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Tytuł:
Alternative therapies in Staphylococcus aureus diseases
Autorzy:
Kurlenda, Julianna
Grinholc, Mariusz
Powiązania:
https://bibliotekanauki.pl/articles/1039729.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Staphylococcus aureus diseases
alternative therapies
Opis:
Staphylococcus aureus is a common pathogen responsible for health-care-associated infections as well as community acquired ones. It is the etiological factor of a wide spectrum of infections. Therapeutic problems are caused by resistance of S. aureus to many antibiotics, specifically to methicillin (methicillin-resistant S. aureus, MRSA). In such cases a limited spectrum of antibiotics may be used and prolonged hospitalization is costly. Hence, there is an urgent need for the development of alternative antibiotic therapeutics. This work reviews the current knowledge concerning prospective treatment of staphylococcal diseases.
Źródło:
Acta Biochimica Polonica; 2012, 59, 2; 171-184
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sepsa jako powikłanie drobnego zranienia
Sepsis as a complication of a small injury
Autorzy:
Jurkiewicz, Beata
Powiązania:
https://bibliotekanauki.pl/articles/1031553.pdf
Data publikacji:
2010
Wydawca:
Medical Communications
Tematy:
Staphylococcus aureus
children
infection
sepsis
wound
rana
zakażenie
sepsa
dzieci
staphylococcus aureus
Opis:
Sepsis is a severe generalised infection caused usually by pathogenic bacteria. Natural defence mechanisms are destroyed by bacterial toxin and systemic inflammatory response syndrome (SIRS) is developed. High virulence pathogens like meningococcus, pneumococcus, Haemophilus influenzae, Salmonella, Streptococcus, Staphylococcus (generally Staphylococcus aureus) are factors causing general infection. Other microorganisms causing SIRS are viruses, fungus, or parasites. Mechanisms developing sepsis are complex. Respiratory system, infection in abdominal cavity, encephalomyelitis, and urinary system infection are usually entry of septicaemia. Particular type of infection is sepsis developed after surgical procedure or invasive diagnostic investigation. Rare cause of fully symptomatic SIRS are small skin wounds causing damage of skin barrier and penetration of skin bacteria inside the organism. In propitious conditions i.e. decrease of immunity bacteria can spread via bloodstream, destroy vessel endothelium and provoke septic shock. The article presents two cases of sepsis induced by Staphylococcus aureus. No other deviation but small wounds were found in general state of those children. Early diagnostics and highly specialistic treatment carried out on Pediatric Surgery and Orthopedics Department resulted in complete recovery of presented patients.
Sepsa jest to ciężkie uogólnione zakażenie, powstające najczęściej na skutek zakażenia bakteriami chorobotwórczymi. Toksyny bakteryjne uszkadzają naturalne mechanizmy obronne organizmu, wywołując uogólniony zespół odczynu zapalnego (SIRS). Do czynników wywołujących zakażenie należą bakterie chorobotwórcze o dużej zjadliwości, takie jak: meningokoki, pneumokoki, pałeczka hemofilna, salmonella, paciorkowce czy gronkowce (najczęściej Staphylococcus aureus). Innymi drobnoustrojami odpowiadającymi za wystąpienie zespołu SIRS mogą być wirusy, grzyby lub pasożyty. Mechanizm powstawania sepsy jest złożony. Wrotami zakażenia krwi najczęściej są układ oddechowy, infekcje w obrębie jamy brzusznej, zapalenie opon mózgowo-rdzeniowych i zakażenia układu moczowego. Szczególnym rodzajem zakażenia jest sepsa rozwijająca się po zabiegach operacyjnych lub inwazyjnych badaniach diagnostycznych. Rzadką przyczyną wystąpienia pełnoobjawowego zespołu SIRS mogą być drobne zranienia skóry powodujące uszkodzenie bariery skórnej i przeniknięcie do organizmu bakterii, które zwykle znajdują się na powierzchni skóry. W sprzyjających warunkach, na przykład zmniejszonej odporności, mogą one rozprzestrzenić się drogą krwionośną, uszkadzając śródbłonek naczyń, i w efekcie wywołać wstrząs septyczny. W pracy przedstawiono dwa przypadki sepsy wywołanej bakterią Staphyloccocus aureus u dzieci, u których stwierdzono jedynie drobne zranienia skóry bez żadnych innych odchyleń od stanu prawidłowego. Wczesna diagnostyka i wczesne wysokospecjalistyczne leczenie wprowadzone w Oddziale Chirurgii i Ortopedii Dziecięcej pozwoliło na opanowanie sepsy i doprowadziło do całkowitego wyleczenia dzieci.
