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    Wyświetlanie 1-13 z 13
    Tytuł:
    Applicability of artificial intelligence in smart healthcare systems for automatic detection of Parkinson’s Disease
    Autorzy:
    Pallathadka, Harikumar
    Padminivalli V., S.J.R.K.
    Vasavi, M.
    Nancy, P.
    Naved, Mohd
    Kumar, Harish
    Ray, Samrat
    Powiązania:
    https://bibliotekanauki.pl/articles/38709253.pdf
    Data publikacji:
    2024
    Wydawca:
    Instytut Podstawowych Problemów Techniki PAN
    Tematy:
    Parkinson’s disease
    detection
    machine learning
    relief algorithm
    LDA algorithm
    SVM-RBF
    accuracy
    sensitivity
    specificity
    choroba Parkinsona
    wykrywanie
    nauczanie maszynowe
    algorytm ulgi
    Algorytm LDA
    dokładność
    wrażliwość
    specyficzność
    Opis:
    Parkinson’s disease is associated with memory loss, anxiety, and depression in the brain. Problems such as poor balance and difficulty during walking can be observed in addition to symptoms of impaired posture and rigidity. The field dedicated to making computers capable of learning autonomously, without having to be explicitly programmed, is known as machine learning. An approach to the diagnosis of Parkinson’s disease, which is based on artificial intelligence, is discussed in this article. The input for this system is provided through photographic examples of Parkinson’s disease patient handwriting. Received photos are preprocessed using the relief feature option to begin the process. This is helpful in the process of selecting characteristics for the identification of Parkinson’s disease. After that, the linear discriminant analysis (LDA) algorithm is employed to reduce the dimensions, bringing down the total number of dimensions that are present in the input data. The photos are then classified via radial basis function-support vector machine (SVM-RBF), k-nearest neighbors (KNN), and naive Bayes algorithms, respectively.
    Źródło:
    Computer Assisted Methods in Engineering and Science; 2024, 31, 2; 175-185
    2299-3649
    Pojawia się w:
    Computer Assisted Methods in Engineering and Science
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Clinical Evaluation and Instrumental Diagnostics in Acute Acromioclavicular Joint Dislocation
    Autorzy:
    Bezruchenko, Serhii
    Dolhopolov, Oleksii
    Yarova, Maryna
    Luchko, Roman
    Mazevych, Vadim
    Powiązania:
    https://bibliotekanauki.pl/articles/28408830.pdf
    Data publikacji:
    2022-03-02
    Wydawca:
    Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
    Tematy:
    diagnostics
    sensitivity and specificity
    acromioclavicular joint
    MRI
    outcomes
    Opis:
    Background. The aim was to improve the diagnosis of acromioclavicular joint dislocation by studying the capabilities and characteristics of clinical and instrumental diagnostic methods. The idea is expressed that modern clinical and instrumental diagnostic methods comprise a large number of techniques, but no single algorithm for diagnosing injury to the AC joint has been developed. A gold standard for investigating and diagnosing acute AC joint dislocation does not currently exist. Materials and Methods. A retrospective study of the characteristics and capabilities of clinical and instrumental diagnostic methods was performed in 152 patients with traumatic shoulder pathology. The patients were divided into two groups: Group I of 102 patients (67%) with acromioclavicular joint dislocation type III-VI according to Rockwood classification and Group II of 50 patients (33%) with a partial tear of the rotator cuff. Clinical and instrumental examinations involved specific provocative tests; the radiological diagnostics comprised conventional radiographs with the Zanca, axillary and Alexander views, and CT, MRI, and ultrasound examinations. Results. The characterization of examination methods was based on the records of patients in Group I and II. The most sensitive clinical test to establish Rockwood type V of acromioclavicular joint dislocation was the Paxinos test (91%). The lowest sensitivity across the tests used was observed with the active compression test to diagnose type IV of dislocation (50%). As regards the X-ray examination, the axial view was 100% sensitive for detecting type IV and VI AC joint dislocation. The Zanca view is highly sensitive for patients with Rockwood type V and Alexander view for Rockwood type III and V dislocations. The accuracy of ultrasound work-up in Group I was 95%, with 96% sensitivity and 93% specificity, while MRI accuracy was 97%, with 96% sensitivity and 98% specificity, and CT accuracy was 81%, with 83% sensitivity and 75% specificity. Conclusions. 1. Determination of the sensitivity and specificity of the X-ray examination revealed the absence of a 100% effective X-ray view for type III and V AC joint dislocation. 2. The accuracy and sensitivity of the ultrasound, MRI, and CT examinations are high. 3. There is currently no consensus on a protocol to view acute AC joint injuries. 4. Complete and timely early diagnosis of acromioclavicular dislocation allows for a differentiated approach to surgical treatment tactics, preventing possible complications and restoring the function of the injured shoulder joint to the fullest extent.
    Źródło:
    Ortopedia Traumatologia Rehabilitacja; 2022, 24(1); 1-12
    1509-3492
    2084-4336
    Pojawia się w:
    Ortopedia Traumatologia Rehabilitacja
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Triplex qRT-PCR with specific probe for synchronously detecting Bovine parvovirus, bovine coronavirus, bovine parainfluenza virus and its applications
    Autorzy:
    Geng, J.
    Niu, Y.
    Wei, L.
    Li, Q.
    Gong, Z.
    Wei, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/2087278.pdf
    Data publikacji:
    2020
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    bovine parvovirus
    bovine coronavirus
    bovine parainfluenza virus
    qRT-PCR
    specificity
    sensitivity
    Źródło:
    Polish Journal of Veterinary Sciences; 2020, 23, 4
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Clinical value of colonoscopy and positron emission tomography with computed tomography for colorectal cancer diagnosis
    Autorzy:
    Nowicki, Andrzej
    Kula, Zbigniew
    Dobrzyń, Paulina
    Powiązania:
    https://bibliotekanauki.pl/articles/1392370.pdf
    Data publikacji:
    2019
    Wydawca:
    Index Copernicus International
    Tematy:
    colorectal cancer
    colonoscopy
    PET / CT
    sensitivity
    specificity
    accuracy
    Opis:
    Introduction: Colonoscopy and PET / CT are among the major diagnostic tests for colorectal cancer. The sensitivity, specificity, and accuracy of these studies are still being assessed differently. Objective: The aim of the study was to compare the sensitivity, specificity and accuracy of colonoscopy and PET / CT in the diagnosis of colorectal cancer. Material and methods: The medical records of 125 patients with colonoscopy and PET / CT in the years 2014-2015 were analyzed retrospectively. The research was done at the Professor Franciszek Łukaszczyk Oncology Center in Bydgoszcz. Based on the macroscopic description of colonoscopy, the results were divided into two groups: with and without probability of cancer. The average SUV value in PET / CT for colorectal cancer was calculated and without this diagnosis. The average value of SUV 14 and higher was considered probable, while 11 or less had no probability of cancer. Standardized mathematical formulas were used to evaluate the sensitivity, specificity and accuracy. Results: More than half of the patients - 78 (62.4%) were males. The majority of patients -42 (36.6%) were aged 65-74. The majority (106) (68.8%) were diagnosed as polyps and 24 (15.6%) as tumor-like lesions. Polyps were placed in the rectum -32 (30.2%), in the sigmoid colon - 26 (24.5%) and 15 (13.2%) in the ascending colon. Tumors were located in the rectum - 11 (45.8%) and 4 (16.7%) in the recto-sigmoid junction. 38 (24.6%) adenocarcinomas and 67 (43.5%) adenomas were diagnosed. The detection rate of RJG was 32% in colonoscopy and PET / CT. The sensitivity of the colonoscopy was 80%, the specificity - 68.4% and the accuracy - 71.4%. The sensitivity, specificity and accuracy of PET / CT were 65%, 75%, 4% and 72.7%, respectively. Conclusions: Colonoscopy has a higher sensitivity in colorectal cancer diagnosis, but specificity and accuracy are higher in PET / CT. Keywords: colorectal cancer, colonoscopy, PET / CT, sensitivity, specificity, accuracy
    Źródło:
    Polish Journal of Surgery; 2019, 91, 1; 6-9
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Diagnostic accuracy of sonoelastography in different diseases
    Wartość diagnostyczna sonoelastografii w różnych jednostkach chorobowych
    Autorzy:
    Manzoor, Iqra
    Bacha, Raham
    Gilani, Syed Amir
    Powiązania:
    https://bibliotekanauki.pl/articles/1033265.pdf
    Data publikacji:
    2018
    Wydawca:
    Medical Communications
    Tematy:
    accuracy
    different diseases
    sensitivity
    sonoelastography
    specificity
    Opis:
