Temat: serum marker - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Identification and genetics of betaglobulin [BgC1] and alphaglobulin [AmiF1] antigenic markers in cattle
Autorzy:: Wegrzyn, J
Skiba, E
Wegrzyn, Z
Powiązania:: https://bibliotekanauki.pl/articles/2047266.pdf
Data publikacji:: 1996
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: genetics
alpha-globulin
serum
cattle
antigenic determinant
protein
beta-globulin
genetic marker
alpha-microglobulin
Opis:: Alloantibodies detecting antigenic determinants called BgC1 and AmiF1 were obtained in cattle. The analysis of determinants' inheritance was done on 1754 offsprings after 72 sires and 1740 dams. The molecule-carriers of both traits were characterized using serological and physico-chemical methods. It was found that the identified determinants are markers of beta-globulin and alpha-microglobulin proteins, and of autosomal, dominant genes BgC1 and AmiF1 from independent loci, which control them.
Źródło:: Journal of Applied Genetics; 1996, 37, 3; 285-292
1234-1983
Pojawia się w:: Journal of Applied Genetics
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Clinical usefulness of MMP-2 and TIMP-2 concentrations in the preoperative serum of patients with colorectal cancer
Autorzy:: Pryczynicz, A.
Gryko, M.
Dymicka-Piekarska, V.
Lewczuk, Ł.
Wakulewska, A.
Ozimkiewicz, M.
Lebelt, A.
Guzińska-Ustymowicz, K.
Powiązania:: https://bibliotekanauki.pl/articles/1917768.pdf
Data publikacji:: 2016
Wydawca:: Uniwersytet Medyczny w Białymstoku
Tematy:: Colorectal cancer
matrix metalloproteinases
MMP-2
TIMP-2
serum marker
Opis:: Purpose: To evaluate the clinical significance of MMP-2 and TIMP-2 concentrations in the sera of patients diagnosed with colorectal cancer. Methods: The study group comprised 48 patients with colorectal carcinoma and 24 healthy controls. The serum concentration of MMP-2 and TIMP-2 proteins was evaluated by the ELISA method. Results: The mean level of MMP-2 in the sera of patients with colorectal cancer was 39.4 ng/ml and was significantly lower compared with the control (p<0.001). A decrease in TIMP-2 protein in the sera of patients with colorectal cancer was also observed where its mean level was 132.3 ng/ml. The concentration of MMP-2 and TIMP-2 did not correlated with any clinicopathological parameters, except for the patients’ age. In addition, the concentration of MMP-2 in the sera of patients with CRC correlated negatively with the number of white blood cells in the blood and the prothrombin index. The concentration of TIMP-2 correlated positively with potassium and urea concentration in the blood. Conclusions: The results of our study indicate lack of clinical usefulness of determining the levels of MMP-2 and TIMP-2 in the sera of patients with colorectal cancer. However, these proteins play an important role in the carcinogenesis of colorectal cancer.
Źródło:: Progress in Health Sciences; 2016, 6(1); 32-39
2083-1617
Pojawia się w:: Progress in Health Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Serum metallothionein in newly diagnosed patients with childhood solid tumours
Autorzy:: Krizkova, Sona
Masarik, Michal
Majzlik, Petr
Kukacka, Jiri
Kruseova, Jarmila
Adam, Vojtech
Prusa, Richard
Eckschlager, Tomas
Stiborova, Marie
Kizek, Rene
Powiązania:: https://bibliotekanauki.pl/articles/1040324.pdf
Data publikacji:: 2010
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: cancer
Brdicka reaction
serum
marker
metallothionein
Opis:: Tumour markers are substances produced by malignant cells or by the organism as a response to cancer development. Determination of their levels can, therefore, be used to monitor the risk, presence and prognosis of a cancer disease or to monitor the therapeutic response or early detection of residual disease. Time-consuming imaging methods, examination of cerebrospinal fluid or tumour tissue and assays for hormones and tumour markers have been used for cancer diagnosis. However, no specific marker for diagnosis of childhood solid tumours has been discovered yet. In this study, metallothionein (MT) was evaluated as a prospective marker for such diseases. Serum metallothionein levels of patients with childhood solid tumours were determined using differential pulse voltammetry - Brdicka reaction. A more than 5-fold increase in the amount of metallothionein was found in sera of patients suffering from cancer disease, compared with those in sera of healthy donors. The average metallothionein level in the sera of healthy volunteers was 0.5 ± 0.2 μmol · dm-3 and was significantly different (p<0.05, determined using the Schefe test) from the average MT level found in serum samples of patients suffering from childhood solid tumours (3.4 ± 0.8 μmol · dm-3). Results found in this work indicate that the MT level in blood serum can be considered as a promising marker for diagnostics, prognosis and estimation of therapy efficiency of childhood tumours.
Źródło:: Acta Biochimica Polonica; 2010, 57, 4; 561-566
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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