Źródło:
Pediatria i Medycyna Rodzinna; 2010, 6, 4; 324-327
1734-1531
2451-0742
Pojawia się w:
Pediatria i Medycyna Rodzinna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Differences in metabolic profiles of planktonic and biofilm cells in Staphylococcus aureus - 1H Nuclear Magnetic Resonance search for candidate biomarkers
Autorzy:
Junka, Adam
Deja, Stanisław
Smutnicka, Danuta
Szymczyk, Patrycja
Ziółkowski, Grzegorz
Bartoszewicz, Marzenna
Młynarz, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1039470.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Staphylococcus aureus
biofilm
NMR
metabolomics
glycine-betaine
Opis:
Staphylococcus aureus is responsible for many types of infections related to biofilm presence. As the early diagnostics remains the best option for prevention of biofilm infections, the aim of the work presented was to search for differences in metabolite patterns of S. aureus ATCC6538 biofilm vs. free-swimming S. aureus planktonic forms. For this purpose, Nuclear Magnetic Resonance (NMR) spectroscopy was applied. Data obtained were supported by means of Scanning Electron Microscopy, quantitative cultures and X-ray computed microtomography. Metabolic trends accompanying S. aureus biofilm formation were found using Principal Component Analysis (PCA). Levels of isoleucine, alanine and 2,3-butanediol were significantly higher in biofilm than in planktonic forms, whereas level of osmoprotectant glycine-betaine was significantly higher in planktonic forms of S. aureus. Results obtained may find future application in clinical diagnostics of S. aureus biofilm-related infections.
Źródło:
Acta Biochimica Polonica; 2013, 60, 4; 701-706
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zakażenia miejsca operowanego – przegląd aktualnej wiedzy, metody zapobiegania
Autorzy:
Kolasiński, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/1392190.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
antybiotykoterapia okołooperacyjna
chlorheksydyna
Staphylococcus aureus
zakażenie miejsca operowanego
Opis:
Wstęp: Infekcje miejsca operowanego (ang. Surgical site infections – SSI) towarzyszą ludzkości od zarania dziejów. Wraz z rozwojem medycyny udało się zmniejszyć ich odsetek, jednak do dziś stanowią poważny problem, z którym mierzymy się każdego dnia. Zakażenia miejsca operowanego powodują wzrost kosztów leczenia. Dlatego też na całym świecie poszukuje się metod skutecznego zapobiegania tym powikłaniom. Materiały i metody: Celem pracy jest przedstawienie aktualnych poglądów na temat etiologii i sposobów zapobiegania infekcjom miejsca operowanego. Wyniki: Za zakażenia miejsca operowanego najczęściej odpowiadają patogeny własne chorego. Dopiero przy hospitalizacjach powyżej 5–7 dni przewagę zdobywa flora egzogenna, szpitalna. Głównie izolowanym patogenem jest Staphylococcus aureus. Rośnie odsetek szczepów metycylinoopornych – MRSA. Przedoperacyjna antybiotykoterapia przyczynia się do zmniejszania częstości infekcji miejsca operowanego w wielu procedurach chirurgicznych. Czas podania, rodzaj i dawka antybiotyku, odgrywają ważną rolę w zapobieganiu infekcjom pooperacyjnym. Również antyseptyka pola operacyjnego jest istotna. Dwa najczęściej używane składniki to: glukonian chlorheksydyny i jodpowidon. Najnowsze doniesienia wskazują na alkoholowy roztwór chlorheksydyny jako ten o wyższym stopniu skuteczności. Wnioski: W 2017 roku Europejskie Centrum ds. Zapobiegania i Kontroli Chorób (ang. Centers for Disease Control and Prevention) opublikowało wytyczne przedstawiające nowe i zaktualizowane zalecenia dotyczące zapobiegania SSI. Powinny one zostać wprowadzone do postępowania chirurgicznego w celu poprawy bezpieczeństwa pacjentów.
Źródło:
Polish Journal of Surgery; 2019, 91, 4; 41-47
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antibiofilm activity of mushroom extracts against Staphylococcus aureus
Autorzy:
Čuvalová, Anna
Strapáč, Imrich
Handrová, Livia
Kmeť, Vladimir
Powiązania:
https://bibliotekanauki.pl/articles/2183555.pdf
Data publikacji:
2018-12-31
Wydawca:
Uniwersytet Pedagogiczny im. Komisji Edukacji Narodowej w Krakowie
Tematy:
biofilm
fungi
ixodid ticks (Acari)
milk
Staphylococcus aureus
Opis:
Mushrooms are a renowned source of products with an array of bioactivities, from antibacterial to antiviral, cytotoxic, antifeeding, antifungal or antioxidant and might be a valuable resource in the search of new bioactive extracts to inhibit biofilm production. We demonstrate the effect of five mushroom water extracts Macrolepiota procera, Pleurotus ostreatus, Auricularia auricula-judae, Armillaria mellea and Laetiporus sulphurous on biofilm formation of four Staphylococcus aureus strains isolated from ixodid ticks (Acari) and ewe´s milk. The PCR was used for detection of virulence genes (hla, isdA, B, bbp, sirB, fnbpA, sdrE, agr II). The ability of biofilm formation and anti-biofilm activity of mushrooms extracts was assessed in a quantitative crystal violet assay. The biofilm formation of S. aureus strains was significantly reduced by all mushrooms extracts (p < 0.001). We showed that more significant anti-biofilm effect of the extracts was of Staphylococcus aureus isolated from ixodid ticks in comparison to Staphylococcus aureus isolated from ewe´s milk. In the present study, A. mellea, P. ostreatus, L. sulphurous, A. auricula-judae and M. procera extracts inhibited biofilm formation by 70.87%, 67.00%, 64.14%, 62.77% and 47.71%, respectively. The results suggest that compounds in mushrooms extracts might be useful to control and handle detrimental infections caused by animal and human pathogens.
