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Tytuł:
Adipokines and parameters of peritoneal membrane transport in newly started peritoneal dialysis patients
Autorzy:
Golembiewska, Edyta
Safranow, Krzysztof
Ciechanowski, Kazimierz
Bober, Joanna
Bogacka, Anna
Stepniewska, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1039455.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
peritoneal dialysis
serum adiponectin
serum leptin
solute transport
Opis:
Aim: Adiponectin and leptin are two adipokines playing important roles in the regulation of body weight, appetite, carbohydrate and lipid metabolism. In patients with chronic kidney disease (CKD) adipokines accumulate in serum due to reduced renal clearance. Since adipokines have pleiotropic actions, the adipokine balance may have an impact on peritoneal membrane transport. The aim of this study was to assess whether serum adiponectin and leptin levels were related to peritoneal transport and residual renal function (RRF) in newly started peritoneal dialysis patients. Methods: 25 clinically stable patients, 4 to 6 weeks after the onset of PD, were included in the study. For each patient clinical and laboratory data were reviewed and standard PET test was performed. Serum adiponectin and leptin concentrations were determined and leptin/adiponectin (L/A) ratio was calculated. Results: Serum adiponectin correlated negatively with weight, BMI and glucose concentration. Serum leptin and L/A ratio correlated positively with BMI. Serum adiponectin correlated positively with dialysate to plasma (D/P) creatinine ratio and ultrafiltration in PET test. Serum leptin level and L/A ratio correlated strongly negatively with peritoneal creatinine clearance. Conclusions: Serum adiponectin concentration is positively associated with baseline solute transport. Leptin concentration and L/A ratio are negatively associated with dialysis adequacy in newly started PD patients.
Źródło:
Acta Biochimica Polonica; 2013, 60, 4; 617-621
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
An attempt to use the serum concentration of the phosphate (Pi) and the Ca x P productas markers of the progression of chronic kidney disease in cats
Autorzy:
Sławuta, P.
Kumiega, E.
Sikorska-Kopyłowicz, A.
Sapikowski, G.
Kurosad, A.
Powiązania:
https://bibliotekanauki.pl/articles/2087386.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
chronic kidney disease (CKD)
serum phosphate concentration
serum Ca x Pproduct
cats
Źródło:
Polish Journal of Veterinary Sciences; 2019, 4; 647-652
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dynamic changes of immunoglobulin concentrations in pig colostrum and serum around parturition
Autorzy:
Markowska-Daniel, I
Pomorska-Mol, M.
Pejsak, Z.
Powiązania:
https://bibliotekanauki.pl/articles/30942.pdf
Data publikacji:
2010
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
pig
serum
colostrum
immunoglobulin
immunity
dynamic change
parturition
perinatal period
piglet
porcine serum
Opis:
The aim of the study was the determination of IgA, IgM and IgG concentrations in porcine serum and colostrum, in order to evaluate their variations in the perinatal period, as well as to clarify whether there is a correlation between colostrum intake, initial level of immunoglobulins (Ig) in piglet serum and development of their own immunity. The mean IgA, IgM and IgG concentrations in sow serum 10 days before parturition were 1.58, 6.12 and 39.56 mg/ml, respectively. Seven days later only the IgG level was insignificantly lower (34.94 mg/ml, p=0.55), while concentrations of IgA and IgM increased to 2.25 and 7.25 mg/ml, respectively (p=0.23 and 0.62, respectively). The mean initial IgG concentration in colostrum at farrowing was 118.5 mg/ml and differed between sows. The average value of IgA in colostrum at birth was 23.8 mg/ml and decreased to 7.85 mg/ml at 6 hours (h) and to 4.59 mg/ml at 24 h after the onset of farrowing. IgM concentration at birth was 12.1 mg/ml and decreased to 4.23 mg/ml at 24 h postpartum. Positive relationships were found between concentrations of IgM and IgA in serum of piglets at 14 and 56 days of life (r = 0.41 and 0.80, respectively, p≤0.05) as well as for IgG concentration in the piglets serum at 7 days and 56 days of age (r = 0.48, p≤0.05). The above observations suggest that there is a correlation between the level of Ig in piglet serum in the first days of life and improvement of their own immunity.
Źródło:
Polish Journal of Veterinary Sciences; 2010, 13, 1; 21-27
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Barwniki skwaryliowe jako sondy fluorescencyjne do oznaczania biocząsteczek
Skwarylium dyes as fluorescence probes for biomolecules determination
Autorzy:
Jurek, K.
Kabatc, J.
Powiązania:
https://bibliotekanauki.pl/articles/159602.pdf
Data publikacji:
2015
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Elektrotechniki
Tematy:
sondy fluorescencyjne
barwniki skwaryliowe
serum albuminy wołowej
squarylium dyes
fluorescent probes
bovine serum albumin
Opis:
Chemiczna modyfikacja struktury barwników skwaryliowych daje nowe układy chromoforowe o szerokim zakresie właściwości optycznych, takich jak absorpcja światła i emisja fluorescencji, z zakresu światła od widzialnego do bliskiej podczerwieni. Otrzymano nowe funkcjonalne barwniki, w których pod wpływem bodźca zewnętrznego lub oddziaływań chemicznych, zachodzą zmiany w rozmieszczeniu ładunku elektronowego w chromoforze skwaryliowym. Z uwagi na wyraźne zmiany ich właściwości spektroskopowych pod wpływem połączenia z substancją analizowaną, mogą zaleźć praktyczne zastosowanie, jako markery fluorescencyjne do oznaczania biocząsteczek.
Chemical modification of the structure of squarylium dyes gives a new chromophoric systems that have a wide range of optical properties, such as the light absorption and fluorescence emission in the range from the visible light to the near infrared one. The new functional dyes in which the changes of the electron charge distribution in chromophore under the influence of an external stimulus or chemical undergo have been obtained. The interaction between dye and analyte leads to the significant changes of their spectroscopic properties. It can give the possibility of practical application of these new dyes as the fluorescent markers for biomolecules labeling.
Źródło:
Prace Instytutu Elektrotechniki; 2015, 268; 57-64
0032-6216
Pojawia się w:
Prace Instytutu Elektrotechniki
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The detection of specific acute phase serum protein complexes and immune complexes by Congo Red binding
Autorzy:
Rybarska, J
Konieczny, L.
Piekarska, B.
Stopa, B.
Roterman, I.
Powiązania:
https://bibliotekanauki.pl/articles/70851.pdf
Data publikacji:
1995
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
serum protein
hemoglobin
human serum
acute phase
Congo Red
rabbit
antibody
haptoglobin
Źródło:
Journal of Physiology and Pharmacology; 1995, 46, 2
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Serum metallothionein in newly diagnosed patients with childhood solid tumours
Autorzy:
Krizkova, Sona
Masarik, Michal
Majzlik, Petr
Kukacka, Jiri
Kruseova, Jarmila
Adam, Vojtech
Prusa, Richard
Eckschlager, Tomas
Stiborova, Marie
Kizek, Rene
Powiązania:
https://bibliotekanauki.pl/articles/1040324.pdf
Data publikacji:
2010
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cancer
Brdicka reaction
serum
marker
metallothionein
Opis:
Tumour markers are substances produced by malignant cells or by the organism as a response to cancer development. Determination of their levels can, therefore, be used to monitor the risk, presence and prognosis of a cancer disease or to monitor the therapeutic response or early detection of residual disease. Time-consuming imaging methods, examination of cerebrospinal fluid or tumour tissue and assays for hormones and tumour markers have been used for cancer diagnosis. However, no specific marker for diagnosis of childhood solid tumours has been discovered yet. In this study, metallothionein (MT) was evaluated as a prospective marker for such diseases. Serum metallothionein levels of patients with childhood solid tumours were determined using differential pulse voltammetry - Brdicka reaction. A more than 5-fold increase in the amount of metallothionein was found in sera of patients suffering from cancer disease, compared with those in sera of healthy donors. The average metallothionein level in the sera of healthy volunteers was 0.5 ± 0.2 μmol · dm-3 and was significantly different (p<0.05, determined using the Schefe test) from the average MT level found in serum samples of patients suffering from childhood solid tumours (3.4 ± 0.8 μmol · dm-3). Results found in this work indicate that the MT level in blood serum can be considered as a promising marker for diagnostics, prognosis and estimation of therapy efficiency of childhood tumours.
Źródło:
Acta Biochimica Polonica; 2010, 57, 4; 561-566
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
How dose walking exercise affect serum lipids in underweight female adults?
Autorzy:
Habibzadeh, N.
Powiązania:
https://bibliotekanauki.pl/articles/1917590.pdf
Data publikacji:
2015
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
walking exercise
serum lipids
underweight women
Opis:
Introduction:Fat profile is an extremely important substrate for muscle contraction, both at rest and during exercise as yet, there is still no clear consequence of exercise on lipid profile regulation in underweight subjects and thus the purpose of this study was to compare lipids serums in underweight young women (BMI≤ 20) before and after walking intervention.Materials and methods:20 underweight young non-athlete women volunteered to participate in this study and then they were randomly assigned into two exercise (E: n=10, BMI=17.8±1.2, age: 21.1±1.7yr) and control (C: n=10, BMI=17.5 ±1.1, age: 21.9 ± 1.2) groups. Pre and post assessment were contained somatic (age, height, weight, BMI) and lipids profile (FBS, LDL, HDL, triglycerides and totalcholesterol) measurements. Exercise programme was consisted of 30-minutesupervised walking exercise at 60 % HR max at intensity equal with 40% VO2max 3 days per week for 2 months.Results:Data analysis showed post-BMI as well as body weight did not altered in comparison with pre - exercise programme (p>0.05). Subsequently all post - lipids variables included FBS, LDL, HDL, triglycerides and totalcholesterol were elevated compared with pre- intervention walking exercise (p< 0.05.)Conclusions:This study outlined that walking programme can be a stimuli toward ideal weight in slim individual because an increased lipids profile as indicators of an increased body mass in underwent individual who are at risk of diseases such as anorexia nervosa shows this notion. However, more investigation with longer duration is needed to justify thisconclusion.
