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    Tytuł:
    Chitosan/poly(vinyl alcohol) hydrogels as controlled drug delivery systems
    Autorzy:
    Kocemba, Aleksandra
    Mucha, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/1034608.pdf
    Data publikacji:
    2017
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan/PVA hydrogel
    gentamicin
    glutaraldehyde
    release kinetics
    swelling
    Opis:
    In order to achieve hydrogel and drug release profiles, a comprehensive knowledge of the types, properties and syntheses of hydrogel polymer networks are needed. For this reason, a natural biopolymer hydrogel based on chitosan was described. Chitosan has many advantages, which meet the requirements necessary for the preparation of medical materials; for example, wound dressings. This article focused on the biomedical use of a chitosan hydrogel: chitosan–poly(vinyl alcohol) (PVA). The method of preparation of hydrogels containing a drug as an active wound dressing was described. To obtain a hydrogel dressing to be applied in patients with burns or difficult curative wounds, gentamicin (an aminoglycoside antibiotic) was used as a medicament. The effect of the PVA concentration in hydrogels on the release rate of the antibiotic was examined. For this, the crosslinking agent of the hydrogel, glutaraldehyde, was used. The release process of gentamicin was described by using an equation of first order kinetics.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2017, 22; 97-105
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Encapsulation of l-menthol in hydroxypropyl-β-cyclodextrin and release characteristics of the inclusion complex
    Autorzy:
    Zhu, G.
    Xiao, Z.
    Zhou, R.
    Niu, Y.
    Powiązania:
    https://bibliotekanauki.pl/articles/778623.pdf
    Data publikacji:
    2016
    Wydawca:
    Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
    Tematy:
    l-menthol
    inclusion complex
    release characteristics
    binding energy
    release kinetics
    Opis:
    l-menthol has been widely used in flavour, food and pharmaceuticals. Because of its high volatility and whisker growth, l-menthol-hydroxypropyl-β-cyclodextrin inclusion complex was produced to improve shelf-life, provide protection, and enhance the stability of l-menthol. The inclusion complex was characterized by Fourier transform infrared spectroscopy, X-ray diffraction. The results show that l-menthol was successfully encapsulated in hydroxypropyl-β-cyclodextrin. l-menthol loading capacity is about 8.44%. Geometries and binding energies of l-menthol-hydroxypropyl-β-cyclodextrin inclusion complexes were investigated using molecular mechanics calculations. The shape and orientation of the most stable complex, and the minimum binding energy were determined. L-menthol release from complex was determined by thermogravimetric analysis. Two l-menthol release rate peaks were observed at 69.3 and 279.1°C. The l-menthol release reaction order, release activation energy and the preexponential factor were obtained.
    Źródło:
    Polish Journal of Chemical Technology; 2016, 18, 3; 110-116
    1509-8117
    1899-4741
    Pojawia się w:
    Polish Journal of Chemical Technology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    FORMULATION AND IN VITRO EVALUATION OF FLOATING TABLETS OF PSYLLIUM HUSK & TRAGACANTH USING SITAGLIPTIN PHOSPHATE AS A MODEL DRUG
    Autorzy:
    Ghumman, Shazia A.
    Andleeb, Sahrish
    Bashir, Sajid
    Muhammad, Sarfraz R.
