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Tytuł:
Adipose-derived stem cells: a review of osteogenesis differentiation
Autorzy:
Skubis, Aleksandra
Sikora, Bartosz
Zmarzły, Nikola
Wojdas, Emilia
Mazurek, Urszula
Powiązania:
https://bibliotekanauki.pl/articles/764811.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:
mesenchymal stem cells
regenerative medicine
adipose tissue
Opis:
Komórki macierzyste to komórki posiadające zdolność nieograniczonych podziałów oraz umiejętność do wielokierunkowego różnicowania. Mezenchymalne komórki macierzyste (MSC) to somatyczne komórki występujące w tkankach i narządach dorosłego organizmu takich jak: szpik kostny, tkanka tłuszczowa oraz mięśnie. Ulegają one różnicowaniu w kierunku komórek pochodzących z jednego listka zarodkowego jakim jest mezoderma. To pozwala na wykorzystanie ich w regeneracji chrząstki, kości lub wypełnienia ubytków tkanką tłuszczowa między innymi w chirurgi plastycznej. Obecnie głównym źródłem z którego pozyskiwano MSC był szpik kostny, jednak coraz szersze zastosowanie wykazuje tkanka tłuszczowa. Komórki z niej pochodzące wykazują takie same właściwości jak te pochodzące z szpiku kostnego, a procedura izolacji jest dużo mniej inwazyjna dla pacjenta. Bardzo często natomiast ich ilość jest nieporównywanie większa. Stąd też niniejsza praca porusza  temat wykorzystania MSC z tkanki tłuszczowej w regeneracji tkanki kostnej.
This review article provides an overview on adipose-derived stem cells (ADSCs) for implications in bone tissue regeneration. Firstly this article focuses on mesenchymal stem cells (MSCs) which are object of interest in regenerative medicine. Stem cells have unlimited potential for self-renewal and develop into various cell types. They are used for many therapies such as bone tissue regeneration. Adipose tissue is one of the main sources of mesenchymal stem cells (MSCs). Regenerative medicine intends to differentiate ADSC along specific lineage pathways to effect repair of damaged or failing organs. For further clinical applications it is necessary to understand mechanisms involved in ADSCs proliferation and differentiation. Second part of manuscript based on osteogenesis differentiation of stem cells. Bones are highly regenerative organs but there are still many problems with therapy of large bone defects. Sometimes there is necessary to make a replacement or expansion new bone tissue. Stem cells might be a good solution for this especially ADSCs which manage differentiate into osteoblast in in vitro and in vivo conditions.
Źródło:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica; 2016, 12; 38-47
1730-2366
2083-8484
Pojawia się w:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Application of polymer- and graphene- based materials in biomedical research
Autorzy:
Sekuła, M.
Domalik-Pyzik, P.
Noga, S.
Karnas, E.
Kosowska, K.
Hunger, M.
Złocista-Szewczyk, N.
Jagiełło, J.
Lipińska, L.
Pielichowska, K.
Chłopek, J.
Zuba-Surma, E.
Powiązania:
https://bibliotekanauki.pl/articles/283753.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
polymers
graphene
regenerative medicine
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 66
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Aromatic peptides as components of potential scaffolds for regenerative medicine
Autorzy:
Strzempek, W.
Menaszek, E.
Dziadek, M.
Stodolak-Zych, E.
Boguń, M.
Kolesińska, B.
Powiązania:
https://bibliotekanauki.pl/articles/284726.pdf
Data publikacji:
2017
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
peptides
components
regenerative medicine
Źródło:
Engineering of Biomaterials; 2017, 20, no. 143 spec. iss.; 74
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bio-Inspiered Blood-Contacting Materials Elaborated For The Heart Assist System
Inspirowane biologicznie materiały do kontaktu z krwią dedykowane dla systemu wspomagania serca
Autorzy:
Major, R.
