Temat: set expression - Katalog OPAC zbiorów

Skocz do pozycji: 2.

Tytuł:: Single-shot determination of differential gene network on multiple disease subtypes
Autorzy:: Sadhu, Arnab
Bhattacharyya, Balaram
Mukhopadhyay, Tathagato
Powiązania:: https://bibliotekanauki.pl/articles/27312910.pdf
Data publikacji:: 2022
Wydawca:: Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydawnictwo AGH
Tematy:: phenotype interwoven network
fuzzy rough set-based attribute selection
gene interaction network
differential co-expression
Opis:: A differential gene expressional network determines the prominent genes under altered phenotypes. The traditional approach requires n(n − 2)/2 comparisons for n phenotypes. We present a direct method for determining a differentia network under multiple phenotypes. We explore the non-discrete nature of gene expression as a pattern in a fuzzy rough set. An edge between a pair of genes represents a positive region of a fuzzy similarity relationship upon a phenotypic change. We apply a weight-ranking formula and obtain a directed ranked network; we label this as a phenotype interwoven network. Those nodes with large in-degree connectivity bubble up as significant genes under respective phenotypic changes. We tested the method on six diseases and achieved good corroboration with the results of previous studies in the two-step approach. The subgraphs of the isolated genes achieved good significance upon validation through an information theoretic approach. The top-ranking genes determined in all of our case studies are in consonance with the findings of the respective wet-lab tests.
Źródło:: Computer Science; 2022, 23 (2); 247--276
1508-2806
2300-7036
Pojawia się w:: Computer Science
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Informacja

Wyszukujesz frazę "set expression" wg kryterium: Temat

Źródło danych

Dostawca treści

Kolekcja

Rok wydania

Wydawca

Temat

Autor

Typ dokumentu

Język