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    Wyświetlanie 1-11 z 11
    Tytuł:
    Genotype TNF-α(-308) and Silicosis on Factory Workers in Vietnam in 2020
    Autorzy:
    Nguyen, Viet
    Nguyen, Thi Thu Huyen
    Dao, Xuan Dat
    Vu, Xuan Quy
    Pham, Thi Quan
    Le, Thi Kim Chung
    Tran, Huy Thinh
    Le, Thi Huong
    Nguyen, Ngoc Anh
    Nguyen, Viet Nhung
    Nguyen, Ngoc Hong
    Luong, Mai Anh
    Le, Thi Thanh Xuan
    Powiązania:
    https://bibliotekanauki.pl/articles/2020235.pdf
    Data publikacji:
    2021
    Wydawca:
    Polskie Towarzystwo Przeróbki Kopalin
    Tematy:
    silicosis
    genotype
    TNF-α
    Vietnam
    Wietnam
    genotyp
    Opis:
    The studFigy aims to determine the TNF-α single-nucleotide polymorphism TNF-α (-308) and assess the association of TNF-a(-308) SNP with the risk of silicosis among workers directly exposed to silica dust in Vietnam. A study was undertaken among 78 cases with silicosis and 103 controls without silicosis in Vietnam. Blood samples were collected for genomic DNA extraction from each subject. The phenotyping of TNF-α(-308) was performed using polymerase chain reaction‐based restriction fragment length polymorphism (PCR‐RFLP) and dye termination sequencing. Results: The average exposure time of the case group was slightly higher than that of the control group (12.46 ± 6.732 years vs. 12.09 ± 7.854 years). The majority of genotypes in both silicosis and non-silicosis was GG. When analyzing the concentration of TNF-α in the study participants' blood, it is shown that the average concentration of TNFα in the case group was higher than that in the control group. The genotype AG in the case group was 1.368 times higher than that in the control group. The percentage of all A alleles in the case group with silicosis was 1.342 times higher than the control group without the disease, similar to previous studies. Conclusion: The majority of genotypes in both groups was GG. The average concentration of TNF-α in blood, genotype AG, and the percentage of all A alleles in the case group was higher than that in the control group.
    Źródło:
    Inżynieria Mineralna; 2021, 2; 459--466
    1640-4920
    Pojawia się w:
    Inżynieria Mineralna
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Epidemiology of silicosis reported to the central register of occupational diseases over last 20 years in Poland
    Autorzy:
    Nowak-Pasternak, Joanna
    Lipińska-Ojrzanowska, Agnieszka
    Świątkowska, Beata
    Powiązania:
    https://bibliotekanauki.pl/articles/2152952.pdf
    Data publikacji:
    2022
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    Polska
    occupational diseases
    epidemiology
    silica
    silicosis
    pneumoconioses
    Opis:
    Objectives The aim of the study was to investigate and assess the incidence of silicosis cases acknowledged as occupational diseases in Poland in 2000–2019. Material and Methods The cases of all medically recognized pneumoconioses, including silicoses, certified as occupational diseases were studied. The records were extracted from the Central Register of Occupational Diseases, the only official Polish central electronic data base of occupational diseases. Results During the period 2000–2019, 2066 confirmed cases of silicoses and 10 665 cases of other pneumoconioses including asbestosis and coal workers’ pneumoconiosis were reported to the Central Register of Occupational Diseases. Silicoses accounted for 12.8–21.2% of all pneumoconioses. The number of confirmed silicoses cases was growing along with the length of latency period and was the highest for the period of ≥40 years (513 cases). Over 70% of silicoses cases occurred after occupational exposure >20 years. The most workers who evolved silicosis were employed in manufacturing, predominantly casting of iron, mining and quarrying and construction. Conclusions The number of confirmed cases of silicosis in Poland decreased in 2000–2019 but the disease still remains an important health problem. Prevention is crucial to reduce further disease incidence. The medical monitoring standards of exposed workers should be improved. Developing new diagnosing guidelines with the use of other imaging examinations, like high-resolution computed tomography, has to be considered. The analysis should contribute into the implementation of silicosis preventative programmes, both at the enterprise and national level.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2022, 35, 5; 561-570
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Pneumomediastinum, bilateral pneumothorax and subcutaneous emphysema complicating acute silicosis
    Autorzy:
    Dixit, Ramakant
    Meena, Manoj
    Patil, Chetan B.
