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    Wyświetlanie 1-3 z 3
    Tytuł:
    PEGYLATED GEMCITABINE AND METHOTREXATE: IN VITRO CYTOTOXICITY ANALYSIS AND IN VIVO DRUG RELEASE PROFILING TO ASSESS THEIR ENHANCED BLOOD CIRCULATION
    Autorzy:
    Ahmed, Mahmood
    Powiązania:
    https://bibliotekanauki.pl/articles/895274.pdf
    Data publikacji:
    2019-08-30
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    drug delivery
    anti-proliferation
    Pegylation
    spheroids
    Opis:
    In the present study, four new pegylated drugs were synthesized to investigate the anticancer activity. All the compounds were characterized on the basis of FTIR and 1HNMR. The new compounds were evaluated against HCT116 cell line by CellTiter-Glo® 3D cell viability assay. The sustained release pattern of newly synthesized compounds were also evaluated, slow released lasts for 240 h which was confirmed by in vivo and in vitro drug release profile. The sustained and controlled release behavior of pegylated drugs over the extended period of time showed a linear profile and this release pattern was not limited to diffusion process instead supporting chemically controlled release pattern which was dependent only on how fast the compound hydrolyzed. The newly designed pegylated drugs showed almost same killing effect against the cancer cells as the free drugs. The compounds with lower cLogP value showed more antiproliferative (lower IC50) effect due their higher cell permeability.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 4; 653-659
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    An integrated gas removing system for microfluidic application. Design and evaluation
    Autorzy:
    Hofman, I. M.
    Ziółkowska, K.
    Dybko, A.
    Brzózka, Z.
    Powiązania:
    https://bibliotekanauki.pl/articles/115931.pdf
    Data publikacji:
    2013
    Wydawca:
    Fundacja na Rzecz Młodych Naukowców
    Tematy:
    gas removing system
    debubbler
    debubbling system
    lab-on-a-chip
    microfluidics
    long-term cell culture
    cell spheroids
    HT-29 cells
    Opis:
    Microfluidic systems are used in a wide range of applications, including medical diagnostics, cell engineering and bioanalytics. In this work we focused on “Lab-on-a-chip” microsystems for cell cultivation. A troublesome problem of gas bubbles entering microdevices causing signal interferences and cells damage was emphasized. A novel, integrated debubbler in the form of cylindrical traps covered with thin PDMS membrane was designed and manufactured. Demonstrated debubbler was successfully applied in a long-lasting culture of HT-29 cell aggregates.
    Źródło:
    Challenges of Modern Technology; 2013, 4, 3; 10-15
    2082-2863
    2353-4419
    Pojawia się w:
    Challenges of Modern Technology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Systemy Cell-on-a-chip jako zaawansowane modele hodowli komórek in vitro
    Cell-on-a-chip systems as advanced cell culture models
    Autorzy:
    Jastrzębska, Elżbieta
    Powiązania:
    https://bibliotekanauki.pl/articles/172363.pdf
    Data publikacji:
    2019
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    Cell-on-a-chip
    mikrosystem
    sferoidy
    hydrożel
    hodowla komórek
    zaawansowany model in vitro
    microsystem
    spheroids
    hydrogel
    cell cultures
    advanced in vitro model
    Opis:
    In vitro study at the cellular level is an important step in evaluation of biological properties of newly developed drugs. In addition, thanks to the use of cell cultures, it is possible to study the function of the cells of a specific tissue and to mimic the conditions of cell growth or disease state. Standard (conventional) cell cultures are most often based on monolayer (two-dimensional, 2D) culture. In such culture, the cells adhere to the surface of the bottle/plate in which they grow. Nevertheless, spatial (three-dimensional, 3D) cultures are also increasingly used in culture research. However, conventional cell cultures still have a limited ability to mimic the natural environment of cell growth. Lab-on-a-chip systems (called Cell-on-a-chip) are new miniature constructional and methodical solutions useful for in vitro cell cultures. Microsystems allow the development of more advanced cell models than standard in vitro cultures so far used in biological laboratories. Thanks to this, it is possible to study cell functions under conditions that mimic the natural environment of cell growth. It should be emphasized, that the microsystems cannot completely replace animal testing. Cell-on-a-chip systems can provide alternative or complementary solutions / tools for in vivo tests, while ensuring high reliability of the obtained results. So far, Lab-on-a-chip systems have been used to assess the cytotoxicity of compounds, model intercellular interactions and mimic the function of various tissues. In this article we describe Cell-on-a-chip systems which can be used as advanced models of cell cultures. At the beginning of the manuscript, Cell-on-a- chip systems and materials used for fabrication microsystems are characterized. Next, the microsystems used as platforms for cytotoxicity study are presented. A special attention has been paid to Cell-on-a-chip for spatial cell cultures using: spheroids, hydrogels, multilayers and nanoscaffolds. Finally, Organ-on-a-chip systems are shortly discussed. Schemes of Cell-on-a-chip system, types of cell cultures obtained in microscale are presented in the article. A table showing a construction materials is also added. At the end, the article is summarized.
    Źródło:
    Wiadomości Chemiczne; 2019, 73, 11-12; 715-735
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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