    Badshah, Munair
    Khattak, Majeedullah
    Powiązania:
    https://bibliotekanauki.pl/articles/895403.pdf
    Data publikacji:
    2018-06-30
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    sustained release
    Release kinetics
    Tragacanth
    floating tablets
    Sitagliptin phosphate
    psyllium husk
    Opis:
    Abstract A novel floating controlled release drug delivery system of Sitagliptin phosphate was formulated in an effort to increase the gastric retention time of the dosage form and thereby increased drug bioavailability. The tablets were prepared by wet granulation method using Psyllium Husk and tragacanth gum as a release retarding polymers and sodium bicarbonate as a gas generating agent. All the designed nine batches of floating tablets were evaluated for physical characteristics viz. weight variation, thickness, content uniformity, hardness, floating capacity, swelling studies. All formulations had floating lag time of less than 1 min and constantly floated for 12 h except F1, F4 and F7 (that dissolved completely in 8 h or less than 8 h). In vitro drug release studies were carried out for 8 h and release mechanism was further evaluated by linear regression analysis, F9 composed of 30% Psyllium Husk, 10% tragacanth gum and 18% sodium bicarbonate sustained the drug release for longer period. The formulations followed first order kinetics, Higuchi drug release kinetics with diffusion as the dominant mechanism of drug release and the release exponent ranged (0.452-0.635) indicating that the drug release from all formulations was by non-Fickian diffusion mechanism. The prepared floating tablets of STP (F9) might be a promising drug delivery system with sustained release action and improved bioavailability.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 3
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    BOX BEHNKEN DESIGN: A STATISTICAL APPROACH TO EVALUATE THE EFFECT OF CROSSLINKED CARBOXYMETHYL CELLULOSE AND SODIUM STARCH GLYCOLATE ON RELEASE KINETICS OF DRUG
    Autorzy:
    Hanif, Muhammad
    Abbas, Ghulam
    Rasul, Akhtar
    Khan, Sajid M.
    Amir, Muhammad N.
    Powiązania:
    https://bibliotekanauki.pl/articles/895395.pdf
    Data publikacji:
    2018-08-31
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    FTIR
    XRD
    DSC
    quality by design
    domperidone maleate
    drug release kinetics
    Opis:
    The aim of study was to evaluate the release kinetics of domperidone maleate (DM) from immediate release (IR) tablets prepared by wet granulation method. Box behnken design (BBD) was used to optimize and evaluate the main, interaction and quadratic effects of independent variables i.e. crosslinked carboxymethyl cellulose (CMC) (X1), sodium starch glycolate (SSG) (X2) and starch (X3) on responses R2 of first order (YI) and β value of weibull model (Y2). Prepared tablets were characterized by various physical tests, in-vitro drug release, fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD) and differential scanning calorimetry (DSC). Accelerated stabilities studies were performed on optimized formulation D9. Y1 and Y2 were ranged from 0.9959 to 0.9994 and 0.041 to 0.912 respectively. β value of weibull model indicated the parabolic shape of dissolution curve. The quadratic model fit the data well and the resulting equations were used to predict the responses in the box behnken design. FTIR spectra showed the compatibility of DM with CMC and SSG. XRD presented diffraction lines indicates crystalline nature of drug. DSC thermograms indicated endothermic peak at 220 0C for DM. Stabilities studies revealed that no significant change in hardness, friability, disintegration time and dissolution release profile of DM. It is concluded that a combination of CMC and SSG can be used to enhance the dissolution and release kinetics of IR tablets of DM.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 4; 965-975
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Emulsions as vehicles for the controlled release of astaxanthin in topical application
    Autorzy:
    Dymek, Michał
    Sikora, Elżbieta
    Powiązania:
    https://bibliotekanauki.pl/articles/2086812.pdf
    Data publikacji:
    2021
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    astaxanthin
    release kinetics
    skin delivery systems
    emulsions
    antioxidant activity
    astaksantyna
    kinetyka uwalniania
    emulsja
    aktywność antyoksydacyjna
    Opis:
    In the work, the antioxidant activity of astaxanthin (AST) and the influence of the base formulation on the kinetics of AST release were studied. Three stable O/W AST-loaded emulsions, differing in droplet size (12.7 m(E1), 3.8 m(E2), 3.2 m(E3)) and a nanoemulsion (0.13 m, NE) were prepared. The results confirmed very strong antioxidant activity of AST. The emulsion internal phase droplet size did not significantly affect the AST release. The amount of released AST was respectively: 13.60% (E1), 11.42% (E2), 9.45% (E3), 9.71% (NE). The best fit to experimental data was obtained using the Higuchi model for emulsions and the Korsmeyer-Peppas model for NE. The results show that the AST release process is limited by the diffusion through carriers and the prepared O/W emulsions can be applied as vehicles for delivery of astaxanthin to the skin, ensuring effective anti-aging action of the cosmetics.
