- Tytuł:
- The effects of 1-methylnaphthalene after inhalation exposure on the serum corticosterone levels in rats
- Autorzy:
-
Świercz, Radosław
Stępnik, Maciej - Powiązania:
- https://bibliotekanauki.pl/articles/2116549.pdf
- Data publikacji:
- 2020-09-17
- Wydawca:
- Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
- Tematy:
-
rat
corticosterone
HPA
inhalation exposure
1-methylnaphthalene
restraining stress - Opis:
- ObjectivesThis paper reports on the trend of the stressogenic stimulus caused by a repeated exposure to 1-methylnaphthalene (1-MN) vapors at the nominal concentrations of 0 mg/m3 (the control restrainer), 50 mg/m3 or 200 mg/m3 in the nose-only inhalation system, by analyzing the serum corticosterone (CORT) levels in rats.Material and MethodsThree groups of rats were exposed in restrainers to 1-MN vapors at the nominal concentrations of 0 mg/m3, 50 mg/m3 or 200 mg/m3 for 5 days. One control group of animals spent all the time during the experiment in an individually ventilated plastic cage. The serum CORT concentrations were determined in all 4 groups of the rats. The blood samples drawn from the tail vein were collected every day after termination of the 6-h exposure. On the fifth day, blood samples were collected 15 min, 30 min, 45 min, 1 h, and 3 h after termination of the 6-h exposure.ResultsOn the fifth day of the study, no statistically significant changes in body weights between all groups of animals were found. After 5 days of the observation, increased food intake in the control groups was noted. Significantly higher CORT concentrations in the rats exposed to 1-MN at 200 mg/m3 and in the animals from the control restrainer were found, comparing to the animals exposed to 1-MN at 50 mg/m3 and the animals from the control cage.ConclusionsThe application of 6-h restraining induced high concentrations of the stress hormone, CORT, in the blood of rats. The short-term exposure of rats to 1-MN non-linearly reduced the restraint stress measured with CORT concentration.
- Źródło:
-
International Journal of Occupational Medicine and Environmental Health; 2020, 33, 5; 691-699
1232-1087
1896-494X - Pojawia się w:
- International Journal of Occupational Medicine and Environmental Health
- Dostawca treści:
- Biblioteka Nauki
Artykuł