    Powiązania:
    https://bibliotekanauki.pl/articles/2177340.pdf
    Data publikacji:
    2015-04-15
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    silicosis
    Pneumothorax
    pneumomediastinum
    subcutaneous emphysema
    stone factories
    Opis:
    A case of acute silicosis complicating as spontaneous pneumomediastinum, bilateral pneumothorax and subcutaneous emphysema is described in a 35-year-old male engaged in stone crusher unit. Diagnosis was established on clinical and radiological assessment and supported by occupational history of the patient. This case is unique one as all these 3 complications at the same time are very uncommon in acute silicosis.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2015, 28, 3; 635-638
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A study of oxidative stress and pulmonary damage after silica instillation in rats and the effect of curcumin administration
    Autorzy:
    Barsan, Maria
    Rajnoveanu, Armand G.
    Cocarla, Aristotel
    Bolfa, Pompei
    Login, Cezar C.
    Socaciu, Andreea I.
    Decea, Nicoleta
    Leucuta, Daniel-Corneliu
    Powiązania:
    https://bibliotekanauki.pl/articles/2081923.pdf
    Data publikacji:
    2021-06-30
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    curcumin
    silicosis
    experimental study
    silica
    oxidative stress
    lung tissue
    Opis:
    BackgroundThe authors’ aim was to study the dynamics of oxidative stress in experimental exposure to silica dust, to evaluate the histopathological findings in the phase preceding the formation of fibrous/fibrohyaline pulmonary nodules, and to assess the effects of curcumin administration.Material and MethodsThe research was performed on 48 male Wistar rats with an average weight of 320 g. Overall, 38 rats were instilled with a single dose of 0.3 ml suspension containing 30 mg of a SiO2/ml saline solution, and were sacrificed 30, 90 and 120 days after instillation; 14 of those sacrificed on days 90 and 120 also received curcumin. The control group included 10 animals which were instilled with a saline solution. Malondialdehyde (MDA), carbonyl proteins (CPs), total thiolic proteins (TPs) and reduced glutathione (GSH) were determined in blood and the lung tissue. The standard technique for pulmonary toxicology developed by Porter was applied to semi-quantitatively assess the histopathological findings.ResultsIt was found that MDA had increased significantly early on in both biological environments and remained elevated, and adding curcumin proved beneficial, while CPs only increased moderately in the lung tissue without a curcumin impact. Moreover, TPs dropped abruptly, significantly and persistently in the lung tissue and blood, and were not influenced by curcumin. Finally, GSH decreased significantly and intensely in the lung tissue and blood, with curcumin lowering the levels towards those found within the control group. The histopathological examination identified nodules of a cellular type, without any fibrosis, but with spots of associated lipoproteinosis. The early lesions in the airways and vessels were suggestive of a remodeling process. Curcumin diminished the occurrence of alveolitis but not the remodeling process.ConclusionsThe study confirms the early onset of oxidative stress in experimental silicosis. It also simultaneously and dynamically researches markers of oxidative stress in blood and the lung tissue. Curcumin proved beneficial on oxidative stress and lesions in the alveolar epithelia, but ineffective in preventing vascular and airway remodeling. Med Pr. 2021;72(3):239–47
    Źródło:
    Medycyna Pracy; 2021, 72, 3; 239-247
    0465-5893
    2353-1339
    Pojawia się w:
    Medycyna Pracy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of differential serum expression of three factors and pulmonary function in patients with silicosis
    Autorzy:
    Zhu, Ying
    Duan, Xia Yu
    Cheng, Yun Qi
    Yao, Xin Jing
    Xu, Hong
    Zhang, Kui Sheng
    Li, Feng Shi
    Yang, Fang
    Liu, Liang He
    Yuan, Xiang Ju
    Powiązania:
    https://bibliotekanauki.pl/articles/2086531.pdf
    Data publikacji:
    2021-08-05