Powiązania:
https://bibliotekanauki.pl/articles/353048.pdf
Data publikacji:
2015
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
surface modification
cell-material interaction
tissue precursors
materials for regenerative medicine
modyfikacja powierzchni
interakcje komórka-materiał
materiały dla medycyny regeneracyjnej
Opis:
The paper presents the main achievements of the author on the development of blood contacting materials. The main objective of the work is to elaborate materials dedicated for the heart support systems. Appropriately designed biomaterial surfaces enable fully controlled cellular differentiation, proliferation, and even restoration of the tissue structure on solids. The paper presents two approaches to modify the surface, which can control the life processes of tissue. The first solution considers the topography in the form of cell niches. The main objective of the study is a modified surface of thin films deposited on the polymer substrate constituting the microenvironment for the cells caused by residual stress and optimized stiffness of the surface using the plasma methods. The research hypothesis was the plasma surface modification method generating a controlled contribution of residual stress in the coating affect the surface topography in the form of nano- wrinkles similar to the niches in the tissue environment. Topography and stiffness of the surface coating allows the targeted cellular differentiation. The properly formed surface topography effectively inhibits blood clotting processes. The second solution considers implementation of self-organizing feature of extracellular matrix like coatings and selective cell mobilization. The multiscale analysis and phenomenologic description were performed to experimental research. For this purpose, the deposition method was based on electrostatic interactions in polyelectrolytes. This type of cell-polymer structure imitate the native structures.
Praca przedstawia najważniejsze osiągniecia autora dotyczące rozwoju materiałów do kontaktu z krwią. Głównym celem prowadzonych prac są materiały o przeznaczeniu w komorach wspomagania serca. Odpowiednio zaprojektowana powierzchnia biomateriału umożliwia w pełni kontrolowane różnicowanie komórkowe, proliferację i nawet odtworzenie struktury tkanki na ciele stałym. W pracy przedstawiono dwa podejścia modyfikacji powierzchniowej, które pozwalają sterować procesami życiowymi tkanki. Pierwszym rozwiązaniem są powłoki o topografii nisz komórkowych. Celem głównym badań jest zmodyfikowana powierzchnia materiałów cienkowarstwowych nałożonych na podłoże polimerowe stanowiąca mikrośrodowisko dla wychwytu i kontrolowanego różnicowania komórek uzyskane przez odpowiedni udział naprężeń własnych i zoptymalizowaną sztywność powierzchniową. Ukierunkowana mikrostrukturą i właściwościami powierzchniowymi monowarstwa hamuje procesy wykrzepiania krwi. Drugie rozwiązanie dotyczy powłok o strukturze macierzy zewnątrzkomórkowej. Celem badań jest wieloskalowa analiza i opis fenomenologiczny samoorganizujących się powłok z funkcją selektywnej mobilizacji komórkowej. Jest to nowoczesne podejście na poziomie badań eksperymentalnych, dotyczące wytworzenia materiałów biologicznie kompozytowych i ich kompleksowej analizy z wykorzystaniem metod inżynierii materiałowej i inżynierii biomedycznej. Do tego celu została zastosowana metoda oparta o oddziaływania elektrostatyczne. Tego typu komórkowo-polimerowa struktura imituje struktury natywne tkanek.
Źródło:
Archives of Metallurgy and Materials; 2015, 60, 3; 2279-2287
1733-3490
Pojawia się w:
Archives of Metallurgy and Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bioactivity assessment of ceramic nanoparticels used as a filler in nanocomposite materials
Autorzy:
Gęgotek, K.
Zych, Ł.
Stodolak-Zych, E.
