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    Wyświetlanie 1-37 z 37
    Tytuł:
    Lipids and signal transduction in the nucleus.
    Autorzy:
    Dygas, Anna
    Barańska, Jolanta
    Powiązania:
    https://bibliotekanauki.pl/articles/1044152.pdf
    Data publikacji:
    2001
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    signal transduction
    nucleus
    Opis:
    During the last few years a growing amount of data has accumulated showing phospholipid participation in nuclear signal transduction. Very recent data strongly support the hypothesis that signal transduction in the nucleus is autonomic. Local production of inositol polyphosphates, beginning with the activation of phospholipase C is required for their specific function in the nucleus. Enzymes which modify polyphosphoinositols may control gene expression. Much less information is available about the role of other lipids in nuclear signal transduction. The aim of this minireview is to stress what is currently known about nuclear lipids with respect to nuclear signal transduction.
    Źródło:
    Acta Biochimica Polonica; 2001, 48, 2; 541-549
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Hydrolysis of cyclic GMP in rat peritoneal macrophages.
    Autorzy:
    Witwicka, Hanna
    Kobiałka, Marcin
    Gorczyca, Wojciech
    Powiązania:
    https://bibliotekanauki.pl/articles/1043691.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    signal transduction
    phosphodiesterases
    cyclic nucleotides
    macrophages
    Opis:
    Intact rat peritoneal macrophages (rPM) treated with 3-isobutyl-1-methylxanthine (IBMX), an inhibitor of phosphodiesterases (PDEs), accumulated more cGMP than untreated cells. A PDE activity toward [3H]cGMP was detected in the soluble and particulate fractions of rPM. The hydrolysis of cGMP was Ca2+/calmodulin-independent but increased in the presence of cGMP excess. Similar results were obtained when [3H]cAMP was used as a substrate. The hydrolytic activity towards both nucleotides was inhibited in the presence of IBMX. Therefore, the PDEs of families 2, 5, 10 and 11 are potential candidates for cGMP hydrolysis in the rPM. They may not only regulate the cGMP level in a feedback-controlled way but also link cGMP-dependent pathways with those regulated by cAMP.
    Źródło:
    Acta Biochimica Polonica; 2002, 49, 4; 891-897
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Signal transmission via G protein-coupled receptors in the light of rhodopsin structure determination.
    Autorzy:
    Ciarkowski, Jerzy
    Drabik, Piotr
    Giełdoń, Artur
    Kaźmierkiewicz, Rajmund
    Ślusarz, Rafał
    Powiązania:
    https://bibliotekanauki.pl/articles/1044085.pdf
    Data publikacji:
    2001
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    signal transduction
    neurohypophyseal receptors
    molecular modeling
    GPCRs
    Opis:
    G protein-coupled receptors (GPCRs) transducing diverse external signals to cells via activation of heterotrimeric GTP-binding (G) proteins, estimated to mediate actions of 60% of drugs, had been resistant to structure determination until summer 2000. The first atomic-resolution experimental structure of a GPCR, that of dark (inactive) rhodopsin, thus provides a trustworthy 3D prototype for antagonist-bound forms of this huge family of proteins. In this work, our former theoretical GPCR models are evaluated against the new experimental template. Subsequently, a working hypothesis regarding the signal transduction mechanism by GPCRs is presented.
    Źródło:
    Acta Biochimica Polonica; 2001, 48, 4; 1203-1207
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The basic biology of erbB-2 and its participation in colorectal cancers
    Autorzy:
    Stawińska, Magdalena
    Bryś, Magdalena
    Krajewska, Wanda M
    Powiązania:
    https://bibliotekanauki.pl/articles/764806.pdf
    Data publikacji:
    2005
    Wydawca:
    Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
    Tematy:
    ErbB-2
    colorectal cancers
    signal transduction
    tumour growth
    Opis:
    ErbB-2 is one of Tour cell surface growth factor receptors involved in transmission of signals controlling normal cell growth and differentiation. A range of growth factors serve as ligands, but none is specific for the ErbB-2 receptor. Ligand binding to ErbB-1, ErbB-3 and ErbB-4 induces rapid receptor dimerization, with a marked preference for ErbB-2 as a dimer partner. When ErbB-2 is overexpressed multiple ErbB-2 heterodimers are formed and cell signalling is stronger, resulting in enhanced responsiveness to growth factors and malignant growth. This explains why ErbB-2 overexpression is an indicator of poor prognosis in colorectal cancers and may be predictive of response to treatment. ErbB-2 is a highly specific and promising target for new colon cancer treatments.
    Źródło:
    Acta Universitatis Lodziensis. Folia Biologica et Oecologica; 2005, 2
    1730-2366
    2083-8484
    Pojawia się w:
    Acta Universitatis Lodziensis. Folia Biologica et Oecologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Slowing down aging from within: mechanistic aspects of anti-aging hormetic effects of mild heat stress on human cells.
    Autorzy:
    Rattan, Suresh
    Gonzalez-Dosal, Regina
    Nielsen, Elise
    Kraft, David
    Weibel, Jens
    Kahns, Søren
    Powiązania:
    https://bibliotekanauki.pl/articles/1043285.pdf
    Data publikacji:
    2004
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    aging
    signal transduction
    anti-aging
    longevity
    proteasome
    heat shock
    Opis:
    Since aging is primarily the result of a failure of maintenance and repair mechanisms, various approaches are being developed in order to stimulate these pathways and modulate the process of aging. One such approach, termed hormesis, involves challenging cells and organisms by mild stress that often results in anti-aging and life prolonging effects. In a series of experimental studies, we have reported that repeated mild heat stress (RMHS) has anti-aging hormetic effects on growth and various cellular and biochemical characteristics of human skin fibroblasts undergoing aging in vitro. These beneficial effects of repeated challenge include the maintenance of stress protein profile, reduction in the accumulation of oxidatively and glycoxidatively damaged proteins, stimulation of the proteasomal activities for the degradation of abnormal proteins, improved cellular resistance to other stresses, and enhanced levels of cellular antioxidant ability. In order to elucidate the molecular mechanisms of hormetic effects of RMHS, we are now undertaking studies on signal transduction pathways, energy production and utilisation kinetics, and the proteomic analysis of patterns of proteins synthesised and their posttranslational modifications in various types of human cells undergoing cellular aging in vitro. Human applications of hormesis include early intervention and modulation of the aging process to prevent or delay the onset of age-related conditions, such as sarcopenia, Alzheimer's disease, Parkinson's disease, cataracts and osteoporosis.