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    silicosis
    pulmonary function
    early diagnosis
    ROC
    PTPN2
    factor B
    Opis:
    ObjectivesSilicosis is a chronic occupational lung disease. As was previously found by the authors, some proteins increased in the lung tissue of activated rats, and protein tyrosine phosphatase non-receptor type 2 (PTPN2), factor B, and vaccinia-related kinase 1 (VRK1) showed highly differential expressions.Material and MethodsIn this study, serum and bronchoalveolar lavage fluid samples were collected from patients with silicosis and healthy people to verify the expression of PTPN2, factor B, and VRK1. The diagnostic value of differentially expressed proteins for silicosis was judged.ResultsThe expression levels of serum PTPN2, VRK1, and factor B in patients with silicosis were significantly higher than those in the control group (p < 0.01). Higher serum PTPN2 and factor B concentrations significantly and negatively correlated with the ratio of forced expiratory volume in 1 s to forced vital capacity (FEV1/FVC), maximum vital capacity (VCmax), FEV1, and FVC, suggesting that the high expression of PTPN2 and factor B is associated with decreased pulmonary ventilation function and restrictive ventilatory impairment in patients with silicosis. All area under curve (AUC) measurements generated from single detection events were >0.744, with PTPN2 reaching the highest value (0.858). The AUC, sensitivity, and specificity for the combined diagnosis using factor B and PTPN2 were 0.907, 86.91% and 85.07%, respectively, for factor B and PTPN2. The 3 differentially expressed proteins are potential classes of predictive biomarkers for silicosis.ConclusionsRegarding the economy and test practicality, the best diagnostic combination is factor B and PTPN2 for the analysis of AUC, sensitivity and specificity.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2021, 34, 4; 527-540
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Silicosis in Switzerland
    Autorzy:
    Koller, Michael F.
    Scholz, Stefan M.
    Pletscher, Claudia
    Miedinger, David
    Powiązania:
    https://bibliotekanauki.pl/articles/2162017.pdf
    Data publikacji:
    2018-10-23
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    lung cancer
    silicosis
    quartz
    occupational exposure limit
    crystalline silica
    Switzerland
    Opis:
    Objectives The correlation between quartz dust concentrations in the Swiss enterprises and the incidence of silicosis and other related diseases acknowledged as occupational diseases (OD) was investigated. Material and Methods Quartz dust concentrations were obtained from Suva’s databases of occupational health surveillance measurements between 2005 and 2014. Information on quartz dust-related diseases was from medical dossiers of workers with OD acknowledged by Suva between 2005 and 2014. Results The median quartz dust concentration of the 2579 measurements between 2005 and 2014 was 0.09 mg/m³ (alveolar fraction). Out of all measurements, 28% were above the Swiss occupational exposure limit (OEL) of 0.15 mg/m³ (alveolar fraction). One hundred eighty-one individuals suffered from acknowledged quartz dust-related disease (179 silicosis and 2 chronic obstructive pulmonary disease (COPD)). Additionally, 8 out of these workers were diagnosed with lung cancer and 55 with COPD of a non-specified cause. Out of all workers, 46% were exposed to silica dust for the first time before 1975 when the current Swiss OEL was introduced. Out of the foreign workers, 63% began to work abroad, during which they could have at least partly acquired their silicosis. Out of all workers, 75% were ever-smokers. Conclusions The incidence of silicosis decreased drastically from approximately 300 cases/year in the 1970s to fewer than 20 cases/year 20 years ago. Several findings of this study that could help to interpret the ongoing occurrence of the disease include excessive exposure in or outside of Switzerland in former or current times, vulnerability to the development of silicosis due to cigarette smoke, or poor compliance with wearing breathing masks. Int J Occup Med Environ Health 2018;31(5):659–676