Powiązania:
https://bibliotekanauki.pl/articles/285902.pdf
Data publikacji:
2013
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
nanocomposite
bioactivity
scaffolds
regenerative medicine
bioceramics
zeta potential
Opis:
The paper presents research on degree of bioactivity of nanometric ceramic particles used as a nanofiller in nanocomposite materials based on polymers. The nanoperticles used in our examination were: different bioceramics powders such as: hydroxyapatite (HAp), β-phosphate (V) calcium (βTCP), silica (SiO2) and bioglass (BG). Based on ζ-potential measurements dynamics of processes occurring on the surface of nanoparticles in stimulated body fluid (SBF) was determined and it confirmed possibility of apatite formation. This study showed predominance of bioglass over other bioceramic materials, Bioglass nanoparticles were the most bioactive ones. In the end of the experiment the bioacermic particles were used as a nanofiller of poli-L/DL-lactide (PLDLA) matrix composites. The composite materials were prepared by casting from solution. Bioactivity tests were performed in simulated body fluid (artificial plasma of various ions concentration, and SBF 2SBF). Based on surface microstructure observed in the SEM (EDS) analysis were confirmed the degree of bioactivity of various materials depending on the type nanofiller.
Źródło:
Engineering of Biomaterials; 2013, 16, no. 122-123 spec. iss.; 73-74
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Biomaterial-based regenerative medicine: challenges & opportunities
Autorzy:
Kirkpatrick, C. J.
Powiązania:
https://bibliotekanauki.pl/articles/284067.pdf
Data publikacji:
2014
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
biomaterials
regenerative medicine
Opis:
For the author there are three major challenges in Regenerative Medicine (RegMed), namely to develop strategies which are translatable, materials which are functional and methods which are predictive. New strategies in RegMed depend on a concerted interdisciplinary effort between the exact and engineering sciences on the one side and the life sciences on the other. As cells synthesize and reside in an extracellular matrix (ECM), which they remodel, a main focus of biomaterial research is the development of injectable, bioresorbable hydrogels containing biological signals which could be released by tissue responses. These interactive materials will certainly increase in importance in the future. However, a major challenge is how to combine them, for example, in composites with load-bearing capacity relevant for human applications. Where synthetic materials such as metals are still essential, as in orthopaedics and traumatology, there is the possibility of adding such responsive materials as coatings to the bulk material. The use of decellularized matrix is also part of the bioinspired approach to developing biomaterials. In the life sciences great effort is being invested in understanding the so-called „regenerative niche“, which differs from tissue to tissue. Great progress made in stem cell biology has opened up new vistas on the possibility to target a regenerative niche. Cell-cell and cell-matrix interactions remain a central element of this activity. One of the paradigm shifts we need to master is the step from what is usual even in complex cell biological models, namely the use of purely physiological conditions, to a more realistic situation as would be found in the clinical setting. Thus, we need to understand regeneration in hostile environments, which include post-trauma, cancer and multimorbidity. This will be discussed with examples from the author’s own research. One of the important in vitro methods to investigate the mechanisms involved in regeneration is the use of coculture systems with relevant human cells, usually on tissue culture plastic and, as knowledge progresses, on more complex 3D biomaterial scaffolds. As major limiting factors in bone regeneration are the speed and extent of vascularization, we have established human osteoblast (pOB)-endothelial cell (EC) cocultures to study cellular crosstalk and its possible use for translational strategies [1,2]. Concerning the background, if two cell populations, that is, human pOB and human dermal microvascular EC (HDMEC), are seeded as cell suspensions on an open porous biomaterial scaffold, such as can be made from microfibres of the silk protein fibroin, the two cell types will interact in such a way that lumen-containing, capillary-like structures (CLS) will form as a vascular network [3]. Further molecular studies on the cellular crosstalk revealed that the EC induce an upregulation of growth factor and matrix production in pOB, such as VEGF and collagen type I resp. The EC then respond to these signals by promoting the angiogenic phenotype [4,5]. The following additional approaches have been adopted to study CLS formation: use of early embryonic signals, such as sonic hedgehog (shh), to accelerate both osteoand angiogenesis [6,7], use of intermittent hypoxia, but not constant hypoxia, to promote vascular sprout formation, and study of possible stimulatory roles for macrophages in the bone regenerative niche [8]. How this is investigated in coculture models will be discussed in the context of future evelopments. Naturally, all phenomena from in vitro studies require proof of concept in relevant in vivo models, as only this approach can lead to a translational perspective. Thus, we were able to demonstrate that these in vitro pre-formed vessels can rapidly become inosculated, that is, incorporated into the pre-existing microcirculation of host tissue in a subcutaneous implantation model [9]. The major role of the osteoblasts as a natural „drug delivery system“ was shown by the fact that host vascular response can be stimulated by these cells even in the absence of a pre-cultivation with endothelial cells [10]. A further aspect offering a promising perspective for the future is NanoMedicine, which uses advances in nanotechnology for medical applications. For reasons of time this will not be addressed in the context of the presentation. In conclusion, biomaterials, especially so-called responsive biomaterials, are an essential element of modern regenerative medicine, and must be accompanied by state of the art life sciences, from cell and molecular biology to good clinical practice. To achieve this the multidisciplinary approach is a conditio sine qua non.
