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Wyszukujesz frazę "steroid" wg kryterium: Temat


Tytuł:
Efficacy of oral steroid therapy in the treatment of acute maculopathy in the course of hand, foot and mouth disease - 3 case reports
Skuteczność doustnej steroidoterapii w leczeniu ostrej makulopatii będącej powikłaniem choroby dłoni, stóp i ust w oparciu o analizę trzech przypadków
Autorzy:
Cywiński, Adam
Ferda-Lewińska, Daniela
Gacek, Marcin
Powiązania:
https://bibliotekanauki.pl/articles/6567721.pdf
Data publikacji:
2023-03-31
Wydawca:
Medical Education
Tematy:
hand foot and mouth disease
retinitis
steroid therapy
sudden visual loss
bostonka
zapalenie siatkówki
steroidoterapia
nagła utrata widzenia
Opis:
Oral steroid therapy was administered in three patients with skin symptoms, diagnosed with hands, mouth and foot disease (HMFD, commonly known as “Boston’s disease”) and in the course of which there was a rapid deterioration of vision in one eye. Each of the patients had previous contact with a person with disease. Hospitalization of the first patient, during which general antibiotic therapy, antiviral drugs and short-term intravenous steroid therapy were used, brought only a slight improvement in visual acuity. Given the accompanying colour discrimination dysfunction, oral steroid therapy was introduced in this patient, already in the outpatient setting. The therapy brought a significant improvement in visual acuity in a short time and restored the ability to distinguish colours. This form of treatment was used in another two patients with similar, good result.
U trzech pacjentów z objawami skórnymi, u których rozpoznano chorobę dłoni, stóp i jamy ustnej (HMFD, hands, mouth and foot disease, potocznie zwaną „bostonką”) i u których w jej przebiegu doszło do jednostronnego, gwałtownego pogorszenia widzenia, zastosowano steroidoterapię doustną. Każdy z pacjentów miał wcześniej kontakt osobą chorą. Hospitalizacja pierwszego pacjenta, w trakcie której zastosowano ogólną antybiotykoterapię, leki przeciwwirusowe oraz krótkotrwałą dożylną steroidoterapię, przyniosła tylko nieznaczną poprawę ostrości wzroku. Ze względu na towarzyszącą dysfunkcję w zakresie rozróżniania barw u tego pacjenta wprowadzono doustną steroidoterapię już w trybie leczenia ambulatoryjnego. Przyniosła ona w krótkim czasie znaczącą poprawę ostrości wzroku oraz przywróciła możliwość rozróżniania barw. Tę formę leczenia zastosowano u kolejnych dwóch pacjentów, z podobnym, korzystnym efektem.
Źródło:
OphthaTherapy; 2023, 10, 1; 48-56
2353-7175
2543-9987
Pojawia się w:
OphthaTherapy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hormony steroidowe, leki przeciwzapalne, pigułki antykoncepcyjne. związki i ludzie : notatki historyczne (część I i II)
Hormones, antiinflammatory drugs, contraceptive pills. compounds and the people : historic notes (part I and II)
Autorzy:
Wicha, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1409983.pdf
Data publikacji:
2021
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
notatki historyczne
steroidy
hormony płciowe
kortykosteroidy
pigułki antykoncepcyjne
transformacje steroidowe
synteza totalna
historic notes
steroids
sex hormones
corticosteroids
contraceptive pills
steroid transformations
total synthesis
Opis:
A short historical outlook of steroid hormones isolation, structure elucidation and hormonal drugs development following by a survey of contraceptive therapeutics syntheses and advancements is given. Structural evolution of the first pills, “the pill”, to the presently used oral contraceptives for women is scrutinized. Comments on activities of selected major researchers in the field: Josef Fried, Russell E. Marker, Arthur J. Birch, Carl Djerassi, Georgy G. Pincus, M. C. Chang, John Rock, Igor V. Torgov, Zoltan G. Hajos and Herchel Smith from the personal prospect are presented. Steroid sex hormones, estrogens (female), androgens (male) and gestagens (progesterone, pregnancy hormone) were isolated and identified as chemical entities in 20-tiest and 30-ties of the 20th century. Development of partial synthesis of basic hormones from cholesterol made possible the initial steroid drugs production: Testosterone propionate and 