Źródło:
Annales Universitatis Paedagogicae Cracoviensis Studia Naturae; 2018, 3 (suppl.); 17-23
2543-8832
2545-0999
Pojawia się w:
Annales Universitatis Paedagogicae Cracoviensis Studia Naturae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antibiofilm activity against Staphylococcus aureus and content analysis of Taraxacum Officinale phenolic extract
Autorzy:
Xu, P.
Xu, X.B.
Khan, A.
Fotina, T.
Wang, S.H.
Powiązania:
https://bibliotekanauki.pl/articles/2087162.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Taraxacum Officinale
phenolic
antibacterial mechanism
HPLC
Staphylococcus aureus
Źródło:
Polish Journal of Veterinary Sciences; 2021, 24, 2; 243-251
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nasal carriage of various staphylococcal species in small ruminant lentivirus-infected asymptomatic goats
Autorzy:
Moroz, A.
Szaluś-Jordanow, O.
Czopowicz, M.
Brodzik, K.
Petroniec, V.
Augustynowicz-Kopeć, E.
Lutyńska, A.
Roszczynko, M.
Gołoś-Wójcicka, A.
Korzeniowska-Kowal, A.
Gamian, A.
Mickiewicz, M.
Frymus, T.
Petelicka, H.
Kaba, J.
Powiązania:
https://bibliotekanauki.pl/articles/2087322.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
caprine arthritis-encephalitis
MALDI-TOF
PFGE
Staphylococcus aureus
Źródło:
Polish Journal of Veterinary Sciences; 2020, 23, 2; 203-209
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The study on bactericidal effect and ultrastructural alterations of chlorocresol nanoemulsion disinfectant against Staphylococcus aureus
Autorzy:
Zhang, Y.F.
Sun, Y.W.
Liu, X.H.
An, Z.X.
Yang, X.F.
Powiązania:
https://bibliotekanauki.pl/articles/16647452.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
chlorocresol
nanoemulsion
disinfectant
Staphylococcus aureus
bactericidal effect
ultrastructure
Opis:
Chlorocresol nanoemulsion disinfectant (CND) is an environmental disinfectant prepared with nanoemulsion as its drug carrier. This study aimed to investigate the bactericidal effect of CND on Staphylococcus aureus ( S. aureus) and its effect on bacterial ultrastructure. The neutralizing effect of CND against S. aureus was first screened by suspension quantitative evaluation experiment procedure of neutralizer. Disinfection performance was evaluated by the determination of Minimal Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC), quantitative bactericidal experiment, and comparative experiment of disinfection performance between 0.1% CND and 0.1% chlorocresol aqueous solution. Meanwhile, the effect of CND on the ultrastructure of S. aureus was investigated with scanning electron microscope (SEM) and transmission electron microscope (TEM) to preliminarily explore the bactericidal mechanism. The results showed that 3% Tween-80 in PBS could be screened as the neutralizer of CND against S. aureus. MIC and MBC were 100 μg/mL and 200 μg/mL, respectively. The bactericidal rates were all 100% when 0.06% and 0.08% disinfectant acted for 15 and 5 min, respectively. Furthermore, compared with 0.1% chlorocresol aqueous solution, the bactericidal effect of 0.1% CND was significantly enhanced (p<0.01). After treatment with CND for 10 min, SEM observation showed that the morphology of S. aureus cells were changed and the integrity destroyed. TEM observation showed that the cell shape changed, and the structures of the cell wall, cell membrane and cytoplasm were damaged in varying degrees. CND showed the strong bactericidal effect on S. aureus and could cause ultrastructure alterations of S. aureus.
Źródło:
Polish Journal of Veterinary Sciences; 2023, 26, 1; 13-20
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Leonurus cardiaca L. herb - a derived extract and an ursolic acid as the factors affecting the adhesion capacity of Staphylococcus aureus in the context of infective endocarditis
Autorzy:
Micota, Bartłomiej
Sadowska, Beata
Podsędek, Anna
Redzynia, Małgorzata
Różalska, Barbara
Powiązania:
https://bibliotekanauki.pl/articles/1039309.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
ECM
Leonurus cardiaca
ursolic acid
Staphylococcus aureus
Opis:
The objective was an assessment of the impact of Leonurus cardiaca L. extract (LCE) and ursolic acid (UA) on the adhesive properties of Staphylococus aureus NCTC 8325 strain, expressing virulence factors important in the pathogenesis of infective endocarditis. The adhesion and biofilm formation of bacteria cultured in the presence of subinhibitory concentrations of LCE or UA on the abiotic surface or covered with fibrinogen, fibronectin or collagen, were evaluated. Inhibitory effects of LCE and UA on staphylococcal adherence to both types of surface were demonstrated. This, in the case of UA, resulted in a significant reduction of biofilm formation.