Źródło:
Engineering of Biomaterials; 2014, 17, no. 128-129; 1-2
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Biomaterials in Regenerative Medicine: view of the Past & Vision for the future
Autorzy:
Kirkpatrick, Charles James
Powiązania:
https://bibliotekanauki.pl/articles/1844842.pdf
Data publikacji:
2021
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
biomaterials
regenerative medicine
history
biomateriały
medycyna regeneracyjna
historia
Opis:
In the past two decades, the fields of Tissue Engineering (TE) and Regenerative Medicine (RegMed) have received important input from advances in stem cell research as well as in the biomaterial sciences, including new developments in composite materials and interactive polymer systems. In the latter, for example, biodegradable scaffolds and hydrogels can mimic essential characteristics of the extracellular matrix (ECM), which is the microenvironment of cells in their natural state in situ. Being able to simulate such cell-cell and cell-matrix interactions in vitro is important not only for testing new biomaterials, but also for understanding regenerative mechanisms after implantation. However, this is far from a trivial challenge, although it can be usefully assisted by employing co-culture models in three dimensions. The situation becomes even more complex, when novel biomaterials and strategies for regeneration are investigated in vivo. Testing in animals introduces namely a complexity which makes mechanistic interpretation of observations exceedingly difficult, if not impossible. Moreover, in the past the accepted norms in testing have generally involved, for example, implantation in healthy animals, although in reality most patients receive a biomaterial for a disease state. Thus, for in vivo models there is an acute need to develop relevant models of disease. Future developments must also address the challenges of understanding the effects of, for example, ageing, multi-morbidity and medication on tissue reactions at the implant interface. Such multifactorial considerations play a special role in the case of cancer patients. In the future, biomaterials and TE & RegMed will be increasingly influenced by the broadening interface with biotechnology. The latter is so vast that it is difficult to put its elements into a single presentation slide which an audience could read without binoculars and a prolonged time slot! However, the COVID-19 pandemic has focussed attention on the power of mRNA technology in modulating the body's immune system. It remains to be established how this technology could be adapted to control unwanted reactions at specific sites, for example, at a tissue-biomaterial interface. Returning to biotechnology as a driver of future progress, it seems highly likely that both major scientific branches of biomaterials, namely the materials sciences and the life sciences, will receive transforming impulses from advances in biotechnology. Fields such as artificial intelligence, green technology, robotics and nanotechnology underline just how diverse biotechnology is. In addition, this diversity stresses the essential role of interdisciplinarity and its implications for university teaching for future generations of materials and life scientists.
Źródło:
Engineering of Biomaterials; 2021, 24, 163; 7
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Biomateriały polimerowe w regeneracji ubytków skóry : artykuł przeglądowy
Polymer biomaterials for skin regeneration : a review
Autorzy:
Martowicz, M.
Laska, J.