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2018, 31, 5; 659-676
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Subcutaneous administration of infliximab-attenuated silica-induced lung fibrosis
    Autorzy:
    Zhang, Hua
    Sui, Jun-Na
    Gao, Lei
    Guo, Jian
    Powiązania:
    https://bibliotekanauki.pl/articles/2162006.pdf
    Data publikacji:
    2018-07-04
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    infliximab
    silicosis
    TNF-α
    rat model
    NF-κB
    iNOS
    Opis:
    Objectives To investigate the influence of the anti-tumor necrosis factor-α infliximab (IFX) in the case of rats with silicosis. Material and Methods Forty-eight Wistar rats were randomly divided into 3 groups. The study group (N = 16) – silicosis was induced by intratracheal instillation of 50 mg silica on day 1, and IFX was subcutaneously administered at a dose of 15 mg/kg of body weight from day 2 to day 6, the vehicle group (N = 16) – silica used as the study group but without IFX, the sham group (N = 16) – 1 ml of saline was intratracheal-used. Eight rats in each group were euthanized on day 7 and on day 14, respectively. Lung tissue sections were stained with hematoxylin and eosin or Masson’s trichromedye. The nuclear factor-κB p65 (NF-κB p65) positioning in the lung tissues were determined by immunohistochemical staining. Levels of tumor necrosis factor α (TNF-α) in rat serum and bronchoalveolar lavage fluid were measured with enzyme linked immunosorbent assay. The inducible nitric oxide synthase (iNOS) mRNA in the lung tissues was measured by quantitative real-time polymerase chain reaction, as well as inhibitor protein-κB (I-κB) and NF-κB p65 expression were measured quantitatively by western blotting. Results Silica installation increased the lung tissues inflammation reaction, oxidative stress and pulmonary fibrosis. Infliximab treatment significantly improved silica-induced lung pathological changes (inflammatory cells, collagen deposition), decreased the TNF-α inhibited NF-κB signaling (I-κB, NF-κB p65) as well as oxidant status (iNOS). Conclusions Infliximab may improve silica-induced pulmonary inflammation by decreasing the TNF-α, inhibiting NF-κB signaling (I-κB, NF-κB p65) as well as oxidant status (iNOS), which suggest that IFX has potential role in the treatment of silica-induced lung damage. Int J Occup Med Environ Health 2018;31(4):503–515
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2018, 31, 4; 503-515
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effectiveness of a Mobile Application-Based Intervention to Improve Knowledge and Practice Regarding Silicosis Among High-Risk Workers of Dust Exposure in a Northern Province of Vietnam
    Autorzy:
    Nguyen, Thi Thu Huyen
    Ta, Thi Kim Nhung
    Pham, Thi Quan
    Nguyen, Thanh Thao
    Nguyen, Ngoc Anh
    Nguyen, Thi Lien Huong
    Le, Thi Huong
    Luong, Mai Anh
    Le, Thi Thanh Xuan
    Powiązania:
    https://bibliotekanauki.pl/articles/27323251.pdf
    Data publikacji:
    2023
    Wydawca:
    Polskie Towarzystwo Przeróbki Kopalin
    Tematy:
    knowledge
    practice
    workers
    silicosis
    mobile application
    effectiveness
    praca
    aplikacja mobilna
    Wietnam
    Opis:
    Objectives: to analyze changes in knowledge and practices regarding silicosis in groups of workers at high risk of silicosis before - after an intervention. Methods: The study was conducted from 2018 to 2019 based on structured questions related to knowledge and practices of silicosis of workers directly exposed to silica dust in a Northern province of Vietnam. The mobile app-based intervention was applied to steel workers, then compared with ironworkers in improvements in silicosis knowledge and practices. Results: Significant changes in the intervention group related to workers' knowledge about the signs suggestive of silicosis, disease consequences, measures to reduce the risk of silicosis, and participation in annual occupational disease examinations were reported. Conclusion: Mobile applicationbased interventions could improve silicosis knowledge and practice among workers at high risk of exposure to silica dust.