    Źródło:
    Acta Biochimica Polonica; 2004, 51, 2; 481-492
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Molecular cloning, characterization and expression of a guanylyl cyclase (HpGC1) involved in the stress signalling in Hippeastrum x hybr.
    Autorzy:
    Swiezawska, B.
    Szewczuk, P.
    Pawelek, A.
    Jaworski, K.
    Szmid-Jaworska, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/81222.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    molecular cloning
    expression
    characteristics
    guanylyl cyclase
    signal transduction
    light signal transduction
    biotic stress
    abiotic stress
    stress tolerance
    Hippeastrum x hybridum
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of aluminium on plant growth and metabolism.
    Autorzy:
    Mossor-Pietraszewska, Teresa
    Powiązania:
    https://bibliotekanauki.pl/articles/1044097.pdf
    Data publikacji:
    2001
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    aluminium
    signal transduction pathway
    phytotoxicity
    plant response
    oxidative stress
    Opis:
    Aluminium toxicity is one of the major factors that limit plant growth and development in many acid soils. Root cells plasma membrane, particularly of the root apex, seems to be a major target of Al toxicity. However, strong interaction of Al3+, the main Al toxic form, with oxygen donor ligands (proteins, nucleic acids, polysaccharides) results in the inhibition of cell division, cell extension, and transport. Although the identification of Al tolerance genes is under way, the mechanism of their expression remains obscure.Soil chemical factors that limit root growth in acid soils, diminish crop production, include Al, Mn and various cations, and also deficiency or unavailability of Ca, Mg, P, Mo, and Si. These effects are further complicated by interactions of Al with other ions in different plant genotypes and under stress conditions (Foy, 1992). Cytotoxicity of Al has been well documented in plants (Delhaize & Ryan, 1995; Horst et al., 1999; Kollmeier et al., 2000; Marienfeld et al., 2000). It is generally known that plants grown in acid soils due to Al solubility at low pH have reduced root systems and exhibit a variety of nutrient-deficiency symptoms, with a consequent decrease in yield. In many countries with naturally acid soils, which constitute about 40% of world arable soil (LeNoble et al., 1996), Al toxicity is a major agricultural problem, and is intensively studied in plant systems.The effects of aluminium on plant growth, crop yield, uptake and nutrients distribution in vegetative and reproductive parts are still not fully understood. This review discusses recent information on aluminium toxicity with an emphasis on plant response to Al stress.
    Źródło:
    Acta Biochimica Polonica; 2001, 48, 3; 673-686
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Particulate guanylyl cyclases: multiple mechanisms of activation.
    Autorzy:
    Kobiałka, Marcin
    Gorczyca, Wojciech
    Powiązania:
    https://bibliotekanauki.pl/articles/1044281.pdf
    Data publikacji:
    2000
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    signal transduction
    calcium-binding proteins
    guanylyl cyclases
    cyclic nucleotides
    Opis:
    Cyclic GMP (cGMP), a key messenger in several signal transduction pathways, is synthesized from GTP by a family of enzymes termed guanylyl cyclases, which are found in two forms: cytosolic (soluble) and membrane-bound (particulate). The past decade has brought significant progress in understanding the molecular mechanisms that underlie the regulation of particulate guanylyl cyclases and new members of their family have been identified. It has become more evident that the basic mechanism of catalysis of guanylyl cyclases is analogous to that recognized in adenylyl cyclases. Here we review the known basic mechanisms that contribute to the regulation of particulate guanylyl cyclases.
    Źródło:
    Acta Biochimica Polonica; 2000, 47, 3; 517-528
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Structure and functions of plant calcium-dependent protein kinases
    Autorzy:
    Klimecka, Maria
    Muszyńska, Grażyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1041065.pdf
    Data publikacji:
    2007
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    signal transduction
    stress responses
    cross-talk
    calcium
    plant protein kinases
    Opis:
    Calcium ions as second messengers play an essential role in many important cellular processes. In plants, transient changes in calcium content in the cytosol (calcium signatures) have been observed during growth, development and under stress conditions. Such diverse functions require many different calcium sensors. One of the largest and most differentiated group of calcium sensors are protein kinases, among them calcium-dependent protein kinases (CDPKs) which were identified only in plants and protists. CDPKs have a regulatory domain which is able to bind calcium ions. For regulation of CDPKs activities not only calcium ions but also specific phospholipids and autophosphorylation are responsible. CDPKs have many different substrates, which reflects the diversity of their functions. Potential protein substrates of CDPK are involved in carbon and nitrogen metabolism, phospholipid synthesis, defense responses, ion and water transport, cytoskeleton organization, transcription and hormone responses. Presently, participation of CDPKs in stress signal transduction pathways (e.g., cold, drought, high salinity, wounding) is intensively studied in many laboratories. An intriguing, but still not fully clarified problem is the cross-talk via CDPKs among different signaling pathways that enables signal integration at different levels and ensure appropriate downstream responses.
    Źródło:
    Acta Biochimica Polonica; 2007, 54, 2; 219-233
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Arabidopsis thaliana MKKK18 is involved in abscisic acid signalling
    Autorzy:
    Mitula, F.
    Tajdel, M.
    Sadowski, J.
    Ludwikow, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/81146.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    Arabidopsis thaliana
    abscisic acid
    MAP kinase inhibitor
    signal transduction
    gfp gene
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Steroid signal transduction activated at the cell membrane: from plants to animals.