Powiązania:
https://bibliotekanauki.pl/articles/286082.pdf
Data publikacji:
2010
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
materiały polimerowe
polimery resorbowalne
sztuczna skóra
medycyna regeneracyjna
inżynieria tkankowa
polymer biomaterials
resorbable polymers
artificial skin
regenerative medicine
tissue engineering
Opis:
Leczenie rozległych ubytków skórnych przy pomocy syntetycznych materiałów lub z wykorzystaniem inżynierii tkankowej jest obecnie najbardziej rozwiniętą dziedziną medycyny regeneracyjnej. Pierwsze materiały stosowane w leczeniu rozległych oparzeń bazowały na materiałach naturalnych i kolagenie. Kolagen jest podstawą praktycznie wszystkich substytutów skórnych stosowanych aktualnie w leczeniu klinicznym. Jednak zauważalne jest zapotrzebowanie na inne materiały, w tym, przede wszystkim, polimery syntetyczne. Szczególnie ważną rolę w opracowywaniu nowych ulepszonych substytutów skóry odgrywają polimery resorbowalne. Bardzo ważną cechą polimerów syntetycznych jest możliwość modyfikacji ich właściwości na etapie syntezy oraz uzyskiwania odpowiedniej mikrostruktury. Niniejszy artykuł stanowi przegląd biomateriałów polimerowych stosowanych w regeneracji skóry. W artykule omówiono materiały stosowane i badane klinicznie, jak i najnowsze trendy w badaniach laboratoryjnych substytutów skóry.
The treatment of extensive skin defects both with the use of synthetic materials or by tissue engineering is the most developed branch of regenerative medicine. First materials applied in the treatment of extensive burns were based on natural materials and collagen. Collagen is the basis of practically all skin substitutes applied in the clinical skin treatment. However the need for different materials, especially synthetic polymers, is noticeable. Resorbable polymers play particularly important role in the research on new improved substitutes of skin. The possibility of the modification of their properties on the stage of the synthesis and achieving suitable microstructure is a very important feature of synthetic polymers. In this review polymer biomaterials applied in the regeneration of skin are described. Materials which were already clinically tested, as well as the new trends in the laboratory investigations of substitutes of skin are presented.
Źródło:
Engineering of Biomaterials; 2010, 13, 95; 2-9
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cell therapy for regenerative medicine: facts and controversy
Fakty i kontrowersje związane z terapią komórkową w medycynie regeneracyjnej
Autorzy:
Sarnowska, Anna
Machaliński, Bogusław
Radoszkiewicz, Klaudia
Bużańska, Leonora
Powiązania:
https://bibliotekanauki.pl/articles/2121315.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
cell therapy
regenerative medicine
human mesenchymal stem cells
human induced pluripotent stem cells
Opis:
Cellular therapy, as a part of regenerative medicine, implies to the treatment of human disorders with cells as a medical product, so called – “living drugs”. Usually such therapy is applied when other alternative efficient pharmacological therapies are not available. Stem cells of different origin: 1) tissue specific e.g. hematopethic, epithelial, neuronal, limbal; 2) mesenchymal stem cells (MSC) harvested from variety of tissues; 3) pluripotent stem cells: embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC) – serve as a source of cells for regenerative medicine application, depending upon disease and application re- quirements. Currently MSC are the type of stem cells that are most frequently used in registered regenerative medicine clinical trials. In this paper we provide the information on the application of cell therapy in orthopedics, hematology, ophthalmology, dermatology, gastrology and neurology. The influence of origin of MSCs and iPSCs on their mode of action as therapeutic, regenerative agents are discussed. Advantages and disadvantages of application of different cell types for cell therapy are underlined. Last, but not least current low regulations in Poland and requirements of European regulatory bodies for cell therapy are pointed out and discussed.