Źródło:
Acta Biochimica Polonica; 2014, 61, 2; 385-388
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Proteomics in studies of Staphylococcus aureus virulence
Autorzy:
Bonar, Emilia
Wójcik, Iwona
Wladyka, Benedykt
Powiązania:
https://bibliotekanauki.pl/articles/1038964.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Staphylococcus aureus
proteomics
virulence factors
secretome
surfacome
Opis:
Staphylococcus aureus is a widespread, opportunistic pathogen that causes community and hospital acquired infections. Its high pathogenicity is driven by multifactorial and complex mechanisms determined by the ability of the bacterium to express a wide variety of virulence factors. The proteome secreted into extracellular milieu is a rich reservoir of such factors which include mainly nonenzymatic toxins and enzymes. Simultaneously, membrane proteins, membrane-cell wall interface proteins and cell wall-associated proteins also strongly influence staphylococcal virulence. Proteomics shows a great potential in exploring the role of the extracellular proteome in cell physiology, including the pathogenic potential of particular strains of staphylococci. In turn, understanding the bacterial physiology including the interconnections of particular factors within the extracellular proteomes is a key to the development of the ever needed, novel antibacterial strategies. Here, we briefly overview the latest applications of gel-based and gel-free proteomic techniques in the identification of the virulence factors within S. aureus secretome and surfacome. Such studies are of utmost importance in understanding the host-pathogen interactions, analysis of the role of staphylococcal regulatory systems and also the detection of posttranslational modifications emerging as important modifiers of the infection process.
Źródło:
Acta Biochimica Polonica; 2015, 62, 3; 367-381
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Isolation of vanconycin resistant Staphylococcus aureus from the wounds of hospital patients in Uyo, Akwa Ibom State, Nigeria
Autorzy:
Anosike, I. K.
Ebana, R. U. B.
Edet, U. O.
Umoh, I. S.
Powiązania:
https://bibliotekanauki.pl/articles/1076716.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Methicillin
Staphylococcus aureus
Vancomycin
Wounds
antibiotic resistance
Opis:
Staphylococcus aureus is a very important human pathogen that generates a number of human infections. Isolation of vancomycin-resistant Staphylococcus aureus (VRSA) was carried out from wound samples of patients attending University of Uyo Teaching Hospital, Akwa Ibom state, Nigeria. A total of 45 wound samples from 15 patients were collected aseptically in triplicate, using sterile cotton swabs moistened in sterile normal saline. Microbiological analysis and susceptibility to vancomycin, including minimum inhibitory and minimum bactericidal concentrations (MIC and MBC), were carried out using standard methodologies. A total of 15 isolates were obtained and these showed varying MIC and MBC patterns. Out of the 15 S. aureus isolated, only one isolate had an MIC of approximately 4 µg/ml, while twelve isolates gave MIC values that ranged from 15.62 µg/ml to 250 µg/ml. The remaining 2 isolates gave MIC values that were ≥ 500 µg/ml. These 2 isolates exhibited alpha haemolysis on blood agar, unlike the others that were beta haemolytic. The results of the MBC also showed variations amongst the isolates. A total of 10 isolates gave MBC values that ranged from 62.5 µg/ml to 500 µg/ml, while the remaining 5 isolates gave MBC values that were ≥ 500 µg/ml. The high MIC and MBC values obtained showed that vancomycin-resistant Staphylococcus aureus is increasing at an alarming rate, and this accounts for the gradual decline in the effectiveness associated with the use of vancomycin. Given the widespread prevalence of VRSA, there is a need for newer therapeutics that can reverse this surge.
Źródło:
World News of Natural Sciences; 2019, 24; 134-144
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antibacterial activity of covered paper after storage
Autorzy:
Jarosz, Michał
Sumińska, Patrycja
Kowalska, Urszula
Mizielińska, Małgorzata
Powiązania:
https://bibliotekanauki.pl/articles/1112792.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Staphylococcus aureus
active coatings
covered paper
polylysine
Opis:
The paper covered with a hydrophobic Topscreen coating was coated with the second layer. The goal of paper covering was to obtain the antimicrobial properties of the external coating. The samples were stored 2 months at 20 ºC. The influence of storage on the antimicrobial properties of the external coating was analyzed. The results of the study showed that paper covered with Topscreen coating did not have an influence on the growth of Staphylococcus aureus cells. The second (external) layer containing 2% polylysine as an active substance decreased the growth of S. aureus. The 2 months storage of the covered paper did not influence the antimicrobial properties of coating with polylysine against S. aureus. It was demonstrated that paper covered with hydrophobic coating had no influence on the growth of E. coli cells as well. In this case the influence of 2 months storage on the antimicrobial properties of the coating with polylysine was observed. In contrast to the results obtained for the samples that were not store, the decrease of the growth of the bacterial cells after 24 h contact with a hydrophobic coating devoid of an active substance was noticed.
Źródło:
World News of Natural Sciences; 2018, 17; 141-146
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Production of bioactive metabolites from different marine endophytic Streptomyces species and testing them against methicillin-resistant Staphylococcus aureus (MRSA) and cancer cell lines
Autorzy:
El-Gendy, M.M.A.A.
Mohamed, Z.K.
Hekal, N.Z.
Ali, F.M.
Yousef, A.E.M.