    Autorzy:
    Marcinkowska, Ewa
    Więdłocha, Antoni
    Powiązania:
    https://bibliotekanauki.pl/articles/1043743.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    signal transduction pathways
    membrane receptors
    nuclear receptors
    transcription factors
    translocation
    steroid hormones
    Opis:
    Steroid hormones in plants and in animals are very important for physiological and developmental regulation. In animals steroid hormones are recognized by nuclear receptors, which transcriptionally regulate specific target genes following binding of the ligand. In addition, numerous rapid effects generated by steroids appear to be mediated by a mechanism not depending on the activation of nuclear receptors. Although the existence of separate membrane receptors was postulated many years ago and hundreds of reports supporting this hypothesis have been published, no animal membrane steroid receptor has been cloned to date. Meanwhile, a plant steroid receptor from Arabidopsis thaliana has been identified and cloned. It is a transmembrane protein which specifically recognizes plant steroids (brassinosteroids) at the cell surface and has a serine/threonine protein kinase activity. It seems that plants have no intracellular steroid receptors, since there are no genes homologous to the family of animal nuclear steroid receptors in the genome of A. thaliana. Since the reason of the rapid responses to steroid hormones in animal cells still remains obscure we show in this article two possible explanations of this phenomenon. Using 1,25-dihydroxyvitamin D3 as an example of animal steroid hormone, we review results of our and of other groups concordant with the hypothesis of membrane steroid receptors. We also review the results of experiments performed with ovarian hormones, that led their authors to the hypothesis explaining rapid steroid actions without distinct membrane steroid receptors. Finally, examples of polypeptide growth factor that similarly to steroids exhibit a dual mode of action, activating not only cell surface receptors, but also intracellular targets, are discussed.
    Źródło:
    Acta Biochimica Polonica; 2002, 49, 3; 735-745
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Environmental factors-induced stomatal signalling
    Autorzy:
    Merilo, E.
    Laanemets, K.
    Xue, S.
    Margna, L.
    Schroeder, J.
    Brosche, M.
    Kollist, H.
    Powiązania:
    https://bibliotekanauki.pl/articles/80937.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    environmental factor
    stomatal signalling
    signal transduction
    stomatal conductance
    carbon dioxide
    air humidity
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Metabolism of cyclic GMP in peritoneal macrophages of rat and guinea pig.
    Autorzy:
    Kobiałka, Marcin
    Witwicka, Hanna
    Siednienko, Jakub
    Gorczyca, Wojciech
    Powiązania:
    https://bibliotekanauki.pl/articles/1043463.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    guinea pig
    rat
    signal transduction
    phosphodiesterases
    guanylyl cyclases
    protein kinases
    cyclic nucleotides
    macrophages
    Opis:
    The aim of our studies was to establish which enzymes constitute the "cGMP pathway" in rat and guinea pig peritoneal macrophages (PM). We found that in guinea pig PM synthesis of the nucleotide was significantly enhanced in response to activators of soluble guanylyl cyclase (sGC) and it was only slightly stimulated by specific activators of particulate guanylyl cyclases (pGC). In contrast, rat PM responded strongly to atrial natriuretic peptide (ANP), the activator of pGC type A. The rat cells synthesized about three-fold more cGMP than an equal number of the guinea pig cells. The activity of phosphodiesterases (PDE) hydrolyzing cGMP was apparently regulated by cGMP itself in PM of both species and again it was higher in the rat cells than in those isolated from guinea pig. However, guinea pig PM revealed an activity of Ca2+/calmodulin-dependent PDE1, which was absent in the rat cells. Using Western blotting analysis we were unable to detect the presence of cGMP-dependent protein kinase 1 (PKG1) in PM isolated from either species. In summary, our findings indicate that particulate GC-A is the main active form of GC in the rat PM, while in guinea pig macrophages the sGC activity dominates. Since the profiles of the PDE activities in rat and guinea pig PM are also different, we conclude that the mechanisms regulating cGMP metabolism in PM are species-specific. Moreover, our results suggest that targets for cGMP other than PKG1 should be present in PM of both species.
    Źródło:
    Acta Biochimica Polonica; 2003, 50, 3; 837-847
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    TGF beta signalling and its role in tumour pathogenesis.
    Autorzy:
    Kaminska, Bozena
    Wesolowska, Aleksandra
    Danilkiewicz, Malgorzata
    Powiązania:
    https://bibliotekanauki.pl/articles/1041410.pdf
    Data publikacji:
    2005
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Smad propteins
    RNA interference.
    TGF beta signal transduction
    tumour invasion
    cancer therapy
    MAP kinases
    Opis:
    Transforming growth factor beta (TGF-β) is a multifunctional cytokine involved in the regulation of cell proliferation, differentiation and survival/or apoptosis of many cells. Knock-out experiments in mice for the three isoforms of TGF-β have demonstrated their importance in regulating inflammation and tissue repair. TGF-β is implicated in the pathogenesis of human diseases, including tissue fibrosis and carcinogenesis. TGF-β receptors act through multiple intracellular pathways. Upon binding of TGF-β with its receptor, receptor-regulated Smad2/3 proteins become phosphorylated and associate with Smad4. Such complex translocates to the nucleus, binds to DNA and regulates transcription of specific genes. Negative regulation of TGF-β/Smad signalling may occur through the inhibitory Smad6/7. Furthermore, TGF-β-activated kinase-1 (TAK1) is a component of TGF-β signalling and activates stress-activated kinases: p38 through MKK6 or MKK3 and c-Jun N-terminal kinases (JNKs) via MKK4. In the brain TGF-β, normally expressed at the very low level, increases dramatically after injury. Increased mRNA levels of the three TGF-β isoforms correlate with the degree of malignancy of human gliomas. TGF-βs are secreted as latent precursors requiring activation into the mature form. TGF-β may contribute to tumour pathogenesis by direct support of tumour growth and influence on local microenvironment, resulting in immunosuppression, induction of angiogenesis, and modification of the extracellular matrix. TGF-β1,2 may stimulate production of vascular endothelial growth factor (VEGF) as well as plasminogen activator inhibitor (PAI-I), that are involved in vascular remodelling occurring during angiogenesis. Blocking of TGF-β action inhibits tumour viability, migration, metastases in mammary cancer, melanoma and prostate cancer model. Reduction of TGF-β production and activity may be a promising target of therapeutic strategies to control tumour growth.