17a-Methyltestosterone (Ciba) as well as Proviron, Progynon, Proluton (Schering AG). In 1940th and 1950th corticosteroids were isolated and recognized as “magic” anti-inflammatory and antiarthritic drugs. Growing demand for antiarthritic drugs in 1950th stimulated search for new corticosteroid analogues and new steroid row materials. Exploration of Mexican plant Dioscorea “cabeza” by Synthex SA provided economical starting material, diosgenin, and opened the new prospects for hormonal drug research and the production. Subsequently, highly active corticosteroid analogues were developed by several pharmaceutical companies and 19-norprogesterone analogues of high gestagenic activity were synthesized - Norethisterone (Synthex) and Norethyndrel (Searle). Complex studies on the application of Norethyndrel as oral contraceptive for women were carried out in the Worcester Foundation for Experimental Biology. In 1959 the first drug “the pill”, which was developed on the grounds of Searls’ Norethyndrel - Enovid was registered by Food and Drug Administration in the USA. Shortly after that Norlutin, based upon Synthex’s Norethisterone, had also been approved for application. Commercial success of “the pill”, Enovid and Norlutin, triggered a broad research aimed at the partial synthesis and application of related progesterone analogues. In the end of 1950th and the beginning of 1960th the total synthesis of estrogens and 19-norsteroids gained practical importance. On these grounds Norgestrel and its active enancjomer Levonorgestrel were developed and commercialized by Wyeth Laboratories Inc. in the USA as the first contraceptive products by total synthesis. Starting from 1970th medicinal applications of corticosteroids gradually diminished, whereas growing attention was given to the development of hormonal contraceptives suitable for general application. Several synthetic modifications of Norethisterone and Levonorgestrel were developed and produced in a large scale. Another class of oral contraceptives stem from the steroid total synthesis developed in the Russell Uclaf laboratories. Structurally these compounds are characterized by 19-norsteroid core and the presence of bulky substituent at the position 11ß, as 4-(N,N-dimethylamino)phenyl- in Mifepristone (RU 486). The synthesis of 19-norpregnane derivatives bearing at the position 11ß various large aromatic or alphatic groups, which currently is receiving a great deal of attention, is considered.
Źródło:
Wiadomości Chemiczne; 2021, 75, 5-6; 677-753
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Treatment outcomes of peri-articular steroid injection for patients with work-related sacroiliac joint pain and lumbar para-spinal muscle strain
Autorzy:
Medani, Khalid
Bvute, Kushinga
Narayan, Natasha
Reis, Cesar
Sharip, Akbar
Powiązania:
https://bibliotekanauki.pl/articles/2086116.pdf
Data publikacji:
2021-01-07
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
sacroiliac joint pain
peri-articular steroid injection
trigger point injection
lumbar strain
para-spinal muscle strain
work-related low back pain
Opis:
ObjectivesEvaluating treatment outcomes of local corticosteroid injections for work-related lower back pain (LBP) as the current evidence for the American College of Occupational and Environmental Medicine guidelines is considered insufficient to recommend this practice.Material and MethodsThe authors conducted a retrospective study involving the patients who were treated with peri-articular and lower lumbar corticosteroid injections for work-related LBP at their occupational medicine clinic.ResultsSixty-four patients met the inclusion criteria. The average pain level was reduced from M±SD 5.1±2.0 to M±SD 3.1±2.3 after the corticosteroid injection (p < 0.0001). Thirty-five patients (55%) were discharged to regular duty; 23 (36%) were transferred to orthopedics due to persistent pain; and 6 (9%) were lost to follow-up.ConclusionsCorticosteroid injections for work-related LBP are effective in reducing pain and enhancing discharge to regular duty. Nonetheless, larger prospective trials are needed to validate these findings.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2021, 34, 1; 111-120