Powiązania:
https://bibliotekanauki.pl/articles/81078.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Staphylococcus aureus
infection
methicillin-resistant Staphylococcus aureus
endophyte
Streptomyces
bioactive metabolite
Actinomycetes
marine invertebrate
anticancer activity
cancer cell line
lung cancer
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2018, 99, 1
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Self-reported methicillin-resistant Staphylococcus aureus infection in USA pork producers
Autorzy:
Leedom, Larson K R
Smith, T.C.
Donham, K.J.
Powiązania:
https://bibliotekanauki.pl/articles/51288.pdf
Data publikacji:
2010
Wydawca:
Instytut Medycyny Wsi
Tematy:
pork production
pork producer
USA
animal farm
pig
agricultural worker
human disease
infection
methicillin-resistant Staphylococcus aureus
Staphylococcus aureus
Źródło:
Annals of Agricultural and Environmental Medicine; 2010, 17, 2; 331-334
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zmiany w epidemiologii inwazyjnych klonów MRSA w wybranych szpitalach w Polsce
Changes in epidemiology of invasive MRSA clones in selected Polish hospitals
Autorzy:
Karyński, Michał
Krzysztoń-Russjan, Jolanta
Grzesiowski, Paweł
Powiązania:
https://bibliotekanauki.pl/articles/437692.pdf
Data publikacji:
2012
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
Staphylococcus aureus
MRSA
typ spa
klon
spa type
clone
Opis:
Wstęp: Staphylococcus aureus jest patogenem, który może wywoływać szerokie spektrum chorób od względnie łagodnych zakażeń skóry do zagrażających życiu chorób układowych. Badanie przeprowadzono w celu oceny klonalności meticylinoopornych izolatów S. aureus (MRSA) w wybranych polskich szpitalach. Materiał i metoda: Kolekcja szczepów składała się ze 183 meticylinoopornych izolatów S. aureus (MRSA) i 4 meticylinowrażliwych izolatów S. aureus (MSSA) z lat 2002-2005. Izolaty pochodziły z 29 szpitali. Oczyszczony całkowity DNA z izolatów był użyty w amplifiacji regionu X genu spa. Następnie, sekwencjonowano amplikony i określano typy spa. Wyniki: W wyniku przeprowadzonej analizy izolatów wykazano istnienie 30 typów spa. Dwoma najczęściej występującymi typami izolowanymi w ciągu okresu badania były t037 i t052. Typy te należały, odpowiednio, do tzw. klonów brazylijsko- -węgierskiego i iberyjskiego. W okresie 4 lat obserwacji stwierdzono zanik typu spa t052 (z 43% w 2002 do 0% w 2005). Równolegle z zanikiem typu spa t052, odsetek typu spa t037 zwiększył się z 26% w 2002 do 47% w 2005. Wnioski: Zmiany w częstości występowania izolatów t052 i t037 wskazują, że klon iberyjski, wykazujący w większości wrażliwość na ko-trimoksazol, został wyparty przez klon brazylijsko-węgierski wykazujący w większości oporność na ko-trimoksazol. Zmiany w strukturze populacji MRSA w szpitalach wytypowanych do badania obrazują dynamiczne zmiany w epidemiologii klonów, najprawdopodobniej związane z presją selekcyjną antybiotyków stosowanych w terapii zakażeń szpitalnych.
Introduction: Staphylococcus aureus is a pathogen that can cause a wide spectrum of diseases from relatively mild skin infections to life-threatening systemic disease. The study was conducted to assess the clonality of methicillin-resistant isolates of S. aureus (MRSA) in selected Polish hospitals. Material and Methods: A collection of strains consisted of 183 methicillin-resistant isolates of S. aureus (MRSA) and 4 methicillin susceptible isolates of S. aureus (MSSA) from 2002-2005. Isolates came from 29 hospitals. Purifid total DNA of isolates was used to amplify the region X of the gene spa. Subsequently, the amplicons were sequenced and spa types determined. Results: The analysis of isolates demonstrated the existence of 30 types of spa. The two most common types isolated during the study period were t037 and t052. These types belonged, respectively, to the so-called Brazilian-Hungarian and Iberian clones. During 4 years of observation period, the loss of spa type t052 was observed (from 43% in 2002 to 0% in 2005). In parallel with the disappearance of a spa type t052, a spa t037 percentage increased from 26% in 2002 to 47% in 2005. Conclusions: The changes in the frequency of occurrence of t052 and t037 isolates show that the Iberian clone, mostly showing susceptibility to cotrimoxazole, was supplanted by the Brazilian/Hungarian clone, mostly showing resistance to cotrimoxazole. The alterations in the structure of the MRSA population in the hospitals selected for the study represent dynamic changes in the epidemiology of clones, most probably related to the selection pressure of antibiotics used in the therapy of hospital infections.
Źródło:
Medical Review; 2012, 3; 311-317
2450-6761
Pojawia się w:
Medical Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Staphylococcus aureus as an infectious agent: overview of biochemistry and molecular genetics of its pathogenicity
Autorzy:
Plata, Konrad
Rosato, Adriana
Węgrzyn, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/1040468.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Staphylococcus aureus
virulence
pathogenicity genes
toxins
methicillin resistance
Opis:
Although it is estimated that 20-30% of the general human population are carriers of Staphylococcus aureus, this bacterium is one of the most important etiological agents responsible for healthcare-associated infections. The appearance of methicillin resistant S. aureus (MRSA) strains has created serious therapeutical problems. Detailed understanding of the mechanisms of S. aureus infections seems necessary to develop new effective therapies against this pathogen. In this article, we present an overview of the biochemical and genetic mechanisms of pathogenicity of S. aureus strains. Virulence factors, organization of the genome and regulation of expression of genes involved in virulence, and mechanisms leading to methicilin resistance are presented and briefly discussed.