    Źródło:
    Acta Biochimica Polonica; 2005, 52, 2; 329-337
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Protein phosphatase 2A: Variety of forms and diversity of functions
    Autorzy:
    Lechward, Katarzyna
    Awotunde, Olubunmi
    Świątek, Wojciech
    Muszyńska, Grażyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1044037.pdf
    Data publikacji:
    2001
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    protein phosphatase 2A
    signal transduction
    protein-protein interactions
    reversible phosphorylation
    cell cycle
    carcinogenesis.
    Opis:
    Protein phosphatase 2A (PP2A) comprises a diverse family of phosphoserine-and phosphothreonine-specific phosphatases present in all eukaryotic cells. All forms of PP2A contain a catalytic subunit (PP2Ac) which forms a stable complex with the structural subunit PR65/A. The heterodimer PP2Ac-PR65/A associates with regulatory proteins, termed variable subunits, in order to form trimeric holoenzymes attributed with distinct substrate specificity and targeted to different subcellular compartments. PP2Ac activity can be modulated by reversible phosphorylation on Tyr307 and methylation on C-terminal Leu309. Studies on PP2A have shown that this enzyme may be implicated in the regulation of metabolism, transcription, RNA splicing, translation, differentiation, cell cycle, oncogenic transformation and signal transduction.
    Źródło:
    Acta Biochimica Polonica; 2001, 48, 4; 921-933
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    CRK5 as a convergence and abiotic stress node between senescence responses
    Autorzy:
    Burdiak, P.
    Glow, D.
    Rusaczonek, A.
    Karpinski, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/80997.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    abiotic stress
    plant
    receptor-like kinase
    signal transduction
    cysteine
    transcription factor
    Arabidopsis thaliana
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Regulation of wound-responsive calcium-dependent protein kinase from maize (ZmCPK11) by phosphatidic acid
    Autorzy:
    Klimecka, Maria
    Szczegielniak, Jadwiga
    Godecka, Luiza
    Lewandowska-Gnatowska, Elżbieta
    Dobrowolska, Grażyna
    Muszyńska, Grażyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1039858.pdf
    Data publikacji:
    2011
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Zea mays
    calcium-dependent protein kinases
    abiotic/wound stress signal transduction
    phosphatidic acid
    phospholipids
    Opis:
    In plant cells, phospholipids are not only membrane components but also act as second messengers interacting with various proteins and regulating diverse cellular processes, including stress signal transduction. Here, we report studies on the effects of various phospholipids on the activity and expression of maize wound-responsive calcium-dependent protein kinase (ZmCPK11). Our results revealed that in leaves treated with n-butanol, a potent inhibitor of phosphatidic acid (PA) synthesis catalyzed by phospholipase D, a significant decrease of ZmCPK11 activity was observed, indicating contribution of PA in the kinase activation. Using lipid binding assays, we demonstrate that among various phospholipids only saturated acyl species (16 : 0 and 18 : 0) of phosphatidic acid are able to bind to ZmCPK11. Saturated acyl species of PA are also able to stimulate phosphorylation of exogenous substrates by ZmCPK11 and autophosphorylation of the kinase. The level of ZmCPK11 autophosphorylation is correlated with its enzymatic activity. RT-PCR analysis showed that transcript level of ZmCPK11 in maize leaves increased in response to PA treatment. The influence of PA on the activity and transcript level of ZmCPK11 suggests an involvement of this kinase in a PA-mediated wound signal transduction pathway.
    Źródło:
    Acta Biochimica Polonica; 2011, 58, 4; 589-595
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Przeciwciała monoklonalne w regulacji transdukcji sygnału receptora naskórkowego czynnika wzrostu (EGFR) w komórkach nowotworowych
    Monoclonal antibodies in regulation of signal transduction of Epidermal Growth Factor Receptor (EGFR) pathway in cancer cells
    Autorzy:
    Kampa, Rafał Paweł
    Sypniewski, Daniel
    Bednarek, Ilona
    Powiązania:
    https://bibliotekanauki.pl/articles/1035845.pdf
    Data publikacji:
    2018
    Wydawca:
    Śląski Uniwersytet Medyczny w Katowicach
    Tematy:
    kancerogeneza
    terapia przeciwnowotworowa
    transdukcja sygnału
    egfr
    przeciwciała monoklonalne
    carcinogenesis
    anticancer therapy
    signal transduction
    monoclonal antibodies
    Opis:
    In recent years intensive research has been dedicated to the Epidermal Growth Factor Receptor (EGFR) due to its significant role in the pathogenesis of malignant tumors. In many types of cancers intracellular pathways modulated by EGFR have been identified as crucial factors influencing tumor survival and development. On the other hand, EGFR has also been shown to be a promising molecular target for potential therapeutic agents. Attempts to modify the signal transduction exerted by EGF have been made either by blocking the activity of certain elements of the EGFR pathway or by direct inhibition of the EGF receptor itself. It has also been demonstrated that the use of monoclonal antibodies to block the EGF receptor increases the effectiveness of conventional anticancer agents such as cisplatin. Thus, many anticancer therapies based on inhibitors of the selected components of the EGFR signaling pathway have been established, and many of them apply monoclonal antibodies.
    Receptor naskórkowego czynnika wzrostu EGFR (Epidermal Growth Factor Receptor), ze względu na jego ważny udział w patogenezie nowotworów złośliwych, jest obiektem intensywnych badań naukowych ostatnich lat. W wielu typach nowotworów wewnątrzkomórkowe szlaki sygnalizacyjne pobudzane przez EGFR mają wręcz kluczowe znaczenie w ich rozwoju. Z drugiej strony wykazano, iż EGFR może stanowić bardzo obiecujący punkt uchwytu dla czynników terapeutycznych. Podjęto próby modyfikacji transdukcji sygnału przekazywanego przez aktywny EGFR wewnątrz komórek poprzez blokowanie aktywności elementów tego szlaku bądź samego receptora. Wykazano też, że blokowanie receptora EGFR przez przeciwciała monoklonalne podwyższa efektywność stosowanych w terapii kon-wencjonalnych czynników przeciwnowotworowych, np. cisplatyny. Dodatkowo opracowano wiele terapii przeciwno-wotworowych opierając się na zastosowaniu inhibitorów wybranych, kluczowych składowych szlaku sygnalizacyj-nego EGFR, z których wiele bazuje na zastosowaniu przeciwciał monoklonalnych.
