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    Wyświetlanie 1-11 z 11
    Tytuł:
    Synthesis characterization and antimicrobial activity of ethyl-4-(2,4-dichlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-thioxopyrimidine-5-carboxylate
    Autorzy:
    Pasupathi, M.
    Santhi, N.
    Powiązania:
    https://bibliotekanauki.pl/articles/1076112.pdf
    Data publikacji:
    2019
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    MIC
    antimicrobial
    mesoporous
    pyrimidine
    Opis:
    Heteroatoms like nitrogen, sulfur, and oxygen containing biologically active ethyl 4-(2,4-dichlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-thioxopyrimidine-5-carboxylate was synthesized from 2,4-dichloro benzaldehyde, acetoacetic ester and thiourea using AlTiTUD-1 as a catalyst. The synthesized compound was characterized by FT-IR, 1H and 13C NMR spectral values. The compound possesses good antimicrobial activity is determined by well diffusion method against gram positive, gram negative and fungal species. The minimum inhibitory concentration value of the compound was determined by broth dilution method.
    Źródło:
    World Scientific News; 2019, 117; 212-220
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synthesis and Characterization of Aroylhydrazino Derivatives of Pharmacologically Active Pyrimidine-5-carbonitrile
    Autorzy:
    Pragna, T.
    Dhaval, H.
    Jayesh, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/411928.pdf
    Data publikacji:
    2014
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    pyrimidine-5-carbonitrile
    aroylchlorides
    benzohydrazide
    Opis:
    The target compound N'-(5-Cyano-4-(4-fluorophenyl)-1,6-dihydro-1-methyl-6-oxopyrimidin-2-yl)-4-methylbenzohydrazide have been synthesized by the condensation of 4-(4-Fluorophenyl)-2-hydrazinyl-1,6-dihydro-1-methyl-6-oxopyrimidine-5-carbonitrile with different aroylchlorides. The obtained products were characterized by 1H NMR, Mass and IR Spectra.
    Źródło:
    International Letters of Chemistry, Physics and Astronomy; 2014, 20, 2; 129-135
    2299-3843
    Pojawia się w:
    International Letters of Chemistry, Physics and Astronomy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synthesis and characterization of 2-(methylthio)-6-oxo-6H-chromeno[3,4-e]pyrazolo[1,5-a]pyrimidine-3-carbonitrile derivatives
    Autorzy:
    Ajudiya, Yogesh M.
    Babariya, Jayesh S.
    Upadhyay, J. J.
    Powiązania:
    https://bibliotekanauki.pl/articles/1070890.pdf
    Data publikacji:
    2019
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Pyrazolo pyrimidine
    Schiff base
    coumarine
    Opis:
    Some new 2-(methylthio)-6-oxo-6H-chromeno[3,4-e]pyrazolo[1,5-a]pyrimidine-3-carbonitrile derivatives Having coumarine nucleus were synthesized by novel synthetic rout from 4-chloro 3-carbaldehyde coumarine derivatives and previously prepared 5-amino-3-(methylthio)-1H-pyrazole-4-carbonitrile using methanol as a solvent and catalytic amount of glacial acetic acid. All the synthesised libraries were characterized by IR, NMR and mass spectral analysis.
    Źródło:
    World Scientific News; 2019, 123; 258-264
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Ultrasonic velocity, density and viscosity measurement of pyrimidine derivatives in 1,4-dioxane and DMF at various temperatures
    Autorzy:
    Baluja, Shipra
    Nandha, Kajal
    Ramavat, Paras
    Powiązania:
    https://bibliotekanauki.pl/articles/1190220.pdf
    Data publikacji:
    2016
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Pyrimidine derivatives
    ultrasonic velocity
    viscometry
    molecular interaction
    apparent molar compressibility
    Opis:
    The estimation of density, viscosity and ultrasonic velocity of solution of pyrimidine derivatives in 1,4-dioxane and N,N-dimethylformamide was carried out as functions of concentration (0.01 to 0.1 M) and temperature (298.15 to 318.15 K). Some acoustical and apparent parameters such as acoustical impedance (Z), intermolecular free length (Lf), adiabatic compressibility (κs), molar compressibility (W), Vander Waals constant (b), relaxation strength (r), internal pressure (π), apparent molar compressibility (fk), apparent molar volume (fv) etc., have been evaluated using experimental data of ultrasonic velocity (U), density (ρ) and viscosity (η). The characterization of these synthesized compounds was done by IR, 1H NMR and mass spectral data.
