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    Wyświetlanie 1-5 z 5
    Tytuł:
    The ribosome filter hypothesis and specialized ribosomes
    Autorzy:
    Filipek, Kamil
    Deryło, Kamil
    Michalec-Wawiórka, Barbara
    Powiązania:
    https://bibliotekanauki.pl/articles/1178213.pdf
    Data publikacji:
    2018
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    filter hypothesis
    rRNA
    ribosomal proteins
    ribosome
    specialized ribosomes
    Opis:
    The ribosome is a macromolecular complex of proteins and RNA, which plays a key role in every living organism, being a heart of the process of translation. Recent findings have shown that it can be also regarded as a regulatory element that adjusts cellular proteome to highly variable environmental conditions. The ribosome is believed to possess the ability to “filter” populations of mRNAs for choosing their appropriate set to meet current demands of the cell. The filter mechanism is based on a specific interaction between mRNA and rRNA or mRNA and ribosomal proteins. The ribosome “filtering activity” is reflected by the ribosomal particles heterogeneity, which originates mainly from variations or modifications within particular components of translational apparatus. Alternations of ribosomal proteins or/and rRNA generate a specific class of ribosomes called specialized ribosomes, which having unique composition can display selectivity toward particular mRNAs representing an additional step of gene expression regulation at the translational level. This work describes a basis of ribosome filter hypothesis illustrated by interesting examples from different domains of life.
    Źródło:
    World Scientific News; 2018, 93; 19-29
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The KRR1 gene encodes a protein required for 18S rRNA synthesis and 40S ribosomal subunit assembly in Saccharomyces cerevisiae.
    Autorzy:
    Gromadka, Robert
    Rytka, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1044220.pdf
    Data publikacji:
    2000
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    ribosome
    rRNA processing
    yeast
    Opis:
    The newly discovered Saccharomyces cerevisiae gene KRR1 (YCL059c) encodes a protein essential for cell viability. Krr1p contains a motif of clustered basic amino acids highly conserved in the evolutionarly distant species from yeast to human. We demonstrate that Krr1p is localized in the nucleolus. The KRR1 gene is highly expressed in dividing cells and its expression ceases almost completely when cells enter the stationary phase. In vivo depletion of Krr1p leads to drastic reduction of 40S ribosomal subunits due to defective 18S rRNA synthesis. We propose that Krr1p is required for proper processing of pre-rRNA and the assembly of preribosomal 40S subunits.
    Źródło:
    Acta Biochimica Polonica; 2000, 47, 4; 993-1005
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The cell-free protein biosynthesis - applications and analysis of the system.
    Autorzy:
    Lamla, Thorsten
    Mammeri, Kerstin
    Erdmann, Volker
    Powiązania:
    https://bibliotekanauki.pl/articles/1044140.pdf
    Data publikacji:
    2001
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    in vitro protein biosynthesis
    ribosome display
    2D-gel elctrophoresis
    His-tag and function
    in vitro evolution of proteins
    Strep-tag affinity peptide
    Opis:
    The in vitro protein biosynthesis has the potentials to become a powerful technology for biochemical research. Beside the determination of structure and function the in vitro evolution of proteins is also of great interest. The system described was used to produce bovine heart fatty acid binding protein (FABP) and bacterial chloramphenicol acetyltransferase (CAT) with and without fusion of the Strep-tag II affinity peptide. The proteins were purified after and during protein biosynthesis by using a StrepTactin Sepharose matrix. No significant influence of the Strep-tag and the conditions during the affinity chromatography on maturation or activity of the protein was observed. The in vitro evolution of proteins is feasible by means of ribosome display. The selection of a specific mRNA coding for a shortened FABP with a N-terminal His-tag via the accompanying protein property was shown. Goal of the selection was to bind the FABP via the His-tag on Ni(II)-IDA-agarose. After nine cycles of transcription, translation, affinity selection and RT-PCR the protein with the His-tag could be enriched 108-fold. In order to correlate a possible relationship between changes in protein population and biological function studies were initiated in which 2-dimensional protein patterns of the total in vitro system were compared after 0 and 2 h reaction time. The very interesting findings are that a number of proteins disappear, while others are newly formed during protein synthesis.
    Źródło:
    Acta Biochimica Polonica; 2001, 48, 2; 453-465
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The participation of ribosome-UDP-GalNAc complex in the initiation of protein glycosylation in vitro
    Autorzy:
    Paszkiewicz-Gadek, Anna
    Porowska, Halina
    Gindzieński, Andrzej
    Powiązania:
    https://bibliotekanauki.pl/articles/1044369.pdf
    Data publikacji:
    2000
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    glycosylation
    UDP-GalNAc-transferase
    UDP-GalNAc
    apomucin
    ribosome
    Opis:
    The gastric epithelial cells ribosome-UDP-GalNAc complex is a donor of UDP- GalNAc as the substrate for N-acetylgalactosaminyltransferase, which catalyse the transfer of GalNAc residue to the polypeptide, existing on polysomes. It was observed that the deglycosylated porcine mucin and synthetic peptide (PTSSPIST) can be also glycosylated with participation of N-acetylgalactosaminyltransferase and ribosome- UDP-GalNAc complex. The probability of the ribosome-UDP-GalNAc complex as an intermediate in the O-glycosylation is considered.
    Źródło:
    Acta Biochimica Polonica; 2000, 47, 2; 421-426
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Contributions of the Hfq protein to translation regulation by small noncoding RNAs binding to the mRNA coding sequence
    Autorzy:
    Wroblewska, Zuzanna
    Olejniczak, Mikolaj
    Powiązania:
    https://bibliotekanauki.pl/articles/1038726.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Hfq
    sRNA
    mRNA
    coding sequence
    RNase E
    ribosome
    Opis:
    The bacterial Sm-like protein Hfq affects the regulation of translation by small noncoding RNAs (sRNAs). In this way, Hfq participates in the cell adaptation to environmental stress, regulation of cellular metabolism, and bacterial virulence. The majority of known sRNAs bind complementary sequences in the 5'-untranslated mRNA regions. However, recent studies have shown that sRNAs can also target the mRNA coding sequence, even far downstream of the AUG start codon. In this review, we discuss how Hfq contributes to the translation regulation by those sRNAs which bind to the mRNA coding sequence.
    Źródło:
    Acta Biochimica Polonica; 2016, 63, 4; 701-707
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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