    The objective of this study was to evaluate the diagnostic accuracy of sonoelastography in patients of primary and secondary health care settings. Google scholar, PubMed, Medline, Medscape, Wikipedia and NCBI were searched in October 2017 for all original studies and review articles to identify the relevant material. Two reviewers independently selected articles for evaluation of the diagnostic accuracy of sonoelastography in different diseases based on titles and abstracts retrieved by the literature search. The accuracy of sonoelastography in different diseases was used as the index text, while B-mode sonography, micro pure imaging, surgery and histological findings were used as reference texts. Superficial lymph nodes, neck nodules, malignancy in thyroid nodules, benign and malignant cervical lymph nodes, thyroid nodules, prostate carcinoma, benign and malignant breast abnormalities, liver diseases, parotid and salivary gland masses, pancreatic masses, musculoskeletal diseases and renal disorders were target conditions. The data extracted by the two reviewers concerning selected study characteristics and results were presented in tables and figures. In total, 46 studies were found for breast masses, lymph nodes, prostate carcinoma, liver diseases, salivary and parotid gland diseases, pancreatic masses, musculoskeletal diseases and renal diseases, and the overall sensitivity of sonoelastography in diagnosing all these diseases was 83.14% while specificity was 81.41%. This literature review demonstrates that sonoelastography is characterized by high sensitivity and specificity in diagnosing different disorders of the body.
    Celem badania była ocena dokładności diagnostycznej sonoelastografii u chorych leczonych w warunkach placówek podstawowej i specjalistycznej opieki zdrowotnej. W październiku 2017 roku dokonano przeglądu baz danych Google Scholar, PubMed, MEDLINE, Medscape, Wikipedia oraz NCBI w celu pozyskania prac oryginalnych i poglądowych, które stanowiły materiał do badania. Prace wybierało dwóch badaczy niezależnie. Oceniono dokładność sonoelastografii w diagnostyce różnych chorób na podstawie tytułów i streszczeń wyszukanych prac. Główny termin stanowiła „skuteczność sonoelastografii w diagnostyce różnych chorób”, a terminy „ultrasonografia w trybie B-mode”, „obrazowanie MicroPure”, „zabieg operacyjny” i „wynik badania histopatologicznego” stosowano jako terminy referencyjne. Badane patologie dotyczyły: powierzchownych węzłów chłonnych, guzków okolicy szyi, złośliwych guzów tarczycy, łagodnych i złośliwych zmian w węzłach chłonnych szyjnych, guzków tarczycy, raka gruczołu krokowego, łagodnych i złośliwych zmian w piersiach, chorób wątroby, zmian w śliniankach przyusznych i gruczołach ślinowych, zmian w trzustce, chorób układu mięśniowo-szkieletowego oraz chorób nerek. Pozyskane przez dwóch badaczy dane dotyczące charakterystyki ocenianych prac oraz wyniki analizy przedstawiają tabele i ryciny. W sumie wyszukano 46 badań dotyczących zmian w piersiach, węzłów chłonnych, raka gruczołu krokowego, chorób wątroby, chorób gruczołów ślinowych i ślinianek przyusznych, zmian w trzustce, chorób układu mięśniowo-szkieletowego i chorób nerek, a ogólna czułość i swoistość sonoelastografii w diagnostyce tych chorób wynosiły odpowiednio 83,14% i 81,41%. Niniejszy przegląd literatury wskazuje na wysoką czułość i swoistość sonoelastografii w diagnostyce różnych chorób. Artykuł w wersji polskojęzycznej jest dostępny na stronie http://jultrason.pl/index.php/issues/volume-18-no-72
    Źródło:
    Journal of Ultrasonography; 2018, 18, 72; 29-36
    2451-070X
    Pojawia się w:
    Journal of Ultrasonography
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Multinomial Logistic Regression Approach For The Evaluation Of Binary Diagnostic Test In Medical Research
    Autorzy:
    Dwivedi, Alok Kumar
    Mallawaarachchi, Indika
    Figueroa-Casas, Juan B.
