- Tytuł:
- Renal tubular acidosis - underrated problem?
- Autorzy:
-
Golembiewska, Edyta
Ciechanowski, Kazimierz - Powiązania:
- https://bibliotekanauki.pl/articles/1039734.pdf
- Data publikacji:
- 2012
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
molecular pathophysiology
kidney transplantation
renal tubular acidosis
gene mutations - Opis:
- Renal tubular acidosis (RTA) is a hyperchloremic metabolic acidosis characterized by a normal anion gap and normal (or near normal) glomerular filtration rate in the absence of diarrhoea. Inherited isolated forms of renal tubular acidosis are not common. However, they can also be a part of a more generalized tubule defect, like in Fanconi syndrome. In recent years more and more gene mutations have been found which are associated with RTA (mutations in the gene SLC4A4, encoding a Na+-HCO3- cotransporter (NBC-1); in the gene SLC4A1, encoding Cl-/HCO3- exchanger (AE1); in the gene ATP6B1, encoding B1 subunit of H+-ATPase; in the gene CA2 encoding carbonic anhydrase II; and others) and allow better understanding of underlying processes of bicarbonate and H+ transport. Isolated renal tubular acidosis can be frequently acquired due to use of certain drug groups, autoimmune disease or kidney transplantation. As the prevalence of acquired forms of RTA is common, new therapeutic options for the currently used supplementation of oral alkali, are awaited.
- Źródło:
-
Acta Biochimica Polonica; 2012, 59, 2; 213-217
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł