- Tytuł:
- Atopic eczema: genetics or environment?
- Autorzy:
-
Wuthrich, B
Cozzio, A.
Roll, A.
Senti, G.
Kundig, T.
Schmid-Grendelmeier, P. - Powiązania:
- https://bibliotekanauki.pl/articles/49593.pdf
- Data publikacji:
- 2007
- Wydawca:
- Instytut Medycyny Wsi
- Tematy:
-
inflammatory skin disease
environmental factor
food
atopy patch test
non-atopic eczema
Staphylococcus aureus
contact allergen
chronic disease
human disease
genetic condition
therapy
Malassezia sympodialis
skin disease
immunological deviation
atopic eczema
skin structure
skin infection
skin barrier - Opis:
- Atopic eczema (AE) is a multifactorial skin disease caused by a variety of factors such as genetic conditions, alterated skin structure, immunologic deviations and environmental factors, among others. There are two main subtypes of AE, i.e. the IgE-associated (“atopic eczema”) and the non-IgE-associated type (“nonatopic eczema”) with different prognosis concerning the development of respiratory diseases (“atopy march”). Recently, it was demonstrated that Filaggrin (= fi lament-aggregating protein, FL) is a major gene for atopic eczema. Filaggrin binds to and aggregates the keratin cytoskeleton in the epidermis. Homozygous FLG mutation leads to complete loss of fi laggrin expression in skin. Half or more of children with moderate to severe AE carry FLG mutations. Moreover, fi laggrin loss-of-function mutations predispose to phenotypes involved in the atopy march. The altered skin structure and a defi ciency in antimicrobial peptides favour colonization with Staphylococcus aureus and yeasts (Malassezia sp.). Sensitization to the yeast occurs almost exclusively in AE patients. S. aureus enterotoxins with superantigenic activity stimulate activation of T cells and macrophages. So far, AE skin lesions are orchestrated by the local tissue expression of proinfl ammatory cytokines and chemokines with activation of T lymphocytes, dendritic cells, macrophages, keratinocytes, mast cells, and eosinophils which lead to the skin infl ammatory responses. From the therapeutic point of view, besides emollients and local corticosteroids, topic immunomodulatory drugs (tacrolimus and pimecrolimus) have substantially improved the treatment of AE.
- Źródło:
-
Annals of Agricultural and Environmental Medicine; 2007, 14, 2
1232-1966 - Pojawia się w:
- Annals of Agricultural and Environmental Medicine
- Dostawca treści:
- Biblioteka Nauki
Artykuł