    Powiązania:
    https://bibliotekanauki.pl/articles/465774.pdf
    Data publikacji:
    2015
    Wydawca:
    Główny Urząd Statystyczny
    Tematy:
    multinomial logistic regression predictive values
    sensitivity, specificity
    acute appendicitis
    pulmonary abnormalities
    medical diagnostic test
    Opis:
    Evaluating the effect of variables on diagnostic measures (sensitivity, specificity, positive, and negative predictive values) is often of interest to clinical researchers. Logistic regression (LR) models can be used to predict diagnostic measures of a screening test. A marginal model framework using generalized estimating equation (GEE) with logit/log link can be used to compare the diagnostic measures between two or more screening tests. These individual modeling approaches to each diagnostic measure ignore the dependency among these measures that might affect the association of covariates with each diagnostic measure. The diagnostic measures are computed using joint distribution of screening test result and reference test result which generates a multinomial response data. Thus, multinomial logistic regression (MLR) is a more appropriate approach to modeling these diagnostic measures. In this study, the validity of LR and GEE approaches as compared to MLR model was assessed for modeling diagnostic measures. All methods provided unbiased estimates of diagnostic measures in the absence of any covariate. LR and GEE methods produced more biased estimates as compared to MLR approach especially for small sample size studies. No bias was obtained in predicting sensitivity measure using MLR method for one screening test. Our proposed MLR method is robust for modeling diagnostic measures of a screening test as opposed to LR method. MLR method and GEE method produced similar estimates of diagnostic measures for comparing two screening tests in large sample size studies. The proposed MLR model for diagnostic measures is simple, and available in common statistical software. Our study demonstrates that MLR method should be preferred as an alternative for modeling diagnostic measures.
    Źródło:
    Statistics in Transition new series; 2015, 16, 2; 203-222
    1234-7655
    Pojawia się w:
    Statistics in Transition new series
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Validity test of the IPD-Work consortium approach for creating comparable job strain groups between Job Content Questionnaire and Demand-Control Questionnaire
    Autorzy:
    Choi, Bongkyoo
    Ko, Sangbaek
    Ostergren, Per-Olof
    Powiązania:
    https://bibliotekanauki.pl/articles/2177398.pdf
    Data publikacji:
    2015-03-26
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    epidemiological studies
    Malmö
    sensitivity
    specificity
    scoring methods
    misclassification
    Opis:
    Objectives This study aims to test the validity of the IPD-Work Consortium approach for creating comparable job strain groups between the Job Content Questionnaire (JCQ) and the Demand-Control Questionnaire (DCQ). Material and Methods A random population sample (N = 682) of all middle-aged Malmö males and females was given a questionnaire with the 14-item JCQ and 11-item DCQ for the job control and job demands. The JCQ job control and job demands scores were calculated in 3 different ways: using the 14-item JCQ standard scale formulas (method 1); dropping 3 job control items and using the 11-item JCQ standard scale formulas with additional scale weights (method 2); and the approach of the IPD Group (method 3), dropping 3 job control items, but using the simple 11-item summation-based scale formulas. The high job strain was defined as a combination of high demands and low control. Results Between the 2 questionnaires, false negatives for the high job strain were much greater than false positives (37–49% vs. 7–13%). When the method 3 was applied, the sensitivity of the JCQ for the high job strain against the DCQ was lowest (0.51 vs. 0.60–0.63 when the methods 1 and 2 were applied), although the specificity was highest (0.93 vs. 0.87–0.89 when the methods 1 and 2 were applied). The prevalence of the high job strain with the JCQ (the method 3 was applied) was considerably lower (4–7%) than with the JCQ (the methods 1 and 2 were applied) and the DCQ. The number of congruent cases for the high job strain between the 2 questionnaires was smallest when the method 3 was applied. Conclusions The IPD-Work Consortium approach showed 2 major weaknesses to be used for epidemiological studies on the high job strain and health outcomes as compared to the standard JCQ methods: the greater misclassification of the high job strain and lower prevalence of the high job strain.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2015, 28, 2; 321-333