Źródło:
Progress in Health Sciences; 2015, 5, 2; 249-252
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Diagnostic values of calcium and magnesium forms determined in human serum and saliva
Wartosc diagnostyczna form wapnia i magnezu oznaczonych w ludzkiej surowicy krwi i slinie
Autorzy:
Andrusishina, I N
Powiązania:
https://bibliotekanauki.pl/articles/15539.pdf
Data publikacji:
2010
Wydawca:
Uniwersytet Warmińsko-Mazurski w Olsztynie / Polskie Towarzystwo Magnezologiczne im. Prof. Juliana Aleksandrowicza
Tematy:
diagnostic value
calcium form
magnesium form
determination
human serum
serum
human saliva
saliva
atomic absorption spectrometry
Opis:
Calcium and magnesium are known to be necessary for the normal function of various systems in animal and human organisms. There are many diseases caused by abnormal concentration of electrolytes, e.g. arterial hypertension or nervous system diseases such as multiple sclerosis, Mb. Alzheimer or Mb. Parkinson. The mechanisms of homeostasis indicate only the ionized forms of these elements. It is known that ionized calcium serves as an endocellular intermediary in action of enzymes and hormones in cells. Therefore, it is very important to define levels of total and ionized forms of Ca2+ and Mg2+ in blood serum and saliva by the method of atomic absorption spectrometry and to show their diagnostic value for various pathological conditions of a human body. The 39 persons, aged 21 to 47 years take part in these investigations. The results of determinations of calcium and magnesium forms present in human serum and saliva, representing physiological states are presented. The age and daily fluctuations of Ca2+ and Mg2+ content in serum and saliva were studied by atomic absorption spectrometry. The levels of non albumin forms of these elements were found by FAAS. The significance of determination of calcium and magnesium levels in serum and saliva under various pathological conditions (arterial hypertension and osteoporosis) was shown.
Wapń i magnez to pierwiastki niezbędne do prawidłowego funkcjonowania organizmów zwierzęcych i ludzkich. Istnieje wiele chorób wywoływanych przez nieprawidłowe stężenia elektrolitów, np. nadciśnienie tętnicze lub choroby układu nerwowego, takie jak SM, choroba Alzheimera lub Parkinsona. Mechanizmy homeostazy wskazują jedynie na zjonizowane formy tych pierwiastków. Wiadomo, że zjonizowana forma wapnia służy jako międzykomórkowy pośrednik między enzymami i hormonami w komórkach. Dlatego tak ważne jest określenie zawartości całkowitych tych pierwiastków oraz jonów Ca2+ i Mg2+ w surowicy krwi oraz w ślinie za pomocą metody absorpcyjnej spektrometrii atomowej oraz wykazanie ich roli w diagnostyce różnych stanów patologicznych w organizmie człowieka. Badaniami objęto 39 osób w wieku od 21 do 47 lat. W pracy przedstawiono wyniki oznaczeń form wapnia i magnezu występujących w ludzkiej surowicy krwi oraz ślinie odpowiadające stanom fizjologicznym. Wahania w zawartości Ca2+ i Mg2+ w surowicy i ślinie, w zależności od wieku i pory dnia, badano za pomocą aborpcyjnej spektrofotometrii atomowej. Zawartości niealbuminowych form tych pierwiastków określono za pomocą FAAS. Wykazano istotność oznaczeń zawartości wapnia i magnezu dla różnych stanów chorobowych (nadciśnienie tętnicze, osteoporoza).
Źródło:
Journal of Elementology; 2010, 15, 3; 425-433
1644-2296
Pojawia się w:
Journal of Elementology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Characterization of bovine serum albumin glycated with glucose, galactose and lactose
Autorzy:
Ledesma-Osuna, Ana
Ramos-Clamont, Gabriela
Vázquez-Moreno, Luz
Powiązania:
https://bibliotekanauki.pl/articles/1040702.pdf
Data publikacji:
2008
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
bovine serum albumin glycoconjugates
Maillard reaction
glycation
Opis:
The non-enzymatic reaction between reducing sugars and proteins, known as glycation, has received increased attention from nutritional and medical research. In addition, there is a large interest in obtaining glycoconjugates of pure well-characterized oligosaccharides for biological research. In this study, glycation of bovine serum albumin (BSA) by d-glucose, d-galactose and d-lactose under dry-heat at 60°C for 30, 60, 120, 180 or 240 min was assessed and the glycated products studied in order to establish their biological recognition by lectins. BSA glycation was monitored using gel electrophoresis, determination of available amino groups and lectin binding assays. The BSA molecular mass increase and glycation sites were investigated by mass spectrometry and through digestion with trypsin and chymotrypsin. Depending on time and type of sugar, differences in BSA conjugation were achieved. Modified BSA revealed reduction of amino groups' availability and slower migration through SDS/PAGE. d-galactose was more reactive than d-glucose or d-lactose, leading to the coupling of 10, 3 and 1 sugar residues, respectively, after 120 minutes of reaction. BSA lysines (K) were the preferred modified amino acids; both K256 and K420 appeared the most available for conjugation. Only BSA-lactose showed biological recognition by specific lectins.
Źródło:
Acta Biochimica Polonica; 2008, 55, 3; 491-497
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and characterisation of alginate micro- and nanospheres loaded with bovine serum albumin
Autorzy:
Wirecka, R.
Arruebo, M.
Sebastian, V.
Kyzioł, A.