    Źródło:
    Chemical and Process Engineering; 2021, 42, 4; 439--450
    0208-6425
    2300-1925
    Pojawia się w:
    Chemical and Process Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Analysis of model drug release kinetics from complex matrices of polylactide-chitosan
    Autorzy:
    Balcerzak, Jacek
    Mucha, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/1035492.pdf
    Data publikacji:
    2010
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan
    kinetics
    polylactide
    polymer composite
    prolonged release
    Opis:
    In the present paper the Authors analyse the experimental results of a model drug (ibuprofen) release approximated with three commonly used semi-empirical models: Korsmeyer-Peppas, first order kinetics and Gallagher-Corrigan equation. Drug carriers in the form of films composed of chitosan matrix and polylactide microparticles were produced by ultrasonic emulsification with solvent evaporation followed by film casting technique. Additionally, polylactide shield layers (5μm thick) were attached to both sides of obtained films by means of spray-coating process. A microscopic analysis confirmed the uniform distribution of polylactide microparticles (diameter: 1-2 μm) within chitosan films. Based on the of microscopic study, molecular drug dispersion within composite matrices was found. Fraction of ibuprofen released into medium of pH equal to 1.4 or 7.2 (GI tract) was measured by means of UV-VIS spectrophotometry. The finest approximation was obtained by fitting two-stage release model derived by K. M. Gallagher and O. I. Corrigan to the release data. Analysis of model parameters led to the conclusion that the increase of composite films thickness as well as weight fraction of PLA microparticles within films prolong drug release.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2010, 15; 117-126
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Kinetics of active substance release from flat biopolymer multilayer films
    Autorzy:
    Michalak, Iwona
    Traczyk, Dariusz
    Mucha, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/1035524.pdf
    Data publikacji:
    2010
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan
    drug release
    polylactid
    polymer films
    swelling kinetics
    Opis:
    Abstract. Polymer films were made of different biodegradable materials. Solid support of model active substance (salicylic acid) was unmodified and modified (crosslinked with glutaraldehyde) chitosan and outside layers were polylactid acid (PLA). The aim of the study was to obtain the controlled release kinetics of active substance, in medium of pH 5.6 which is similar to conditions occurring on the human skin surface. The chitosan films were investigated with swelling kinetics while multilayer films were studied with release kinetics of active substance (salicylic acid). The amount of salicylic acid released from film was measured using a UV-VIS spectrophotometer. The appropriate mathematical model was also adjusted to the experimental points. The results prove that the swelling process follows the first order kinetics but the results of release process are fitted with Peppas model.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2010, 15; 107-116
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Salicylic acid release from chitosan pellets coated with polylactide
    Autorzy:
    Mucha, Maria
    Balcerzak, Jacek
    Filipiak, Adam
    Powiązania:
    https://bibliotekanauki.pl/articles/1035411.pdf
    Data publikacji:
    2011
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan
    first order kinetics
    polylactide
    prolonged drug release
    salicylic acid
    Opis:
    The aim of the study was to prepare a bi-polymer drug carrier composed of chitosan pellets (CS) coated with polylactide shell (PLA) providing prolonged model drug – salicylic acid (SA) release into phosphate buffer of pH = 7.2. Pellets were obtained through a coacervation followed by a freeze-drying process. In a terms of model drug loading, porous pellets were impregnated with a SA solution under vacuum. Afterwards, loaded and dried beads were coated with PLA films through their dipping in a PLA organic solution. FTIR spectroscopy was implemented to analyse the efectiveness of SA loading process. The UV-Vis spectrophotometry kinetic studies of a model drug release from PLA coated and non-coated pellets into phosphate buffer were conducted. Increasing time of CS pellets impregnation with SA solution resulted in decrease of salicylic acid release rate.This tendency was more evident for the SA release from pellets coated with an additional layer of PLA. Model drug release kinetic points were well approximated with first order kinetics model.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2011, 16; 79-88