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Adrenomyeloneuropathy – a case report
Autorzy:
Leksa, Natalia
Aebisher, David
Galiniak, Sabina
Uberman-Kluz, Dominika
Bartosz, Serweryn
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/454995.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
adrenoleukodystrophy
fatty acids
steroid therapy
Opis:
Introduction. Adrenoleukodystrophy is a genetic disorder linked to the X chromosome, in which the peroxisomal beta-oxidation process is disturbed. It is a metabolic disease that results in the accumulation of very long chain fatty acids (VLCFAs - very long chain fatty acids) responsible for the symptoms of damage to the adrenal cortex, gonads and the brain. Aim. A clinical case is reported. Description of case. This article describes the case of a 64-year-old woman who had neurological symptoms for many years, gradually increasing without significant improvement after the treatment (periodic steroid therapy). Conclusion. Based on tests (including the determination of the ABCD1 gene and very long chain fatty acids - VLCFA), adrenoleukodystrophy was suspected.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 3; 274-276
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Roux-en-Y gastric bypass as a cure of iatrogenic steroid-induced diabetes
Autorzy:
Poznanska, Grazyna
Hogendorf, Piotr
Czupryniak, Leszek
Smolewski, Piotr
Grząsiak, Oliwia
Szmiel, Aneta
Kasiarz, Anna
Strzelczyk, Janusz
Durczyński, Adam
Powiązania:
https://bibliotekanauki.pl/articles/1392077.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
bariatric surgery
cure
iatrogenic diabetes
Roux-en-Y gastric bypass
steroid induced diabetes
treatment
Opis:
Background: Steroid-induced diabetes (SIDM) is a frequently found clinical condition since steroid-based therapies continue to be widely used in hospital and ambulatory care. Recommended optimal treatment of SIDM includes similar glucose lowering strategies as in type 2 diabetes. This typical management cannot cure the disease, it can only control blood glucose. Recently, bariatric surgery has emerged as an effective treatment for type 2 diabetes mellitus. However, up to now, the usefulness of bariatric surgery in treatment of SIDM has not been evaluated. Case report: A 49-year-old female oncologic patient with steroid induced diabetes was referred for surgical treatment to the Department of General and Transplant Surgery in November 2009. Six years earlier, she underwent successful oncologic treatment with cladribine and high doses of steroids due to hairy cell leukemia. Finally complete hematologic remission with normalization of morphology and reduction of spleen size has been obtained. Prior to steroid treatment, blood glucose and urine examinations were within normal range. The patient was non-obese and had no family history of diabetes. Nevertheless, the patient developed diabetes secondary to corticosteroid therapy, poorly controlled by oral hypoglycemic agent (acarbosum), successfully converted to insulin therapy. Upon admission to the Department of General and Transplant Surgery, the patient was treated with 58 units of insulin per day. The patient was scheduled for Roux-en-Y gastric bypass (RYGB). Insulin was withdrawn immediately after the surgery and within six months after the surgery, plasma glucose and glycated hemoglobin (HbA1c-5.5%) levels reached and remained within normal range. Currently, eight years after surgery, body weight and BMI are 80 kg and 27.68 kg/m2, respectively. Plasma glucose and glycated hemoglobin are also normal. Importantly, from an oncological point of view, the patient has remained in continuous complete remission since October 2003. Conclusions: Our report is the first to our knowledge describing the effect of gastric bypass surgery on SIDM in a patient with prior hematologic malignancy. It proves that surgically altered anatomy of the small intestine improves glucose homeostasis previously disturbed with pro-diabetic medication.
Źródło:
Polish Journal of Surgery; 2019, 91, 5; 52-54
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of changes in the growth and chemical constituents of Anoectochilus formosanus Hayata grown under hydroponic conditions
Autorzy:
Nguyen, H.C.