    Źródło:
    Annales Academiae Medicae Silesiensis; 2018, 72; 12-20
    1734-025X
    Pojawia się w:
    Annales Academiae Medicae Silesiensis
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Drought responsive changes in barley leaf proteome
    Autorzy:
    Rodziewicz, P.
    Stobiecki, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/79847.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    barley
    drought
    abiotic stress
    water deficit
    gene expression
    signal transduction
    proteomic analysis
    leaf protein
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The role of miRNAs upon metal stress in Arabidopsis thaliana
    Autorzy:
    Gielen, H.
    Remans, T.
    Vangronsveli, J.
    Cuypers, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/80906.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    microRNA
    metal stress
    plant
    Arabidopsis thaliana
    reactive oxygen species
    gene expression
    oxidative stress
    signal transduction
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effects of endogenous signals and F. oxysporum on the mechanism regulating genistein synthesis and accumulation in yellow lupine and their impact on plant cell cytoskeleton
    Autorzy:
    Morkunas, I.
    Formela, M.
    Marczak, L.
    Samardakiewicz, S.
    Kasprowicz, A.
    Wojtaszek, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/80535.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    Fusarium oxysporum
    endogenous signal
    genistein
    accumulation
    yellow lupin
    plant cell
    cytoskeleton
    phenylpropanoid
    gene coding
    signal transduction pathway
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Endocrine disruptor actions through receptor crosstalk
    Autorzy:
    Kiyama, R.
    Powiązania:
    https://bibliotekanauki.pl/articles/363184.pdf
    Data publikacji:
    2016
    Wydawca:
    Uniwersytet Warmińsko-Mazurski w Olsztynie
    Tematy:
    endocrine disruptor
    pathway analysis
    receptor crosstalk
    risk assessment
    signal transduction
    biomimetyk hormonalny
    analiza ryzyka
    transdukcja sygnału
    Opis:
    Endocrine disruptors interfere with hormonal action through receptors and signaling pathways, but receptor crosstalk involved in the actions of endocrine disruptors has not yet been well documented. This review summarizes what is known about the actions of endocrine disruptors through receptor crosstalk, focusing on three model cases: crosstalk involving the estrogen receptor, the androgen receptor, and the thyroid hormone receptor. Here, crosstalk is categorized as bidirectional or unidirectional, with the latter category further subdivided into ligand-dependent or -independent crosstalk. More research needs to be done to develop a clearer understanding of the involvement of receptor crosstalk in cell signaling that is induced by endocrine disruptors. This understanding will help to develop in vitro and in silico assays that can replace animal tests.
    Źródło:
    Environmental Biotechnology; 2016, 12, 1; 1-16
    1734-4964
    Pojawia się w:
    Environmental Biotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    MPK4 is involved in growth and photosynthesis regulation
    Autorzy:
    Gawronski, P.
    Vashutina, K.
    Kozlowska-Makulska, A.
    Bederska, M.
    Witon, D.
    Rusaczonek, A.
    Karpinski, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/80506.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    mitogen-activated protein kinase
    signal transduction
    Arabidopsis thaliana
    photosynthesis
    salicylic acid
    photosystem
    reactive oxygen species
    homeostasis
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    CRK5 as a convergence node between senescence and abiotic stress responses
    Autorzy:
    Burdniak, P.
    Glow, D.
    Rusaczonek, A.
    Karpinski, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/80846.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    receptor-like protein kinase
    signal transduction
    signalling pathway
    cysteine-rich receptor-like kinase
    Arabidopsis thaliana
    senescence
    abiotic stress
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    S-nitrosylation promotes functional and structural changes in the mitochondrial psPrxII F protein
    Autorzy:
    Camejo, D.
    Lazaro, J.
    Romero-Puertas, M.
    Lazaro-Payo, A.
    Sevilla, F.
    Jimenez, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/80481.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    peroxiredoxin
    reactive oxygen species
    nitric oxide
    signal transduction
    post-translational modification
    salt stress
    functional change
    structural change
    S-nitrosylation
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    New insights into the signaling and function of cytokinins in higher plants
    Autorzy:
    Ciesielska, A.
    Ruszkowski, M.
    Kasperska, A.
    Femiak, I.
    Michalski, Z.
    Sikorski, M.M.
    Powiązania:
    https://bibliotekanauki.pl/articles/81076.pdf
    Data publikacji:
    2012
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    signal transduction
    cytokinin
    phytohormone
    histidine
    legume plant
    symbiosis
    organogenesis
    cell division
    elongation
    differentiation
    reproduction
    sex determination
    biotic stress
    abiotic stress
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2012, 93, 4
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    LlGA20ox1 and LlGA20ox2 – the Lupinus luteus homologues of Arabidopsis genes involved in gibberellin biosynthesis pathway
    Autorzy:
    Marciniak, K.
    Kesy, J.
    Glazinska, P.
    Wilmowicz, E.
    Kucko, A.
    Wojciechowski, W.
    Banach, M.
