; 2017, 7(1); 44-53
2083-1617
Pojawia się w:: Progress in Health Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Macrophages in Diabetes Mellitus: A Review on Understanding of Macrophage Function
Autorzy:: Chatterjee, Susraba
Guria, Srikanta
Powiązania:: https://bibliotekanauki.pl/articles/1059398.pdf
Data publikacji:: 2019
Wydawca:: Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:: Alloxan
Beta-cell Therapy
Cytokines
Diabetes mellitus
Diabetic Nephropathy
Diabetic Retinopathy
Macrophage
Macrophage Type 1
Macrophage Type 2
Streptozotocin
Opis:: Diabetes mellitus (DM) causes millions of deaths all over the world. Immune system contains macrophages that play very important role in DM. Excessive secretion of different cytokines can induce the DM development. Diabetes mellitus (DM) also affect the function of macrophage. We review the important findings regarding the role of macrophage in DM. This review may emphasize future direction towards development of novel immune-modulatory therapeutic intervention.
Źródło:: World Scientific News; 2019, 134, 2; 319-325
2392-2192
Pojawia się w:: World Scientific News
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Female mouse model of diabetes mellitus induced by streptozotocin and high-carbohydrate high-fat diet
Autorzy:: Guo, R.
Dong, J.
Wang, D.Q.
Gu, Y.F.
Powiązania:: https://bibliotekanauki.pl/articles/16627528.pdf
Data publikacji:: 2022
Wydawca:: Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:: diabetes mellitus
female mouse
pathological analysis
streptozotocin
high-carbohydrate high-fat diet
Opis:: With the improvement of people’s living standards and rapid economic development, the incidence of diabetes mellitus (DM) is increasing in most parts of the world. DM presents an important potential threat to human health. In the present study, a model of diabetes in female mice was established, and fasting blood glucose was detected at week 4, after which the biochemical profiles were evaluated by histopathological analysis. The success rate of modeling in the normal control (NC) group and the low/ middle/high-dose streptozotocin (STZ) group were 0, 0, 25% and 60%, respectively. In the middle-dose and high-dose STZ groups, the liver index was increased significantly compared with the NC group (p<0.05). The blood biochemical indicators of total cholesterol and low density lipoprotein cholesterol in three STZ injection groups were as follows: alanine aminotransferase and aspartate transaminase in middle- and high-dose STZ groups, high-density lipoprotein cholesterol and serum creatinine in the high-dose STZ group, and blood urea nitrogen in the middle-dose STZ group were significantly increased (p<0.05). The level of total triglycerides was lower, obviously, in the high-dose STZ group than in the NC group (p<0.05). The mice showed marked steatosis, green-dyed fiber tissue coloring in varying degrees, and the contour of the hepatic lobules basically disappeared in STZ injection groups. The results suggest that to establish a diabetes model for female ICR mice, the optimum dose of STZ is 100 mg/kg.
Źródło:: Polish Journal of Veterinary Sciences; 2022, 25, 4; 547-555
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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