Nhu, T.Q.M.
Dung, P.V.
Hieu, N.D.
Tuan, T.T.
Huyen, P.X.
Truong, D.-H.
Powiązania:
https://bibliotekanauki.pl/articles/80522.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Anoectochilus formosanus
medicinal plant
mineral nutrition
hydroponic cultivation
chemical constituent
antioxidant activity
phytochemical screening
alkaloid content
flavonoids
glycoside
terpenoid
steroid
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2018, 99, 4
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
SOCS3 is epigenetically up-regulated in steroid resistant nephrotic children
Autorzy:
Zaorska, Katarzyna
Zawierucha, Piotr
Ostalska-Nowicka, Danuta
Nowicki, Michał
Powiązania:
https://bibliotekanauki.pl/articles/1038853.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
methylation
nephrotic syndrome
single nucleotide polymorphism
steroid resistance
Opis:
Background. The mechanism of steroid resistance in children with the nephrotic syndrome is yet unknown. About 20% of patients demonstrate steroid unresponsiveness and progress to end stage renal disease. Aberrant SOCS3 and SOCS5 expression in steroid resistant and sensitive patients has previously been demonstrated. Here, we investigate genetic and epigenetic mechanisms of regulation of SOCS3 and SOCS5 transcription in nephrotic children. Methods. 76 patients with the nephrotic syndrome (40 steroid resistant and 36 steroid sensitive) and 33 matched controls were included in this study. We performed genotyping of a total of 34 single nucleotide polymorphisms for SOCS3 and SOCS5 promoters and evaluated their methylation status using MS-PCR and QMSP methods. Results. Steroid resistant patients had a significantly lower methylation of one region of SOCS3 promoter in comparison with steroid sensitive patients and controls (p < 0.0001). However, the relative methylation level in the steroid sensitive patients and controls differed significantly even before the first steroid dose (p = 0.001758). Other SOCS3 and SOCS5 promoter regions displayed no differences in methylation or were fully methylated/unmethylated in all study groups, showing site-specific methylation. The allele and genotype distribution for SOCS3 and SOCS5 markers did not differ statistically between the groups. Conclusions. We demonstrate an epigenetic mechanism of SOCS3 up-regulation in steroid resistant children with the nephrotic syndrome. The assessment of methylation/unmethylation of SOCS3 promoter might be an early marker for steroid responsiveness in NS patients.
Źródło:
Acta Biochimica Polonica; 2016, 63, 1; 131-138
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Enzymatyczne reakcje rozszczepienia wiązania C–C : zastosowanie w syntezie związków zapachowych, farmaceutyków oraz w bioremediacji
Enzymatic reactions of the C–C bond cleavage : applications in synthesis of aroma compounds, pharmaceuticals and in bioremediation
Autorzy:
Panek, A.
Milecka-Tronina, N.
Świzdor, A.
Powiązania:
https://bibliotekanauki.pl/articles/172055.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
β-oksydacja
wanilina
γ-dekalakton
metyloketony
leki steroidowe
bioremediacja
β-oxidation
vanillin
γ-decalactone
methyl ketones
steroid drugs
bioremediation
Opis:
The microorganisms are able to utilize natural and synthetic compounds of broad structural diversity as a source of carbon and energy, converting these substrates into low molecular weight products (mainly H2O, CO2 and NH3). The main role in this metabolism is played by the enzymes that catalyze reactions of the C–C bond cleavage. Such reactions are the key step of the primary metabolism of fatty acids in eukaryotic cells by the β-oxidation. The enzymatic systems associated with the C–C bond cleavage have been applied in the synthesis of valuable natural products and in the bioremediation processes. Microbial transformations of natural compounds, in which the reactions of β-oxidation cycle are used, allow the formation of natural aromatic compounds (used as food additives), pharmaceuticals and ingredients of cosmetic compositions. Using this path one can obtain methyl ketones (e.g. responsible for the characteristic smell of cheeses), γ-lactones determining the scent of several popular fruits, and vanillin. A modification of the natural steroids: saponins, alkaloids, sterols, bile acids to products useful in the synthesis of steroid drugs is the most important area of use of the enzymatic C–C bond cleavage, due to the practical significance of the products. Enzymes that catalyze the C–C bonds cleavage are important in the process of biodegradation of toxic aromatic hydrocarbons and their derivatives (bioremediation).