Źródło:
Nauka; 2021, 4; 67-92
1231-8515
Pojawia się w:
Nauka
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cell therapy in surgical treatment of fistulas. Preliminary results
Autorzy:
Piejko, Marcin
Romaniszyn, Michał
Borowczyk-Michałowska, Julia
Drukała, Justyna
Wałęga, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1393600.pdf
Data publikacji:
2017
Wydawca:
Index Copernicus International
Tematy:
anal fistula
stem cell-based therapy
recurrent fistula
regenerative medicine
rectovaginal fistula
Opis:
Risk of recurrence after surgical treatment of a recurrent fistula is up to 50%. It has be known that more aggressive surgical treatment is associated with a high risk of anal sphincter damage and leads to incontinence. Several studies have been designed to elaborate minimally invasive treatment of rectovaginal and anal fistulas. The properties of Adipose-derived Stem Cells (ASC) significantly enhance a natural healing potency. Here, we present our experience with combined surgical and cell therapy in the treatment of fistulas. Materials and Methods: Four patients were enrolled in our study after unsuccessful treatments in the past – patients 1-3 with rectovaginal fistulas including two women after graciloplasty, and patient 4 - a male with complex perianal fistula. Adipose tissue was obtained from subcutaneous tissue. ASCs were isolated, cultured up to 10+/-2 mln cells and injected into the walls of fistulas. Follow-up physical examination and anoscopy were performed at 1, 4, 8, and 12 weeks, 6 and 12 months after implantation. Results: Up to 8 weeks after ASC implantation, symptoms of fistulas’ tracts disappeared. At 8 weeks, in patients 1-3, communication between vaginal and rectal openings was closed and at 12-16 w. intestinal continuity was restored in patient 3 and 4. After a 6-month follow-up, the fistula tract of patient 4 was closed. Up to 12 m. after ASC implantation no recurrences or adverse events were observed. Conclusion: ASCs combined with surgical pre-treated fistula tracts were used in four patients. All of them were healed. This encouraging result needs further trials to evaluate the clinical efficiency and the cost-effectiveness ratio.
Źródło:
Polish Journal of Surgery; 2017, 89, 3; 48-51
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Current status and future prospects of genome-scale metabolic modeling to optimize the use of mesenchymal stem cells in regenerative medicine and biomaterials
Autorzy:
Sigurjonsson, Olafur E.
Powiązania:
https://bibliotekanauki.pl/articles/1844931.pdf
Data publikacji:
2020
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
regenerative medicine
biomaterials
mesenchymal stem cells
medycyna regeneracyjna
biomateriały
metabolizm
Opis:
Mesenchymal stem cells are a promising source for externally grown tissue replacements and patient-specific immunomodulatory treatments. This promise has not yet been fulfilled in part due to production scaling issues and the need to maintain the correct phenotype after reimplantation. One aspect of extracorporeal growth that may be manipulated to optimize cell growth and differentiation is metabolism. The metabolism of MSCs changes during and in response to differentiation and immunomodulatory changes. MSC metabolism may be linked to functional differences but how this occurs and influences MSC function remains unclear. Understanding how MSC metabolism relates to cell function is however important as metabolite availability and environmental circumstances in the body may affect the success of implantation. Genome-scale constraint based metabolic modelling can be used as a tool to fill gaps in knowledge of MSC metabolism, acting as a framework to integrate and understand various data types (e.g., genomic, transcriptomic and metabolomic). These approaches have long been used to optimize the growth and productivity of bacterial production systems and are being increasingly used to provide insights into human health research. Production of tissue for implantation using MSCs requires both optimized production of cell mass and the understanding of the patient and phenotype specific metabolic situation. This review considers the current knowledge of MSC metabolism and how it may be optimized along with the current and future uses of genome scale constraint based metabolic modelling to further this aim.
Źródło:
Engineering of Biomaterials; 2020, 23, 158 spec. iss.; 7
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Design and preclinical validations of polysaccharide-based nano/micro/macrosystems for tissue engineering and molecular imaging
Autorzy:
Letourneur, D.