Powiązania:
https://bibliotekanauki.pl/articles/284154.pdf
Data publikacji:
2017
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
drug delivery systems
bovine serum albumin
synthesis
Źródło:
Engineering of Biomaterials; 2017, 20, no. 143 spec. iss.; 35
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
miRNA-146a-5p is upregulated in serum and cartilage samples of patients with osteoarthritis
Autorzy:
Skrzypa, Marzena
Szala, Dariusz
Gablo, Natalia
Czech, Joanna
Pajak, Justyna
Kopanska, Marta
Trzeciak, Mateusz
Gargasz, Krzysztof
Snela, Sławomir
Zawlik, Izabela
Powiązania:
https://bibliotekanauki.pl/articles/1391948.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
circulating microRNA
osteoarthritis
serum
cartilage
biomarker
Opis:
Introduction: Osteoarthritis (OA) is a widely prevalent joint disease leading to motor disability and pain. Appropriate indicators for identifying patients at risk for this progressive disease, identifying molecular events for detecting early phases of the disease, or biomarkers to screen for treatment responses, however, are lacking. Micro RNAs (miRNAs), which play crucial roles in OA, could be potential biomarkers of OA. Because circulating miRNA levels reflect the disease state, they may be useful for OA screening and as diagnostic tools, reducing the need for invasive procedures and minimizing the cost of current diagnostic methods. Materials and methods: The expression levels of 18 microRNAs (let-7e-5p, miR-21-5p, miR-93-5p, miR-101-3p, miR-103a-3p, miR-130a-3p miR-146a-5p, miR-16-5p, miR-193b-3p miR-199a-3p, miR-210-3p, miR-222-3p, miR-22-3p, miR-27a-3p, miR-27b-3p, miR-335-5p, miR-454-3p, and miR-98-5p) were analyzed by quantitative real-time polymerase chain reaction in the cartilage tissues and serum samples of 28 OA patients and were compared to those of 2 healthy controls. Results: Expression of microRNA-146a-5p was significantly upregulated in the cartilage (p=0.006) and serum (p=0.002) of OA patients. The expression levels of miR-146a-5p in the serum were positively correlated with those in the cartilage (Pearson correlation coefficient R=0.32; p=0.002). Conclusion: miR-146a-5p was significantly overexpressed in patients with OA, both in the articular cartilage tissue and serum, with a positive correlation between the levels in both types of samples. Therefore, the miR-146a-5p serum level could reflect the molecular processes in the cartilage, suggesting its clinical utility as a biomarker for OA management. Implementing noninvasive biomarker using serum miRNAs involves the analysis of the misregulated miRNAs linked to the cartilage pathology.
Źródło:
Polish Journal of Surgery; 2019, 91, 3; 1-5
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Panel of serum metabolites discriminates cancer patients and healthy participants of lung cancer screening - a pilot study
Autorzy:
Roś-Mazurczyk, Małgorzata
Wojakowska, Anna
Marczak, Łukasz
Polański, Krzysztof
Pietrowska, Monika
Polanska, Joanna
Dziadziuszko, Rafał
Jassem, Jacek
Rzyman, Witold
Widlak, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1038611.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
early detection
lung cancer screening
metabolomics
serum biomarkers
Opis:
Introduction. Blood biomarkers may support early diagnosis of lung cancer by enabling pre-selection of candidates for computed tomography screening or discrimination between benign and malignant screening-detected nodules. We aimed to identify features of serum metabolome distinguishing individuals with early-detected lung cancer from healthy participants of the lung cancer screening program. Methods. Blood samples were collected in the course of a low-dose computed tomography screening program performed in the Gdansk district (Northern Poland). The analysis included 31 patients with screening-detected lung cancer and the pair-matched group of 92 healthy controls. The gas chromatography coupled to mass spectrometry (GC/MS) approach was used to identify and quantify small metabolites present in serum. Results. There were several metabolites detected in the sera whose abundances discriminated patients with lung cancer from controls. Majority of the differentiating components were downregulated in cancer samples, including amino acids, carboxylic acids and tocopherols, whereas benzaldehyde was the only compound significantly upregulated. A classifier including nine serum metabolites allowed separation of cancer and control samples with 100% sensitivity and 95% specificity. Conclusions. Signature of serum metabolites discriminating between cancer patients and healthy participants of the early lung cancer screening program was identified using a GC/MS metabolomics approach. This signature, though not validated in an independent dataset, deserves further investigation in a larger cohort study.
Źródło:
Acta Biochimica Polonica; 2017, 64, 3; 513-518
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A simple method for the determination of the cholesterol esterase activity
Autorzy:
Stępień, Agnieszka
Gonchar, Mykhailo
Powiązania:
https://bibliotekanauki.pl/articles/1039538.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cholesterol esterase
cholesterol
activity determination
human serum
Opis:
The proposed method determines the activity of cholesterol esterase (CEH) and takes advantage of its ability to catalyze the hydrolysis of cholesterol esters naturally present in human serum. The assay is based on Allain's method of spectrophotometric determination of cholesterol by means of cholesterol oxidase, peroxidase, but using 3,5-dichloro-dihydroxybenzenesulfonic acid (DHBS) as phenolic chromogen and human serum as a source of substrate for the CEH as a novelty. Furthermore, it is characterized by low costs and high precision. It can be employed to control the activity of CE preparations used for the preparation of enzymatic kits for the determination of cholesterol or for screening of potential bacterial enzyme producers.
Źródło:
Acta Biochimica Polonica; 2013, 60, 3; 401-403
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Infuence of HbA1c, serum lipids, blood pressure and BMI on Auditory Brainstem Response in diabetic patients
Autorzy:
Dąbrowski, Mariusz
Mielnik-Niedzielska, Grażyna
Nowakowski, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/454729.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
auditory brainstem response diabetes mellitus
serum lipids
Opis:
Introduction. Impaired hearing organ function including abnormalities in auditory brainstem response (ABR) are more frequent in diabetic subjects compared to the general population. The aim of our study was to assess the impact of selected modifiable factors on ABR latencies in diabetic subjects. Material and Methods. 58 patients with type 1 and type 2 diabetes, aged <45 years, with diabetes duration <10 years, and without clinically overt hearing impairment or diabetic neuropathy, were included. In all subjects vital signs and blood samples were obtained, and ABR audiometry was performed. Results. Significantly delayed latencies in ABR were found in patients with total cholesterol <192 mg/dL, with HDL-cholesterol <49.5 mg/dL, with triglycerides >89 mg/dL, with presence of hypertension, and with systolic and diastolic blood pressure >135 and >78 mm Hg respectively. A linear correlation between triglycerides and wave I and III latencies, and between systolic blood pressure and wave III latency were revealed. A relationship between ABR latencies and HbA1c, LDL-cholesterol or BMI was not found. Conclusions. Several modifiable factors affect functioning of the retrocochlear part of the auditory pathway. If these results were confirmed in further studies, a vast area of possible therapeutic interventions to preserve hearing function in diabetic patients would become available.