Źródło:
Wiadomości Chemiczne; 2015, 69, 5-6; 337-368
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Exogenous steroid hormones stimulate full development of autonomous endosperm in Arabidopsis thaliana
Autorzy:
Rojek, J.
Pawelko, L.
Kapusta, M.
Naczk, A.
Bohdanowicz, J.
Powiązania:
https://bibliotekanauki.pl/articles/59176.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Botaniczne
Tematy:
steroid hormone
endosperm
Arabidopsis thaliana
apomixis
DNA methylation
Opis:
Most flowering plants, including important crops, require double fertilization to form an embryo and endosperm, which nourishes it. Independence from fertilization is a feature of apomictic plants that produce seeds, from which the plants that are clones of the mother plant arise. The phenomenon of apomixis occurs in some sexual plants under specific circumstances. Since the launch of a fertilization-independent mechanism is considered a useful tool for plant breeding, there have been efforts to artificially induce apomixis. We have been able to produce fertilization-independent endosperm in vitro in Arabidopsis over the last few years. This paper demonstrates the methods of improving the quality of the endosperm obtained using plant and mammalian steroid hormones. Additionally, it shows the study on the autonomous endosperm (AE) formation mechanism in vitro. This paper examines the effect of exogenous steroid hormones on unfertilized egg and central cell divisions in culture of unpollinated pistils of Arabidopsis Col-0 wild-type andfie-1 mutant. All media with hormones used (estrone, androsterone, progesterone, and epibrassinolide) stimulated central cell divisions and fertilization-independent endosperm development. The stages of AE development followed the pattern of Arabidopsis thaliana wild type after fertilization. Subsequent stages of AE were observed from 2-nuclear up to cellular with the most advanced occurring on medium with 24-epibrassinolide and progesterone. The significant influence of mammalian sex hormones on speed of AE development and differentiation was noticed. Using restriction analysis, the changes in methylation of FIE gene was established under in vitro condition. The authors of this paper showed that Arabidopsis thaliana has a high potency to fertilization-independent development.
Źródło:
Acta Societatis Botanicorum Poloniae; 2015, 84, 2
0001-6977
2083-9480
Pojawia się w:
Acta Societatis Botanicorum Poloniae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Qa-SNARE protein SYP22 negatively regulates brassinosteroid signaling in the dark
Autorzy:
Yao, T.S.
Zhu, X.F.
Jung, J.H.
Xuan, Y.H.
Powiązania:
https://bibliotekanauki.pl/articles/19201.pdf
Data publikacji:
2015
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
SNARE protein
SYP22 gene
brassinosteroid
steroid hormone
signalling
dark
Arabidopsis
Źródło:
Acta Biologica Cracoviensia. Series Botanica; 2015, 57, 2
0001-5296
Pojawia się w:
Acta Biologica Cracoviensia. Series Botanica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zagadnienia prawne obrotu steroidami anaboliczno-androgennymi
Legal issues in marketing of anabolic-androgenic steroids
Autorzy:
Mazurek, Adam
Jop, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/499759.pdf
Data publikacji:
2015
Wydawca:
Centralne Laboratorium Kryminalistyczne Policji
Tematy:
steroidy anaboliczno-androgenne
surowce farmaceutyczne
regulacje prawne
nielegalny obrót
sprzedaż bez recepty
Internet
nadużywanie steroidów
konsekwencje zdrowotne
anabolic-androgenic steroids
pharmaceutical raw materials
legał regulations
illicit marketinc sales without prescription
steroid abuse
health-related conseguences
Opis:
W artykule omówiono zagrożenia związane z nielegalnym wprowadzaniem do obrotu steroidów anaboliczno--androgennych (SAA) w Polsce. Zagrożenie to Narodowy Instytut Leków dostrzega w trakcie opracowywanych opinii kryminalistycznych, wykonywanych dla Policji, prokuratur, Straży Granicznej i innych instytucji. Opinie dotyczą preparatów z SAA, z różnych powodów niedopuszczonych do obrotu w Polsce, oraz surowców do ich produkcji, a także preparatów dopuszczonych do obrotu, ale wprowadzanych do obrotu z naruszeniem obowiązujących przepisów lub preparatów sfałszowanych. W niniejszym opracowaniu przedstawiono przepisy prawa karnego, które kryminalizują nielegalny obrót produktami, w skład których wchodzą SAA. Struktura przepisów karnych w Polsce nie sprzyja ograniczaniu ilości nielegalnie wprowadzanych produktów zawierających w składzie SAA na rynku polskim. Produkty zawierające w składzie SAA mają co do zasady status produktów leczniczych dostępnych z przepisu lekarza. Przedstawiono możliwości stosowania przez policję i prokuratury innych, bardziej dolegliwych przepisów kodeksu karnego i innych ustaw. Dla porównania przedstawiono inny system obowiązujący przy obrocie SAA w Stanach Zjednoczonych. Obowiązują tam bardziej restrykcyjne przepisy w tym względzie. SAA są traktowane jako substancje kontrolowane na równi z narkotykami, a ich obecnością na rynku zajmuje się DEA - agencja rządowa powołana do zwalczania przestępczości narkotykowej.
This article provides an insight into the issue of illicit marketing of anabolic-androgenic steroids (AAS) i Poland. This risk attached to this phenomenon is particularly reflected in forensic opinions elaborated b the National Medicines Institute for the Police, prosecutor's offices, Border Guard and other agencies. Th casework opinions concern AAS preparations not admitted to trading in Poland for various reasons, ra\ materials used in the production process, preparations admitted to trading, yet marketed in breach of th applicable provisions of law, and finally, falsified preparations. The article presents a rangę of the provision of law, penalizing illicit marketing of AAS-containing products. The structure of criminal law provisions i Poland does not support the efficient reduction of AAS-containing products unlawfully introduced on th Polish market. As a rule, AAS-containing products are classified as medicinal products subject to medicj prescription. The authors discuss the possibilities of applying alternative, morę restrictive provisions of th Penal Codę and other acts by the Police and prosecutors. For comparison purposes, a U.S. scheme of dealin with AAS marketing phenomenon was presented. The provisions of law in the U.S. are morę restrictive a regards AAS, which are regarded as controlled substances equally with narcotics and dealt with by the Dru Enforcement Administration - a government agency responsible for combating drug-related crime.
Źródło:
Problemy Kryminalistyki; 2015, 287; 17-27, 75-84
0552-2153
Pojawia się w:
Problemy Kryminalistyki
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Phytopharmacological study of red, white and black variety of Abrus precatorius L.
Autorzy:
Garaniya, N.H.
Bapodra, A.H.
Ladva, K.D.
Powiązania:
https://bibliotekanauki.pl/articles/11319.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
phytopharmacology
red variety
white variety
black variety
Abrus precatorius
medicinal plant
flavonoids
steroid
Opis:
Abrus precatorius L. is a leguminous plant of family fabaceae. Plant parts are widely used for medicinal purpose in different region of the world. Seed behavior and phytochemical evaluation of different solvent extracts (i.e. Petroleum ether, Ethyl acetate, Methanol & Water) of leaf and seed of red, white and black varieties of Abrus precatorius L. is carried out in the present study. This study indicates presence of different phytoconstituents i.e. alkaloids, steroids, glycosides, proteins, etc. the present study concludes that the plant parts can be used as very good natural remedy to diagnosed variety of dieses.