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Detekcja błędów segmentacji sygnału fotopletyzmograficznego
    The detection of segmentation errors in a photoplethysmographic signal
    Autorzy:
    Bołtrukiewicz, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/157309.pdf
    Data publikacji:
    2014
    Wydawca:
    Stowarzyszenie Inżynierów i Techników Mechaników Polskich
    Tematy:
    błąd segmentacji
    wskaźnik błędów
    sygnał fotopletyzmograficzny
    zmienność rytmu serca
    przedziały tolerancji
    czułość
    specyficzność
    error of segmentation
    factor of errors
    photoplethysmographic signal
    PPG
    heart rate variability
    HRV
    ranges of tolerance
    sensitivity
    specificity
    Opis:
    Tematyka pracy związana jest z analizą zmienności rytmu serca, a dotyczy w szczególności detekcji błędów powstających podczas segmentacji procedury wyznaczającej zbiór okresów przebiegu. W artykule omówiono i zilustrowano podstawowe przyczyny błędów segmentacji. Zaproponowano dwa algorytmy detekcyjne wykorzystujące statystyczne przedziały tolerancji, które następnie przetestowano i oceniono przy użyciu posiadanego zbioru 5-minutowych przebiegów sygnału fotopletyzmograficznego.
    The paper concerns the detection of segmentation errors in a photoplethysmographic signal (PPG). In the paper, the causes of segmentation errors are considered. The technical causes are presented in Figs. 1 and 2 while the biological causes are shown in Fig. 3. Two algorithms of detection of errors are proposed. Both algorithms use statistical tolerance ranges, which are described by Eq. 1. The principles of operation of these algorithms are given in Eqs. 2 and 3. In the study the efficiency of these algorithms was evaluated using the factor of errors defined by Eq. 4. For both algorithms the sensitivity (SE), specificity (SP) and positive prediction value (PPV) and negative prediction value (NPV) were calculated, too. In the experiments real photoplethysmographic signals were analyzed. Time duration of each signal was equal to 5 min. The coefficients of errors obtained for both algorithms are presented in Fig. 4. The comparison of the sensitivity and the positive prediction value is shown in Fig. 5. The causes of differences between the obtained values of the coefficients are considered. The possibility of improvement of SE and PPV is also analyzed.
    Źródło:
    Pomiary Automatyka Kontrola; 2014, R. 60, nr 8, 8; 541-543
    0032-4140
    Pojawia się w:
    Pomiary Automatyka Kontrola
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Meta-analysis techniques applied in prevalence rate estimation
    Autorzy:
    Martins, João
    Felgueiras, Miguel
    Santos, Rui
    Powiązania:
    https://bibliotekanauki.pl/articles/729858.pdf
    Data publikacji:
    2013
    Wydawca:
    Uniwersytet Zielonogórski. Wydział Matematyki, Informatyki i Ekonometrii
    Tematy:
    compound tests
    estimation of prevalence
    meta-analysis
    sensitivity
    specificity
    Opis:
    In some cases, the estimators obtained in compound tests have better features than the traditional ones, obtained from individual tests, cf. Sobel and Elashoff (1975), Garner et al. (1989) and Loyer (1983). The bias, the efficiency and the robustness of these estimators are investigated in several papers, e.g. Chen and Swallow (1990), Hung and Swallow (1999) and Lancaster and Keller-McNulty (1998). Thus, the use of estimators based on compound tests not only allows a substantial saving of costs, but they also can (in some situations) be more accurate than the estimators based on the individual tests.
    Nevertheless, each laboratory produces estimates for the prevalence rate of a given infection using different methodologies, such as halving nested procedures (Sobel and Elashoff, 1975) and square array testing (Kim et al., 2007). The logistic regression or the weighted least squares regression can be used in order to combine different prevalence rate estimates (Chen and Swallow, 1990). In this work some meta-analytical techniques are proposed as an alternative approach. This methodology has the advantage of being quite simple and flexible to account for the error source.
    Źródło:
    Discussiones Mathematicae Probability and Statistics; 2013, 33, 1-2; 79-97
    1509-9423
    Pojawia się w:
    Discussiones Mathematicae Probability and Statistics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Oznaczenia klasycznych markerów nowotworowych u chorych na nowotwory złośliwe narządu rodnego
    Role of classic tumor markers in genital malignancies in the females
    Autorzy:
    Kozakiewicz, Barbara
    Stefaniak, Małgorzata
    Dmoch-Gajzlerska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/1031190.pdf
    Data publikacji:
    2012
    Wydawca:
    Medical Communications
    Tematy:
    CA-125
    CEA
    CYFRA 21-1
    HE4
    SCC-AG
    TATI
    TPA
    TPS
    czułość
    markery nowotworowe
    prognostic value
    sensitivity
    specificity
    swoistość
    tumor markers
    wartość predykcyjna badania
    β-HCG
    Opis:
    Since the 1970s we are witnessing a continuing search for new markers that would assist in the treatment and follow- up of patients with malignant tumors. First reports on benefits of assessment of tumor markers authored by Goldman and Freedman date back to 1965. Discovery of the first carcinoembryonic antigen (CEA) initiate an era of search for substances, still insufficiently sensitive and specific as to be used to screen tumors, but increasingly helpful in the assessment of treatment effects. This paper discusses the role of tumor markers, increasingly often referred to as “classic” in the monitoring of tumors. We present an update on markers with the longest history in oncology practice, e.g. CEA and on the recently introduced marker TATI. Selection of markers was made based on their role in three basic processes taking place in tumor cells, i.e. proliferation, differentiation and apoptosis. We highlight novel and expanding fields of research – genomics and proteomics, which appear to be the future of oncology. They are extremely useful in the evaluation of molecular prognostic factors, enabling implementationof individually tailored targeted therapies in cancer patients. We discuss classic markers and the few known cancer- specific substances. To sum-up, we state that understanding of the role of more sensitive and more specific markers in oncology may contribute to a more personalized treatment and thus may improve the outcome in cancer patients.
    Od lat siedemdziesiątych XX wieku nieustannie poszukuje się nowych markerów, które mogą być pomocne w leczeniu i kontroli po jego ukończeniu u chorych na nowotwory złośliwe. Po raz pierwszy przydatność określania markerów nowotworowych opisali Goldman i Freedman w 1965 roku. Oznaczyli pierwszy marker CEA (karcynoembrionalny) i tak zapoczątkowali erę odkryć substancji o wciąż niezadowalającej czułości i swoistości, aby mogły być używane do skriningu chorób nowotworowych, lecz coraz bardziej przydatnych w ocenie efektu leczenia. W pracy opisano zastosowanie markerów nowotworowych coraz częściej określanych mianem klasycznych w procesie śledzenia chorób nowotworowych. Zaprezentowano najnowsze informacje o markerach najdłużej stosowanych w praktyce onkologicznej, na przykład CEA, jak również o nowo wykorzystywanym markerze TATI. Doboru markerów dokonano na podstawie ich udziału w trzech procesach toczących się w komórkach nowotworowych: proliferacji, różnicowaniu i obumieraniu komórek. Zwrócono uwagę na rozwijające się nowe dyscypliny nauki – genomikę i proteomikę, stanowiące przyszłość onkologii. Są one niezwykle pomocne w określeniu molekularnych czynników predykcyjnych umożliwiających stosowanie leczenia celowanego u chorych na nowotwory złośliwe. Opisano markery klasyczne, a także nieliczne markery molekularne występujące w różnych nowotworach. W podsumowaniu stwierdzono, że poznanie natury markerów o znaczącej czułości i swoistości w chorobach nowotworowych może wpłynąć na personalizację leczenia i tą drogą na poprawę wyleczeń chorych na nowotwory złośliwe.