Źródło:
European Journal of Clinical and Experimental Medicine; 2017, 3; 185-191
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Osocze vs surowica – czy rodzaj materiału biologicznego ma wpływ na wyniki oznaczeń parathormonu?
Plasma vs serum – does the type of biological material affects the results of parathyroid hormone determinations?
Autorzy:
Beda-Maluga, Karolina
Paczuszka, Paulina
Pisarek, Hanna
Świętosławski, Jacek
Winczyk, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1035389.pdf
Data publikacji:
2019
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
surowica
osocze
parathormon
serum
plasma
parathyroid hormone
Opis:
Introduction: The recommended biological material for the parathyroid hormone (PTH) assay is venous blood plasma. According to diagnostic kit manufacturers, the PTH concentration can also be determined in blood serum. The aim of the study was to determine whether differences exist between PTH measured in serum and in plasma. Material and methods: The study was conducted on venous blood samples (plasma and serum) obtained from 92 patients at the Clinic of Endocrinology, University Hospital WAM – CSW. The PTH concentration was measured with an Immulite 1000 analyzer (Siemens), and iPTH kit. Results: The PTH values in plasma and serum were the same only in 3 cases. In 46 samples (50%), a higher hormone level was observed in the plasma, and in 43 cases (47%), a higher concentration was obtained in serum. The absolute differences between the PTH values in the tested biological materials ranged from 0 to 38 pg/mL, and increased together with the hormone concentration. The relative differences (percentage ratio of absolute differences to plasma PTH concentration) ranged from 0 to 34.3%. However, neither the absolute nor the relative differences were statistically significant (p > 0.05). The classification of PTH concentrations according to the reference values for each biological material (i.e. normal, reduced or elevated) was found to be concordant in 83 tested samples (90%). Conclusion: The identified PTH concentrations in the plasma and serum were not identical but comparable and in most cases the differences did not affect the clinical interpretation of the results.
WSTĘP: Materiałem biologicznym zalecanym do oznaczania parathormonu (parathyroid hormone – PTH) jest osocze krwi żylnej pobranej na wersenian sodowo-potasowy, jednak według producentów zestawów diagnostycznych do pomiaru PTH można stosować zarówno osocze, jak i surowicę krwi. Celem pracy było zbadanie, czy wartości PTH oznaczane w surowicy i w osoczu krwi żylnej są porównywalne. MATERIAŁ I METODY: W badaniu wykorzystano próbki krwi żylnej (osocze i surowica) uzyskane od 92 pacjentów Poradni Endokrynologicznej Uniwersyteckiego Szpitala Klinicznego im. Wojskowej Akademii Medycznej – Centralnego Szpitala Weteranów (USK im. WAM – CSW) w Łodzi. Oznaczenia hormonu wykonano na analizatorze Immulite 1000 (Siemens) zestawem iPTH. WYNIKI: Wartości PTH oznaczone w osoczu i w surowicy były jednakowe tylko w 3 przypadkach. W 46 próbkach (50%) wyższe wartości hormonu odnotowano w osoczu, a w 43 przypadkach (47%) w surowicy. Różnice bezwzględne między wartościami PTH w badanych materiałach wahały się od 0 do 38 pg/mL i zwiększały się wraz ze wzrostem stężenia hormonu. Różnice względne (procentowy stosunek różnic bezwzględnych do stężenia PTH w osoczu) wynosiły od 0 do 34,3%. Jednak zarówno różnice bezwzględne, jak i względne nie były znamienne statystycznie (p > 0,05). Po klasyfikacji stężeń – na prawidłowe, obniżone lub podwyższone – na podstawie wartości referencyjnych PTH dla danego materiału biologicznego uzyskano zgodność wyników w 83 badanych próbkach (90%). WNIOSKI: Stężenia PTH oznaczane w osoczu i w surowicy nie są identyczne, ale porównywalne, a różnice w większości przypadków nie wpływają na interpretację kliniczną wyników.
Źródło:
Annales Academiae Medicae Silesiensis; 2019, 73; 25-30
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Molecular recognition of glyconanoparticles by RCA and E. coli K88 - designing transports for targeted therapy
Autorzy:
Gallegos-Tabanico, Amed
Sarabia-Sainz, Jose
Sarabia-Sainz, H.
Carrillo Torres, Roberto
Guzman-Partida, Ana
Monfort, Gabriela
Silva-Campa, Erika
Burgara-Estrella, Alexel
Angulo-Molina, Aracely
Acosta-Elias, Mónica
Pedroza-Montero, Martín
Vazquez-Moreno, Luz
Powiązania:
https://bibliotekanauki.pl/articles/1038557.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
bovine serum albumin
neoglycan
nanoparticles
drug delivery
bio-recognition
Opis:
The targeted drug delivery has been studied as one of the main methods in medicine to ensure successful treatments of diseases. Pharmaceutical sciences are using micro or nano carriers to obtain a controlled delivery of drugs, able to selectively interact with pathogens, cells or tissues. In this work, we modified bovine serum albumin (BSA) with lactose, obtaining a neoglycan (BSA-Lac). Subsequently, we synthesized glyconanoparticles (NPBSA-Lac) with the premise that it would be recognized by microbial galactose specific lectins. NPBSA-Lac were tested for bio-recognition with adhesins of E. coli K88 and Ricinus communis agglutinin I (RCA). Glycation of BSA with lactose was analyzed by electrophoresis, infrared spectroscopy and fluorescence. Approximately 41 lactoses per BSA molecule were estimated. Nanoparticles were obtained using water in oil emulsion method and spheroid morphology with a range size of 300-500 nm was observed. Specific recognition of NPBSA-Lac by RCA and E. coli K88 was displayed by aggregation of nanoparticles analyzed by dynamic light scattering and atomic force microscopy. The results indicate that the lactosylated nanovectors could be targeted at the E. coli K88 adhesin and potentially could be used as a transporter for an antibacterial drug.
