- Tytuł:
- Leukemic stem cells: from metabolic pathways and signaling to a new concept of drug resistance targeting
- Autorzy:
-
Styczynski, Jan
Drewa, Tomasz - Powiązania:
- https://bibliotekanauki.pl/articles/1040856.pdf
- Data publikacji:
- 2007
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
stem cell markers
metabolic pathways
drug resistance
leukemic stem cells
cancer stem cells - Opis:
- Cancer stem cells are a small subset of cancer cells constituting a reservoir of self-sustaining cells with the exclusive ability to self-renew and maintain the tumor. These cells are identified by specific stem cell markers: antigens, molecules and signaling pathways. Transcription factors and molecules associated with oncogenesis, such as NF-κB, Bmi-1, Notch, WNT beta-catenin, Sonic hedgehog and their biochemical pathways, active only in a small minority of cancer cells might play key roles in determining the biology and the overall long-term behavior of a tumor. The molecules and pathways specific for cancer stem cells, which contribute to their drug resistance, are potential targets for new therapeutic strategies.
- Źródło:
-
Acta Biochimica Polonica; 2007, 54, 4; 717-726
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł