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Wyszukujesz frazę "pyrazoles" wg kryterium: Temat

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    Wyświetlanie 1-4 z 4
    Tytuł:
    Synthesis and antimicrobial activity of 5-(2’-n-butyl-4’-chloro-1’-H-imidazol-5’-yl)-3-aryl-4,5-dihydro-{1-H/1-acetyl/1-phenyl}-pyrazoles
    Autorzy:
    Joshi, A. K.
    Purohit, D. M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1031465.pdf
    Data publikacji:
    2021
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Acetyl Pyrazoles
    Antimicrobial activity
    Phenyl Pyrazoles
    Simple Pyrazoles
    Opis:
    5-(2’-n-butyl-4’-chloro 1’-H-imidazol- 5’-yl)-3-aryl-4, 5-dihydro-1-H-pyrazoles. (2a-2j); 1-[5’-(2”-n-butyl-4”- chloro-1”-H-imidazol-5”-yl)-3’-Aryl-4’, 5’-dihydro-1’-H-pyrazol-1-yl]-ethanones. (3a-3j); 5-(2’-n-butyl-4’-chloro-1’-H-imidazol-5’-yl)-3-Aryl-1-phenyl-4, 5-dihydro-1-H-pyrazoles. (4a-4j) have been synthesized. The products have been assayed for their antimicrobial activity against Gram +ve bacteria and Gram –ve bacteria and antifungal activity. The products have been characterised by IR, 1HNMR, Mass Spectra and TLC.
    Źródło:
    World News of Natural Sciences; 2021, 35; 38-47
    2543-5426
    Pojawia się w:
    World News of Natural Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    4-(3-(2-amino-3,5-dibromophenyl)-1-(4-substitutedbenzoyl)-4,5-dihydro-1H-pyrazol-5-yl)benzonitrile as a novel anti-Inflammatory scaffold: synthesis, biological evaluation and docking studies
    Autorzy:
    Bharathi, R.
    Santhi, N.
    Powiązania:
    https://bibliotekanauki.pl/articles/1075445.pdf
    Data publikacji:
    2019
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    anti-inflammatory
    benzonitrile
    pyrazoles
    spectral IR
    spectral NMR
    Opis:
    A new series, 4-(3-(2-amino-3,5-dibromophenyl)-1-(4-substitutedbenzoyl)-4,5-dihydro-1H-pyrazol-5-yl)benzonitrile (4a-h), were synthesized and evaluated for in vitro anti-inflammatory activities. The spectral (IR, NMR) and elemental analyses data of the product indicated the formation of new pyrazoles 4a-h. Compound 4e exhibited potent anti-inflammatory property about 85.45 % inhibitions. This value was compared with standard diclofenac sodium. Additionally, molecular docking increased our understanding of their receptor-ligand binding. These results demonstrated that pyrazole derivatives are potential inhibitors. Overall, the results suggest that the pyrazoles 4a-h is important lead compounds for the continuing battle against inflammation.
    Źródło:
    World Scientific News; 2019, 126; 148-162
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    DESIGN, SYNTHESIS AND BIOLOGICAL ESTIMATION OF INNOVATIVE PYRAZOLES AS ANTICANCER AGENTS TARGETING CDK2
    Autorzy:
    Ibrahim, Diaa A.
    Radini, Ibrahim A.
    KHIDRE, Rizk E.
    Powiązania:
    https://bibliotekanauki.pl/articles/895649.pdf
    Data publikacji:
    2019-06-28
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    Pharmacophore
    binding energy
    pyrazoles
    anti-proliferative activity
    CDK2 inhibitors
    Docking study
    Opis:
    CDK2, which exhibits an indispensable role as an organizer of cell growth, is the powerfully studied protein Kinases objective of anticancer suppressors. The present study was dedicated to design (pharmacophore, docking, and binding energy) and to prepare an inspired derivatives of pyrazole and pyrazolo[1,5-d]pyrimidine as promising anticancer agents, which can act by targeting CDK2. The promising compounds were selected according to their fit-value and binding energy scores. The anticancer activity against MCF-7 was tested for the prepared compounds and compounds 2, 3b, and 7b showed expressive activity with IC50 1.75, 0.89 and 1.32 µM respectively. The CDK2 evaluation was carried out to estimate the efficiency of the prepared compounds as promising inhibitors. The results revealed that compound 3b with effective inhibitory activity against tumor growth and with its potent inhibition against the CDK2 enzyme with percent inhibition 86 would be a prospective anticancer agent. The prepared compounds with high biological activity could be used as lead inhibitors for the CDK2 kinase domain.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 3; 453-468
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synthesis and spectral correlation study of some 3-(3,4-dichlorophenyl)-5-(substituted phenyl)-4,5-dihydro-1H-pyrazole-1-yl-ethanones
    Autorzy:
    Thirunarayanan, G.
    Ravi, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/412390.pdf
    Data publikacji:
    2013
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Solvent-free cyclization cum acetylation
    N-acetyl pyrazoles
    IR spectra
    NMR spectra
    Hammett correlations
    Opis:
    Some N-acetyl pyrazoles including 3-(3,4-dichlorophenyl)-5-(substituted phenyl)-4,5-dihydro-1H-pyrazole-1-yl-ethanones have been synthesised by solvent free cyclization cum acetylation of chalcones including substituted styryl 3,4-dichlorophenyl ketones using hydrazine hydrate and acetic anhydride in presence of catalytic amount of fly-ash: H2SO4 catalyst. The yield of these N-acetyl pyrazole derivatives are more than 75 %. The synthesised N-acetyl pyrazoline derivatives were characterized by their physical constants and spectral data. The infrared spectral νC=N and C=O (cm-1) frequencies, NMR chemical shifts (δ, ppm) of Ha, Hb, Hc, CH3 protons, C=N, C=O and CH3 carbons of 1-(3-(3,4-dichlorophenyl)-5-(substitutedphenyl)-4,5-dihydro-1H-pyrazole-1-yl) ethanones have been assigned and correlated with Hammett substituent constants and Swain-Lupton’s parameters using single and multi-regression analysis. From the results of statistical analyses the effect of substituents on the above group frequencies and chemical shifts of the acetylated pyrazoles were discussed.
    Źródło:
    International Letters of Chemistry, Physics and Astronomy; 2013, 14; 44-57
    2299-3843
    Pojawia się w:
    International Letters of Chemistry, Physics and Astronomy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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