Źródło:
Acta Biochimica Polonica; 2009, 56, 4; 597-612
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Gold nanoparticles in an enhancement of antimicrobial activity
Autorzy:
Wanarska, Ewelina
Maliszewska, Irena
Powiązania:
https://bibliotekanauki.pl/articles/1450221.pdf
Data publikacji:
2020
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
gold nanoparticles
photodynamic therapy
methylene blue
staphylococcus aureus
Opis:
The effect of antimicrobial photodynamic therapy (aPDT) on Gram-positive bacterium Staphylocccus aureus was studied. Methylene blue (MB) at non-toxic concentration of 31.25µg/ml was used as a photosensitizer. LEDs diodes were used as a light source to study the effect of methylene blue alone and the MB-gold nanoparticle mixture on the viability of S. aureus cells. Biogenic gold nanoparticles (biolAuNPs, 10ppm) and chemically synthesized gold nanoparticles (chemAuNPs, 3ppm) were tested as enhancement agents. In the presence of MB alone as a photosensitizer, the killing effect was about 92% after 30min of irradiation. The aPDT therapy was enhanced by addition of biolAuNPs and chemAuNPs and killing rate of S. aureus was 95-96% after 30min of irradiation. The probable mechanism of enhancement of MB-mediated photodynamic bactericidal efficacy against S. aureus in the presence of gold nanoparticles is discussed leading to the conclusion that colloidal gold increases the accumulation of MB in bacterial cells.
Źródło:
Physicochemical Problems of Mineral Processing; 2020, 56, 6; 269-279
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of P1 substrate specificity of staphylococcal SplB protease
Autorzy:
Pustelny, Katarzyna
Stach, Natalia
Wladyka, Benedykt
Dubin, Adam
Dubin, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/1039355.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
serine protease
serine protease-like
SplB
Staphylococcus aureus
substrate specificity
Opis:
Staphylococcus aureus is a dangerous human pathogen characterized by growing antibiotic resistance. Virulence of S. aureus relies on a variety of secreted and cell surface associated virulence factors among which certain proteolytic enzymes play an important role. Amid staphylococcal extracellular proteases, those encoded by the spl operon remain poorly characterized, both in terms of enzymology and their physiological role. Initial data demonstrated that Spl proteases exhibit restricted substrate specificity. This study describes development of convenient protein FRET substrates for SplB protease and characterization of the substrate preference of the protease at the P1' position. Kinetic data on hydrolysis of a panel of substrates substituted at the said position is provided.
Źródło:
Acta Biochimica Polonica; 2014, 61, 1; 149-152
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Drug resistance profile and detection of genes responsible for methicillin resistance in Staphylococcus aureus isolated from municipal waste
Autorzy:
Wolny-Koładka, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/2203548.pdf
Data publikacji:
2023
Wydawca:
Instytut Technologiczno-Przyrodniczy
Tematy:
drug resistance
mecA gene
methicillin resistance
municipal waste
Staphylococcus aureus
Opis:
Currently, we are facing the ever-increasing phenomenon of bacteria being resistant to antibiotics. It is the consequence of excessive and incorrect use of drugs. The phenomenon is a global problem affecting bacteria both in their hospital population and in the natural environment. Municipal waste is an environment conducive to the development of microorganisms, therefore it contains various groups of bacteria, including drug-resistant staphylococci. The aim of the study was to identify species of bacteria, determine their antibiotic resistance, and assess the occurrence of genes responsible for methicillin resistance in Staphylococcus aureus isolated from mixed municipal waste. Strains were isolated by Koch’s serial dilution method with the use of microbiological media. Species were identified using the MALDI TOF-MS technique, whereas the drug resistance profile was determined by disk diffusion and molecular PCR methods. 250 isolates of S. aureus were collected. The highest resistance found was to cefoxitin, erythromycin and tetracycline. Among the bacteria collected, resistance to 1, 2, 3 or 4 antibiotics at the same time was the most common, with a maximum of 10. Additionally, 45 (18%) MDR (multidrug-resistant) isolates were detected. Methicillin resistance was found by the disk diffusion test in 60 (24%) strains, while the mecA gene was detected in as many as 180 (72%) isolates.
