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    Wyświetlanie 1-4 z 4
    Tytuł:
    Expression analysis of multifunctional RNA-binding protein hnRNP K during development of mammalian testis
    Autorzy:
    Xu, H.
    Zhang, P.
    Li, R.
    Wu, W.
    Wang, S.
    Xu, Y.
    Powiązania:
    https://bibliotekanauki.pl/articles/2087724.pdf
    Data publikacji:
    2018
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    hnRNP K
    testis development
    spermatogenesis
    pig
    rat
    Źródło:
    Polish Journal of Veterinary Sciences; 2018, 21, 2; 343-352
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Expression of a constitutively active mutant of heat shock factor 1 under the control of testis-specific hst70 gene promoter in transgenic mice induces degeneration of seminiferous epithelium.
    Autorzy:
    Widłak, Wiesława
    Benedyk, Konrad
    Vydra, Natallia
    Głowala, Magdalena
    Ścieglińska, Dorota
    Małusecka, Ewa
    Nakai, Akira
    Krawczyk, Zdzisław
    Powiązania:
    https://bibliotekanauki.pl/articles/1043633.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    spermatogenesis
    hst70 heat shock gene
    transgenic mouse
    apoptosis
    HSF1
    Opis:
    Heat shock activates in somatic cells a set of genes encoding heat shock proteins which function as molecular chaperones. The basic mechanism by which these genes are activated is the interaction of the specific transcription factor HSF1 with a regulatory DNA sequence called heat shock element (HSE). In higher eukaryotes HSF1 is present in unstressed cells as inactive monomers which, in response to cellular stress, aggregate into transcriptionally competent homotrimers. In the present paper we showed that the expression of a transgene encoding mutated constitutively active HSF1 placed under the control of a spermatocyte-specific promoter derived from the hst70 gene severely affects spermatogenesis. We found the testes of transgenic mice to be significantly smaller than those of wild-type males and histological analysis showed massive degeneration of the seminiferous epithelium. The lumen of tubules was devoid of spermatids and spermatozoa and using the TUNEL method we demonstrated a high rate of spermatocyte apoptosis. The molecular mechanism by which constitutively active HSF1 arrests spermatogenesis is not known so far. One can assume that HSF1 can either induce or repress so far unknown target genes involved in germ cell apoptosis.
    Źródło:
    Acta Biochimica Polonica; 2003, 50, 2; 535-541
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The GC-box is critical for high level expression of the testis-specific Hsp70.2/Hst70 gene
    Autorzy:
    Widłak, Wiesława
    Vydra, Natalia
    Dudaladava, Volha
    Ścieglińska, Dorota
    Winiarski, Bolesław
    Krawczyk, Zdzisław
    Powiązania:
    https://bibliotekanauki.pl/articles/1041120.pdf
    Data publikacji:
    2007
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Sp1
    GC-box
    regulation of gene expression
    spermatogenesis
    heat shock protein
    Opis:
    The Hsp70.2/Hst70 gene, which belongs to the 70 kDa heat-shock protein (HSP) family, is expressed specifically in primary spermatocytes and spermatids. The regulatory elements required for a high level of testis-specific expression of the gene are placed between the two major transcription start sites T1 and T2 (approximately 350 and 115 bp upstream of the starting ATG codon). Here we have shown that sequences proximal to the exon1/intron splicing site in the 5' untranslated region of the Hsp70.2/Hst70 gene, which include a highly conserved element called box B, are required for efficient expression of the chloramphenicol acetyltransferase reporter gene in testes of transgenic mice. However, in spite of the drastically reduced overall activity, the stage-specific expression pattern of the transgene was preserved after removal of these sequences. We have also shown that GC-box located downstream of the box B (approximately 210 bp upstream of the starting ATG codon) is indispensable for efficient expression of the Hsp70.2/Hst70 gene promoter in spermatogenic cells. The GC-box specifically binds proteins present in nuclear extracts from testes (putatively Sp1-like factors). A change in the pattern of such GC-box-interacting factors corresponds to activation of the Hsp70.2/Hst70 gene, confirming the importance of this regulatory element.
    Źródło:
    Acta Biochimica Polonica; 2007, 54, 1; 107-112
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Annual reproductive cycle in two free living populations of three-spined stickleback (Gasterosteus aculeatus L.): patterns of ovarian and testicular development
    Autorzy:
    Sokolowska, E.
    Kulczykowska, E.
    Powiązania:
    https://bibliotekanauki.pl/articles/47889.pdf
    Data publikacji:
    2006
    Wydawca:
    Polska Akademia Nauk. Instytut Oceanologii PAN
    Tematy:
    free living population
    stickleback
    gonad
    environment change
    reproductive cycle
    wild population
    Oliva Stream
    natural habitat
    fresh water
    breeding
    Vistula River
    Gasterosteus aculeatus
    spermatogenesis
    vitellogenesis
    Opis:
    The annual reproductive cycle in two wild populations of three-spined stickleback was studied. Sticklebacks from the Dead Vistula River (Martwa Wisła) (brackish water) and the Oliva Stream (Potok Oliwski) (freshwater) were exposed to annual environmental changes in their natural habitats. Ovaries and livers (females), and testes and kidneys (males) were collected during 1–2 years. The gonadosomatic IG, hepatosomatic IH, nephrosomatic IN indices, kidney epithelium height (KEH) and size of oocytes were calculated. The number of mature oocytes and percentage of ovulating females were determined during the spawning season. Histological changes in the ovaries and testes were described throughout a year. Annual reproductive cycles were similar in both populations of sticklebacks. This is the first histological and morphological study carried out throughout a year, simultaneously in two wild populations of three-spined sticklebacks inhabiting different environments. An improved scale of gonadal development in conjunction with the determined indices and fecundity give a comprehensive description of the reproductive cycle. These newobserv ations, in combination with previously reported features, provide a universal scale that can be successfully used to distinguish all phases of gametogenesis in sticklebacks in different habitats.
    Źródło:
    Oceanologia; 2006, 48, 1
    0078-3234
    Pojawia się w:
    Oceanologia
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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