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The Effect of Wetting and Drying Cycles on Potassium Release in Three Soil Orders
    Autorzy:
    Al-Silevany, Baybeen Saeed Hasen
    Mehmedany, Lazkeen Ahmed Merween
    Powiązania:
    https://bibliotekanauki.pl/articles/2202343.pdf
    Data publikacji:
    2023
    Wydawca:
    Polskie Towarzystwo Inżynierii Ekologicznej
    Tematy:
    potassium
    release of potassium
    soil orders
    kinetics model
    wetting and drying cycles
    Opis:
    This research was conducted to study the potassium release under ten wetting and drying cycles in three soil orders (Mollisols, Vertisols, and Aridisols) collected from three different locations (Sharya, Semeel, and Kanishrin) in Dohuk governorate in Iraqi-Kurdistan region by using Ca-resin capsules, and K+ desorption (Kd) fitted to four model equations to choose the best equation to describe K+. The results of the experiments showed that flocculated water content wetting and drying cycles increased cumulative K-release from Ca-resin capsules until a tenth of the wetting-drying cycle. Potassium desorption according to the kinetic approach showed a significant effect of time on potassium desorption, and potassium desorption conformed to parabolic diffusion equations kinetics was the best equation to describe the Kd of potassium by using Ca-resin with a high coefficient of determination (R2) and low standard error and the order of the equation in terms of their preference in describing the desorption process is as follows: 1 – Parabolic diffusion, 2 – Power function, 3 – Elovich equation, 4 – First-order. The apparent desorption rate coefficient for the parabolic diffusion equation ranged from 0.1084–0.0877–0.1040 cmol kg-1∙day -1 from Mollisols, Vertisols, and Aridisols respectively. The rate coefficient K+ desorption according to the parabolic diffusion equation had a significant and positive correlation with SO42-, K+, T-CaCO3, HCO3, CEC, and Ca2+ but negatively significant correlated with EC and active CaCO3.
    Źródło:
    Journal of Ecological Engineering; 2023, 24, 1; 218--226
    2299-8993
    Pojawia się w:
    Journal of Ecological Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Procesy adsorpcyjne w tworzeniu hybrydowych układów do kontrolowanego uwalniania preparatów farmaceutycznych
    Adsorption processes in forming of hybrid structures for controlled release of pharmaceuticals
    Autorzy:
    Zarzycki, R.
    Modrzejewska, Z.
    Nawrotek, K.
    Skwarczyńska, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/106372.pdf
    Data publikacji:
    2009
    Wydawca:
    Towarzystwo Chemii i Inżynierii Ekologicznej
    Tematy:
    adsorpcja
    kontrolowane uwalnianie
    chitozan
    równowaga adsorpcyjna
    kinetyka
    adsorption
    controlled release
    chitosan
    equilibrium
    kinetics
    Opis:
    Przedstawiono możliwości wytwarzania układów hybrydowych do kontrolowanego uwalniania środków farmakologicznych przy wykorzystaniu nośników hydrożelowych i struktury w skali mikro i nano. Szczególną uwagę zwrócono na wytwarzanie takich układów w procesie adsorpcji, korzystając z nośnika chitozanowego. Przedstawiono modele opisujące stan równowagi oraz kinetykę w procesie sorpcji substancji modelowych.
    Possibilities of formation of hybrid systems for controlled drug release from hydrogel carriers and structures in micro- and nanoscale are discussed in the study. Attention is focussed on the formation of such systems in the adsorption process from a chitosan carrier. Models which describe the equilibrium state and sorption kinetics of model substances are presented.
    Źródło:
    Chemistry-Didactics-Ecology-Metrology; 2009, 14, 1-2; 85-94
    2084-4506
    Pojawia się w:
    Chemistry-Didactics-Ecology-Metrology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-10 z 10

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