    Źródło:
    Inżynieria Mineralna; 2023, 2; 295--302
    1640-4920
    Pojawia się w:
    Inżynieria Mineralna
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Concept of health surveillance programme for workers exposed to respirable crystalline silica at present and in the past
    Autorzy:
    Nowak-Pasternak, Joanna
    Świątkowska, Beata
    Lipińska-Ojrzanowska, Agnieszka
    Powiązania:
    https://bibliotekanauki.pl/articles/23388842.pdf
    Data publikacji:
    2023-11-14
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    epidemiology
    silicosis
    lung diseases
    occupational diseases
    prevention and control
    silicon dioxide
    Opis:
    In the paper authors present general assumptions of health surveillance programme concept for workers employed in respirable crystalline silica (RCS) exposure at present and in the past. There is no effective treatment for silicosis thus disease prevention is of paramount significance. For decades efforts of World Health Organization (WHO) and International Work Organization (ILO) have been focused on eliminating silicosis globally. Unfortunately silicosis is still one of the most lethal occupational diseases and the preventative programmes have not yet been successful. The authors identify main steps to complete an overview of RCS exposure and suggest lines of actions to be taken before launching the health surveillance programme. Introduction of the health surveillance programme would increase awareness of harmful health effects of the RCS exposure, emphasize the significance of preventive medical check-ups and early diagnostics of occupational diseases as well as the importance of using appropriate protective equipment. The programme development on a national level might be carried out with the cooperation of multiple backgrounds and institutions. This would allow for detailed planning, implementation, monitoring and effective evaluation of its results. Having a better and updated knowledge of silicosis epidemiology, early diagnostics, the possible sources of RCS occupational exposure and evaluation of undertaken preventive actions are crucial factors in disease prevention. The programme introduction would be of educational significance for all the stakeholders and the groups engaged in the project implementation, which would contribute to high effectiveness of the preventive activities and their improvement in the future.
    Źródło:
    Medycyna Pracy. Workers’ Health and Safety; 2023, 74, 4; 341-346
    0465-5893
    2353-1339
    Pojawia się w:
    Medycyna Pracy. Workers’ Health and Safety
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Ocena narażenia zawodowego na frakcję respirabilną krzemionki krystalicznej powstającą w trakcie pracy
    Assessment of occupational exposure to the respirable fraction of crystalline silica produced in technological processes
    Autorzy:
    Pośniak, Małgorzata
    Dobrzyńska, Elżbieta
    Powiązania:
    https://bibliotekanauki.pl/articles/31342487.pdf
    Data publikacji:
    2022
    Wydawca:
    Centralny Instytut Ochrony Pracy
    Tematy:
    krzemionka krystaliczna
    frakcja respirabilna
    czynnik rakotwórczy
    pylica krzemowa
    narażenie zawodowe
    crystalline silica
    respirable fraction
    carcinogen
    silicosis
    occupational exposure
    Opis:
    Wśród form krystalicznej krzemionki (minerałów zbudowanych z ditlenku krzemu), które najpowszechniej występują w środowisku naturalnym i w środowisku pracy, są kwarc i krystobalit. Są one wykorzystywane w różnych gałęziach przemysłu, m.in. w branży ceramicznej, szklarskiej czy budowlanej, i stanowią poważne zagrożenie dla zdrowia pracowników. Frakcja respirabilna krzemionki krystalicznej (FRKK), która przedostaje się do obszaru wymiany gazowej płuc, wywołuje przewlekłe reakcje zapalne, następnie zmiany zwłóknieniowe tkanki płucnej i w efekcie pylicę krzemową, często prowadzącą do raka płuc. Zarówno pracodawcy, jak i osoby zarządzające bhp, mają duże trudności z interpretacją oraz stosowaniem przepisów prawnych dotyczących pomiarów stężeń FRKK (w celu oceny narażenia zawodowego) i klasyfikacji prac w narażeniu na respirabilny pył powstający w trakcie procesów technologicznych. Informacje przedstawione w artykule powinny pomóc w rozwiązywaniu tych problemów.
    Among the forms of crystalline silica (silicon dioxide minerals) that are most common in the natural and work environments are quartz and cristobalite. They are used in various industries, including in the ceramics, glass and construction industries and pose a serious health risk to workers. The respirable of crystalline silica (RCS), which penetrates into the gas exchange area of the lungs causes chronic inflammatory reactions, followed by fibrotic changes in the lung tissue and, as a result, silicosis pneumoconiosis, often leading to lung cancer. Both employers and health and safety managers have great difficulties with the interpretation and application of legal provisions concerning the measurement of RCS concentrations (for the purpose of occupational exposure assessment) and the classification of work involving exposure to respirable dust generated during technological processes. The information in this article should help you resolve these issues.