    Źródło:
    World Scientific News; 2016, 44; 257-278
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Solubility of pyrimidine derivatives in different organic solvents at different temperatures
    Autorzy:
    Baluja, Shipra
    Powiązania:
    https://bibliotekanauki.pl/articles/1190176.pdf
    Data publikacji:
    2016
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    pyrimidine derivatives
    Apelblat equation
    Buchowski-Ksiazack λh equation
    Gibb׳s energy
    Opis:
    The objective of this study was to measure and correlate the solubility of pyrimidine derivatives in five different solvents namely chloroform, N,N-dimethylformamide, tetrahydrofuran, 1,4-dioxane and ethyl acetate from 298.15 to 328.15 K under atmospheric pressure of 0.1 MPa using gravimetric method. The characterization of all the synthesized compounds was done by IR, NMR and mass spectra. The modified Apelblat and Buchowski-Ksiazczak λh equations were used to correlate the experimental solubility data. Using Van’t Hoff and Gibb’s equations, some thermodynamic parameters such as Gibb’s free energy, enthalpy and entropy of dissolution were evaluated from solubility data. It is found that solubility increases with temperature.
    Źródło:
    World Scientific News; 2016, 44; 13-34
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synthesis of novel 2-mercapto-4-(p-aminophenyl sulphonylamino)-6-(aryl)-pyrimidine-5-carboxamide derivatives via the Biginelli reaction
    Autorzy:
    Bhuva, N. H.
    Gothalia, V. K.
    Singala, P. M.
    Talpara, P. K.
    Faldu, V. J.
    Shah, V. H.
    Powiązania:
    https://bibliotekanauki.pl/articles/412069.pdf
    Data publikacji:
    2014
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    2-mercapto-4-(p-aminophenylsulphonylamino)-6-(aryl)-pyrimidine-5-carboxamide
    Biginelli condensation
    Opis:
    Series of 2-mercapto-4-(p-aminophenylsulphonylamino)-6-(aryl)-pyrimidine-5-carboxamide Aa-h were synthesized via the biginelli condensation. 2-mercapto-4-amino-6-(aryl)-pyrimidine-5-carboxamide react with p-acetamidophenylsulphonylchloride in the presence of pyridine 2 to form 2-mercapto-4-(p-acetamidophenylsulphonylamino)-6-(aryl)-pyrimidine-5-carboxamide 3. It was treated with diluted HCl under reflux afforded 2-mercapto-4-(p-aminophenylsulphonylamino)-6-(aryl)-pyrimidine-5-carboxamide A a-h. The newly synthesized compounds were characterized by elemental analyses, infrared (IR), 1H NMR and 13 C NMR spectroscopic investigation.
    Źródło:
    International Letters of Chemistry, Physics and Astronomy; 2014, 17, 2; 168-173
    2299-3843
    Pojawia się w:
    International Letters of Chemistry, Physics and Astronomy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Aktywność biologiczna pochodnych tiazolo[4,5-d]pirymidyny
    Biological activity of thiazolo[4,5-d]pyrimidine derivatives
    Autorzy:
    Becan, L.