Źródło:
Journal of Water and Land Development; 2023, 56; 136--141
1429-7426
2083-4535
Pojawia się w:
Journal of Water and Land Development
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The inhibition of methicillin-resistant Staphylococcus aureus by essential oils isolated from leaves and fruits of Schinus areira depending on their chemical compositions
Autorzy:
Celaya, Liliana
Alabrudzińska, Marta
Molina, Ana
Viturro, Carmen
Moreno, Silvia
Powiązania:
https://bibliotekanauki.pl/articles/1039327.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Schinus areira
essential oils
antibacterial
Methicillin-resistant Staphylococcus aureus
Opis:
Schinus areira L. is a native plant from South America used for centuries in traditional medicine. Here, we investigate the antimicrobial activity of four essential oils extracted from leaves and fruits of S. areira exhibiting different chemical profiles. The antibacterial activity against the human pathogenic bacteria Staphylococcus aureus susceptible as well as methicillin resistant strain was assessed by the broth microdilution assay. The results showed that the limonene-rich oil extracted from the leaves and fruits have potent antibacterial effect on S. aureus ATCC 25923, while the α-phellandrene-rich fruit oil having a lower content of limonene showed the lowest antibacterial efficacy. In this work, for the first time, we demonstrated the bactericidal activity of essential oils isolated from fruits and leaves of S. areira against susceptible and methicillin resistant S. aureus strains. All results point out the potential use of the S. areira oils as antimicrobial agents to be used, at least against Staphylococcal infections.
Źródło:
Acta Biochimica Polonica; 2014, 61, 1; 41-46
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Surgical site infections – review of current knowledge, methods of prevention
Autorzy:
Kolasiński, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/1392141.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
chlorhexidine
perioperative antibiotic therapy
Staphylococcus aureus
surgical site infections
Opis:
Introduction: Surgical site infections have accompanied humanity since the dawn of time. Development of medicine has reduced their percentage, but still they are a huge problem to face with. Surgical site infections cause a significant increase in a cost of hospitalization. This is the main reason why the whole scientific world is looking for prevention of these complications. Materials and methods: The aim of the paper is to present current views on the etiology and methods of prevention of surgical site infection. Results: Patients own pathogens are most often responsible for surgical site infections. In hospitalizations over 5–7 days exogenous and hospital flora have the advantage. The most common isolated pathogen is Staphylococcus aureus. The percentage of MRSA – resistant methicillin strains is increasing. Pre-operative antibiotic therapy reduces the frequency of surgical site infection in many surgical procedures. Time of administration, type and dose of antibiotic play an important role in preventing post-operative infections. Pre-operative skin antiseptic is also important. The two most commonly used ingredients are chlorhexidine gluconate and povidone iodine. Recent reports point the chlorhexidine alcohol solution as an agent with a higher degree of efficacy. Conclusions: In 2017 Centers for Disease Control and Prevention published the new guidelines for prevention of surgical site infections. This practical tips and tricks should be implemented to every surgical procedure.
Źródło:
Polish Journal of Surgery; 2019, 91, 4; 41-47
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Gentamicin loaded PLGA nanoparticles as local drug delivery system for the osteomyelitis treatment
Autorzy:
Posadowska, U.
Brzychczy-Włoch, M.
Pamuła, E.
Powiązania:
https://bibliotekanauki.pl/articles/307168.pdf
Data publikacji:
2015
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
nanocząsteczki
gentamycyna
gronkowiec złocisty
nanoparticles
gentamicin sulphate
ostemyelitis
Staphylococcus aureus
Staphylococcus epidermidis
Opis:
Since there are more and more cases of multiresistance among microorganisms, rational use of antibiotics (especially their systemic vs. local application) is of great importance. Here we propose polymeric nanoparticles as locally applied gentamicin delivery system useful in osteomyelitis therapy. Gentamicin sulphate (GS) was encapsulated in the poly(lactide-co-glycolide) (PLGA 85:15) nanoparticles by double emulsification (water/oil/water, W1/O/W2). The nanoparticles were characterized by dynamic light scattering, laser electrophoresis and atomic force microscopy. UV-vis spectroscopy (O-phthaldialdehyde assay, OPA) and Kirby-Bauer tests were used to evaluate drug release and antimicrobial activity, respectively. Physicochemical characterization showed that size, shape and drug solubilization of the nanoparticles mainly depended on GS content and concentration of surface stabilizer (polyvinyl alcohol, PVA). Laser electrophoresis demonstrated negative value of zeta potential of the nanoparticles attributed to PLGA carboxyl end group presence. Drug release studies showed initial burst release followed by prolonged 35-day sustained gentamicin delivery. Agar-diffusion tests performed with pathogens causing osteomyelitis (Staphylococcus aureus and Staphylococcus epidermidis, both reference strains and clinical isolates) showed antibacterial activity of GS loaded nanoparticles (GS-NPs). It can be concluded that GS-NPs are a promising form of biomaterials useful in osteomyelitis therapy.
Źródło:
Acta of Bioengineering and Biomechanics; 2015, 17, 3; 41-48
1509-409X
2450-6303
Pojawia się w:
Acta of Bioengineering and Biomechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Silver-clay nanohybrid as a coating for improvement of the antibacterial properties of paper
Autorzy:
Alikhah, Tahereh
Babavand, Arash
Afra, Elyas
Ghasemian, Ali
Saraeian, Ahmadreza
Powiązania:
https://bibliotekanauki.pl/articles/342609.pdf
Data publikacji:
2020
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Technologii Drewna
Tematy:
paper coating
silver-clay nanohybrid
antibacterial property
Escherichia coli
Staphylococcus aureus
Opis:
This comparative study was carried out to investigate the effect of nanosilver, silver-clay nanohybrid, and silver-milled clay nanohybrid coatings on the antibacterial characteristics of paper. Nanosilver (25 ppm) was used as a singleand double-layer coating. The results demonstrated that treatment with pure nanosilver was more efficient in the reduction of microbial growth. Also, milling of clay enabled better maintenance of silver nanoparticles, and led to a greater decrease in bacterial growth than in the case of the original silver-clay nanohybrid. Evaluation of the sustainability of antibacterial characteristics confirmed that, although pure nanosilver treatment achieved better performance in the first 15 minutes than nanohybrid samples, the performance of the nanohybrids improved with the passing of time. As expected, the treatments decreased the brightness of paper, while the opacity increased significantly; pure nanosilver treatment led to lower brightness than the others, and the opacity was higher in the case of the silver-clay nanohybrid than with the other treatments.
Źródło:
Drewno. Prace Naukowe. Doniesienia. Komunikaty; 2020, 62, 205; 109-124
1644-3985
Pojawia się w:
Drewno. Prace Naukowe. Doniesienia. Komunikaty
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Characteristics of advanced methods used for typing bacterial isolates from mastitis with particular reference to Staphylococci
Autorzy:
Lisowska-Łysiak, K.
Dudko, P.
Kosecka-Strojek, M.
Walczak, J.
Wójcik, P.
Międzobrodzki, J.
Powiązania:
https://bibliotekanauki.pl/articles/2087754.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
coagulase-negative staphylococci
genetic methods
mastitis
phenotypic methods
Staphylococcus aureus
Źródło:
Polish Journal of Veterinary Sciences; 2018, 21, 1; 229-239
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antibacterial effects of celandine oil and extracts derived from roots and stalks of greater celandine (Chelidonium majus L.) collected from central Pomeranian region
Właściwości przeciwbakteryjne olejku glistnikowego oraz ekstraktów z korzeni i łodyg glistnika jaskółcze ziele (Chelidonium majus L.) zebranego z północnej części Pomorza
Autorzy:
Stefanowski, Nataniel
Tkachenko, Halina
Kurhaluk, Natalia
Lukash, Oleksandr
Buyun, Lyudmyla
Powiązania:
https://bibliotekanauki.pl/articles/27322958.pdf
Data publikacji:
2021
Wydawca:
Uniwersytet Pomorski w Słupsku
Tematy:
antibacterial activities
Chelidonium majus L.
Staphylococcus aureus subsp. aureus
Escherichia coli strains
coastal zones
Pomeranian regions
Opis:
A convincing number of studies indicating that alkaloids such as chelidonine and sanguinarine together with other secondary metabolites exhibit potent antibacterial, antifungal, and antiparasitic properties prompted us to examine the antimicrobial efficacy of Chelidonium majus L., a representative of the Papaveraceae family, against Staphylococcus aureus subsp. aureus Rosenbach (ATCC® 29213™) (mecA negative, Oxacillin sensitive, weak β-lactamase producing strain), S. aureus NCTC® 12493™ (mecA positive, Methicillin-resistant, EUCAST QC strain for cefoxitin), Escherichia coli (Migula) Castellani and Chalmers (ATCC® 25922™), E. coli (Migula) Castellani and Chalmers (ATCC® 35218™). In the current work, we decided to evaluate the antimicrobial efficacy of ethanolic extracts derived from stalks and roots of C. majus, as well as commercial 100% natural fatty celandine oil (Botanica, Russia) against different S. aureus and E. coli strains. Fresh stalks and roots were washed, weighed, crushed, and homogenized in 96% ethanol (in proportion of 1:19, w/w) at room temperature. The extracts were then filtered and investigated for their antimicrobial activity. Antimicrobial activity was determined using the agar disk diffusion assay. The extracts obtained from roots and stalks of C. majus and commercial natural fatty celandine oil exhibited different antibacterial activities against tested strains. The ethanolic extracts of C. majus revealed weak antibacterial activity against both E. coli (Migula) Castellani and Chalmers (ATCC® 25922™) and E. coli (Migula) Castellani and Chalmers (ATCC® 35218™) strains. The highest antibacterial activity was demonstrated for stalk extracts of C. majus against S. aureus NCTC® 12493™ compared to the control samples. We observed similar trends when measuring the zones of growth inhibition according to S. aureus subsp. aureus Rosenbach (ATCC® 29213™) strain. Since the antimicrobial efficacy of medicinal plants varies according to the accumulation of secondary metabolites (i.e., alkaloids, flavonoids, tannins, etc.), it is not surprising that differences in this efficacy have been noted even using samples taken from the same plant but different parts of the plant (stalks, roots). The antimicrobial activity of crude ethanolic extracts obtained from stalks and roots of greater celandine can be attributed to specific compounds or a combination of compounds. The current study lays the foundation for future research to confirm the potential use of C. majus as a candidate for the treatment of infections caused by S. aureus and E. coli in human and veterinary medicine.
Źródło:
Baltic Coastal Zone. Journal of Ecology and Protection of the Coastline; 2021, 25; 31-44
1643-0115
Pojawia się w:
Baltic Coastal Zone. Journal of Ecology and Protection of the Coastline
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-25 z 58

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