    Źródło:
    Bezpieczeństwo Pracy : nauka i praktyka; 2022, 1; 13-19
    0137-7043
    Pojawia się w:
    Bezpieczeństwo Pracy : nauka i praktyka
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Health effects of occupational exposure to crystalline silica in the light of current research results
    Zdrowotne skutki narażenia zawodowego na krystaliczną krzemionkę w świetle wyników aktualnych badań
    Autorzy:
    Maciejewska, Aleksandra
    Powiązania:
    https://bibliotekanauki.pl/articles/2166204.pdf
    Data publikacji:
    2015-03-09
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    crystalline silica
    quartz
    silicosis
    health effects
    lung cancer
    occupational exposure
    krystaliczna krzemionka
    kwarc
    krzemica
    skutki zdrowotne
    Rak płuca
    narażenie zawodowe
    Opis:
    Krystaliczna krzemionka powszechnie występuje w środowisku pracy. Możliwe zdrowotne skutki zawodowego narażenia są nadal przedmiotem wielu badań. Celem niniejszej pracy była analiza aktualnych wyników badań dotyczących zdrowotnych skutków narażenia na krystaliczną krzemionkę, z uwzględnieniem różnych poziomów ekspozycji. Podstawę opracowania stanowiły publikacje zawarte w bazach: EBSCO, Scopus, ScienceDirect oraz Web of Science, znalezione z użyciem słów kluczowych: crystalline silica, quartz, health effects. Przegląd wyników badań potwierdza wielokierunkowe szkodliwe działanie krystalicznej krzemionki. W następstwie długotrwałej zawodowej ekspozycji, oprócz krzemicy płuc i nienowotworowych chorób układu oddechowego, może rozwijać się rak płuca, a także choroby o niewyjaśnionej ostatecznie patogenezie – choroby autoimmunizacyjne i choroby nerek. Ekspozycja na krystaliczną krzemionkę występującą w zakresie stężeń zbliżonych do obecnie obowiązujących wartości dopuszczalnych nie wyklucza ryzyka wystąpienia następujących patologii: krzemicy, raka płuca, innych chorób płuc oraz chorób nerek. Wyeliminowanie pyłu krystalicznej krzemionki ze środowiska pracy jest praktycznie niemożliwe, a głównym sposobem ograniczania zdrowotnych skutków narażenia nadal pozostaje jego minimalizowanie. Ważnym elementem zapobiegania szkodliwemu działaniu krzemionki może być dalszy postęp w dokładnym wyjaśnieniu mechanizmów interakcji pyłu krzemionkowego z komórkami, ustalenie znaczenia właściwości powierzchniowych cząstek w patogenezie oraz dokładne poznanie interakcji z pyłami współwystępującymi w środowisku pracy. Med. Pr. 2014;65(6):799–818
    Crystalline silica is commonly found in the work environment. Possible health effects of occupational exposure continue to be the subject of extensive research. The aim of this paper was to analyze the recent findings concerning the health effects of exposure to crystalline silica, taking into account different levels of exposure. This work is based on the relevant information from the papers retrieved from the following databases: EBSCO, Scopus, ScienceDirect, and Web of Science, using the following keywords: crystalline silica, quartz, health effects. The review of the results confirms the multi-faceted harmful effects of crystalline silica. Prolonged occupational exposure, apart from silicosis and non-cancer respiratory diseases, may also result in the development of lung cancer, and autoimmune and chronic kidney diseases, the pathogenesis, which has not been completely explained yet. The exposure to the crystalline silica at concentrations close to the current occupational exposure limit value does not exclude the risk of the following pathologies: silicosis, lung cancer, other lung diseases and renal diseases. It is not feasible to completely eliminate the crystalline silica dust from the work environment. The best way to reduce the health effects of the exposure is to minimize the concentrations of silica dust. Further progress in clarifying the true mechanisms of interaction between silica dust and lung cells, the determination of the importance of surface properties of the silica particles in the pathogenic processes and explaining the effects of co-morbid dust in the work environment may help to prevent the harmful effects of silica dust. Med Pr 2014;65(6):799–818
    Źródło:
    Medycyna Pracy; 2014, 65, 6; 799-818
    0465-5893
    2353-1339
    Pojawia się w:
    Medycyna Pracy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-11 z 11

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