Źródło:
International Letters of Natural Sciences; 2014, 09
2300-9675
Pojawia się w:
International Letters of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polymorphic variants of MIF gene and prognosis in steroid therapy in children with idiopathic nephrotic syndrome
Autorzy:
Świerczewska, Monika
Ostalska-Nowicka, Danuta
Kempisty, Bartosz
Szczepankiewicz, Aleksandra
Nowicki, Michał
Powiązania:
https://bibliotekanauki.pl/articles/1039333.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
nephrotic syndrome
steroid resistance
MIF gene
single nucleotide polymorphism
short tandem repeat
Opis:
Nephrotic syndrome (NS) is the most common reason of proteinuria in children and can be caused by the pathology of renal glomeruli. Steroid therapy is typically used in this disorder. It has been shown that MIF is a cytokine which counteracts the immunosuppressive properties of glucocorticoids. The aim of this study was looking for a correlation between MIF polymorphisms and genetic susceptibility to steroid resistance in children with INS (Idiopathic NS). Methods: The study was performed in 71 patients with INS including SRNS (steroid resistance nephrotic syndrome) (41) and SSNS (steroid sensitive nephrotic syndrome) (30) and in 30 control subjects. We employed Sanger sequencing and capillary electrophoresis. Linkage disequilibrium was made using Haploview and PHASE. Results: We didn't observe a statistical significance between SNPs detected in patients with INS and controls. Our studies revealed statistical significance for two polymorphisms: rs2070767C > T and rs2000466T > G between patients with SRNS and SSNS. The results for rs34383331T > A are close to being statistically significant. Statistical significance was revealed for CATT5/CATT6 genotype in SRNS group vs SSNS group (OR=4.604, 95%CI=1.356-15.632, p=0.0168). We found that the frequency of 5/X-CATT genotype compared with X/X-CATT genotype was significantly higher in SRNS patients vs SSNS (OR=3.167, 95%CI=1.046-9.585, p=0.0426). In linkage disequilibrium analysis we didn't show involvement in susceptibility to INS and steroid sensitive phenotype. Conclusions: Our results suggest that the role of MIF polymorphisms in the susceptibility to positive response to steroid therapy is still unresolved. It indicates that MIF may be involved in indirect and complex molecular mechanisms of steroid activity in hormone-dependent metabolic pathways in children with INS. Because of ambiguous findings, pleiotropic features of this cytokine require that more research should be undertaken.
Źródło:
Acta Biochimica Polonica; 2014, 61, 1; 67-75
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ambaŭflanka Neŭropatio De La Optaj Nervoj Respondanta Al Steroidoj Ĉe Malsanulino Kiu Suferas De La Hiper Imunglobulino-Dd-Sindromo
Bilateral Optic Neuropathy Responsive to Steroids in A Patient with Hyper-Immunoglobulin-D-Syndrome
Autorzy:
KLAWE, Christoph
George, Jennifer
Broehl, Annika
Maschke, Matthias
Powiązania:
https://bibliotekanauki.pl/articles/1034043.pdf
Data publikacji:
2013
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
Hyper-IgD-syndrome
bilateral optic neuritis
chronic inflammatory optic neuritis
hereditary periodic fever
steroid-responsiveness
Opis:
We present the case of a young woman with hyper-IgD syndrome (HIDS) due to heterozygous V377I and I268T mutations, who developped a bilateral optic neuritis. While the CSF was normal and no NMO-antibodies where detected, she showed signs of systemic inflammation with a raised CRP. The bilateral optic neuritis responded to 5 days of high-dosage corticosteroids in due course. To our knowledge this is until now the first case of such complaints described in a patient with HIDS.
Źródło:
Medicina Internacia Revuo; 2013, 25, 100; 96- 98
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł

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