    Powiązania:
    https://bibliotekanauki.pl/articles/171536.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    pochodne tiazolo[4,5-d]pirymidyny synteza
    aktywność biologiczna
    thiazolo[4,5-d]pyrimidine derivatives synthesis
    biological activity
    Opis:
    Thiazolo[4,5-d]pyrimidine is one of the six structural isomers of the bicyclic ring system containing thiazole moiety fused with the pyrimidine. There are six structural isomers depending on the position of the nitrogen atoms. The isomer [4,5-d] does not contain the bridge-head nitrogen and can be considered as 7-thio analogue of the natural purine bases such as guanine and adenine. Due to the great of their biological potential the newly synthesized compounds are evaluated for various pharmacological activities. This review presents numerous thiazolo[4,5-d]pyrimidine derivatives reported for their interesting biological activity including antibacterial [2, 3, 5, 7, 8, 10, 19], antifungal [2–6, 9, 10], antiviral [11–13], analgesic [18, 19], antidepressant [17] and anticancer properties [23–26]. Some urea and thiourea derivatives exhibited significant antiparkinsonian activity [14–16]. Tumor necrosis factor (TNF) promotes an inflammatory response, which in turn causes many of the clinical problems associated with autoimmune disorders. Ethyl 4-(2-amino-5,7-dioxo-3,4,5,7-tetrahydro-thiazolo[4,5-d]pyrimidin- 6(2H)-yl)butanoate derivatives 29 (Fig. 24) as a TNFα inhibitors have a potential use in the treatment of diseases such as refractory asthma, psoriasis, rheumatoid arthritis, irritable bowel syndrome, and other [21]. Blocade of the CXCR2 receptor by thiazolo[4,5-d]pyrimidine-2(3H)-ones also represents an attractive strategy for treatment of inflammatory diseases [20]. Recently there have been developed CX3CR1 receptor antagonists for the treatment of multiple sclerosis [22]. Isatoribine, 5-amino-3-β-D-ribofuranosyl-3H-thiazolo[4,5-d]pyrimidin-2-one (20) (Fig. 15) is a small molecule toll-like receptor 7 (TLR7) agonist and an activator of innate immunity. Its orally bioavailable analogue ANA 975 (Fig. 16) has been reported for probable use in treating disease states associated with abnormal cell growth, such as cancer and has anti HCV activity [13]. Thiazolo[4,5-d]pyrimidines inhibit the growth of the weeds which implies that they have a potential as herbicides [27].
    Źródło:
    Wiadomości Chemiczne; 2013, 67, 11-12; 1051-1074
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synthesis and characterization of diversely substituted pyrimidine-3-carboxamide and their antimicrobial evaluation
    Autorzy:
    Senjani, Hardik K.
    Joshi, H. D.
    Powiązania:
    https://bibliotekanauki.pl/articles/1031771.pdf
    Data publikacji:
    2020
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    1-4-dihydropyrimidine
    analgesic
    anti-inflammatory
    antibacterial
    anticonvulsant
    antifungal
    antimicrobial
    antituberculosis
    antitumor
    biginalli
    dihydropyrimidine
    insecticidal
    multi-component reaction
    pyrimidine
    Opis:
    Pyrimidine related fused heterocycles are attracted to every chemist during the last decade for their biological and chemotherapeutic importance. Pyrimidine derivatives play a vital role in their broad spectrum of biological activities including antituberculosis, anticonvulsant, anti-inflammatory, insecticidal, antifungal, analgesic, and antitumor properties and there of interest as potential bioactive molecules. The nitrogen-containing fragment may be an amidine, urea, thiourea, or guanidine, and adamantine homologs and aromatic aldehyde serve as an excellent illustrative example in that it readily undergoes as Biginali MCRs reaction. Pyrimidines and their derivatives are considered to be important for drugs and agricultural chemicals. Pyrimidine derivatives possess several interesting biological activities. Pyrimidine is a basic nucleus in DNA & RNA, it is associated with diverse biological activities so, we have designed and prepared a novel highly functionalized pyrimidine library of 1,4 DHP and DHPM via a one-pot multi-component (MCRs) synthesis and we screened for antimicrobial activity against various strains.
    Źródło:
    World Scientific News; 2020, 150; 39-77
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Syntezy układu tiazolo[4,5-d]pirymidyny
    Syntheses of the thiazolo[4,5-d]pyrimidine system
    Autorzy:
    Becan, L.
    Powiązania:
    https://bibliotekanauki.pl/articles/172601.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    pochodne tiazolo[4,5-d]pirymidyny
    metoda otrzymywania
    synteza
    synteza bicyklicznego układu
    thiazolo[4,5-d]pyrimidine derivatives
    synthesis
    ring system
    method of obtaining
    Opis:
    This review is focused on the literature data about the preparation of the thiazolo[4,5-d]pyrimidine scaffold. The synthesis of this ring system has been accomplished by various methods. The synthesis can proceed via a pyrimidine onto which a thiazole ring can be annulated. The second approach involve annulation of a pyrimidine ring onto the preformed thiazole ring. Thiazolo[4,5-d]pyrimidines have been obtained by condensation of pyrimidine derivatives with thioamides [2], thionyl chloride [3], thiourea [4], bromomalononitrile [5], isothiocyanates [6] or under the influence of temperature [7]. However, most of the literature refers the methods of synthesis which begin with formation of the appropriately substituted thiazole ring. This synthetic route for preparation of fused derivatives utilizes orhtoesters [8, 9], acetic anhydride [9,10], formic acid derivatives [11, 12], carbon disulfide [13,14], appropriate isothiocyanates [15-18], urea and hydrazine derivatives [19–23], aromatic aldehydes and acid chlorides [24, 25] as key building blocks. Cyclization also occurs in high temperature or acidic reaction medium [26, 27]. The solid-phase synthesis was also described [28].