Powiązania:
https://bibliotekanauki.pl/articles/284502.pdf
Data publikacji:
2016
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
regenerative medicine
tissue engineering
biomaterials
Opis:
This presentation intends to present polysaccharidebased matrices for regenerative medicine and as drug delivery systems and targeted contrast agents for molecular imaging. One main challenge of tissue engineering is to create an optimal environment for growing therapeutic cells to regenerate damaged tissues. This environment can be reconstituted by using 3D matrices, in which cells can be organized into a tissue-like structure. We have prepared polysaccharide-based porous matrices having controlled pores and porosity for several cell types. These porous hydrogels made of natural biodegradable and biocompatible polysaccharides have architectural characteristics adapted to the cell culture in 3D. We have developed them to different shapes and sizes. Further studies have demonstrated the performance of these matrices for tissue repair in vitro as well as in small and large animals. Examples for heart, vessel, and bone will be presented. Moreover, polysaccharide-based nano and microsystems were also designed and used for the imaging of cardiovascular pathologies as targeted contrast agents for molecular imaging. Examples will be provided using several types of imaging modalities for thrombus detection. We will also present how to use nanomaterials for regenerative medicine. Indeed, adhesion by aqueous nanoparticle solutions can be used in vivo to achieve rapid and strong closure and healing of deep wounds in rat skin and liver. Nanoparticles can also be used to fix polymer membranes to tissues even in the presence of blood flow, such as occurring after liver resection, yielding permanent hemostasis within a minute. Furthermore, medical devices and tissue engineering constructs could be fixed to organs such as a beating heart.
Źródło:
Engineering of Biomaterials; 2016, 19, 138; 9
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Development and optimization of myocardial tissue culture in ovo
Autorzy:
Hotowy, A.
Sawosz, E.
Grodzik, M.
Wierzbicki, M.
Kutwin, M.
Jaworski, S.
Chwalibog, A.
Powiązania:
https://bibliotekanauki.pl/articles/285627.pdf
Data publikacji:
2017
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
myocardial tissue
implantation
regenerative medicine
Źródło:
Engineering of Biomaterials; 2017, 20, no. 143 spec. iss.; 54
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of repair of osteochondral defects in rabbits using new composite biomaterials during three-month observation
Autorzy:
Żylińska, B.
Stodolak-Zych, E.
Nowicka, K.
Silmanowicz, P.
Powiązania:
https://bibliotekanauki.pl/articles/284436.pdf
Data publikacji:
2012
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
osteochondral defects
regenerative medicine
scaffolds
hydroksyapatite
alginate
Opis:
In this work nanocomposite porous pins were implanted into rabbit knees. The pins were made of biodegradable synthetic poly-L/DL-lactide (80:20) which was modified with nanometric hydroksyapatite particles (HAp) and covered with biopolymer layer of sodium alginate (NA). In vivo experiments were conducted on a 4-element group of the New Zealand rabbits. Osteogenesis was observed using scanning electron microscope (SEM/EDS) after 12 weeks of implantation.
Źródło:
Engineering of Biomaterials; 2012, 15, no. 116-117 spec. iss.; 118-119
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of repair of osteochondral defects in rabbits using new composite biomaterials during three-month observation
Autorzy:
Żylińska, B.
Stodolak-Zych, E.
Nowicka, K.
Silmanowicz, P.
Powiązania:
https://bibliotekanauki.pl/articles/285641.pdf
Data publikacji:
2012
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
osteochondral defects
regenerative medicine
scaffolds
hydroksyapatite
alginate
Opis:
In this work nanocomposite porous pins were implanted into rabbit knees. The pins were made of biodegradable synthetic poly-L/DL-lactide (80:20) which was modified with nanometric hydroksyapatite particles (HAp) and covered with biopolymer layer of sodium alginate (NA). In vivo experiments were conducted on a 4-element group of the New Zealand rabbits. Osteogenesis was observed using scanning electron microscope (SEM/EDS) after 12 weeks of implantation.
Źródło:
Engineering of Biomaterials; 2012, 15, no. 116-117 spec. iss.; 141-143
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 29

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