Źródło:
Acta Biochimica Polonica; 2017, 64, 4; 671-677
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Identification of serum proteome components associated with progression of non-small cell lung cancer
Autorzy:
Pietrowska, Monika
Jelonek, Karol
Michalak, Malwina
Roś, Małgorzata
Rodziewicz, Paweł
Chmielewska, Klaudia
Polański, Krzysztof
Polańska, Joanna
Gdowicz-Kłosok, Agnieszka
Giglok, Monika
Suwiński, Rafał
Tarnawski, Rafał
Dziadziuszko, Rafał
Rzyman, Witold
Widłak, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1039297.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cancer staging
early detection
lung cancer
proteomics
serum biomarkers
Opis:
The aim of the present study was to perform comparative analysis of serum from patients with different stages of non-small cell lung cancer (NSCLC) using the three complementary proteomic approaches to identify proteome components associated with the progression of cancer. Serum samples were collected before any treatment from 200 patients with NSCLC, including 103 early stage, 64 locally advanced and 33 metastatic cancer samples, and from 200 donors without malignancy. The low-molecular-weight fraction of serum proteome was MALDI-profiled in all samples. Serum proteins were characterized using 2D-PAGE and LC-MS/MS approaches in a representative group of 30 donors. Several significant differences were detected between serum samples collected from patients with early stage cancer and patients with locally advanced cancer, as well as between patients with metastatic cancer and patients with local disease. Of note, serum components discriminating samples from early stage cancer and healthy persons were also detected. In general, about 70 differentiating serum proteins were identified, including inflammatory and acute phase proteins already reported to be associated with the progression of lung cancer (serum amyloid A or haptoglobin). Several differentiating proteins, including apolipoprotein H or apolipoprotein A1, were not previously associated with NSCLC. No significant differences in patterns of serum proteome components were detected between patients with adenocarcinoma and squamous cell carcinoma. In conclusion, we identified the biomarker candidates with potential importance for molecular proteomic staging of NSCLC. Additionally, several serum proteome components revealed their potential applicability in early detection of the lung cancer.
Źródło:
Acta Biochimica Polonica; 2014, 61, 2; 325-331
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The presence of interfering antibodies in selected control sera on the example of a set for determination of tPSA
Autorzy:
Hajdrowska, B.
Krzakiewicz, K.
Czubasiewicz, Z.
Strzelczyk, J.K.
Szewczyk, M.
Brus, R.
Powiązania:
https://bibliotekanauki.pl/articles/2052429.pdf
Data publikacji:
2015
Wydawca:
Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej
Tematy:
Immunoenzymatic method
control serum
PSA antigen
blocking reagent
Opis:
The human sera often contain substances which interfere in the course of immunochemical reactions. It is essential for the control sera used to determine concentrations of antigen of the prostate not to contain such ingredients. The aim of this study was to test the control sera, three producers, containing low (N) and high (P) concentrations of prostate antigen (tPSA). As a factor blocking the interfering actions, the TRU Bloc Meridian Life Science, Inc. reagent was used which contains antibodies against mouse protein and rheumatoid factor. The sera with a low concentration of tPSA demonstrated the presence of interfering substances.
Źródło:
Health Problems of Civilization; 2015, 09, 2; 55-57
2353-6942
2354-0265
Pojawia się w:
Health Problems of Civilization
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Molecular docking and binding interaction between psychedelic drugs and human serum albumin
Autorzy:
Khastar, H.
Foroughi, K.
Aghayan, S.S.
Yarmohammadi, M.
Jafarisani, M.
Powiązania:
https://bibliotekanauki.pl/articles/2097000.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
human serum albumin
biodistribution
psychedelic drugs
molecular docking
Opis:
Drug-plasma protein interaction is a critical concern in monitoring drug circulation and drug-drug interactions. The present study aimed to investigate the interaction of psychedelic drugs such as lysergic acid diethylamide (LSD), dimethyltryptamine (DMT), 2,5-dimethoxy-4-iodoamphetamine (DOI), psilocybin, psilocin, and mescaline with human serum albumin (HSA). The 3D structures of LSD, DMT, DOI, psilocybin, psilocin, mescaline, and albumin were obtained from the structural databases (www.rcsb.org, https://pubchem.ncbi.nlm.nih.gov/compound). The structures were then prepared for molecular docking analysis by Autodock Vina software. Ultimately, the binding energies between docked HSA and psychedelic drugs were calculated, and their interactions were predicted. It was found that the psychedelic drugs can interact with HSA in the active site and the best minimum binding energies of -7.6 kcal/mol and -6.5 kcal/mol were shown by LSD and psilocybin, respectively. Our results indicated that all psychedelic drugs tested could interact with HSA at subdomains IA and IB. The structural properties of the drugs affect their interaction sites and binding energies. It was concluded that albumin, as the most abundant protein of the serum, could act as the biodistributor of psychedelic drugs.
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2020, 101, 2; 109-116
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pre-analytical-related variability influencing serum peptide profiles demonstrated in a mass spectrometry-based search for colorectal and prostate cancer biomarkers
Autorzy:
Karczmarski, Jakub
Rubel, Tymon
Mikula, Michal
Wolski, Jan
Rutkowski, Andrzej
Zagorowicz, Edyta
Dadlez, Michal
Ostrowski, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1039544.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
mass spectrometry; peptidome; serum; cancer; fibrinopeptide A
apolipoprotein A-IV
Opis:
Although the degradome, which comprises proteolytic fragments of blood proteins, presents a potential source of diagnostic biomarkers, studies on cancer peptide biomarkers have provided inconsistent conclusions. In the present study, we reevaluated the usefulness of serum degradome analyses for searching peptide cancer biomarker candidates. Particular attention was paid to pre-analytical factors influencing the variability of determined peptide levels, including clotting time and control group selection. Studies were conducted on 44 and 86 serum samples collected from cancer patients and healthy individuals, respectively, using liquid chromatography electrospray ionization mass spectrometry (LC-ESI-MS)-based analyses. We identified 1373 unique peptides, nearly 40% of which originated from five blood proteins: fibrinogen alpha chain, apolipoprotein A-IV (APOA4), complement C3, apolipoprotein A-I, and alpha-1-antitrypsin. A set of 118 and 88 peptides exhibited highly significant differences (adjusted p-value ≤ 0.01 and fold change ≥ 2) in pair-wise comparisons of control vs. prostate cancer and control vs. colorectal cancer, respectively, with 37 peptides displaying a consistent direction of change for these pair-wise comparisons. The levels of 67 peptides differed significantly in serum samples collected from healthy individuals immediately prior to colonoscopy and those who underwent colonoscopic examination at least four weeks earlier. Of them, 49 peptides originated from APOA4. Whereas earlier studies, including ours, have utilized fragments of fibrinopeptide A (FPA) to distinguish cancer from healthy cases, here we show that their absolute abundance is a sensitive indicator of clotting time. These observations may have implications for future serum peptidome studies since these issues have not previously been recognized.
Źródło:
Acta Biochimica Polonica; 2013, 60, 3; 417-425
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Peroxidation of proteins and lipids in suspensions of liposomes, in blood serum, and in mouse myeloma cells.
Autorzy:
Gebicki, Janusz
Du, Juan
Collins, James
Tweeddale, Helen
Powiązania:
https://bibliotekanauki.pl/articles/1044208.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
liposomes
lipid peroxides
mouse cells
serum
free radicals
protein peroxides
Opis:
There is growing evidence that proteins are early targets of reactive oxygen species, and that the altered proteins can in turn damage other biomolecules. In this study, we measured the effects of proteins on the oxidation of liposome phospholipid membranes, and the formation of protein hydroperoxides in serum and in cultured cells exposed to radiation-generated hydroxyl free radicals. Lysozyme, which did not affect liposome stability, gave 50% protection when present at 0.3 mg/ml, and virtually completely prevented lipid oxidation at 10 mg/ml. When human blood serum was irradiated, lipids were oxidized only after the destruction of ascorbate. In contrast, peroxidation of proteins proceeded immediately. Protein hydroperoxides were also generated without a lag period in hybrid mouse myeloma cells, while at the same time no lipid peroxides formed. These results are consistent with the theory that, under physiological conditions, lipid membranes are likely to be effectively protected from randomly-generated hydroxyl radicals by proteins, and that protein peroxyl radicals and hydroperoxides may constitute an important hazard to biological systems under oxidative stress.
Źródło:
Acta Biochimica Polonica; 2000, 47, 4; 901-911
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Blood serum microRNA profiles of pregnant women as biomarkers of pre-eclampsia evaluation
Autorzy:
Kondracka, A.
Jaszczuk, I.
Koczkodaj, D.
Filip, A.
Kwasniewska, A.