    Kopcewicz, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/81168.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    plant growth
    plant development
    gene encoding
    gibberellin
    signal transduction pathway
    yellow lupin
    Lupinus luteus
    phytohormone
    gamma-lactone
    2-oxoglutarate
    dioxygenase
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The ancestry and cumulative evolution of immune reactions
    Autorzy:
    Dzik, Jolanta
    Powiązania:
    https://bibliotekanauki.pl/articles/1040306.pdf
    Data publikacji:
    2010
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    signal transduction
    invertebrates
    receptors
    cytokines
    antigen presentation
    nitric oxide
    phagocytosis
    evolution
    innate immunity
    complement
    antibody-based immunity
    superoxide
    protoza
    vertebrates
    sponges
    Opis:
    The last two decades of study enriched greatly our knowledge of how the immune system originated and the sophisticated immune mechanisms of today's vertebrates and invertebrates developed. Even unicellular organisms possess mechanisms for pathogen destruction and self recognition. The ability to distinguish self from non-self is a prerequisite for recognition of sexual compatibility and ensuring survival. Molecules involved in these processes resemble those found in the phagocytic cells of higher organisms. Recognition of bacteria by scavenger receptors induces phagocytosis or endocytosis. The phagocytic mechanisms characterizing the amoeboid protozoans developed further during the evolution towards innate immunity. The scavenger receptor cysteine-rich domain SRCR is encoded in the genomes from the most primitive sponges to mammals. The immune system of sponges comprises signal transduction molecules which occur in higher metazoans as well. Sponges already possess recognition systems for pathogenic bacteria and fungi, based on membrane receptors (a lipopolysaccharide-interacting protein, a cell surface receptor recognizing β(1 → 3)-d-glucans of fungi). Perforin-like molecules and lysozymes are involved, among others, in defense in sponges. Reactive oxygen and nitrogen species function in the immunity of early metazoan. Genes encoding the family of reactive oxygen-generating NADPH oxidases (Noxes) are found in a variety of protists and plants. The NO synthases of cnidarians, mollusks, and chordates are conserved with respect to the mammalian NOS. The antimicrobial peptides of protozoans, amoebapores, are structural and functional analogs of the natural killer cell peptide, NK-lysin, of vertebrates. An ancestral S-type lectin has been found in sponges. Opsonizing properties of lectins and the ability to agglutinate cells justify their classification as primitive recognition molecules. Invertebrate cytokines are not homologous to those of vertebrate, and their functional convergence was presumably enabled by the general similarity of the lectin-like recognition domain three-dimensional structure. Sponges contain molecules with SCR/CCP domains that show high homology to the mammalian regulators of complement activation (RCA family). A multi-component complement system comprising at least the central molecule of the complement system, C3, Factor B, and MASP developed in the cnidarians and evolved into the multilevel cascade engaged in innate and acquired immunity of vertebrates. The adaptive immune system of mammals is also deeply rooted in the metazoan evolution. Some its precursors have been traced as deep as in sponges, namely, two classes of receptors that comprise Ig-like domains, the receptor tyrosine kinases (RTK), and the non-enzymic sponge adhesion molecules (SAM). The antibody-based immune system defined by the presence of the major histocompatibility complex (MHC), T-cell receptor (TCR), B-cell receptor (BCR) or recombination activating genes (RAGs) is known beginning from jawed fishes. However, genes closely resembling RAG1 and RAG2 have been uncovered in the genome of a see urchin. The ancestry of MHC gene remains unknown. Similarly, no homologue of the protein binding domain (PBD) in MHC molecules has been found in invertebrates. The pathway by which endogenous peptides are degraded for presentation with class I MHC molecules utilizes mechanisms similar to those involved in the normal turnover of intracellular proteins, apparently recruited to work also for the immune system. Several cDNAs coding for lysosomal enzymes, e.g., cathepsin, have been isolated from sponges. All chromosomal duplication events in the MHC region occurred after the origin of the agnathans but before the gnathostomes split from them. The V-domains of the subtype found in the receptors of T and B-cells are known from both agnathans and cephalochordates, although they do not rearrange. The rearrangement mechanism of the lymphocyte V-domains suggests its origin from a common ancestral domain existing before the divergence of the extant gnathostome classes. Activation-induced deaminase (AID) - homologous proteins have been found only in the gnathostomes. It appears thus that the adaptive immunity of vertebrates is a result of stepwise accumulation of small changes in molecules, cells and organs over almost half a billion years.
    Źródło:
    Acta Biochimica Polonica; 2010, 57, 4; 443-466
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Involvement of nitric oxide in central histaminergic stimulation of the hypothalamic-pituitary-adrenal axis
    Autorzy:
    Bugajski, A.J.
    Koprowska, B.
    Thor, P.
    Glod, R.
    Bugajski, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/69131.pdf
    Data publikacji:
    2000
    Wydawca:
    Polskie Towarzystwo Fizjologiczne
    Tematy:
    corticosterone secretion
    histamine
    amthamine
    brain
    nitric oxide
    signal transduction
    neuroendocrine regulation
    central histaminergic stimulation
    neurotransmitter
    central nervous system
    hypothalamic-pituitary-adrenal axis
    Źródło:
    Journal of Physiology and Pharmacology; 2000, 51, 4,2
    0867-5910
    Pojawia się w:
    Journal of Physiology and Pharmacology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Recent advances in the role of AMP-activated protein kinase in metabolic reprogramming of metastatic cancer cells: targeting cellular bioenergetics and biosynthetic pathways for anti-tumor treatment
    Autorzy:
    Tyszka-Czochara, M.
    Konieczny, P.
    Majka, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/70060.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Fizjologiczne
    Tematy:
    tumour progression
    metastasis
    cancer cell
    AMP-activated protein kinase
    reactive oxygen species
    signal transduction
    epithelial-mesenchymal transition
    metformin
    biosynthetic pathway
    antitumour treatment
    Źródło:
    Journal of Physiology and Pharmacology; 2018, 69, 3
    0867-5910
    Pojawia się w:
    Journal of Physiology and Pharmacology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Identification and characterization of genes connected with flower morphogenesis in cucumber
    Autorzy:
    Pawelkowicz, M.
    Osipowski, P.
    Wojcieszek, M.
    Woycicki, R.
    Witkowicz, J.
    Hincha, D.
    Przybecki, Z.
    Powiązania:
    https://bibliotekanauki.pl/articles/79966.pdf
    Data publikacji:
    2012
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    Cucumis sativus
    cucumber
    flower
    morphogenesis
    sex determination
    tissue specificity
    vegetative tissue
    generative tissue
    cucumber genome
    protein serine-threonine kinase
    plant hormone
    signal transduction
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2012, 93, 2
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Enhancement of accumulation of salicylates and abscisic acid by sugars and F. oxysporum infection in yellow lupine
    Autorzy:
    Formela, M.
    Drzewiecka, K.
    Chadzinikolau, T.
    Morkunas, I.