    Źródło:
    Wiadomości Chemiczne; 2014, 68, 1-2; 95-116
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Analysis of chromosome aberrations, sister chromatid exchanges [SCE] and cell division kinetics in human lymphocytes exposed in vitro to new monophosphates of pyrimidine acyclonucleosides
    Autorzy:
    Ferenc, T
    Rutkowski, M.
    Bratkowska, W.
    Hubner, H.
    Draminski, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2044452.pdf
    Data publikacji:
    1998
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    statistical analysis
    chromatid gap
    chromosome number
    enzyme activity
    chromosome aberration
    in vitro
    chromosome gap
    pyrimidine
    phosphorylase
    acyclonucleoside monophosphate
    human lymphocyte
    sister chromatid exchange
    cell division
    Opis:
    Five newly synthesised monophosphates of two pyrimidine acyclonucleoside series, namely 1-N-[(2’-hydroxy)ethoxymethyl] and l-N-[(l’,3’-dihydroxy)- 2’-propoxymethyl] derivatives of 5- and 5,6-alkylated uracils were tested in vitro for chromosome aberrations and sister chromatid exchanges (SCE). Metaphase plates were obtained via microculture of human lymphocytes from heparinized peripheral blood. The compounds were tested in doses: 10, 20, 40, 80 and 150 µg per mL of culture. The tested compounds induced mainly chromatid gaps, less frequently chromosome gaps. A low number of mitoses with chromatid and chromosome breaks, acentric fragments, dicentric chromosomes and exchange figures were also observed. The tested compounds in doses: 40, 80 and 150 µg per mL, doubled or tripled the percentage of cells with chromatid gaps and chromosome gaps as compared to the control. The percentage o cells with aberrations (excluding gaps) induced by the tested compounds in all doses did not exceed 2%. The tested compounds induced a higher number of SCE per cell but less than double frequency as compared to the control. SCE frequencies and replication index (RI) values varied depending on the examined compounds. For the highest dose of the tested compounds (150 µg per mL) a significant decrease in RI values was observed for l-N-[(2’-hydroxy)ethoxymethyl]-5,6-tetramethyleneuracil monophosphate and for l-N-[(2’-hydroxy)ethoxymethyl]-5,6-dimethyluracil monophosphate. So far, the results have indicated potential clastogenicity of all the tested compounds except acycloguanosine monophosphate.
    Źródło:
    Journal of Applied Genetics; 1998, 39, 1; 113-127
    1234-1983
    Pojawia się w:
    Journal of Applied Genetics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synthesis and characterization of novel pyrimidine derivatives of N-pentyl-2,7-diphenyl-3,8a-dihydroimidazo[1,2-a]pyrimidin-3-amine via 4-phenylpyrimidin-2-amine
    Autorzy:
    Ramade, Kadachha Raju
    Rojivadiya, Atul J.
    Naliapara, Yogesh T.
    Babariya, Jayesh S.
    Powiązania:
    https://bibliotekanauki.pl/articles/1839572.pdf
    Data publikacji:
    2021
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    imidazole
    pyrimidine
    N-pentyl-2.7-diphenyl-3.8a-dihydroimidazo[1.2-a]pyrimidin-3-amine
    4-phenylpyrimidin-2-amine
    triflouro acetic acid
    benzyldehyde
    Opis:
    The target compound N-pentyl-2,7-diphenyl-3,8a-dihydroimidazo[1,2-a]pyrimidin-3-amine have been synthesized by4-phenylpyrimidin-2-amine with Triflouro acetic acid and benzyldehyde. The obtained products were characterized by 1H NMR, Mass and IR Spectra. Purity of all the compounds has been checked on thin layer chromatographic plate and NMR analysis technique.
    Źródło:
    World News of Natural Sciences; 2021, 37; 92-101
    2543-5426
    Pojawia się w:
    World News of Natural Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-11 z 11

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