Powiązania:
https://bibliotekanauki.pl/articles/2098002.pdf
Data publikacji:
2020
Wydawca:
Instytut Medycyny Wsi
Tematy:
microRNA
blood serum
biomarker
pre-eclampsia
gene expression
pregnant woman
Opis:
Introduction. pre-eclampsia is a pregnancy-related syndrome characterized by hypertension and proteinuria that makes its appearance after 20 weeks of gestation. It develops approximately in 2–10% of all pregnancies. Pre-eclampsia, as a severe complication during pregnancy, is a major cause of maternal and perinatal morbidity and mortality. Objectives. The aim of the study was to assess the possibility of utilizing selected microRNAs at the earliest possible stage as safe biomarkers of severe complications of pregnancy, such as pre-eclampsia. State of konowledge. Nowadays, there are many trials aimed at finding effective methods for pre-eclampsia prediction at the early stage of pregnancy, before the onset of clinical signs. Although the precise pathophysiology of pre-eclampsia remains unknown, early prediction of the syndrome would allow the initiation of proper preventive therapy to savethe mother and future child. Current strategies for pre-eclampsia prediction are assessments of combinations of maternal risk factors, ultrasound parameters and different biomarkers (proteins, circulating cell free DNA and microRNAs). Studies of microRNAs in particular offer great potential for diagnosis and therapy in pregnancy-related disorders. The fraction of specific placenta-related circulating microRNAs in the serum of pregnant women who present symptoms of pre-eclampsia after 20 weeks of gestation, and show the strongest changes in the level, can play an important role in the development of placenta-related complications. Conclusion. Further research into the level of microRNAs in the blood serum of pregnant women with pre-eclampsia will allow a practical way of utilizing selected microRNAs at the earliest possible stage as safe biomarkers of severe complications of pregnancy.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2020, 14, 4; 174-177
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of meditation on premenstrual syndrome in female medical students
Autorzy:
Kaur, Harminder
Kaur, Nimarpreet
Reddy Akula, Gangadhar
Reddy Kodidala, Satyanath
Powiązania:
https://bibliotekanauki.pl/articles/27317665.pdf
Data publikacji:
2023-09-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
cold pressor test
meditation
premenstrual syndrome
serum cortisol
stress
Opis:
Introduction and aim. A symptom complex of cyclic irritability, depression and lethargy is known as the premenstrual syndrome (PMS). Since ages women suffered from PMS. As varied as the etiology, innumerable treatment modalities have been put forward for PMS. Stress is accompanied most closely associated in PMS. Practicing yoga and meditation significantly important for PMS symptoms in reducing its symptoms and period crams as well. The present study aims the impact of meditation in people with PMS. The aim of the study was to see any effect of Shavasana (meditation) training on stress parameters in premenstrual syndrome in female medical students. Material and methods. The present study was approved by institutional ethical committee. Thirty clinically healthy female medical students who were suffering from PMS selected using a premenstrual questionnaire. The values of heart rate, systolic and diastolic blood pressure, and serum cortisol were measured before meditation. Subjects were then taken through Shavasana (meditation) session for 4 weeks at the same time daily. On the last day of meditation session all above parameters were again recorded and the data was analyzed statistically. Results. The baseline values of all parameters in premeditation session compared to post meditation session. The basal SBP, DBP and HR of female medical students with PMS were significantly higher in pre meditation session than post meditation session with p value of SBP=0.0002, DBP=0.0001, HR<0.0001 respectively which indicated the presence of stress. Following a 4 weeks of Shavasana meditation a significant fall in baseline SBP, DBP, HR and the serum Cortisol value was observed. Conclusion. These findings proves that Shavasana is an effective treatment modality to get rid of stress during premenstrual phase
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 3; 529-533
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hyperhomocysteinemia among Omani autistic children: a case-control study
Autorzy:
Ali, Amanat
Waly, Mostafa
Al-Farsi, Yahya
Essa, Musthafa
Al-Sharbati, Marwan
Deth, Richard
Powiązania:
https://bibliotekanauki.pl/articles/1039850.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
autistic children
vitamin B12
Oman
folate
serum homocysteine
Opis:
High serum homocysteine (Hcy) level is regarded as an indicator for impairment of folate-dependent methionine cycle and is associated with oxidative stress. In a case control study, we evaluated eighty 3-5 years old Omani children (40 diagnosed with Autism Spectrum Disorder and 40 their age and gender matched controls) for their fasting serum homocysteine levels as a biomarker of Autism Spectrum Disorder (ASD). Serum folate and vitamin B12 status were also evaluated. The serum homocysteine was measured using an enzyme immunoassay (EIA) technique whereas folate and vitamin B12 were measured using an automated random access immune-assay system. The results indicated that mean serum Hcy levels were significantly (P < 0.05) higher in autistic children (20.1 ± 3.3 µmol/L) as compared to controls (9.64 ± 2.1 µmol/L). Significantly (P < 0.05) lower serum folate (1.8 ± 0.4 µg/L) and vitamin B12 (191.1 ± 0.9 pg/mL) levels were observed in autistic children as compared to controls (6.1 ± 0.6 µg/L and 288.9 ± 1.3 pg/mL, respectively). The levels of homocysteine in autistic children were also much higher as compared to normal reference values (5-15 µmol/L). The results suggest that high fasting serum homocysteine and low folate and vitamin B12 levels could be used as clinical biomarkers for an early diagnosis and management of ASD.
Źródło:
Acta Biochimica Polonica; 2011, 58, 4; 547-551
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nutritional properties of tubers of conventionally bred and transgenic lines of potato resistant to necrotic strain of Potato virus Y (PVYN)
Autorzy:
Juśkiewicz, Jerzy
Zduńczyk, Zenon
Fornal, Józef
Powiązania:
https://bibliotekanauki.pl/articles/1041385.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
potato
rat
ceacal fermentation
genetic modification
serum
nutritional value
Opis:
The potential effect of genetic modification on nutritional properties of potatoes transformed to improve resistance to a necrotic strain of Potato virus Y was determined in a rat experiment. Autoclaved tubers from four transgenic lines were included to a diet in the amount of 40% and compared with the conventional cv. Irga. The experiment lasted 3 weeks and special attention was paid to nutritional properties of diets, caecal metabolism and serum indices. Genetic modification of potato had no negative effect on the chemical composition and nutritional properties of tubers, ecosystem of the caecum, activity of serum enzymes and non-specific defence mechanism of the rats. Obtained results indicate that transgenic potato with improved resistance to PVYN: line R1F (truncated gene coding for PVYN polymerase in sense orientation), R2P (truncated gene coding for PVYN polymerase in antisense orientation), and NTR1.16 (non-translated regions of PVYN genome in sense orientation) are substantial and nutritional equivalence to the non-transgenic cultivar. Tubers of transgenic line NTR2.27 (non-translated regions of PVYN genome in antisense orientation) increased the bulk of caecal digesta and the production of SCFA as compared to tubers of the conventional cultivar and the other transgenic clones. Taking into account some deviations, it seems reasonable to undertake a long-term feeding study to confirm the nutritional properties of tubers of transgenic lines.
Źródło:
Acta Biochimica Polonica; 2005, 52, 3; 725-729
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
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