    Powiązania:
    https://bibliotekanauki.pl/articles/80539.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    plant resistance
    salicylic acid
    jasmonic acid
    abscisic acid
    ethylene
    sugar
    necrotrophic pathogen
    signal transduction pathway
    Fusarium oxysporum f.sp.lupini
    infection
    yellow lupin
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Growth hormone and growth hormone gene of the American mink (Neovison vison) – the current state of knowledge of one of the key hormones in one of the most intensively economically exploited species
    Autorzy:
    Skorupski, Jakub
    Powiązania:
    https://bibliotekanauki.pl/articles/1386056.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
    Tematy:
    American mink
    growth hormone
    growth hormone gene
    physiological function
    secretion
    signal transduction
    Norka amerykańska
    hormon wzrostu
    gen hormonu wzrostu
    funkcje fizjologiczne
    wydzielanie
    transdukcja sygnału
    Opis:
    Despite the fact, that the American mink (Neovison vison) is one of the most intensively economically exploited and problematic, from the ecological point of view, fur-bearing animal, it remains one of the least studied livestock species. It can be proven by the fact, that the research on one of the key hormones, which has systemic effects, that is the growth hormone, are rather poorly advanced. The purpose of this review is to present the summary and the critical analysis of the current state of knowledge on the topic of the growth hormone in the American mink, its biological function, production in physiological conditions, regulation of secretion and transduction of the hormone’s signal. The article contains also an up to date information on the American mink growth growth hormone gene and its protein product.
    Mimo że norka amerykańska (Neovison vison) jest jednym z najintensywniej eksploatowanych gospodarczo, a także problematycznych, z ekologicznego punktu widzenia, gatunków zwierząt futerkowych, pozostaje jednym z najsłabiej zbadanych gatunków zwierząt gospodarskich. Dowodzi tego, między innymi fakt, że badania nad jednym z kluczowych hormonów o działaniu systemowym, jakim jest hormon wzrostu, są słabo zaawansowane. Celem niniejszego artykułu jest przegląd i krytyczna analiza aktualnego stanu wiedzy na temat hormonu wzrostu u norki amerykańskiej, jego funkcji biologicznej, produkcji w warunkach fizjologicznych, regulacji wydzielania oraz transdukcji sygnału. Artykuł zawiera również aktualne informacje o genie hormonu wzrostu oraz jego produkcie białkowym.
    Źródło:
    Acta Biologica; 2017, 24; 101-132
    2450-8330
    2353-3013
    Pojawia się w:
    Acta Biologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Sensing thiol oxidation in Arabidopsis thaliana through a YAP1 genetically encoded probe
    Autorzy:
    Waszczak, C.
    Akter, M.
    Gevaert, K.
    De Jaeger, G.
    Messens, J.
    Van Breusegem, F.
    Powiązania:
    https://bibliotekanauki.pl/articles/80234.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    reactive oxygen species
    hydrogen peroxide
    signalling molecule
    plant development
    metabolic adaptation
    stress condition
    redox signal
    proteomic identification
    sulphenome
    cysteine thiol group
    Arabidopsis thaliana
    protein
    signal transduction
    oxidative stress
    genetically encoding probe
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Components of defence strategy induced in Solanum species by elicitor from Phytophthora infestans
    Autorzy:
    Polkowska-Kowalczyk, L.
    Olszak, K.
    Tarwacka, J.
    Szczegielniak, J.
    Muszynska, G.
    Wielgat, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/80345.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    Solanum
    signal transduction
    protein kinase
    reactive oxygen species
    mitogen-activated protein kinase
    calcium-dependent protein kinase
    signalling network
    gene expression
    signalling pathway
    nitroblue tetrazolium
    elicitor treatment
    Phytophthora infestans
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Melatonina, wielofunkcyjna cząsteczka sygnałowa w organizmie ssaka: miejsca biosyntezy, funkcje, mechanizmy działania
    Melatonin, multifunctional signal molecule in mammals: origin, functions, mechanisms of action
    Autorzy:
    Skwarło-Sońta, Krystyna
    Majewski, Paweł
    Powiązania:
    https://bibliotekanauki.pl/articles/1032921.pdf
    Data publikacji:
    2010
    Wydawca:
    Łódzkie Towarzystwo Naukowe
    Tematy:
    szyszynka
    melatonina
    receptory
    rytm dobowy
    przekaźnictwo sygnału
    immunomodulacja
    zapalenie
    pineal gland
    melatonin
    receptors
    circadian rhythm
    signal
    transduction
    immunomodulation
    inflammation
    Opis:
    Methoxyindole hormone - melatonin (MEL) is produced and released by the mammalian pineal gland in a circadian rhythm exhibiting a low level during the day and an elevation at night, strictly dependent on the environmental lighting conditions. The main MEL function is, therefore, to synchronize diurnal rhythms of several physiological processes and for the diurnally active species (including humans) it gives information on the beginning of sleepiness. For the nocturnal species, however, elevated MEL level serves as a signal to start locomotor and feeding activity. In seasonal breeders the pineal gland function synchronizes the time of gonadal development and sexual activity with the external conditions in a way that progeny appears in the optimal climatic moment. MEL is produced also extrapineally, e.g. in the gastro-intestinal tract and bone marrow, where it exerts a protective effect due to its activity as an antioxidant and a potent free radical scavenger. Being both lipid and water soluble, MEL is able to cross biological barriers and, therefore, it uses several cellular mechanism to exert its physiological activity, including membrane and nuclear receptors, proteins of the cytoskeleton, mitochondrial membrane stabilization. MEL is also involved in immunomodulation, the effects are different and dependent on numerous factors, nevertheless, its immunostimulatory activity is generally well accepted. Additionally, activated immune cells are able to produce MEL acting in an auto- and paracrine way. As an efficient antioxidant MEL exerts the anti-inflammatory effect, which, reciprocally, modulates the pineal gland biosynthetic activity adapting it to temporary endogenous conditions.