    Źródło:
    Current Gynecologic Oncology; 2012, 10, 3; 226-235
    2451-0750
    Pojawia się w:
    Current Gynecologic Oncology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Diagnostic tests used in diagnosis of carpal tunnel syndrome
    Testy diagnostyczne stosowane w rozpoznawaniu zespołu kanału nadgarstka
    Autorzy:
    Georgiew, Filip
    Otfinowska, Ewa
    Adamczyk, Tomasz
    Powiązania:
    https://bibliotekanauki.pl/articles/1939059.pdf
    Data publikacji:
    2008
    Wydawca:
    Akademia Wychowania Fizycznego im. Bronisława Czecha w Krakowie
    Tematy:
    carpal tunnel syndrome (CTS)
    diagnostic tests
    Sensitivity
    Specificity
    zespół kanału nadgarstka (ZKN)
    testy diagnostyczne
    czułosc
    specyficznosc
    Opis:
    In 1854 Paget described for the first time that carpal tunnel syndrome (CTS) results from compression of the median nerve within the carpal tunnel. CTS predominantly involves tingling and numbness in the typical median nerve distribution. Pain, described as deep, aching, or throbbing, occurs diffusely in the hand and radiates up the forearm. Atrophy of the muscles of the thenar is usually seen later in the course of the nerve compression. CTS is most frequent among persons between the ages of 30 to 60 and is two to three times more common in women than in men (peak prevalence in women older than 55 years). Carpal tunnel syndrome may affect 1% to 10% of the population. Incorrect diagnosis of CTS has been identified as one of the most common causes of CTS treatment failure. CTS should be diagnosed clinically. Electro-diagnostic studies are a standard method of establishing the diagnosis. Electrodiagnostic studies are performed to confirm the clinical diagnosis, to assess the severity of median nerve compression and to rule out more proximal compression sites. Abnormalities in nerve conduction study results can be the only objective evidence of carpal tunnel syndrome. Lack of objective data, such as ENG can lead to incorrect diagnosis and inappropriate treatment. Clinical diagnosis should be reinforced by valuable diagnostic tests: the Semmes–Weinstein monofilaments test – performed in neutral and Phalen’s positions, vibration threshold measured by means of tuning forks or a vibrometer, by observation of thenar atrophy and using provocative tests. The use of common, sensitive and specific diagnostic tests should improve decision making about patients referral for specific therapies, facilitate the performance of epidemiologic studies, increase the accuracy of diagnosis. The combination of a results obtained using various methods might be more powerful than a single test in establishing the diagnosis of CTS. The combination of hand diagram, questionnaires, abnormal sensibility, thenar weakness or thenar atrophy and positive provocative tests constitutes a sensitive and specific diagnostic tool to establish the diagnosis of CTS. Standardized clinical criteria for CTS would be an important step in reducing inconsistencies and misdiagnoses.
    Źródło:
    Medical Rehabilitation; 2008, 12(3); 24-35
    1427-9622
    1896-3250
    Pojawia się w:
    Medical Rehabilitation
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Provocative tests used in the diagnosis of carpal tunnel syndrome
    Testy prowokacyjne stosowane w diagnostyce zespołu cieśni nadgarstka
    Autorzy:
    Georgiew, Filip
    Powiązania:
    https://bibliotekanauki.pl/articles/1938585.pdf
    Data publikacji:
    2007
    Wydawca:
    Akademia Wychowania Fizycznego im. Bronisława Czecha w Krakowie
    Tematy:
    Carpal Tunnel Syndrome
    Diagnosis
    Provocative Test
    Sensitivity
    Specificity
    zespół ciesni nadgarstka
    diagnostyka
    testy prowokacyjne
    czułosc
    specyficznosc
    Opis:
    The carpal tunnel syndrome (CTS) is the most often diagnosed compressive neuropathy of the upper limb. As a result of the changes within the tunnel of the median nerve, the disease is associated with hypersensitivity to some external factors such as: an increase in pressure within the carpal tunnel, direct or indirect pressure on the wrist level, hypoxia. These factors are used in provocative tests. The aim of this article is to make a distinction between functional test’s classifications used in the CTS diagnosis, depending on the method of ailment provocation. Different modifications used in common tests and their average sensitivity and specificity are also presented. Carpal tunnel syndrome should be diagnosed clinically; although electro-diagnostic studies are a standard method of establishing the diagnosis, they do have limitations. Clinical diagnostic skill must be reinforced by a valuable provocative test: the Provocative Test, the Phalen test + mCCT, Tinel’s sign, Phalen’s and reverse Phalen’s test, Durkan Carpal Compression Test (mCCT). There are also tests, which, due to their low sensitivity and specificity, be not applied in the CTS diagnostics. Provocative tests are more easily performed than electro-diagnostic studies and are the most appropriate diagnostic tools in the ambulatory setting. Provocative tests are commonly needed for establishing the diagnosis for treatment, screening and determining aetiology. To improve the efficiency of provocative tests, we should apply univocal standards for their performance and interpretation. A combination of tests might be more powerful than a single test in establishing the diagnosis. Taking medical history and performing physical examination should be the primary methods of diagnosing CTS. The combination of hand diagram, questionnaires, abnormal sensibility and positive provocative tests will provide a diagnostic tool for CTS with high sensitivity and specificity. The addition of nerve conduction studies is unnecessary in most cases.
    Źródło:
    Medical Rehabilitation; 2007, 11(4); 15-25
    1427-9622
    1896-3250
    Pojawia się w:
    Medical Rehabilitation
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of polyclonal and monoclonal antibodies for detection and determination of Clavibacter michiganensis subsp. Sepedonicus.
    Autorzy:
    Pánková, Iveta
    Kokošková, Blanka
    Powiązania:
    https://bibliotekanauki.pl/articles/2198781.pdf
    Data publikacji:
    2002-12-22
    Wydawca:
    Instytut Hodowli i Aklimatyzacji Roślin
    Tematy:
    bacterial ring rot of potato
    DAS ELISA
    sensitivity
    specificity
    cross reactions
    Opis:
    Immunochemical diagnostics of Clavibacter michiganensis subsp. sepedonicus (Spieckerman and Kotthoff) Davis et al., the causal agent of bacterial ring rot of potato, is based on the use of high quality polyclonal and monoclonal antibodies. The specificity and sensitivity of the polyclonal Po-Cs 6 and monoclonal Mn-Cs 1 antibodies for detection and identification of C. m. subsp. sepedonicus in pure culture and extracts of potato tuber samples were compared by double antibody sandwich enzyme-linked immunosorbent assay (DAS ELISA). The polyclonal antibody Po-Cs 6 cross-reacted with strains of several Clavibacter michiganensis subspecies, Pantoea agglomerans, and weakly with Pseudomonas fluorescens and Ralstonia solanacearum (race 3)in all serological tests. After cross-absorption with these bacteria, the threshold level of homologous antigen NCPPB 3467 was 10H7 cfu/ml in DAS ELISA. The monoclonal antibody Mn-Cs 1 did not cross react with other michiganensis subspecies or with other plant pathogenic bacteria tested. The monoclonal antibody Mn-Cs 1 cross-reacted very weakly with the saprophytic bacteria P. agglomerans and P. fluorescens. The threshold level of homologous antigen NCPPB 3467 was 104 cfu/ml in DAS ELISA. The monoclonal antibody Mn-Cs 1 proved to be more sensitive and specific than the polyclonal antibody Po-Cs 6 in all serological tests.
    Źródło:
    Plant Breeding and Seed Science; 2002, 46, 2; 17-24
    1429-3862
    2083-599X
    Pojawia się w:
    Plant Breeding and Seed Science
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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