- Tytuł:
- BIOAVAILABILITY OF DRUGS FROM SUPPOSITORIES IN CLINICAL PRACTICE AFTER 1995
- Autorzy:
-
Hermann, Jacek
Hermann, Tadeusz W. - Powiązania:
- https://bibliotekanauki.pl/articles/895280.pdf
- Data publikacji:
- 2020-06-29
- Wydawca:
- Polskie Towarzystwo Farmaceutyczne
- Tematy:
-
morphine
paracetamol
methadone
mesalazine
rectal vs oral
Diazepam - Opis:
- Abstract: A review has been supposed to be arranged on the literature published between 1996 and 2018 concerning applications of suppositories in clinical practice. The rectal route of drug administration has been in use for centuries particularly in children, elderly and comatose patients as well as in palliative care and preterm infants undergoing painful procedures. Morphine, salbutamol, methadone, lidocaine, propranolol, theophylline, and mianserin, which allow to avoid the hepatic first-pass effect, are examples of preference of rectal route over oral one. Only two main classes of antibiotics (β-lactams and macrolides) have been studied recently after the rectal route of their administration. With the help of modern pharmaceutics and novel RDDS, higher bioavailability and controlled release of the drug have become possible. A number of antiepileptic drugs can be given rectally either for acute seizure control or in maintenance therapy. UC can be effectively treated with topical formulations and is superior to rectal corticosteroids. To suppositories most often used in Europe and the United States for their local treatments belong: bisacodyl, glycerol, mesalazine, diclofenac, glyceryl trinitrate, budesonide, prednisolone, and hydrocortisone. Suppositories applied for treatment of systemic conditions are more numerous.
- Źródło:
-
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 3; 417-421
0001-6837
2353-5288 - Pojawia się w:
- Acta Poloniae Pharmaceutica - Drug Research
- Dostawca treści:
- Biblioteka Nauki
Artykuł