    Szyszynka ssaków produkuje i wydziela do krwi melatoninę (MEL) w rytmie dobowym, którego cechą charakterystyczną jest wysoki poziom w nocy niski w dzień, a czas nocnej syntezy zależy od warunków świetlnych otoczenia. Dzięki temu MEL synchronizuje wiele procesów fizjologicznych przebiegających rytmicznie, a jako chemiczny sygnał ciemności przekazuje gatunkom o aktywności dziennej (w tym ludziom) informację o rozpoczęciu pory snu. Gatunki aktywne w nocy inaczej interpretują sygnał melatoninowy. Dla zwierząt rozmnażających się sezonowo informacja niesiona przez MEL stanowi sygnał do takiej synchronizacji funkcji rozrodczych z warunkami klimatycznymi, aby potomstwo mogło pojawić się w optymalnym momencie. Melatonina powstaje także pozaszyszynkowo, np. w układzie pokarmowym, gdzie pełni funkcje ochronne, związane z aktywnym zmiataniem wolnych rodników i właściwościami antyoksydacyjnymi. Jako cząsteczka amfifilowa może przekraczać bariery biologiczne, dlatego swoje efekty może wywierać za pośrednictwem wielu różnych mechanizmów takich jak: wiązanie z receptorami błonowymi i jądrowymi, białkami cytozolowymi, stabilizowanie błony mitochondrialnej. MEL wykazuje działanie immunomodulacyjne, zależne od wielu czynników, choć zasadniczo wydaje się być czynnikiem wspomagającym odporność, a aktywowane komórki odpornościowe także syntetyzują MEL działającą auto- i parakrynowo. Dzięki właściwościom antyoksydacyjnym pełni istotną rolę przeciwzapalną, z kolei toczący się proces zapalny moduluje aktywność biosyntetyczną szyszynki, dostosowując je do aktualnych warunków w organizmie.
    Źródło:
    Folia Medica Lodziensia; 2010, 37, 1; 15-55
    0071-6731
    Pojawia się w:
    Folia Medica Lodziensia
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Zaburzenia procesu O-GlcNAcylacji w nowotworach
    Alterations of O-GlcNAcylation process in cancers
    Autorzy:
    Ciesielski, Piotr
    Krześlak, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/1032551.pdf
    Data publikacji:
    2014
    Wydawca:
    Łódzkie Towarzystwo Naukowe
    Tematy:
    o-glcnacylacja
    nowotwory
    cykl komórkowy
    czynniki
    transkrypcyjne
    transdukcja sygnału
    glikoliza
    metastaza
    o-glcnacylation
    cancers
    cell cycle
    transcription factors
    signal
    transduction
    glycolysis
    metastasis
    Opis:
    O-GlcNAcylation is a post-translational modification involving the addition of a N-acetylglucosamine moiety to the serine/threonine residues of cytosolic or nuclear proteins. Two enzymes are responsible for cyclic O-GlcNAcylation: O-GlcNAc transferase (OGT) which catalyzes the addition of the GlcNAc moiety from UDP-GlcNAc to target proteins and O-GlcNAcase (OGA) which catalyses the hydrolytic removal of the sugar moiety from proteins. Dynamic and reversible O-GlcNAcylation is emerging as an important regulator of diverse cellular processes, such as signal transduction, metabolism, transcription, translation, proteasomal degradation and cell cycle. O-GlcNAcylation occurs on serine or threonine residues of proteins at sites that may also be phosphorylated. Therefore, an extensive crosstalk exists between phosphorylation and O-GlcNAcylation. Recent studies indicate that increased O-GlcNAcylation is a general feature of cancer. Elevated O-GlcNAcylation (hyper-OGlcNAcylation) occurs in many human malignancies including solid tumors such as lung, prostate, breast, colorectal, liver, pancreatic cancers as well as non-solid cancers such as chronic lymphocytic leukemia. The changes in O-GlcNAcylation are associated with the changes in OGT and OGA expression levels. Hyper-O-GlcNAcylation may be linked to the various hallmarks of cancer, including cancer cell proliferation, survival, invasion, metastasis and metabolism. This paper reviews recent findings related to O-GlcNAc-dependent regulation of signaling pathways, cell cycle, transcription factors, and metabolic enzymes in cancer cells.
    O-GlcNAcylacja jest odwracalną potranslacyjną modyfikacją białek polegającą na przyłączeniu wiązaniem O-glikozydowym pojedynczych reszt β-N-acetyloglukozaminy (GlcNAc) do seryny lub treoniny. W proces O-GlcNAcylacji włączone są dwa enzymy: O-GlcNAc transferaza (OGT), enzym odpowiedzialny za przyłączanie reszt N-acetyloglukozaminy i β-N-acetyloglukozaminidaza (OGA), która katalizuje reakcję odłączania reszt GlcNAc. Dynamiczna i odwracalna O-GlcNAcylacja odgrywa istoną rolę w regulacji szeregu procesów komórkowych, takich jak przekazywanie sygnału, metabolizm, transkrypcja, translacja, degradacja białek w proteasomach i cykl komórkowy. Ponieważ O-GlcNAcylacja dotyczy reszt seryny lub treoniny, które znajdują się w miejscach rozpoznawanych przez kinazy białkowe, wpływa ona na poziom fosforylacji wielu białek i isnieje ścisła zależność pomiędzy tymi modyfikacjami. Ostanie badania wskazują, że w komórkach nowotworowych dochodzi do znacznego zwiększenia poziomu O-GlcNAcylacji. Hiper-O-GlcNAcylację stwierdzono w różnych typach nowotworów, włączając w to guzy lite np. płuc, prostaty, piersi, jelita grubego, trzustki, wątroby a także białaczki np. przewlekłą białaczkę limfatyczną. Zaburzenia O-GlcNAcylacji związane są ze zmianami w komórkach nowotworowych ekspresji enzymów odpowiedzialnych za ten proces, tj. OGT i OGA. Hiper-O-GlcNAcylacja wpływa na proliferację, przeżycie i metabolizm komórek nowotworowych, jak również zwiększa ich zdolność do inwazji i metastazy. Prezentowana praca stanowi przegląd aktualnych informacji dotyczących roli O-GlcNAcylacji w regulacji szlaków przekazywania sygnałów, cyklu komórkowego, czynników transkrypcyjnych oraz enzymów i innych białek związanych z metabolizmem komórek nowotworowych.
    Źródło:
    Folia Medica Lodziensia; 2014, 41, 1; 65-91
    0071-6731
    Pojawia się w:
    Folia Medica Lodziensia
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-37 z 37

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