- Tytuł:
- Thermodynamic aspects of the self-assembly of DsrA, a small noncoding RNA from Escherichia coli
- Autorzy:
-
Geinguenaud, Frédéric
Gesson, Maeva
Arluison, Véronique - Powiązania:
- https://bibliotekanauki.pl/articles/1039361.pdf
- Data publikacji:
- 2014
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
DsrA
small noncoding RNA
nucleic acid self-assembly
RNA nanotechnology - Opis:
- DsrA is an Escherichia coli small noncoding RNA that acts by base pairing to some mRNAs in order to control their translation and turnover. It was recently shown that DsrA is able to self-associate in a way similar to DNA and to build nanostructures. Although functional consequence of this RNA self-assembly in vivo is not yet understood, the formation of such an assemblage more than likely influences the noncoding RNA function. We report here for the first time the thermodynamic basis of this natural RNA self-assembly. In particular we show that assembling of the ribonucleic acid is enthalpy driven and that the versatility of the RNA molecule is important for the polymerisation; indeed, an equivalent DNA sequence is unable to make a nanoassembly. The origin of the difference is discussed herein.
- Źródło:
-
Acta Biochimica Polonica; 2014, 61, 1; 179-184
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł